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Q9QUG9

- GRP2_MOUSE

UniProt

Q9QUG9 - GRP2_MOUSE

Protein

RAS guanyl-releasing protein 2

Gene

Rasgrp2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 2 (15 Jan 2008)
      Previous versions | rss
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    Functioni

    Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP. May also activates other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably through inside-out integrin activation. May function in the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway.9 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi439 – 450121PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi468 – 479122PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri498 – 54851Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. guanyl-nucleotide exchange factor activity Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of small GTPase mediated signal transduction Source: InterPro
    2. small GTPase mediated signal transduction Source: InterPro

    Keywords - Molecular functioni

    Guanine-nucleotide releasing factor

    Keywords - Ligandi

    Calcium, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_219232. Effects of PIP2 hydrolysis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RAS guanyl-releasing protein 2
    Alternative name(s):
    Calcium and DAG-regulated guanine nucleotide exchange factor I
    Short name:
    CalDAG-GEFI
    F25B3.3 kinase-like protein
    Gene namesi
    Name:Rasgrp2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:1333849. Rasgrp2.

    Subcellular locationi

    Cytoplasmcytosol By similarity. Cell membrane By similarity; Peripheral membrane protein By similarity. Cell junctionsynapsesynaptosome By similarity. Cell projectionruffle membrane Curated; Peripheral membrane protein Curated
    Note: Found both in the cytosol and associated with membranes. Enriched at juxtamembrane areas and membrane ruffles. Localizes to the cell bodies and axons of striatal neurons.By similarity

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. cytosol Source: UniProtKB
    3. neuron projection Source: UniProtKB-SubCell
    4. plasma membrane Source: UniProtKB
    5. ruffle membrane Source: UniProtKB-SubCell
    6. synapse Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Cell projection, Cytoplasm, Membrane, Synapse, Synaptosome

    Pathology & Biotechi

    Disruption phenotypei

    Mice have a combination of defects in leukocytes and platelet functions which are reminiscent of the human leukocyte adhesion deficiency type III syndrome (LAD3). They display bleeding diathesis due to a defect in platelet aggregation and are resistant to collagen-induced thrombosis. In parallel, they also display impaired response to acute inflammation associated with defects in beta-1 and beta-2 integrin-mediated adhesion of neutrophils.2 Publications

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 608608RAS guanyl-releasing protein 2PRO_0000315609Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei116 – 1161Phosphoserine1 Publication
    Modified residuei117 – 1171Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9QUG9.
    PaxDbiQ9QUG9.
    PRIDEiQ9QUG9.

    PTM databases

    PhosphoSiteiQ9QUG9.

    Expressioni

    Tissue specificityi

    Detected in megakaryocytes, platelet and neutrophils but not in lymphocytes (at protein level). Isoform 1 and isoform 3 are detected in brain basal glanglia, heart, lung, spleen, liver and kidney interstitial cells.3 Publications

    Developmental stagei

    Expressed in embryo with higher expression between E15 and E17.1 Publication

    Gene expression databases

    ArrayExpressiQ9QUG9.
    BgeeiQ9QUG9.
    CleanExiMM_RASGRP2.
    GenevestigatoriQ9QUG9.

    Interactioni

    Subunit structurei

    Forms a signaling complex with RAP1 and BRAF. Interacts with F-actin By similarity. Interacts with RAP1.By similarity1 Publication

    Protein-protein interaction databases

    IntActiQ9QUG9. 1 interaction.
    MINTiMINT-4130449.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9QUG9.
    SMRiQ9QUG9. Positions 7-550.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 126123N-terminal Ras-GEFPROSITE-ProRule annotationAdd
    BLAST
    Domaini154 – 387234Ras-GEFPROSITE-ProRule annotationAdd
    BLAST
    Domaini426 – 46136EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini455 – 49036EF-hand 2PROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The N-terminal Ras-GEF domain mediates association with F-actin.By similarity

