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Protein

Ribonucleoside-diphosphate reductase small chain

Gene

RR-2

Organism
Red sea bream iridovirus (RSIV)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).By similarity

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.PROSITE-ProRule annotation

Cofactori

Fe cationBy similarityNote: Binds 2 iron ions per subunit.By similarity

Pathwayi: DNA replication

This protein is involved in the pathway DNA replication, which is part of Genetic information processing.
View all proteins of this organism that are known to be involved in the pathway DNA replication and in Genetic information processing.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi62Iron 1PROSITE-ProRule annotation1
Metal bindingi94Iron 1PROSITE-ProRule annotation1
Metal bindingi94Iron 2By similarity1
Metal bindingi97Iron 1PROSITE-ProRule annotation1
Active sitei101PROSITE-ProRule annotation1
Metal bindingi156Iron 2By similarity1
Metal bindingi190Iron 2By similarity1
Metal bindingi193Iron 2By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase small chain (EC:1.17.4.1)
Alternative name(s):
Ribonucleotide reductase small subunit
Gene namesi
Name:RR-2
OrganismiRed sea bream iridovirus (RSIV)
Taxonomic identifieri65424 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageIridoviridaeMegalocytivirusunclassified Megalocytivirus
Virus hostiEpinephelus [TaxID: 94231]
Lateolabrax [TaxID: 8163]
Seriola [TaxID: 8160]
Thunnus thynnus (Atlantic bluefin tuna) (Scomber thynnus) [TaxID: 8237]

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001904931 – 312Ribonucleoside-diphosphate reductase small chainAdd BLAST312

Interactioni

Subunit structurei

Heterodimer of a large and a small chain.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9QTF2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

CDDicd01049. RNRR2. 1 hit.
Gene3Di1.10.620.20. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR033909. RNR_small.
IPR030475. RNR_small_AS.
IPR000358. RNR_small_fam.
[Graphical view]
PANTHERiPTHR23409. PTHR23409. 1 hit.
PfamiPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QTF2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRYVLRPND PHLWAMYKKA VASFWTVEEV DLSTDVRHWT DKLTEAERRF
60 70 80 90 100
MSHILAFFAM ADGIVGDNLV CNFAKELDHI PEARAFYGFQ VAIENIHAEM
110 120 130 140 150
YTQLIITLVA KENQAALFSA AEDMPCVKAK AQWAAQWLNA THKPIATRLL
160 170 180 190 200
AFAAVEGVMF SGSFAAIFWL KKRSLMPGLA FSNELISRDE GLHCDFACML
210 220 230 240 250
FRQMANKPCQ DDAHQIISDA VDIETAFFRE ALKTPLLGMN SDSMKLYIQF
260 270 280 290 300
VADRLLDALG YAKMYNVSNP FDFMDNISIE GKTNFFERRV SEYQRMGVFT
310
PSSMEFTMNE EF
Length:312
Mass (Da):35,653
Last modified:May 1, 2000 - v1
Checksum:i7D3E43D5F4F48B0B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018418 Genomic DNA. Translation: BAA82755.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018418 Genomic DNA. Translation: BAA82755.1.

3D structure databases

ProteinModelPortaliQ9QTF2.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00326.

Family and domain databases

CDDicd01049. RNRR2. 1 hit.
Gene3Di1.10.620.20. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR033909. RNR_small.
IPR030475. RNR_small_AS.
IPR000358. RNR_small_fam.
[Graphical view]
PANTHERiPTHR23409. PTHR23409. 1 hit.
PfamiPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRIR2_RSIV
AccessioniPrimary (citable) accession number: Q9QTF2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.