Q9QSK2 (DPOL_IIV6) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
DNA polymerase 037L
EC=2.7.7.7

Gene names

Name:	DPOL
ORF Names:	IIV6-037L

Organism

Invertebrate iridescent virus 6 (IIV-6) (Chilo iridescent virus) [Reference proteome]

Taxonomic identifier

176652 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Iridoviridae › Iridovirus

Virus host

Acheta domesticus (House cricket) [TaxID: 6997]
Chilo suppressalis (striped riceborer) [TaxID: 168631]
Gryllus bimaculatus (Two-spotted cricket) [TaxID: 6999]
Gryllus campestris [TaxID: 58607]
Spodoptera frugiperda (Fall armyworm) [TaxID: 7108]

Protein attributes

Sequence length	1273 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	DNA-directed DNA polymerase involved in viral DNA replication.
Catalytic activity	Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
Sequence similarities	Belongs to the DNA polymerase type-B family.

Ontologies

Keywords
Biological process	DNA replication
Domain	Coiled coil
Ligand	DNA-binding
Molecular function	DNA-directed DNA polymerase Nucleotidyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA replication Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW DNA-directed DNA polymerase activity Inferred from electronic annotation. Source: UniProtKB-KW nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1273	1273	DNA polymerase 037L		PRO_0000376943
Regions
	Coiled coil	679 – 837	159	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9QSK2 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: CC514AD83F7299A3	FASTA	1,273	147,663
	10 20 30 40 50 60 MEKTMFAYSW HQTDDETKNW SKSKESLRIY GITDDGKTIC LIVNDFKPFV HVELPSSINW 70 80 90 100 110 120 RQKIGGQPKV QKIMDYLNFI LGDLKPVKNR TIFIDKYKLY GSNYVQTSPG VFQRKKFPYL 130 140 150 160 170 180 VLFFESRKHI KNLEYKLKNT VDVPGFGKIK LNVRETNVSP ILQLCVERNL PSAGWIGFKV 190 200 210 220 230 240 EGRGALAGYG ELVEEKKKFT DCDEEYVISK NYIYSIDKHV PVKAKVMAWD IEVYSEDGNF 250 260 270 280 290 300 PDAMKPGNVV FQISCIFFIV GTSYKQKYLL TLGDPLEYTT TPINEEGCGK DTIVCKFKTE 310 320 330 340 350 360 EDLIIAFSSL QKREKPHITT GWNIFNFDTT FLLKRAKLHR CLPNFLLQGF PKDQLGKEKE 370 380 390 400 410 420 IKWQSKAYGT TDLKFIDCEG ILCIDLMDVV QKEHKLDSYS LNFVAKHFLG SKKDDLKPKE 430 440 450 460 470 480 IFICYREGIK KEVKNIVIHP LSNNLNIYLG KEEIMIENKK FKKPLKPFFR IQNTGKLVSD 490 500 510 520 530 540 EDDSVFHVNY RGEVFSFLIA VHNEEKYEIK TVSEFNNYKN AYGTYTLSAQ KAMAKVGKYC 550 560 570 580 590 600 VQDSVLVADI FEHLQTWLSF SEMSRTCTTP IMTIHVHGQQ VKFFNQVYKY CYDHKTVTDK 610 620 630 640 650 660 ETYKVDEKER YRGAEVFDPV PGLKRNVVPL DFASLYPSLI IARNMCYSTF VDNDDIPDEM 670 680 690 700 710 720 CHVMEWDDHV ACSHDPKVIR KNAITEELEK LKKIANAKKM YTQGTRTYKK MMCSYLVMEN 730 740 750 760 770 780 TKEKTEMSKH LKDLDRENNE LLNIVNKQTP GYIESIKKKI SDLTSERSEI TKKLSKSVMC 790 800 810 820 830 840 VSNRRYRFLK EPKGILPTII QNLLDARKNT RTEIKNYKSR LALLMEKENK SKEDIDEITS 850 860 870 880 890 900 IENLLPILDK RQNSYKISAN SMYGATGVRV GALPFMPIAM CTTYMGRKSI VEVSQYLKEL 910 920 930 940 950 960 GGRVVYGDTD SNYVTFDDVV DKNVKVGTEE FSREMKKLWN HAIEIAKTIS KKFDNPITLE 970 980 990 1000 1010 1020 FENAIYFKFL ILTKKRYMYY TCGKDGNILM DANGKPKMGQ RGVILSRRDN CKYMKDVYAN 1030 1040 1050 1060 1070 1080 VIDKIFDEQS ENEILNGVVE KMLNLYTRQI EFTSCEKDEN YLKNLIVTKS VGDYGGDKAT 1090 1100 1110 1120 1130 1140 FEPILGKNEK GEDKWKIGNY VVPLITDEII KTCGTNGLPM TQNEIKDWYL ERLPCQVQLE 1150 1160 1170 1180 1190 1200 VKIKRRGHNK EEGQRLSYVV TDIGCKGKQS EKIESVEYFK THSKVLKLDY GYYIERLIEP 1210 1220 1230 1240 1250 1260 LDQVFQAVFK NCQEKETIYS DNFRKTKLFS IFEKRGKHSQ ANFTKELHKL CSVTKPKLIN 1270 EIKSFSKPDL VFV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Analysis of the first complete DNA sequence of an invertebrate iridovirus: coding strategy of the genome of Chilo iridescent virus." Jakob N.J., Mueller K., Bahr U., Darai G. Virology 286:182-196(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Phylogenetic position of the Diadromus pulchellus ascovirus DNA polymerase among viruses with large double-stranded DNA genomes." Stasiak K., Demattei M.V., Federici B.A., Bigot Y. J. Gen. Virol. 81:3059-3072(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 636-910.
[3]	"Comparative genomic analysis of the family Iridoviridae: re-annotating and defining the core set of iridovirus genes." Eaton H.E., Metcalf J., Penny E., Tcherepanov V., Upton C., Brunetti C.R. Virol. J. 4:11-11(2007) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF303741 Genomic DNA. Translation: AAD48150.1. AJ279816 Genomic DNA. Translation: CAC19195.1.
RefSeq	NP_149500.1. NC_003038.1.
3D structure databases
HSSP	HSSP built from PDB template 1S5J based on UniProtKB P26811.
ProteinModelPortal	Q9QSK2.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	921680.
Family and domain databases
Gene3D	3.90.1600.10. 2 hits.
InterPro	IPR006172. DNA-dir_DNA_pol_B. IPR006133. DNA-dir_DNA_pol_B_exonuc. IPR006134. DNA-dir_DNA_pol_B_multi_dom. IPR023211. DNA_pol_palm_dom. IPR012337. RNaseH-like_dom. [Graphical view]
Pfam	PF00136. DNA_pol_B. 1 hit. PF03104. DNA_pol_B_exo1. 1 hit. [Graphical view]
SMART	SM00486. POLBc. 1 hit. [Graphical view]
SUPFAM	SSF53098. RNaseH_fold. 1 hit.
PROSITE	PS00116. DNA_POLYMERASE_B. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DPOL_IIV6

Accession

Primary (citable) accession number: Q9QSK2
Secondary accession number(s): Q9DIE2

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 16, 2009
Last sequence update:	May 1, 2000
Last modified:	April 3, 2013
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program