    Sequence similaritiesi

    Belongs to the RASGRP family.Curated
    Contains 2 EF-hand domains.PROSITE-ProRule annotation
    Contains 1 N-terminal Ras-GEF domain.PROSITE-ProRule annotation
    Contains 1 phorbol-ester/DAG-type zinc finger.PROSITE-ProRule annotation
    Contains 1 Ras-GEF domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri498 – 54851Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG256085.
    GeneTreeiENSGT00750000117506.
    HOGENOMiHOG000293171.
    HOVERGENiHBG007513.
    InParanoidiQ9QUG9.
    KOiK12361.
    OMAiFPYLSAF.
    OrthoDBiEOG72G16V.
    PhylomeDBiQ9QUG9.
    TreeFamiTF312918.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    1.10.840.10. 1 hit.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
    IPR000651. Ras-like_Gua-exchang_fac_N.
    IPR023578. Ras_GEF_dom.
    IPR001895. RasGRF_CDC25.
    [Graphical view]
    PfamiPF00130. C1_1. 1 hit.
    PF13202. EF-hand_5. 2 hits.
    PF00617. RasGEF. 1 hit.
    PF00618. RasGEF_N. 1 hit.
    [Graphical view]
    SMARTiSM00109. C1. 1 hit.
    SM00054. EFh. 2 hits.
    SM00147. RasGEF. 1 hit.
    SM00229. RasGEFN. 1 hit.
    [Graphical view]
    SUPFAMiSSF48366. SSF48366. 1 hit.
    PROSITEiPS00018. EF_HAND_1. 2 hits.
    PS50222. EF_HAND_2. 2 hits.
    PS50009. RASGEF_CAT. 1 hit.
    PS50212. RASGEF_NTER. 1 hit.
    PS00479. ZF_DAG_PE_1. 1 hit.
    PS50081. ZF_DAG_PE_2. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9QUG9-1) [UniParc]FASTAAdd to Basket

    Also known as: CalDAG-GEF1a

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTSTLDLDKG CTVEELLRGC IEAFDDSGKV RDPQLVRMFL MMHPWYIPSS    50
    QLASKLLHFY QQSRKDNSNS LQMKTCHLVR YWISAFPAEF DLNPELAEQI 100
    KELKALLDQE GNRRHSSLID IESVPTYKWK RQVTQRNPVE QKKRKMSLLF 150
    DHLEPMELAE HLTYLEYRSF CKILFQDYHS FVTHGCTVDN PVLERFISLF 200
    NSVSQWVQLM ILSKPTATQR ALVITHFVHV AERLLQLQNF NTLMAVVGGL 250
    SHSSISRLKE THSHVSPDTI KLWEGLTELV TATGNYSNYR RRLAACVGFR 300
    FPILGVHLKD LVALQLALPD WLDPGRTRLN GAKMRQLFCI LEELAMVTSL 350
    RPPVQANPDL LSLLTVSLDQ YQTEDELYQL SLQREPRSKS SPTSPTSCTP 400
    PPRPPVLEEW TSVAKPKLDQ ALVAEHIEKM VESVFRNFDV DGDGHISQEE 450
    FQIIRGNFPY LSAFGDLDQN QDGCISREEM ISYFLRSSSV LGGRMGFVHN 500
    FQESNSLRPV ACRHCKALIL GIYKQGLKCR ACGVNCHKQC KERLSVECRR 550
    RAQSVSLEGS APSPSPTHTH HRAFSFSLPR PGRRSSRPPE IREEEVQSVE 600
    DGVFDIHL 608
    Length:608
    Mass (Da):69,446
    Last modified:January 15, 2008 - v2
    Checksum:i1E6F768EF00B0468
    GO
    Isoform 2 (identifier: Q9QUG9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         472-608: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:471
    Mass (Da):54,054
    Checksum:i3C2F75238F062E1A
    GO
    Isoform 3 (identifier: Q9QUG9-3) [UniParc]FASTAAdd to Basket

    Also known as: CalDAG-GEF1b

    The sequence of this isoform differs from the canonical sequence as follows:
         125-141: PTYKWKRQVTQRNPVEQ → CVGAERKGHYACYTICA
         142-608: Missing.

