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Q9QP77

- NCAP_EBOSB

UniProt

Q9QP77 - NCAP_EBOSB

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Protein

Nucleoprotein

Gene
NP
Organism
Sudan ebolavirus (strain Boniface-76) (SEBOV) (Sudan Ebola virus)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid and serves as template for transcription and replication. During replication, encapsidation by NP is coupled to RNA synthesis and all replicative products are resistant to nucleases By similarity.

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-KW

GO - Biological processi

  1. viral RNA genome packaging Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Ligandi

RNA-binding, Viral nucleoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoprotein
Alternative name(s):
Nucleocapsid protein
Short name:
Protein N
Gene namesi
Name:NP
OrganismiSudan ebolavirus (strain Boniface-76) (SEBOV) (Sudan Ebola virus)
Taxonomic identifieri128948 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesMononegaviralesFiloviridaeEbolavirus
Virus hostiEpomops franqueti (Franquet's epauleted fruit bat) [TaxID: 77231]
Homo sapiens (Human) [TaxID: 9606]
Myonycteris torquata (Little collared fruit bat) [TaxID: 77243]

Subcellular locationi

Virion. Host cytoplasm By similarity

GO - Cellular componenti

  1. helical viral capsid Source: UniProtKB-KW
  2. host cell cytoplasm Source: UniProtKB-SubCell
  3. ribonucleoprotein complex Source: UniProtKB-KW
  4. viral nucleocapsid Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Helical capsid protein, Host cytoplasm, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 738738NucleoproteinPRO_0000222174Add
BLAST

Post-translational modificationi

Phosphorylated and O-glycosylated by host By similarity.

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Homooligomer. Homomultimerizes to form the nucleocapsid. Binds to viral genomic RNA. Interacts with VP35 and VP30 to form the nucleocapsid. Also interacts with VP24 and VP40 By similarity.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili334 – 36330 Reviewed predictionAdd
BLAST

Domaini

This protein can be divided into a hydrophobic N-terminal half, and a hydrophilic and highly acidic C-terminal half By similarity.

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Family and domain databases

InterProiIPR008609. Ebola_NP.
[Graphical view]
PfamiPF05505. Ebola_NP. 1 hit.
[Graphical view]
PIRSFiPIRSF003900. N_FiloV. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9QP77-1 [UniParc]FASTAAdd to Basket

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MDKRVRGSWA LGGQSEVDLD YHKILTAGLS VQQGIVRQRV IPVYVVNDLE    50
GICQHIIQAF EAGVDFQDNA DSFLLLLCLH HAYQGDHRLF LKSDAVQYLE 100
GHGFRFEVRE KENVHRLDEL LPNVTGGKNL RRTLAAMPEE ETTEANAGQF 150
LSFASLFLPK LVVGEKACLE KVQRQIQVHA EQGLIQYPTS WQSVGHMMVI 200
FRLMRTNFLI KFLLIHQGMH MVAGHDANDT VISNSVAQAR FSGLLIVKTV 250
LDHILQKTDL GVRLHPLART AKVKNEVSSF KAALGSLAKH GEYAPFARLL 300
NLSGVNNLEH GLYPQLSAIA LGVATAHGST LAGVNVGEQY QQLREAATEA 350
EKQLQQYAET RELDNLGLDE QEKKILMSFH QKKNEISFQQ TNAMVTLRKE 400
RLAKLTEAIT TASKIKVGDR YPDDNDIPFP GPIYDDTHPN PSDDNPDDSR 450
DTTIPGGVVD PYDDESNNYP DYEDSAEGTT GDLDLFNLDD DDDDSRPGPP 500
DRGQNKERAA RTYGLQDPTL DGAKKVPELT PGSHQPGNLH ITKSGSNTNQ 550
PQGNMSSTLH SMTPIQEESE PDDQKDNDDE SLTSLDSEGD EDGESISEEN 600
TPTVAPPAPV YKDTGVDTNQ QNGPSSTVDS QGSESEALPI NSKKSSALEE 650
TYYHLLKTQG PFEAINYYHL MSDEPIAFST ESGKEYIFPD SLEEAYPPWL 700
SEKEALEKEN RYLVIDGQQF LWPVMSLRDK FLAVLQHD 738
Length:738
Mass (Da):82,008
Last modified:May 1, 2000 - v1
Checksum:i21AFE1423CFBF9CD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF173836 mRNA. Translation: AAD51107.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF173836 mRNA. Translation: AAD51107.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR008609. Ebola_NP.
[Graphical view ]
Pfami PF05505. Ebola_NP. 1 hit.
[Graphical view ]
PIRSFi PIRSF003900. N_FiloV. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Ebola Sudan nucleocapsid protein."
    Crise B., Smith J.F., Bray M.
    Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiNCAP_EBOSB
AccessioniPrimary (citable) accession number: Q9QP77
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 2000
Last modified: October 16, 2013
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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