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Q9QUG9

- GRP2_MOUSE

UniProt

Q9QUG9 - GRP2_MOUSE

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Protein

RAS guanyl-releasing protein 2

Gene
Rasgrp2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP. May also activates other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably through inside-out integrin activation. May function in the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway.9 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi439 – 450121 Reviewed predictionAdd
BLAST
Calcium bindingi468 – 479122 Reviewed predictionAdd
BLAST
Zinc fingeri498 – 54851Phorbol-ester/DAG-typeAdd
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. guanyl-nucleotide exchange factor activity Source: UniProtKB-KW

GO - Biological processi

  1. regulation of small GTPase mediated signal transduction Source: InterPro
  2. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Keywords - Ligandi

Calcium, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_219232. Effects of PIP2 hydrolysis.

Names & Taxonomyi

Protein namesi
Recommended name:
RAS guanyl-releasing protein 2
Alternative name(s):
Calcium and DAG-regulated guanine nucleotide exchange factor I
Short name:
CalDAG-GEFI
F25B3.3 kinase-like protein
Gene namesi
Name:Rasgrp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:1333849. Rasgrp2.

Subcellular locationi

Cytoplasmcytosol By similarity. Cell membrane; Peripheral membrane protein By similarity. Cell junctionsynapsesynaptosome By similarity. Cell projectionruffle membrane; Peripheral membrane protein Reviewed prediction
Note: Found both in the cytosol and associated with membranes By similarity. Enriched at juxtamembrane areas and membrane ruffles By similarity. Localizes to the cell bodies and axons of striatal neurons By similarity.

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. cytosol Source: UniProtKB
  3. neuron projection Source: UniProtKB-SubCell
  4. plasma membrane Source: UniProtKB
  5. ruffle membrane Source: UniProtKB-SubCell
  6. synapse Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Membrane, Synapse, Synaptosome

Pathology & Biotechi

Disruption phenotypei

Mice have a combination of defects in leukocytes and platelet functions which are reminiscent of the human leukocyte adhesion deficiency type III syndrome (LAD3). They display bleeding diathesis due to a defect in platelet aggregation and are resistant to collagen-induced thrombosis. In parallel, they also display impaired response to acute inflammation associated with defects in beta-1 and beta-2 integrin-mediated adhesion of neutrophils.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 608608RAS guanyl-releasing protein 2PRO_0000315609Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei116 – 1161Phosphoserine1 Publication
Modified residuei117 – 1171Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9QUG9.
PaxDbiQ9QUG9.
PRIDEiQ9QUG9.

PTM databases

PhosphoSiteiQ9QUG9.

Expressioni

Tissue specificityi

Detected in megakaryocytes, platelet and neutrophils but not in lymphocytes (at protein level). Isoform 1 and isoform 3 are detected in brain basal glanglia, heart, lung, spleen, liver and kidney interstitial cells.3 Publications

Developmental stagei

Expressed in embryo with higher expression between E15 and E17.1 Publication

Gene expression databases

ArrayExpressiQ9QUG9.
BgeeiQ9QUG9.
CleanExiMM_RASGRP2.
GenevestigatoriQ9QUG9.

Interactioni

Subunit structurei

Forms a signaling complex with RAP1 and BRAF. Interacts with F-actin By similarity. Interacts with RAP1.1 Publication

Protein-protein interaction databases

IntActiQ9QUG9. 1 interaction.
MINTiMINT-4130449.

Structurei

3D structure databases

ProteinModelPortaliQ9QUG9.
SMRiQ9QUG9. Positions 7-550.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 126123N-terminal Ras-GEFAdd
BLAST
Domaini154 – 387234Ras-GEFAdd
BLAST
Domaini426 – 46136EF-hand 1Add
BLAST
Domaini455 – 49036EF-hand 2Add
BLAST

Domaini

The N-terminal Ras-GEF domain mediates association with F-actin By similarity.

Sequence similaritiesi

Belongs to the RASGRP family.
Contains 2 EF-hand domains.
Contains 1 Ras-GEF domain.

