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Protein

External core antigen

Gene

C

Organism
Hepatitis B virus (HBV)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May regulate immune response to the intracellular capsid in acting as a T-cell tolerogen, by having an immunoregulatory effect which prevents destruction of infected cells by cytotoxic T-cells.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Viral immunoevasionUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
External core antigenUniRule annotation
Gene namesi
Name:CUniRule annotationImported
Synonyms:preCImported
OrganismiHepatitis B virus (HBV)Imported
Taxonomic identifieri10407 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesHepadnaviridaeOrthohepadnavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Pan troglodytes (Chimpanzee) [TaxID: 9598]
Proteomesi
  • UP000131616 Componenti: Genome
  • UP000174133 Componenti: Genome
  • UP000111582 Componenti: Genome
  • UP000160519 Componenti: Genome
  • UP000119845 Componenti: Genome
  • UP000137845 Componenti: Genome
  • UP000116163 Componenti: Genome
  • UP000115088 Componenti: Genome
  • UP000137274 Componenti: Genome
  • UP000167433 Componenti: Genome
  • UP000154625 Componenti: Genome
  • UP000100292 Componenti: Genome

Subcellular locationi

  • Secreted UniRule annotation

GO - Cellular componenti

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi23 ↔ 90Combined sources

Post-translational modificationi

Cleaved by host furin.UniRule annotation
Phosphorylated.UniRule annotation

Interactioni

Subunit structurei

Homodimer.SAAS annotation

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3V6ZX-ray3.34E/F20-178[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 27Hep_core_NInterPro annotationAdd BLAST27
Domaini31 – 103Hepatitis_coreInterPro annotationAdd BLAST73
Domaini116 – 173Hepatitis_coreInterPro annotationAdd BLAST58
Domaini174 – 212Hepatitis_coreInterPro annotationAdd BLAST39

Sequence similaritiesi

Belongs to the orthohepadnavirus precore antigen family.UniRule annotation

Keywords - Domaini

RepeatSAAS annotation

Family and domain databases

InterProiView protein in InterPro
IPR013195. Hepatitis_B_virus_capsid_N.
IPR002006. Viral_capsid_core_Hepatitis.
PfamiView protein in Pfam
PF08290. Hep_core_N. 1 hit.
PF00906. Hepatitis_core. 3 hits.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD000874. Vir_capsid_Znf-put_N_Hepatitis. 1 hit.
SUPFAMiSSF47852. SSF47852. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9QMH8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLFHLCLII SCSCPTVQAS KLCLGWLWGM DIDPYKEFGA TVELLSFLPS
60 70 80 90 100
DFFPSVRDLL DTAAALYRDA LESPEHCSPH HTALRQAILC WGELMTLATW
110 120 130 140 150
VGTNLEDPAS RDLVVSYVNT NMGLKFRQLL WFHISCLTFG RETVLEYLVS
160 170 180 190 200
FGVWIRTPPA YRPPNAPILS TLPETTVVRR RGRSPRRRTP SPRRRRSQSP
210
RRRRSQSRES QC
Length:212
Mass (Da):24,322
Last modified:May 1, 2000 - v1
Checksum:i36D77976FBB61196
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ700497 Genomic DNA. Translation: AGB97618.1.
HQ700501 Genomic DNA. Translation: AGB97645.1.
HQ700503 Genomic DNA. Translation: AGB97659.1.
HQ700524 Genomic DNA. Translation: AGB97795.1.
HQ700525 Genomic DNA. Translation: AGB97802.1.
HQ700541 Genomic DNA. Translation: AGB97895.1.
KM606744 Genomic DNA. Translation: AIW67997.1.
KM524345 Genomic DNA. Translation: AJA30208.1.
HQ700581 Genomic DNA. Translation: AJF41506.1.
HQ700583 Genomic DNA. Translation: AJF41520.1.
HQ700584 Genomic DNA. Translation: AJF41527.1.
AB033559 Genomic DNA. Translation: BAA85376.1.
PIRiC94409. NKVLA3.
S33686.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ700497 Genomic DNA. Translation: AGB97618.1.
HQ700501 Genomic DNA. Translation: AGB97645.1.
HQ700503 Genomic DNA. Translation: AGB97659.1.
HQ700524 Genomic DNA. Translation: AGB97795.1.
HQ700525 Genomic DNA. Translation: AGB97802.1.
HQ700541 Genomic DNA. Translation: AGB97895.1.
KM606744 Genomic DNA. Translation: AIW67997.1.
KM524345 Genomic DNA. Translation: AJA30208.1.
HQ700581 Genomic DNA. Translation: AJF41506.1.
HQ700583 Genomic DNA. Translation: AJF41520.1.
HQ700584 Genomic DNA. Translation: AJF41527.1.
AB033559 Genomic DNA. Translation: BAA85376.1.
PIRiC94409. NKVLA3.
S33686.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3V6ZX-ray3.34E/F20-178[»]
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiView protein in InterPro
IPR013195. Hepatitis_B_virus_capsid_N.
IPR002006. Viral_capsid_core_Hepatitis.
PfamiView protein in Pfam
PF08290. Hep_core_N. 1 hit.
PF00906. Hepatitis_core. 3 hits.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD000874. Vir_capsid_Znf-put_N_Hepatitis. 1 hit.
SUPFAMiSSF47852. SSF47852. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ9QMH8_HBV
AccessioniPrimary (citable) accession number: Q9QMH8
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: February 15, 2017
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.