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Q9QP77 (NCAP_EBOSB) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nucleoprotein
Alternative name(s):
Nucleocapsid protein
Short name=Protein N
Gene names
Name:NP
OrganismSudan ebolavirus (strain Boniface-76) (SEBOV) (Sudan Ebola virus)
Taxonomic identifier128948 [NCBI]
Taxonomic lineageVirusesssRNA negative-strand virusesMononegaviralesFiloviridaeEbolavirus
Virus hostEpomops franqueti (Franquet's epauleted fruit bat) [TaxID: 77231]
Homo sapiens (Human) [TaxID: 9606]
Myonycteris torquata (Little collared fruit bat) [TaxID: 77243]

Protein attributes

Sequence length738 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid and serves as template for transcription and replication. During replication, encapsidation by NP is coupled to RNA synthesis and all replicative products are resistant to nucleases By similarity.

Subunit structure

Homooligomer. Homomultimerizes to form the nucleocapsid. Binds to viral genomic RNA. Interacts with VP35 and VP30 to form the nucleocapsid. Also interacts with VP24 and VP40 By similarity.

Subcellular location

Virion. Host cytoplasm By similarity.

Domain

This protein can be divided into a hydrophobic N-terminal half, and a hydrophilic and highly acidic C-terminal half By similarity.

Post-translational modification

Phosphorylated and O-glycosylated by host By similarity.

Sequence similarities

Belongs to the filoviruses nucleoprotein family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 738738Nucleoprotein
PRO_0000222174

Regions

Coiled coil334 – 36330 Potential

Sequences

Sequence LengthMass (Da)Tools
Q9QP77 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 21AFE1423CFBF9CD

FASTA73882,008
        10         20         30         40         50         60 
MDKRVRGSWA LGGQSEVDLD YHKILTAGLS VQQGIVRQRV IPVYVVNDLE GICQHIIQAF 

        70         80         90        100        110        120 
EAGVDFQDNA DSFLLLLCLH HAYQGDHRLF LKSDAVQYLE GHGFRFEVRE KENVHRLDEL 

       130        140        150        160        170        180 
LPNVTGGKNL RRTLAAMPEE ETTEANAGQF LSFASLFLPK LVVGEKACLE KVQRQIQVHA 

       190        200        210        220        230        240 
EQGLIQYPTS WQSVGHMMVI FRLMRTNFLI KFLLIHQGMH MVAGHDANDT VISNSVAQAR 

       250        260        270        280        290        300 
FSGLLIVKTV LDHILQKTDL GVRLHPLART AKVKNEVSSF KAALGSLAKH GEYAPFARLL 

       310        320        330        340        350        360 
NLSGVNNLEH GLYPQLSAIA LGVATAHGST LAGVNVGEQY QQLREAATEA EKQLQQYAET 

       370        380        390        400        410        420 
RELDNLGLDE QEKKILMSFH QKKNEISFQQ TNAMVTLRKE RLAKLTEAIT TASKIKVGDR 

       430        440        450        460        470        480 
YPDDNDIPFP GPIYDDTHPN PSDDNPDDSR DTTIPGGVVD PYDDESNNYP DYEDSAEGTT 

       490        500        510        520        530        540 
GDLDLFNLDD DDDDSRPGPP DRGQNKERAA RTYGLQDPTL DGAKKVPELT PGSHQPGNLH 

       550        560        570        580        590        600 
ITKSGSNTNQ PQGNMSSTLH SMTPIQEESE PDDQKDNDDE SLTSLDSEGD EDGESISEEN 

       610        620        630        640        650        660 
TPTVAPPAPV YKDTGVDTNQ QNGPSSTVDS QGSESEALPI NSKKSSALEE TYYHLLKTQG 

       670        680        690        700        710        720 
PFEAINYYHL MSDEPIAFST ESGKEYIFPD SLEEAYPPWL SEKEALEKEN RYLVIDGQQF 

       730 
LWPVMSLRDK FLAVLQHD 

« Hide

References

[1]"Ebola Sudan nucleocapsid protein."
Crise B., Smith J.F., Bray M.
Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF173836 mRNA. Translation: AAD51107.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR008609. Ebola_NP.
[Graphical view]
PfamPF05505. Ebola_NP. 1 hit.
[Graphical view]
PIRSFPIRSF003900. N_FiloV. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNCAP_EBOSB
AccessionPrimary (citable) accession number: Q9QP77
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 2000
Last modified: October 16, 2013
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families