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Protein

Prion-like protein doppel

Gene

Prnd

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • copper ion binding Source: MGI

GO - Biological processi

  • cellular copper ion homeostasis Source: MGI
  • protein homooligomerization Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Prion

Names & Taxonomyi

Protein namesi
Recommended name:
Prion-like protein doppel
Alternative name(s):
Doppelganger
PrPLP
Gene namesi
Name:Prnd
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1346999. Prnd.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Amyloid, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence analysisAdd
BLAST
Chaini27 – 155129Prion-like protein doppelPRO_0000025747Add
BLAST
Propeptidei156 – 17924Removed in mature formBy similarityPRO_0000025748Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi95 ↔ 148
Glycosylationi99 – 991N-linked (GlcNAc...)
Disulfide bondi109 ↔ 143
Glycosylationi111 – 1111N-linked (GlcNAc...)
Lipidationi155 – 1551GPI-anchor amidated glycineSequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ9QUG3.
PRIDEiQ9QUG3.

Expressioni

Tissue specificityi

Expressed minimally in the CNS.

Developmental stagei

Expressed during embryogenesis.

Gene expression databases

BgeeiENSMUSG00000027338.
CleanExiMM_PRND.
ExpressionAtlasiQ9QUG3. baseline.
GenevisibleiQ9QUG3. MM.

Interactioni

Protein-protein interaction databases

BioGridi204986. 1 interaction.
IntActiQ9QUG3. 1 interaction.
STRINGi10090.ENSMUSP00000105798.

Structurei

Secondary structure

1
179
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi8 – 2013Combined sources
Turni21 – 244Combined sources
Beta strandi59 – 613Combined sources
Helixi73 – 8210Combined sources
Helixi83 – 853Combined sources
Beta strandi88 – 914Combined sources
Helixi102 – 11615Combined sources
Helixi118 – 1258Combined sources
Helixi129 – 14517Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1I17NMR-A51-157[»]
1Z65NMR-A1-30[»]
ProteinModelPortaliQ9QUG3.
SMRiQ9QUG3. Positions 1-30, 51-157.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9QUG3.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni27 – 5024Flexible tailAdd
BLAST
Regioni51 – 155105GlobularAdd
BLAST

Sequence similaritiesi

Belongs to the prion family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J97N. Eukaryota.
ENOG4111EBU. LUCA.
GeneTreeiENSGT00390000017668.
HOGENOMiHOG000232078.
HOVERGENiHBG023907.
InParanoidiQ9QUG3.
OrthoDBiEOG091G0LQ8.
PhylomeDBiQ9QUG3.
TreeFamiTF337532.

Family and domain databases

Gene3Di1.10.790.10. 1 hit.
InterProiIPR021566. Doppel.
IPR022416. Prion/Doppel_prot_b-ribbon_dom.
[Graphical view]
PfamiPF11466. Doppel. 1 hit.
PF00377. Prion. 1 hit.
[Graphical view]
SUPFAMiSSF54098. SSF54098. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QUG3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNRLGTWWV AILCMLLASH LSTVKARGIK HRFKWNRKVL PSSGGQITEA
60 70 80 90 100
RVAENRPGAF IKQGRKLDID FGAEGNRYYA ANYWQFPDGI YYEGCSEANV
110 120 130 140 150
TKEMLVTSCV NATQAANQAE FSREKQDSKL HQRVLWRLIK EICSAKHCDF
160 170
WLERGAALRV AVDQPAMVCL LGFVWFIVK
Length:179
Mass (Da):20,442
Last modified:May 1, 2000 - v1
Checksum:iFC8B788259EE40F2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti156 – 1561A → P in AAF02545 (PubMed:10525406).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29187 Genomic DNA. Translation: AAD52000.1.
AF165165 mRNA. Translation: AAF02544.1.
AF165166 mRNA. Translation: AAF02545.1.
AF192382 mRNA. Translation: AAF09196.1.
AF192383 mRNA. Translation: AAF09197.1.
AF192384 mRNA. Translation: AAF09198.1.
AF192385 mRNA. Translation: AAF09199.1.
BC025140 mRNA. Translation: AAH25140.1.
CCDSiCCDS16767.1.
RefSeqiNP_001119810.1. NM_001126338.2.
NP_001265186.1. NM_001278257.1.
NP_001265449.1. NM_001278520.1.
NP_075530.1. NM_023043.3.
UniGeneiMm.180750.