    Note: The corresponding protein is not undetectable.

    Show »
    Length:141
    Mass (Da):16,187
    Checksum:i242C314B00AD9191
    GO

    Sequence cautioni

    The sequence BAC28797.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti2 – 21T → A in AAC79697. (PubMed:9789079)Curated
    Sequence conflicti2 – 21T → A in AAD12742. (PubMed:9789079)Curated
    Sequence conflicti73 – 731M → V in AAC79697. (PubMed:9789079)Curated
    Sequence conflicti73 – 731M → V in AAD12742. (PubMed:9789079)Curated
    Sequence conflicti83 – 831I → V in AAC79697. (PubMed:9789079)Curated
    Sequence conflicti83 – 831I → V in AAD12742. (PubMed:9789079)Curated
    Sequence conflicti99 – 991Q → P in AAC79697. (PubMed:9789079)Curated
    Sequence conflicti99 – 991Q → P in AAD12742. (PubMed:9789079)Curated
    Sequence conflicti233 – 2331R → K in AAC79697. (PubMed:9789079)Curated
    Sequence conflicti233 – 2331R → K in AAD12742. (PubMed:9789079)Curated
    Sequence conflicti339 – 3391C → S in AAC79697. (PubMed:9789079)Curated
    Sequence conflicti339 – 3391C → S in AAD12742. (PubMed:9789079)Curated
    Sequence conflicti542 – 5421E → D in AAC79697. (PubMed:9789079)Curated
    Sequence conflicti542 – 5421E → D in AAD12742. (PubMed:9789079)Curated
    Sequence conflicti598 – 5981S → T in AAC79697. (PubMed:9789079)Curated
    Sequence conflicti598 – 5981S → T in AAD12742. (PubMed:9789079)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei125 – 14117PTYKW…NPVEQ → CVGAERKGHYACYTICA in isoform 3. 1 PublicationVSP_030577Add
    BLAST
    Alternative sequencei142 – 608467Missing in isoform 3. 1 PublicationVSP_030578Add
    BLAST
    Alternative sequencei472 – 608137Missing in isoform 2. 1 PublicationVSP_030579Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF081193 mRNA. Translation: AAC79697.1.
    U78171 mRNA. Translation: AAD12742.1.
    BC051474 mRNA. Translation: AAH51474.1.
    AK034683 mRNA. Translation: BAC28797.1. Different initiation.
    Y12339 mRNA. Translation: CAA73008.1.
    CCDSiCCDS37898.1. [Q9QUG9-1]
    RefSeqiNP_035372.2. NM_011242.2. [Q9QUG9-1]
    XP_006531748.1. XM_006531685.1. [Q9QUG9-1]
    XP_006531749.1. XM_006531686.1. [Q9QUG9-1]
    XP_006531750.1. XM_006531687.1. [Q9QUG9-1]
    XP_006531751.1. XM_006531688.1. [Q9QUG9-1]
    XP_006531752.1. XM_006531689.1. [Q9QUG9-1]
    XP_006531753.1. XM_006531690.1. [Q9QUG9-1]
    XP_006531754.1. XM_006531691.1. [Q9QUG9-1]
    UniGeneiMm.77017.

    Genome annotation databases

    EnsembliENSMUST00000035716; ENSMUSP00000041135; ENSMUSG00000032946. [Q9QUG9-1]
    ENSMUST00000113471; ENSMUSP00000109099; ENSMUSG00000032946. [Q9QUG9-3]
    ENSMUST00000113472; ENSMUSP00000109100; ENSMUSG00000032946. [Q9QUG9-3]
    ENSMUST00000113475; ENSMUSP00000109103; ENSMUSG00000032946. [Q9QUG9-3]
    ENSMUST00000113476; ENSMUSP00000109104; ENSMUSG00000032946. [Q9QUG9-1]
    ENSMUST00000167240; ENSMUSP00000129873; ENSMUSG00000032946. [Q9QUG9-1]
    GeneIDi19395.
    KEGGimmu:19395.
    UCSCiuc008gip.1. mouse. [Q9QUG9-1]
    uc008gir.1. mouse. [Q9QUG9-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF081193 mRNA. Translation: AAC79697.1 .
    U78171 mRNA. Translation: AAD12742.1 .
    BC051474 mRNA. Translation: AAH51474.1 .
    AK034683 mRNA. Translation: BAC28797.1 . Different initiation.
    Y12339 mRNA. Translation: CAA73008.1 .
    CCDSi CCDS37898.1. [Q9QUG9-1 ]
    RefSeqi NP_035372.2. NM_011242.2. [Q9QUG9-1 ]
    XP_006531748.1. XM_006531685.1. [Q9QUG9-1 ]
    XP_006531749.1. XM_006531686.1. [Q9QUG9-1 ]
    XP_006531750.1. XM_006531687.1. [Q9QUG9-1 ]
    XP_006531751.1. XM_006531688.1. [Q9QUG9-1 ]
    XP_006531752.1. XM_006531689.1. [Q9QUG9-1 ]
    XP_006531753.1. XM_006531690.1. [Q9QUG9-1 ]
    XP_006531754.1. XM_006531691.1. [Q9QUG9-1 ]
    UniGenei Mm.77017.

    3D structure databases

    ProteinModelPortali Q9QUG9.
    SMRi Q9QUG9. Positions 7-550.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9QUG9. 1 interaction.
    MINTi MINT-4130449.

    PTM databases

    PhosphoSitei Q9QUG9.

    Proteomic databases

    MaxQBi Q9QUG9.
    PaxDbi Q9QUG9.
    PRIDEi Q9QUG9.

    Protocols and materials databases

    DNASUi 19395.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000035716 ; ENSMUSP00000041135 ; ENSMUSG00000032946 . [Q9QUG9-1 ]
    ENSMUST00000113471 ; ENSMUSP00000109099 ; ENSMUSG00000032946 . [Q9QUG9-3 ]
    ENSMUST00000113472 ; ENSMUSP00000109100 ; ENSMUSG00000032946 . [Q9QUG9-3 ]
    ENSMUST00000113475 ; ENSMUSP00000109103 ; ENSMUSG00000032946 . [Q9QUG9-3 ]
    ENSMUST00000113476 ; ENSMUSP00000109104 ; ENSMUSG00000032946 . [Q9QUG9-1 ]
    ENSMUST00000167240 ; ENSMUSP00000129873 ; ENSMUSG00000032946 . [Q9QUG9-1 ]
    GeneIDi 19395.
    KEGGi mmu:19395.
    UCSCi uc008gip.1. mouse. [Q9QUG9-1 ]
    uc008gir.1. mouse. [Q9QUG9-2 ]

    Organism-specific databases

    CTDi 10235.
    MGIi MGI:1333849. Rasgrp2.

    Phylogenomic databases

    eggNOGi NOG256085.
    GeneTreei ENSGT00750000117506.
    HOGENOMi HOG000293171.
    HOVERGENi HBG007513.
    InParanoidi Q9QUG9.
    KOi K12361.
    OMAi FPYLSAF.
    OrthoDBi EOG72G16V.
    PhylomeDBi Q9QUG9.
    TreeFami TF312918.

    Enzyme and pathway databases

    Reactomei REACT_219232. Effects of PIP2 hydrolysis.