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri498 – 54851Phorbol-ester/DAG-typeAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG256085.
GeneTreeiENSGT00750000117506.
HOGENOMiHOG000293171.
HOVERGENiHBG007513.
InParanoidiQ9QUG9.
KOiK12361.
OMAiFPYLSAF.
OrthoDBiEOG72G16V.
PhylomeDBiQ9QUG9.
TreeFamiTF312918.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.10.840.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
IPR000651. Ras-like_Gua-exchang_fac_N.
IPR023578. Ras_GEF_dom.
IPR001895. RasGRF_CDC25.
[Graphical view]
PfamiPF00130. C1_1. 1 hit.
PF13202. EF-hand_5. 2 hits.
PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
[Graphical view]
SMARTiSM00109. C1. 1 hit.
SM00054. EFh. 2 hits.
SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
[Graphical view]
SUPFAMiSSF48366. SSF48366. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9QUG9-1) [UniParc]FASTAAdd to Basket

Also known as: CalDAG-GEF1a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MTSTLDLDKG CTVEELLRGC IEAFDDSGKV RDPQLVRMFL MMHPWYIPSS    50
QLASKLLHFY QQSRKDNSNS LQMKTCHLVR YWISAFPAEF DLNPELAEQI 100
KELKALLDQE GNRRHSSLID IESVPTYKWK RQVTQRNPVE QKKRKMSLLF 150
DHLEPMELAE HLTYLEYRSF CKILFQDYHS FVTHGCTVDN PVLERFISLF 200
NSVSQWVQLM ILSKPTATQR ALVITHFVHV AERLLQLQNF NTLMAVVGGL 250
SHSSISRLKE THSHVSPDTI KLWEGLTELV TATGNYSNYR RRLAACVGFR 300
FPILGVHLKD LVALQLALPD WLDPGRTRLN GAKMRQLFCI LEELAMVTSL 350
RPPVQANPDL LSLLTVSLDQ YQTEDELYQL SLQREPRSKS SPTSPTSCTP 400
PPRPPVLEEW TSVAKPKLDQ ALVAEHIEKM VESVFRNFDV DGDGHISQEE 450
FQIIRGNFPY LSAFGDLDQN QDGCISREEM ISYFLRSSSV LGGRMGFVHN 500
FQESNSLRPV ACRHCKALIL GIYKQGLKCR ACGVNCHKQC KERLSVECRR 550
RAQSVSLEGS APSPSPTHTH HRAFSFSLPR PGRRSSRPPE IREEEVQSVE 600
DGVFDIHL 608
Length:608
Mass (Da):69,446
Last modified:January 15, 2008 - v2
Checksum:i1E6F768EF00B0468
GO
Isoform 2 (identifier: Q9QUG9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     472-608: Missing.

Note: No experimental confirmation available.

Show »
Length:471
Mass (Da):54,054
Checksum:i3C2F75238F062E1A
GO
Isoform 3 (identifier: Q9QUG9-3) [UniParc]FASTAAdd to Basket

Also known as: CalDAG-GEF1b

The sequence of this isoform differs from the canonical sequence as follows:
     125-141: PTYKWKRQVTQRNPVEQ → CVGAERKGHYACYTICA
     142-608: Missing.

Note: The corresponding protein is not undetectable.

Show »
Length:141
Mass (Da):16,187
Checksum:i242C314B00AD9191
GO

Sequence cautioni

The sequence BAC28797.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei125 – 14117PTYKW…NPVEQ → CVGAERKGHYACYTICA in isoform 3. VSP_030577Add
BLAST
Alternative sequencei142 – 608467Missing in isoform 3. VSP_030578Add
BLAST
Alternative sequencei472 – 608137Missing in isoform 2. VSP_030579Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 21T → A in AAC79697. 1 Publication
Sequence conflicti2 – 21T → A in AAD12742. 1 Publication
Sequence conflicti73 – 731M → V in AAC79697. 1 Publication
Sequence conflicti73 – 731M → V in AAD12742. 1 Publication
Sequence conflicti83 – 831I → V in AAC79697. 1 Publication
Sequence conflicti83 – 831I → V in AAD12742. 1 Publication
Sequence conflicti99 – 991Q → P in AAC79697. 1 Publication
Sequence conflicti99 – 991Q → P in AAD12742. 1 Publication
Sequence conflicti233 – 2331R → K in AAC79697. 1 Publication
Sequence conflicti233 – 2331R → K in AAD12742. 1 Publication
Sequence conflicti339 – 3391C → S in AAC79697. 1 Publication
Sequence conflicti339 – 3391C → S in AAD12742. 1 Publication
Sequence conflicti542 – 5421E → D in AAC79697. 1 Publication
Sequence conflicti542 – 5421E → D in AAD12742. 1 Publication
Sequence conflicti598 – 5981S → T in AAC79697. 1 Publication
Sequence conflicti598 – 5981S → T in AAD12742. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF081193 mRNA. Translation: AAC79697.1.
U78171 mRNA. Translation: AAD12742.1.
BC051474 mRNA. Translation: AAH51474.1.
AK034683 mRNA. Translation: BAC28797.1. Different initiation.
Y12339 mRNA. Translation: CAA73008.1.
CCDSiCCDS37898.1. [Q9QUG9-1]
RefSeqiNP_035372.2. NM_011242.2. [Q9QUG9-1]
XP_006531748.1. XM_006531685.1. [Q9QUG9-1]
XP_006531749.1. XM_006531686.1. [Q9QUG9-1]
XP_006531750.1. XM_006531687.1. [Q9QUG9-1]
XP_006531751.1. XM_006531688.1. [Q9QUG9-1]
XP_006531752.1. XM_006531689.1. [Q9QUG9-1]
XP_006531753.1. XM_006531690.1. [Q9QUG9-1]
XP_006531754.1. XM_006531691.1. [Q9QUG9-1]
UniGeneiMm.77017.

