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Q9QTF2

- RIR2_RSIV

UniProt

Q9QTF2 - RIR2_RSIV

Protein

Ribonucleoside-diphosphate reductase small chain

Gene

RR-2

Organism
Red sea bream iridovirus (RSIV)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.By similarity

    Catalytic activityi

    2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.PROSITE-ProRule annotation

    Cofactori

    Binds 2 iron ions per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi62 – 621Iron 1PROSITE-ProRule annotation
    Metal bindingi94 – 941Iron 1PROSITE-ProRule annotation
    Metal bindingi94 – 941Iron 2By similarity
    Metal bindingi97 – 971Iron 1PROSITE-ProRule annotation
    Active sitei101 – 1011PROSITE-ProRule annotation
    Metal bindingi156 – 1561Iron 2By similarity
    Metal bindingi190 – 1901Iron 2By similarity
    Metal bindingi193 – 1931Iron 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

    GO - Biological processi

    1. deoxyribonucleoside diphosphate metabolic process Source: InterPro
    2. DNA replication Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    DNA replication

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00326.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonucleoside-diphosphate reductase small chain (EC:1.17.4.1)
    Alternative name(s):
    Ribonucleotide reductase small subunit
    Gene namesi
    Name:RR-2
    OrganismiRed sea bream iridovirus (RSIV)
    Taxonomic identifieri65424 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageIridoviridaeMegalocytivirusunclassified Megalocytivirus
    Virus hostiEpinephelus [TaxID: 94231]
    Lateolabrax [TaxID: 8163]
    Seriola [TaxID: 8160]
    Thunnus thynnus (Atlantic bluefin tuna) (Scomber thynnus) [TaxID: 8237]

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 312312Ribonucleoside-diphosphate reductase small chainPRO_0000190493Add
    BLAST

    Interactioni

    Subunit structurei

    Heterodimer of a large and a small chain.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9QTF2.
    SMRiQ9QTF2. Positions 2-275.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    Gene3Di1.10.620.20. 1 hit.
    InterProiIPR009078. Ferritin-like_SF.
    IPR012348. RNR-rel.
    IPR000358. RNR_small.
    [Graphical view]
    PANTHERiPTHR23409. PTHR23409. 1 hit.
    PfamiPF00268. Ribonuc_red_sm. 1 hit.
    [Graphical view]
    SUPFAMiSSF47240. SSF47240. 1 hit.
    PROSITEiPS00368. RIBORED_SMALL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9QTF2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDRYVLRPND PHLWAMYKKA VASFWTVEEV DLSTDVRHWT DKLTEAERRF    50
    MSHILAFFAM ADGIVGDNLV CNFAKELDHI PEARAFYGFQ VAIENIHAEM 100
    YTQLIITLVA KENQAALFSA AEDMPCVKAK AQWAAQWLNA THKPIATRLL 150
    AFAAVEGVMF SGSFAAIFWL KKRSLMPGLA FSNELISRDE GLHCDFACML 200
    FRQMANKPCQ DDAHQIISDA VDIETAFFRE ALKTPLLGMN SDSMKLYIQF 250
    VADRLLDALG YAKMYNVSNP FDFMDNISIE GKTNFFERRV SEYQRMGVFT 300
    PSSMEFTMNE EF 312
    Length:312
    Mass (Da):35,653
    Last modified:May 1, 2000 - v1
    Checksum:i7D3E43D5F4F48B0B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB018418 Genomic DNA. Translation: BAA82755.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB018418 Genomic DNA. Translation: BAA82755.1 .

    3D structure databases

    ProteinModelPortali Q9QTF2.
    SMRi Q9QTF2. Positions 2-275.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00326 .

    Family and domain databases

    Gene3Di 1.10.620.20. 1 hit.
    InterProi IPR009078. Ferritin-like_SF.
    IPR012348. RNR-rel.
    IPR000358. RNR_small.
    [Graphical view ]
    PANTHERi PTHR23409. PTHR23409. 1 hit.
    Pfami PF00268. Ribonuc_red_sm. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47240. SSF47240. 1 hit.
    PROSITEi PS00368. RIBORED_SMALL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "7.1kbp DNA sequence of red sea bream iridovirus (RSIV) containing largest subunit of the DNA-dependent RNA polymerase (RPO-1) gene, RAD2 homolog gene and ribonucleotide reductase small subunit (RR-2) gene."
      Kurita J., Nakajima K., Hirono I., Aoki T.
      Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Ehime-1.

    Entry informationi

    Entry nameiRIR2_RSIV
    AccessioniPrimary (citable) accession number: Q9QTF2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 27, 2003
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3