    Miscellaneous databases

    NextBioi 296505.
    PROi Q9QUG9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9QUG9.
    Bgeei Q9QUG9.
    CleanExi MM_RASGRP2.
    Genevestigatori Q9QUG9.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    1.10.840.10. 1 hit.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
    IPR000651. Ras-like_Gua-exchang_fac_N.
    IPR023578. Ras_GEF_dom.
    IPR001895. RasGRF_CDC25.
    [Graphical view ]
    Pfami PF00130. C1_1. 1 hit.
    PF13202. EF-hand_5. 2 hits.
    PF00617. RasGEF. 1 hit.
    PF00618. RasGEF_N. 1 hit.
    [Graphical view ]
    SMARTi SM00109. C1. 1 hit.
    SM00054. EFh. 2 hits.
    SM00147. RasGEF. 1 hit.
    SM00229. RasGEFN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48366. SSF48366. 1 hit.
    PROSITEi PS00018. EF_HAND_1. 2 hits.
    PS50222. EF_HAND_2. 2 hits.
    PS50009. RASGEF_CAT. 1 hit.
    PS50212. RASGEF_NTER. 1 hit.
    PS00479. ZF_DAG_PE_1. 1 hit.
    PS50081. ZF_DAG_PE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION AS A RAP ACTIVATOR.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Strain: C57BL/6J.
      Tissue: Mammary gland.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 204-608 (ISOFORM 2).
      Strain: C57BL/6J.
      Tissue: Embryo.
    4. "The germinal centre kinase gene and a novel CDC25-like gene are located in the vicinity of the PYGM gene on 11q13."
      Kedra D., Seroussi E., Fransson I., Trifunovic J., Clark M., Lagercrantz J., Blennow E., Mehlin H., Dumanski J.
      Hum. Genet. 100:611-619(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 349-608 (ISOFORM 1).
    5. Cited for: FUNCTION.
    6. Cited for: TISSUE SPECIFICITY.
    7. Cited for: FUNCTION AS RAP2 ACTIVATOR.
    8. "Requirement for C3G-dependent Rap1 activation for cell adhesion and embryogenesis."
      Ohba Y., Ikuta K., Ogura A., Matsuda J., Mochizuki N., Nagashima K., Kurokawa K., Mayer B.J., Maki K., Miyazaki J., Matsuda M.
      EMBO J. 20:3333-3341(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    9. "Activation of the Rap1 guanine nucleotide exchange gene, CalDAG-GEF I, in BXH-2 murine myeloid leukemia."
      Dupuy A.J., Morgan K., von Lintig F.C., Shen H., Acar H., Hasz D.E., Jenkins N.A., Copeland N.G., Boss G.R., Largaespada D.A.
      J. Biol. Chem. 276:11804-11811(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, ALTERNATIVE SPLICING, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    10. "Megakaryocytes derived from embryonic stem cells implicate CalDAG-GEFI in integrin signaling."
      Eto K., Murphy R., Kerrigan S.W., Bertoni A., Stuhlmann H., Nakano T., Leavitt A.D., Shattil S.J.
      Proc. Natl. Acad. Sci. U.S.A. 99:12819-12824(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    11. "CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formation."
      Crittenden J.R., Bergmeier W., Zhang Y., Piffath C.L., Liang Y., Wagner D.D., Housman D.E., Graybiel A.M.
      Nat. Med. 10:982-986(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN PLATELET AGGREGATION, DISRUPTION PHENOTYPE, INTERACTION WITH RAP1, TISSUE SPECIFICITY.
    12. "The small GTPase Rap1b regulates the cross talk between platelet integrin alpha2beta1 and integrin alphaIIbbeta3."
      Bernardi B., Guidetti G.F., Campus F., Crittenden J.R., Graybiel A.M., Balduini C., Torti M.
      Blood 107:2728-2735(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    13. "Mice lacking the signaling molecule CalDAG-GEFI represent a model for leukocyte adhesion deficiency type III."
      Bergmeier W., Goerge T., Wang H.-W., Crittenden J.R., Baldwin A.C.W., Cifuni S.M., Housman D.E., Graybiel A.M., Wagner D.D.
      J. Clin. Invest. 117:1699-1707(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE.
    14. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-116 AND SER-117, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiGRP2_MOUSE
    AccessioniPrimary (citable) accession number: Q9QUG9
    Secondary accession number(s): O09004, Q80WC0, Q8BSC8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 112 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3