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Protein

Apolipoprotein A-V

Gene

Apoa5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and a inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein A-V
Short name:
Apo-AV
Short name:
ApoA-V
Alternative name(s):
Apolipoprotein A5
Regeneration-associated protein 3
Gene namesi
Name:Apoa5
Synonyms:Rap3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi70903. Apoa5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chylomicron, HDL, Secreted, VLDL

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 367347Apolipoprotein A-VPRO_0000001983Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei52 – 521PhosphoserineCombined sources

Post-translational modificationi

Phosphorylated by FAM20C in the extracellular medium.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9QUH3.
PRIDEiQ9QUH3.

PTM databases

iPTMnetiQ9QUH3.
PhosphoSiteiQ9QUH3.

Expressioni

Tissue specificityi

Liver.1 Publication

Inductioni

Induced in early phase of liver regeneration. Expression is maximally increased 6 hours after partial hepatectomy, both at the liver RNA level and at the plasma protein level.1 Publication

Gene expression databases

BgeeiENSRNOG00000018436.
GenevisibleiQ9QUH3. RN.

Interactioni

Subunit structurei

Interacts with GPIHBP1.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024918.

Structurei

3D structure databases

ProteinModelPortaliQ9QUH3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili231 – 25525Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the apolipoprotein A1/A4/E family.Curated

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiENOG410IKFF. Eukaryota.
ENOG410YHUG. LUCA.
HOGENOMiHOG000253942.
HOVERGENiHBG050545.
InParanoidiQ9QUH3.
KOiK09025.
OrthoDBiEOG091G0IA5.
PhylomeDBiQ9QUH3.
TreeFamiTF334458.

Family and domain databases

InterProiIPR000074. ApoA_E.
[Graphical view]
PfamiPF01442. Apolipoprotein. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QUH3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVITWALA LLSVFATVQA RKSFWEYFGQ NSQGKGMMGQ QQKLAQESLK
60 70 80 90 100
GSLEQDLYNM NNFLEKLGPL REPGKEPPRL AQDPEGIRKQ LQQELEEVST
110 120 130 140 150
RLEPYMAAKH QQVGWNLEGL RQQLKPYTVE LMEQVGLSVQ DLQEQLRMVG
160 170 180 190 200
KGTKAQLLGG VDEAMSLLQD MQSRVLHHTD RVKELFHPYA ERLVTGIGHH
210 220 230 240 250
VQELHRSVAP HAVASPARLS RCVQTLSHKL TRKAKDLHTS IQRNLDQLRD
260 270 280 290 300
ELSTFIRVST DGADNRDSLD PQALSDEVRQ RLQAFRHDTY LQIAAFTQAI
310 320 330 340 350
DQETEEIQHQ LAPPPPSHSA FAPELGHSDS NKALSRLQSR LDDLWEDIAY
360
GLHDQGHSQN NPEGHSG
Length:367
Mass (Da):41,427
Last modified:May 1, 2000 - v1
Checksum:iD5B1A4F4CB016478
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF202887 mRNA. Translation: AAF25659.1.
AF202888 mRNA. Translation: AAF25660.1.
BC089780 mRNA. Translation: AAH89780.1.
RefSeqiNP_001264193.1. NM_001277264.1.
NP_542143.1. NM_080576.2.
UniGeneiRn.48763.

Genome annotation databases

GeneIDi140638.
KEGGirno:140638.
UCSCiRGD:70903. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF202887 mRNA. Translation: AAF25659.1.
AF202888 mRNA. Translation: AAF25660.1.
BC089780 mRNA. Translation: AAH89780.1.
RefSeqiNP_001264193.1. NM_001277264.1.
NP_542143.1. NM_080576.2.
UniGeneiRn.48763.

3D structure databases

ProteinModelPortaliQ9QUH3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024918.

PTM databases

iPTMnetiQ9QUH3.
PhosphoSiteiQ9QUH3.

Proteomic databases

PaxDbiQ9QUH3.
PRIDEiQ9QUH3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi140638.
KEGGirno:140638.
UCSCiRGD:70903. rat.

Organism-specific databases

CTDi116519.
RGDi70903. Apoa5.

Phylogenomic databases

eggNOGiENOG410IKFF. Eukaryota.
ENOG410YHUG. LUCA.
HOGENOMiHOG000253942.
HOVERGENiHBG050545.
InParanoidiQ9QUH3.
KOiK09025.
OrthoDBiEOG091G0IA5.
PhylomeDBiQ9QUH3.
TreeFamiTF334458.

Miscellaneous databases

PROiQ9QUH3.

Gene expression databases

BgeeiENSRNOG00000018436.
GenevisibleiQ9QUH3. RN.

Family and domain databases

InterProiIPR000074. ApoA_E.
[Graphical view]
PfamiPF01442. Apolipoprotein. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAPOA5_RAT
AccessioniPrimary (citable) accession number: Q9QUH3
Secondary accession number(s): Q5FVT8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.