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Protein

Ribonucleoside-diphosphate reductase small chain

Gene

RR-2

Organism
Red sea bream iridovirus (RSIV)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).By similarity

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.PROSITE-ProRule annotation

Cofactori

Fe cationBy similarityNote: Binds 2 iron ions per subunit.By similarity

Pathway: DNA replication

This protein is involved in the pathway DNA replication, which is part of Genetic information processing.
View all proteins of this organism that are known to be involved in the pathway DNA replication and in Genetic information processing.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi62 – 621Iron 1PROSITE-ProRule annotation
Metal bindingi94 – 941Iron 1PROSITE-ProRule annotation
Metal bindingi94 – 941Iron 2By similarity
Metal bindingi97 – 971Iron 1PROSITE-ProRule annotation
Active sitei101 – 1011PROSITE-ProRule annotation
Metal bindingi156 – 1561Iron 2By similarity
Metal bindingi190 – 1901Iron 2By similarity
Metal bindingi193 – 1931Iron 2By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase small chain (EC:1.17.4.1)
Alternative name(s):
Ribonucleotide reductase small subunit
Gene namesi
Name:RR-2
OrganismiRed sea bream iridovirus (RSIV)
Taxonomic identifieri65424 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageIridoviridaeMegalocytivirusunclassified Megalocytivirus
Virus hostiEpinephelus [TaxID: 94231]
Lateolabrax [TaxID: 8163]
Seriola [TaxID: 8160]
Thunnus thynnus (Atlantic bluefin tuna) (Scomber thynnus) [TaxID: 8237]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Ribonucleoside-diphosphate reductase small chainPRO_0000190493Add
BLAST

Interactioni

Subunit structurei

Heterodimer of a large and a small chain.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9QTF2.
SMRiQ9QTF2. Positions 2-275.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di1.10.620.20. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
IPR030475. RNR_small_AS.
[Graphical view]
PANTHERiPTHR23409. PTHR23409. 1 hit.
PfamiPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QTF2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRYVLRPND PHLWAMYKKA VASFWTVEEV DLSTDVRHWT DKLTEAERRF
60 70 80 90 100
MSHILAFFAM ADGIVGDNLV CNFAKELDHI PEARAFYGFQ VAIENIHAEM
110 120 130 140 150
YTQLIITLVA KENQAALFSA AEDMPCVKAK AQWAAQWLNA THKPIATRLL
160 170 180 190 200
AFAAVEGVMF SGSFAAIFWL KKRSLMPGLA FSNELISRDE GLHCDFACML
210 220 230 240 250
FRQMANKPCQ DDAHQIISDA VDIETAFFRE ALKTPLLGMN SDSMKLYIQF
260 270 280 290 300
VADRLLDALG YAKMYNVSNP FDFMDNISIE GKTNFFERRV SEYQRMGVFT
310
PSSMEFTMNE EF
Length:312
Mass (Da):35,653
Last modified:May 1, 2000 - v1
Checksum:i7D3E43D5F4F48B0B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018418 Genomic DNA. Translation: BAA82755.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018418 Genomic DNA. Translation: BAA82755.1.

3D structure databases

ProteinModelPortaliQ9QTF2.
SMRiQ9QTF2. Positions 2-275.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00326.

Family and domain databases

Gene3Di1.10.620.20. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
IPR030475. RNR_small_AS.
[Graphical view]
PANTHERiPTHR23409. PTHR23409. 1 hit.
PfamiPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "7.1kbp DNA sequence of red sea bream iridovirus (RSIV) containing largest subunit of the DNA-dependent RNA polymerase (RPO-1) gene, RAD2 homolog gene and ribonucleotide reductase small subunit (RR-2) gene."
    Kurita J., Nakajima K., Hirono I., Aoki T.
    Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Ehime-1.

Entry informationi

Entry nameiRIR2_RSIV
AccessioniPrimary (citable) accession number: Q9QTF2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: May 1, 2000
Last modified: April 1, 2015
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.