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Protein

Prion-like protein doppel

Gene

Prnd

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • copper ion binding Source: MGI

GO - Biological processi

  • cellular copper ion homeostasis Source: MGI
  • protein homooligomerization Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Prion

Names & Taxonomyi

Protein namesi
Recommended name:
Prion-like protein doppel
Alternative name(s):
Doppelganger
PrPLP
Gene namesi
Name:Prnd
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1346999. Prnd.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Amyloid, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000002574727 – 155Prion-like protein doppelAdd BLAST129
PropeptideiPRO_0000025748156 – 179Removed in mature formBy similarityAdd BLAST24

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi95 ↔ 148
Glycosylationi99N-linked (GlcNAc...)1
Disulfide bondi109 ↔ 143
Glycosylationi111N-linked (GlcNAc...)1
Lipidationi155GPI-anchor amidated glycineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ9QUG3.
PRIDEiQ9QUG3.

Expressioni

Tissue specificityi

Expressed minimally in the CNS.

Developmental stagei

Expressed during embryogenesis.

Gene expression databases

BgeeiENSMUSG00000027338.
CleanExiMM_PRND.
ExpressionAtlasiQ9QUG3. baseline and differential.
GenevisibleiQ9QUG3. MM.

Interactioni

Protein-protein interaction databases

BioGridi204986. 1 interactor.
IntActiQ9QUG3. 1 interactor.
STRINGi10090.ENSMUSP00000105798.

Structurei

Secondary structure

1179
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi8 – 20Combined sources13
Turni21 – 24Combined sources4
Beta strandi59 – 61Combined sources3
Helixi73 – 82Combined sources10
Helixi83 – 85Combined sources3
Beta strandi88 – 91Combined sources4
Helixi102 – 116Combined sources15
Helixi118 – 125Combined sources8
Helixi129 – 145Combined sources17

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1I17NMR-A51-157[»]
1Z65NMR-A1-30[»]
ProteinModelPortaliQ9QUG3.
SMRiQ9QUG3.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9QUG3.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni27 – 50Flexible tailAdd BLAST24
Regioni51 – 155GlobularAdd BLAST105

Sequence similaritiesi

Belongs to the prion family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J97N. Eukaryota.
ENOG4111EBU. LUCA.
GeneTreeiENSGT00390000017668.
HOGENOMiHOG000232078.
HOVERGENiHBG023907.
InParanoidiQ9QUG3.
OrthoDBiEOG091G0LQ8.
PhylomeDBiQ9QUG3.
TreeFamiTF337532.

Family and domain databases

Gene3Di1.10.790.10. 1 hit.
InterProiIPR021566. Doppel.
IPR022416. Prion/Doppel_prot_b-ribbon_dom.
[Graphical view]
PfamiPF11466. Doppel. 1 hit.
PF00377. Prion. 1 hit.
[Graphical view]
SUPFAMiSSF54098. SSF54098. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QUG3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNRLGTWWV AILCMLLASH LSTVKARGIK HRFKWNRKVL PSSGGQITEA
60 70 80 90 100
RVAENRPGAF IKQGRKLDID FGAEGNRYYA ANYWQFPDGI YYEGCSEANV
110 120 130 140 150
TKEMLVTSCV NATQAANQAE FSREKQDSKL HQRVLWRLIK EICSAKHCDF
160 170
WLERGAALRV AVDQPAMVCL LGFVWFIVK
Length:179
Mass (Da):20,442
Last modified:May 1, 2000 - v1
Checksum:iFC8B788259EE40F2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti156A → P in AAF02545 (PubMed:10525406).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29187 Genomic DNA. Translation: AAD52000.1.
AF165165 mRNA. Translation: AAF02544.1.
AF165166 mRNA. Translation: AAF02545.1.
AF192382 mRNA. Translation: AAF09196.1.
AF192383 mRNA. Translation: AAF09197.1.
AF192384 mRNA. Translation: AAF09198.1.
AF192385 mRNA. Translation: AAF09199.1.
BC025140 mRNA. Translation: AAH25140.1.
CCDSiCCDS16767.1.
RefSeqiNP_001119810.1. NM_001126338.2.
NP_001265186.1. NM_001278257.1.
NP_001265449.1. NM_001278520.1.
NP_075530.1. NM_023043.3.
UniGeneiMm.180750.

Genome annotation databases

EnsembliENSMUST00000110169; ENSMUSP00000105798; ENSMUSG00000027338.
ENSMUST00000110170; ENSMUSP00000105799; ENSMUSG00000027338.
ENSMUST00000110171; ENSMUSP00000105800; ENSMUSG00000027338.
ENSMUST00000110172; ENSMUSP00000105801; ENSMUSG00000027338.
GeneIDi26434.
KEGGimmu:26434.
UCSCiuc008mmd.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29187 Genomic DNA. Translation: AAD52000.1.
AF165165 mRNA. Translation: AAF02544.1.
AF165166 mRNA. Translation: AAF02545.1.
AF192382 mRNA. Translation: AAF09196.1.
AF192383 mRNA. Translation: AAF09197.1.
AF192384 mRNA. Translation: AAF09198.1.
AF192385 mRNA. Translation: AAF09199.1.
BC025140 mRNA. Translation: AAH25140.1.
CCDSiCCDS16767.1.
RefSeqiNP_001119810.1. NM_001126338.2.
NP_001265186.1. NM_001278257.1.
NP_001265449.1. NM_001278520.1.
NP_075530.1. NM_023043.3.
UniGeneiMm.180750.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1I17NMR-A51-157[»]
1Z65NMR-A1-30[»]
ProteinModelPortaliQ9QUG3.
SMRiQ9QUG3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204986. 1 interactor.
IntActiQ9QUG3. 1 interactor.
STRINGi10090.ENSMUSP00000105798.

Proteomic databases

PaxDbiQ9QUG3.
PRIDEiQ9QUG3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000110169; ENSMUSP00000105798; ENSMUSG00000027338.
ENSMUST00000110170; ENSMUSP00000105799; ENSMUSG00000027338.
ENSMUST00000110171; ENSMUSP00000105800; ENSMUSG00000027338.
ENSMUST00000110172; ENSMUSP00000105801; ENSMUSG00000027338.
GeneIDi26434.
KEGGimmu:26434.
UCSCiuc008mmd.3. mouse.

Organism-specific databases

CTDi23627.
MGIiMGI:1346999. Prnd.

Phylogenomic databases

eggNOGiENOG410J97N. Eukaryota.
ENOG4111EBU. LUCA.
GeneTreeiENSGT00390000017668.
HOGENOMiHOG000232078.
HOVERGENiHBG023907.
InParanoidiQ9QUG3.
OrthoDBiEOG091G0LQ8.
PhylomeDBiQ9QUG3.
TreeFamiTF337532.

Miscellaneous databases

EvolutionaryTraceiQ9QUG3.
PROiQ9QUG3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027338.
CleanExiMM_PRND.
ExpressionAtlasiQ9QUG3. baseline and differential.
GenevisibleiQ9QUG3. MM.

Family and domain databases

Gene3Di1.10.790.10. 1 hit.
InterProiIPR021566. Doppel.
IPR022416. Prion/Doppel_prot_b-ribbon_dom.
[Graphical view]
PfamiPF11466. Doppel. 1 hit.
PF00377. Prion. 1 hit.
[Graphical view]
SUPFAMiSSF54098. SSF54098. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPRND_MOUSE
AccessioniPrimary (citable) accession number: Q9QUG3
Secondary accession number(s): Q9QZT5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.