Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9QTF2 (RIR2_RSIV) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribonucleoside-diphosphate reductase small chain

EC=1.17.4.1
Alternative name(s):
Ribonucleotide reductase small subunit
Gene names
Name:RR-2
OrganismRed sea bream iridovirus (RSIV)
Taxonomic identifier65424 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageIridoviridaeMegalocytivirusunclassified Megalocytivirus
Virus hostEpinephelus [TaxID: 94231]
Lateolabrax [TaxID: 8163]
Seriola [TaxID: 8160]
Thunnus thynnus (Atlantic bluefin tuna) (Scomber thynnus) [TaxID: 8237]

Protein attributes

Sequence length312 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.

Catalytic activity

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactor

Binds 2 iron ions per subunit By similarity.

Pathway

Genetic information processing; DNA replication.

Subunit structure

Heterodimer of a large and a small chain By similarity.

Sequence similarities

Belongs to the ribonucleoside diphosphate reductase small chain family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 312312Ribonucleoside-diphosphate reductase small chain
PRO_0000190493

Sites

Active site1011 By similarity
Metal binding621Iron 1 By similarity
Metal binding941Iron 1 By similarity
Metal binding941Iron 2 By similarity
Metal binding971Iron 1 By similarity
Metal binding1561Iron 2 By similarity
Metal binding1901Iron 2 By similarity
Metal binding1931Iron 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9QTF2 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 7D3E43D5F4F48B0B

FASTA31235,653
        10         20         30         40         50         60 
MDRYVLRPND PHLWAMYKKA VASFWTVEEV DLSTDVRHWT DKLTEAERRF MSHILAFFAM 

        70         80         90        100        110        120 
ADGIVGDNLV CNFAKELDHI PEARAFYGFQ VAIENIHAEM YTQLIITLVA KENQAALFSA 

       130        140        150        160        170        180 
AEDMPCVKAK AQWAAQWLNA THKPIATRLL AFAAVEGVMF SGSFAAIFWL KKRSLMPGLA 

       190        200        210        220        230        240 
FSNELISRDE GLHCDFACML FRQMANKPCQ DDAHQIISDA VDIETAFFRE ALKTPLLGMN 

       250        260        270        280        290        300 
SDSMKLYIQF VADRLLDALG YAKMYNVSNP FDFMDNISIE GKTNFFERRV SEYQRMGVFT 

       310 
PSSMEFTMNE EF 

« Hide

References

[1]"7.1kbp DNA sequence of red sea bream iridovirus (RSIV) containing largest subunit of the DNA-dependent RNA polymerase (RPO-1) gene, RAD2 homolog gene and ribonucleotide reductase small subunit (RR-2) gene."
Kurita J., Nakajima K., Hirono I., Aoki T.
Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Ehime-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB018418 Genomic DNA. Translation: BAA82755.1.

3D structure databases

ProteinModelPortalQ9QTF2.
SMRQ9QTF2. Positions 2-275.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00326.

Family and domain databases

Gene3D1.10.620.20. 1 hit.
InterProIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view]
PANTHERPTHR23409. PTHR23409. 1 hit.
PfamPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
SUPFAMSSF47240. SSF47240. 1 hit.
PROSITEPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRIR2_RSIV
AccessionPrimary (citable) accession number: Q9QTF2
Entry history
Integrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: May 1, 2000
Last modified: December 11, 2013
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways