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Protein

Glutaredoxin-1

Gene

Glrx

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-499943. Synthesis and interconversion of nucleotide di- and triphosphates.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutaredoxin-1
Alternative name(s):
Thioltransferase-1
Short name:
TTase-1
Gene namesi
Name:Glrx
Synonyms:Glrx1, Grx, Grx1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:2135625. Glrx.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • extracellular exosome Source: MGI
  • mitochondrion Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi23 – 231C → S: Loss of activity. 1 Publication
Mutagenesisi26 – 261C → S: Loss of activity. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 107106Glutaredoxin-1PRO_0000141601Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineCombined sources
Modified residuei9 – 91N6-succinyllysineCombined sources
Disulfide bondi23 ↔ 26Redox-active
Disulfide bondi79 ↔ 83By similarity

Keywords - PTMi

Acetylation, Disulfide bond

Proteomic databases

EPDiQ9QUH0.
MaxQBiQ9QUH0.
PaxDbiQ9QUH0.
PRIDEiQ9QUH0.

PTM databases

iPTMnetiQ9QUH0.
PhosphoSiteiQ9QUH0.
SwissPalmiQ9QUH0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000021591.
CleanExiMM_GLRX.
ExpressionAtlasiQ9QUH0. baseline and differential.
GenevisibleiQ9QUH0. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022082.

Structurei

3D structure databases

ProteinModelPortaliQ9QUH0.
SMRiQ9QUH0. Positions 2-106.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 106104GlutaredoxinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the glutaredoxin family.Curated
Contains 1 glutaredoxin domain.PROSITE-ProRule annotation

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiKOG1752. Eukaryota.
COG0695. LUCA.
GeneTreeiENSGT00390000003677.
HOGENOMiHOG000095204.
HOVERGENiHBG000283.
InParanoidiQ9QUH0.
KOiK03676.
OMAiVFIGEEC.
OrthoDBiEOG091G0WLY.
PhylomeDBiQ9QUH0.
TreeFamiTF326994.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR011767. GLR_AS.
IPR002109. Glutaredoxin.
IPR011899. Glutaredoxin_euk/vir.
IPR014025. Glutaredoxin_subgr.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00462. Glutaredoxin. 1 hit.
[Graphical view]
PRINTSiPR00160. GLUTAREDOXIN.
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR02180. GRX_euk. 1 hit.
PROSITEiPS00195. GLUTAREDOXIN_1. 1 hit.
PS51354. GLUTAREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QUH0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQEFVNCKI QSGKVVVFIK PTCPYCRKTQ EILSQLPFKQ GLLEFVDITA
60 70 80 90 100
TNNTSAIQDY LQQLTGARTV PRVFIGKDCI GGCSDLISMQ QTGELMTRLK

QIGALQL
Length:107
Mass (Da):11,871
Last modified:January 23, 2007 - v3
Checksum:iDC0C7718DCD8805F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB013137 mRNA. Translation: BAA86926.1.
AF109314 mRNA. Translation: AAF04780.1.
AF276917 mRNA. Translation: AAF86464.1.
BC012642 mRNA. Translation: AAH12642.1.
CCDSiCCDS26651.1.
RefSeqiNP_444338.2. NM_053108.4.
XP_006517540.1. XM_006517477.1.
UniGeneiMm.25844.

Genome annotation databases

EnsembliENSMUST00000022082; ENSMUSP00000022082; ENSMUSG00000021591.
GeneIDi93692.
KEGGimmu:93692.
UCSCiuc007rfx.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB013137 mRNA. Translation: BAA86926.1.
AF109314 mRNA. Translation: AAF04780.1.
AF276917 mRNA. Translation: AAF86464.1.
BC012642 mRNA. Translation: AAH12642.1.
CCDSiCCDS26651.1.
RefSeqiNP_444338.2. NM_053108.4.
XP_006517540.1. XM_006517477.1.
UniGeneiMm.25844.

3D structure databases

ProteinModelPortaliQ9QUH0.
SMRiQ9QUH0. Positions 2-106.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022082.

PTM databases

iPTMnetiQ9QUH0.
PhosphoSiteiQ9QUH0.
SwissPalmiQ9QUH0.

Proteomic databases

EPDiQ9QUH0.
MaxQBiQ9QUH0.
PaxDbiQ9QUH0.
PRIDEiQ9QUH0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022082; ENSMUSP00000022082; ENSMUSG00000021591.
GeneIDi93692.
KEGGimmu:93692.
UCSCiuc007rfx.2. mouse.

Organism-specific databases

CTDi2745.
MGIiMGI:2135625. Glrx.

Phylogenomic databases

eggNOGiKOG1752. Eukaryota.
COG0695. LUCA.
GeneTreeiENSGT00390000003677.
HOGENOMiHOG000095204.
HOVERGENiHBG000283.
InParanoidiQ9QUH0.
KOiK03676.
OMAiVFIGEEC.
OrthoDBiEOG091G0WLY.
PhylomeDBiQ9QUH0.
TreeFamiTF326994.

Enzyme and pathway databases

ReactomeiR-MMU-499943. Synthesis and interconversion of nucleotide di- and triphosphates.

Miscellaneous databases

PROiQ9QUH0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021591.
CleanExiMM_GLRX.
ExpressionAtlasiQ9QUH0. baseline and differential.
GenevisibleiQ9QUH0. MM.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR011767. GLR_AS.
IPR002109. Glutaredoxin.
IPR011899. Glutaredoxin_euk/vir.
IPR014025. Glutaredoxin_subgr.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00462. Glutaredoxin. 1 hit.
[Graphical view]
PRINTSiPR00160. GLUTAREDOXIN.
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR02180. GRX_euk. 1 hit.
PROSITEiPS00195. GLUTAREDOXIN_1. 1 hit.
PS51354. GLUTAREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGLRX1_MOUSE
AccessioniPrimary (citable) accession number: Q9QUH0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 131 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.