Genome annotation databases

EnsembliENSMUST00000035716; ENSMUSP00000041135; ENSMUSG00000032946. [Q9QUG9-1]
ENSMUST00000113471; ENSMUSP00000109099; ENSMUSG00000032946. [Q9QUG9-3]
ENSMUST00000113472; ENSMUSP00000109100; ENSMUSG00000032946. [Q9QUG9-3]
ENSMUST00000113475; ENSMUSP00000109103; ENSMUSG00000032946. [Q9QUG9-3]
ENSMUST00000113476; ENSMUSP00000109104; ENSMUSG00000032946. [Q9QUG9-1]
ENSMUST00000167240; ENSMUSP00000129873; ENSMUSG00000032946. [Q9QUG9-1]
GeneIDi19395.
KEGGimmu:19395.
UCSCiuc008gip.1. mouse. [Q9QUG9-1]
uc008gir.1. mouse. [Q9QUG9-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF081193 mRNA. Translation: AAC79697.1 .
U78171 mRNA. Translation: AAD12742.1 .
BC051474 mRNA. Translation: AAH51474.1 .
AK034683 mRNA. Translation: BAC28797.1 . Different initiation.
Y12339 mRNA. Translation: CAA73008.1 .
CCDSi CCDS37898.1. [Q9QUG9-1 ]
RefSeqi NP_035372.2. NM_011242.2. [Q9QUG9-1 ]
XP_006531748.1. XM_006531685.1. [Q9QUG9-1 ]
XP_006531749.1. XM_006531686.1. [Q9QUG9-1 ]
XP_006531750.1. XM_006531687.1. [Q9QUG9-1 ]
XP_006531751.1. XM_006531688.1. [Q9QUG9-1 ]
XP_006531752.1. XM_006531689.1. [Q9QUG9-1 ]
XP_006531753.1. XM_006531690.1. [Q9QUG9-1 ]
XP_006531754.1. XM_006531691.1. [Q9QUG9-1 ]
UniGenei Mm.77017.

3D structure databases

ProteinModelPortali Q9QUG9.
SMRi Q9QUG9. Positions 7-550.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9QUG9. 1 interaction.
MINTi MINT-4130449.

PTM databases

PhosphoSitei Q9QUG9.

Proteomic databases

MaxQBi Q9QUG9.
PaxDbi Q9QUG9.
PRIDEi Q9QUG9.

Protocols and materials databases

DNASUi 19395.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000035716 ; ENSMUSP00000041135 ; ENSMUSG00000032946 . [Q9QUG9-1 ]
ENSMUST00000113471 ; ENSMUSP00000109099 ; ENSMUSG00000032946 . [Q9QUG9-3 ]
ENSMUST00000113472 ; ENSMUSP00000109100 ; ENSMUSG00000032946 . [Q9QUG9-3 ]
ENSMUST00000113475 ; ENSMUSP00000109103 ; ENSMUSG00000032946 . [Q9QUG9-3 ]
ENSMUST00000113476 ; ENSMUSP00000109104 ; ENSMUSG00000032946 . [Q9QUG9-1 ]
ENSMUST00000167240 ; ENSMUSP00000129873 ; ENSMUSG00000032946 . [Q9QUG9-1 ]
GeneIDi 19395.
KEGGi mmu:19395.
UCSCi uc008gip.1. mouse. [Q9QUG9-1 ]
uc008gir.1. mouse. [Q9QUG9-2 ]

Organism-specific databases

CTDi 10235.
MGIi MGI:1333849. Rasgrp2.

