Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein K15

Gene

K15

Organism
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the modulation of host signaling pathways including activation of MAP kinases c-JUN-N-terminal kinase (JNK), ERK2, and NF-kappa-B resulting in the activation of AP-1 and NFAT-dependent gene expression in B-lymphocytes. When expressed in epithelial cells, induces the expression of several inflammatory and angiogenic genes. Interferes also with B-lymphocytes signaling through interaction with host LYN kinase.4 Publications

GO - Biological processi

Keywordsi

Biological processHost-virus interaction

Names & Taxonomyi

Protein namesi
Recommended name:
Protein K15
Gene namesi
Name:K15
OrganismiHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Taxonomic identifieri868565 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeRhadinovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000000942 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei29 – 49HelicalSequence analysisAdd BLAST21
Transmembranei63 – 83HelicalSequence analysisAdd BLAST21
Transmembranei89 – 109HelicalSequence analysisAdd BLAST21
Transmembranei121 – 141HelicalSequence analysisAdd BLAST21
Transmembranei148 – 168HelicalSequence analysisAdd BLAST21
Transmembranei175 – 195HelicalSequence analysisAdd BLAST21
Transmembranei200 – 220HelicalSequence analysisAdd BLAST21
Transmembranei237 – 257HelicalSequence analysisAdd BLAST21
Transmembranei264 – 284HelicalSequence analysisAdd BLAST21
Transmembranei296 – 316HelicalSequence analysisAdd BLAST21
Transmembranei324 – 344HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Host membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000042388527 – 489Protein K15Add BLAST463

Interactioni

Subunit structurei

Interacts with host LYN; this interaction modulated B-cells signaling. Interacts with host ITSN2.2 Publications

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi359 – 364Poly-Arg6

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

InterProiView protein in InterPro
IPR009304. Herpes_LAMP2.
PfamiView protein in Pfam
PF06126. Herpes_LAMP2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QR69-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTLIFFWNL WLWALLVCFW CITLVCVTTN SIDTMASLLV MCILFVSAIN
60 70 80 90 100
KYTQAISSNN PKWPSSWHLG IIACIVLKLW NLSTTNSVTY ACLITTAILS
110 120 130 140 150
LVTAFLTLIK HCTACKLQLE HGILFTSTFA VLMTNMLVHM SNTWQSSWIF
160 170 180 190 200
FPISFTLSLP FLYAFATVKT GNIKLVSSVS FICAGLVMGY PVSCCKTHTC
210 220 230 240 250
TATAAGLSLS SIYLGFTGII STLHKSWAPP KRGILTFLLL QGGVLTTQTL
260 270 280 290 300
TTELLAITST TGNIKGHEIL LLVCLIFLWC LYVWQSFNKA SLVTGMLHLI
310 320 330 340 350
AAWSHTGGCV QLVMLLPSGL TRGILTMIIC ISTLFSTLQG LLVFYLYKEK
360 370 380 390 400
KVVAVNSYRQ RRRRIYTRDQ NLHHNDNHLG NNVISPPPLP PFFRQPVRLP
410 420 430 440 450
SHVTDRGRGS QLLNEVELQE VNRDPPNVFG YASILVSGAE ESREPSPQPD
460 470 480
QSGMSILRVD GGSAFRIDTA QAATQPTDDL YEEVLFPRN
Length:489
Mass (Da):54,316
Last modified:May 1, 2000 - v1
Checksum:i0FDB473474121743
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF148805 Genomic DNA. Translation: AAD46505.1.
RefSeqiYP_001129435.1. NC_009333.1.

Genome annotation databases

GeneIDi4961473.
KEGGivg:4961473.

Similar proteinsi

Entry informationi

Entry nameiK15_HHV8P
AccessioniPrimary (citable) accession number: Q9QR69
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 16, 2013
Last sequence update: May 1, 2000
Last modified: April 1, 2015
This is version 43 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome