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Q9QTF2

- RIR2_RSIV

UniProt

Q9QTF2 - RIR2_RSIV

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Protein
Ribonucleoside-diphosphate reductase small chain
Gene
RR-2
Organism
Red sea bream iridovirus (RSIV)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactori

Binds 2 iron ions per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi62 – 621Iron 1 By similarity
Metal bindingi94 – 941Iron 1 By similarity
Metal bindingi94 – 941Iron 2 By similarity
Metal bindingi97 – 971Iron 1 By similarity
Active sitei101 – 1011 By similarity
Metal bindingi156 – 1561Iron 2 By similarity
Metal bindingi190 – 1901Iron 2 By similarity
Metal bindingi193 – 1931Iron 2 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

GO - Biological processi

  1. DNA replication Source: UniProtKB-UniPathway
  2. deoxyribonucleoside diphosphate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase small chain (EC:1.17.4.1)
Alternative name(s):
Ribonucleotide reductase small subunit
Gene namesi
Name:RR-2
OrganismiRed sea bream iridovirus (RSIV)
Taxonomic identifieri65424 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageIridoviridaeMegalocytivirusunclassified Megalocytivirus
Virus hostiEpinephelus [TaxID: 94231]
Lateolabrax [TaxID: 8163]
Seriola [TaxID: 8160]
Thunnus thynnus (Atlantic bluefin tuna) (Scomber thynnus) [TaxID: 8237]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Ribonucleoside-diphosphate reductase small chain
PRO_0000190493Add
BLAST

Interactioni

Subunit structurei

Heterodimer of a large and a small chain By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ9QTF2.
SMRiQ9QTF2. Positions 2-275.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di1.10.620.20. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view]
PANTHERiPTHR23409. PTHR23409. 1 hit.
PfamiPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QTF2-1 [UniParc]FASTAAdd to Basket

« Hide

MDRYVLRPND PHLWAMYKKA VASFWTVEEV DLSTDVRHWT DKLTEAERRF    50
MSHILAFFAM ADGIVGDNLV CNFAKELDHI PEARAFYGFQ VAIENIHAEM 100
YTQLIITLVA KENQAALFSA AEDMPCVKAK AQWAAQWLNA THKPIATRLL 150
AFAAVEGVMF SGSFAAIFWL KKRSLMPGLA FSNELISRDE GLHCDFACML 200
FRQMANKPCQ DDAHQIISDA VDIETAFFRE ALKTPLLGMN SDSMKLYIQF 250
VADRLLDALG YAKMYNVSNP FDFMDNISIE GKTNFFERRV SEYQRMGVFT 300
PSSMEFTMNE EF 312
Length:312
Mass (Da):35,653
Last modified:May 1, 2000 - v1
Checksum:i7D3E43D5F4F48B0B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB018418 Genomic DNA. Translation: BAA82755.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB018418 Genomic DNA. Translation: BAA82755.1 .

3D structure databases

ProteinModelPortali Q9QTF2.
SMRi Q9QTF2. Positions 2-275.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00326 .

Family and domain databases

Gene3Di 1.10.620.20. 1 hit.
InterProi IPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view ]
PANTHERi PTHR23409. PTHR23409. 1 hit.
Pfami PF00268. Ribonuc_red_sm. 1 hit.
[Graphical view ]
SUPFAMi SSF47240. SSF47240. 1 hit.
PROSITEi PS00368. RIBORED_SMALL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "7.1kbp DNA sequence of red sea bream iridovirus (RSIV) containing largest subunit of the DNA-dependent RNA polymerase (RPO-1) gene, RAD2 homolog gene and ribonucleotide reductase small subunit (RR-2) gene."
    Kurita J., Nakajima K., Hirono I., Aoki T.
    Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Ehime-1.

Entry informationi

Entry nameiRIR2_RSIV
AccessioniPrimary (citable) accession number: Q9QTF2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: May 1, 2000
Last modified: December 11, 2013
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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