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Q9QP77

- NCAP_EBOSB

UniProt

Q9QP77 - NCAP_EBOSB

Protein

Nucleoprotein

Gene

NP

Organism
Sudan ebolavirus (strain Boniface-76) (SEBOV) (Sudan Ebola virus)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid and serves as template for transcription and replication. During replication, encapsidation by NP is coupled to RNA synthesis and all replicative products are resistant to nucleases By similarity.By similarity

    GO - Molecular functioni

    1. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. viral RNA genome packaging Source: InterPro

    Keywords - Molecular functioni

    Ribonucleoprotein

    Keywords - Ligandi

    RNA-binding, Viral nucleoprotein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nucleoprotein
    Alternative name(s):
    Nucleocapsid protein
    Short name:
    Protein N
    Gene namesi
    Name:NP
    OrganismiSudan ebolavirus (strain Boniface-76) (SEBOV) (Sudan Ebola virus)
    Taxonomic identifieri128948 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesMononegaviralesFiloviridaeEbolavirus
    Virus hostiEpomops franqueti (Franquet's epauleted fruit bat) [TaxID: 77231]
    Homo sapiens (Human) [TaxID: 9606]
    Myonycteris torquata (Little collared fruit bat) [TaxID: 77243]

    Subcellular locationi

    Virion. Host cytoplasm By similarity

    GO - Cellular componenti

    1. helical viral capsid Source: UniProtKB-KW
    2. host cell cytoplasm Source: UniProtKB-SubCell
    3. ribonucleoprotein complex Source: UniProtKB-KW
    4. viral nucleocapsid Source: UniProtKB-KW

    Keywords - Cellular componenti

    Capsid protein, Helical capsid protein, Host cytoplasm, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 738738NucleoproteinPRO_0000222174Add
    BLAST

    Post-translational modificationi

    Phosphorylated and O-glycosylated by host.By similarity

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Subunit structurei

    Homooligomer. Homomultimerizes to form the nucleocapsid. Binds to viral genomic RNA. Interacts with VP35 and VP30 to form the nucleocapsid. Also interacts with VP24 and VP40 By similarity.By similarity

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili334 – 36330Sequence AnalysisAdd
    BLAST

    Domaini

    This protein can be divided into a hydrophobic N-terminal half, and a hydrophilic and highly acidic C-terminal half.By similarity

    Sequence similaritiesi

    Belongs to the filoviruses nucleoprotein family.Curated

    Keywords - Domaini

    Coiled coil

    Family and domain databases

    InterProiIPR008609. Ebola_NP.
    [Graphical view]
    PfamiPF05505. Ebola_NP. 1 hit.
    [Graphical view]
    PIRSFiPIRSF003900. N_FiloV. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9QP77-1 [UniParc]FASTAAdd to Basket

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    MDKRVRGSWA LGGQSEVDLD YHKILTAGLS VQQGIVRQRV IPVYVVNDLE    50
    GICQHIIQAF EAGVDFQDNA DSFLLLLCLH HAYQGDHRLF LKSDAVQYLE 100
    GHGFRFEVRE KENVHRLDEL LPNVTGGKNL RRTLAAMPEE ETTEANAGQF 150
    LSFASLFLPK LVVGEKACLE KVQRQIQVHA EQGLIQYPTS WQSVGHMMVI 200
    FRLMRTNFLI KFLLIHQGMH MVAGHDANDT VISNSVAQAR FSGLLIVKTV 250
    LDHILQKTDL GVRLHPLART AKVKNEVSSF KAALGSLAKH GEYAPFARLL 300
    NLSGVNNLEH GLYPQLSAIA LGVATAHGST LAGVNVGEQY QQLREAATEA 350
    EKQLQQYAET RELDNLGLDE QEKKILMSFH QKKNEISFQQ TNAMVTLRKE 400
    RLAKLTEAIT TASKIKVGDR YPDDNDIPFP GPIYDDTHPN PSDDNPDDSR 450
    DTTIPGGVVD PYDDESNNYP DYEDSAEGTT GDLDLFNLDD DDDDSRPGPP 500
    DRGQNKERAA RTYGLQDPTL DGAKKVPELT PGSHQPGNLH ITKSGSNTNQ 550
    PQGNMSSTLH SMTPIQEESE PDDQKDNDDE SLTSLDSEGD EDGESISEEN 600
    TPTVAPPAPV YKDTGVDTNQ QNGPSSTVDS QGSESEALPI NSKKSSALEE 650
    TYYHLLKTQG PFEAINYYHL MSDEPIAFST ESGKEYIFPD SLEEAYPPWL 700
    SEKEALEKEN RYLVIDGQQF LWPVMSLRDK FLAVLQHD 738
    Length:738
    Mass (Da):82,008
    Last modified:May 1, 2000 - v1
    Checksum:i21AFE1423CFBF9CD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF173836 mRNA. Translation: AAD51107.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF173836 mRNA. Translation: AAD51107.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR008609. Ebola_NP.
    [Graphical view ]
    Pfami PF05505. Ebola_NP. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF003900. N_FiloV. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Ebola Sudan nucleocapsid protein."
      Crise B., Smith J.F., Bray M.
      Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiNCAP_EBOSB
    AccessioniPrimary (citable) accession number: Q9QP77
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3