Genome annotation databases

EnsembliENSMUST00000110169; ENSMUSP00000105798; ENSMUSG00000027338.
ENSMUST00000110170; ENSMUSP00000105799; ENSMUSG00000027338.
ENSMUST00000110171; ENSMUSP00000105800; ENSMUSG00000027338.
ENSMUST00000110172; ENSMUSP00000105801; ENSMUSG00000027338.
GeneIDi26434.
KEGGimmu:26434.
UCSCiuc008mmd.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29187 Genomic DNA. Translation: AAD52000.1.
AF165165 mRNA. Translation: AAF02544.1.
AF165166 mRNA. Translation: AAF02545.1.
AF192382 mRNA. Translation: AAF09196.1.
AF192383 mRNA. Translation: AAF09197.1.
AF192384 mRNA. Translation: AAF09198.1.
AF192385 mRNA. Translation: AAF09199.1.
BC025140 mRNA. Translation: AAH25140.1.
CCDSiCCDS16767.1.
RefSeqiNP_001119810.1. NM_001126338.2.
NP_001265186.1. NM_001278257.1.
NP_001265449.1. NM_001278520.1.
NP_075530.1. NM_023043.3.
UniGeneiMm.180750.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1I17NMR-A51-157[»]
1Z65NMR-A1-30[»]
ProteinModelPortaliQ9QUG3.
SMRiQ9QUG3. Positions 1-30, 51-157.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204986. 1 interaction.
IntActiQ9QUG3. 1 interaction.
STRINGi10090.ENSMUSP00000105798.

Proteomic databases

PaxDbiQ9QUG3.
PRIDEiQ9QUG3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000110169; ENSMUSP00000105798; ENSMUSG00000027338.
ENSMUST00000110170; ENSMUSP00000105799; ENSMUSG00000027338.
ENSMUST00000110171; ENSMUSP00000105800; ENSMUSG00000027338.
ENSMUST00000110172; ENSMUSP00000105801; ENSMUSG00000027338.
GeneIDi26434.
KEGGimmu:26434.
UCSCiuc008mmd.3. mouse.

Organism-specific databases

CTDi23627.
MGIiMGI:1346999. Prnd.

Phylogenomic databases

eggNOGiENOG410J97N. Eukaryota.
ENOG4111EBU. LUCA.
GeneTreeiENSGT00390000017668.
HOGENOMiHOG000232078.
HOVERGENiHBG023907.
InParanoidiQ9QUG3.
OrthoDBiEOG091G0LQ8.
PhylomeDBiQ9QUG3.
TreeFamiTF337532.

Miscellaneous databases

EvolutionaryTraceiQ9QUG3.
PROiQ9QUG3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027338.
CleanExiMM_PRND.
ExpressionAtlasiQ9QUG3. baseline.
GenevisibleiQ9QUG3. MM.

Family and domain databases

Gene3Di1.10.790.10. 1 hit.
InterProiIPR021566. Doppel.
IPR022416. Prion/Doppel_prot_b-ribbon_dom.
[Graphical view]
PfamiPF11466. Doppel. 1 hit.
PF00377. Prion. 1 hit.
[Graphical view]
SUPFAMiSSF54098. SSF54098. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPRND_MOUSE
AccessioniPrimary (citable) accession number: Q9QUG3
Secondary accession number(s): Q9QZT5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.