Phylogenomic databases

eggNOGi NOG256085.
GeneTreei ENSGT00750000117506.
HOGENOMi HOG000293171.
HOVERGENi HBG007513.
InParanoidi Q9QUG9.
KOi K12361.
OMAi FPYLSAF.
OrthoDBi EOG72G16V.
PhylomeDBi Q9QUG9.
TreeFami TF312918.

Enzyme and pathway databases

Reactomei REACT_219232. Effects of PIP2 hydrolysis.

Miscellaneous databases

NextBioi 296505.
PROi Q9QUG9.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9QUG9.
Bgeei Q9QUG9.
CleanExi MM_RASGRP2.
Genevestigatori Q9QUG9.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
1.10.840.10. 1 hit.
InterProi IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
IPR000651. Ras-like_Gua-exchang_fac_N.
IPR023578. Ras_GEF_dom.
IPR001895. RasGRF_CDC25.
[Graphical view ]
Pfami PF00130. C1_1. 1 hit.
PF13202. EF-hand_5. 2 hits.
PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
[Graphical view ]
SMARTi SM00109. C1. 1 hit.
SM00054. EFh. 2 hits.
SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
[Graphical view ]
SUPFAMi SSF48366. SSF48366. 1 hit.
PROSITEi PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION AS A RAP ACTIVATOR.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Strain: C57BL/6J.
    Tissue: Mammary gland.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 204-608 (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Embryo.
  4. "The germinal centre kinase gene and a novel CDC25-like gene are located in the vicinity of the PYGM gene on 11q13."
    Kedra D., Seroussi E., Fransson I., Trifunovic J., Clark M., Lagercrantz J., Blennow E., Mehlin H., Dumanski J.
    Hum. Genet. 100:611-619(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 349-608 (ISOFORM 1).
  5. Cited for: FUNCTION.
  6. Cited for: TISSUE SPECIFICITY.
  7. Cited for: FUNCTION AS RAP2 ACTIVATOR.
  8. "Requirement for C3G-dependent Rap1 activation for cell adhesion and embryogenesis."
    Ohba Y., Ikuta K., Ogura A., Matsuda J., Mochizuki N., Nagashima K., Kurokawa K., Mayer B.J., Maki K., Miyazaki J., Matsuda M.
    EMBO J. 20:3333-3341(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  9. "Activation of the Rap1 guanine nucleotide exchange gene, CalDAG-GEF I, in BXH-2 murine myeloid leukemia."
    Dupuy A.J., Morgan K., von Lintig F.C., Shen H., Acar H., Hasz D.E., Jenkins N.A., Copeland N.G., Boss G.R., Largaespada D.A.
    J. Biol. Chem. 276:11804-11811(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, ALTERNATIVE SPLICING, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  10. "Megakaryocytes derived from embryonic stem cells implicate CalDAG-GEFI in integrin signaling."
    Eto K., Murphy R., Kerrigan S.W., Bertoni A., Stuhlmann H., Nakano T., Leavitt A.D., Shattil S.J.
    Proc. Natl. Acad. Sci. U.S.A. 99:12819-12824(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  11. "CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formation."
    Crittenden J.R., Bergmeier W., Zhang Y., Piffath C.L., Liang Y., Wagner D.D., Housman D.E., Graybiel A.M.
    Nat. Med. 10:982-986(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN PLATELET AGGREGATION, DISRUPTION PHENOTYPE, INTERACTION WITH RAP1, TISSUE SPECIFICITY.
  12. "The small GTPase Rap1b regulates the cross talk between platelet integrin alpha2beta1 and integrin alphaIIbbeta3."
    Bernardi B., Guidetti G.F., Campus F., Crittenden J.R., Graybiel A.M., Balduini C., Torti M.
    Blood 107:2728-2735(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  13. "Mice lacking the signaling molecule CalDAG-GEFI represent a model for leukocyte adhesion deficiency type III."
    Bergmeier W., Goerge T., Wang H.-W., Crittenden J.R., Baldwin A.C.W., Cifuni S.M., Housman D.E., Graybiel A.M., Wagner D.D.
    J. Clin. Invest. 117:1699-1707(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  14. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-116 AND SER-117, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiGRP2_MOUSE
AccessioniPrimary (citable) accession number: Q9QUG9
Secondary accession number(s): O09004, Q80WC0, Q8BSC8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: September 3, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi