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Protein

Capsid protein

Gene

C

Organism
Hepatitis B virus (HBV)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Encapsidates hepatitis delta genome.UniRule annotation
May regulate immune response to the intracellular capsid in acting as a T-cell tolerogen, by having an immunoregulatory effect which prevents destruction of infected cells by cytotoxic T-cells.UniRule annotation
Self assembles to form an icosahedral capsid. Most capsid appear to be large particles with a icosahedral symmetry of T=4 and consist of 240 copies of capsid protein, though a fraction forms smaller T=3 particles consisting of 180 capsid proteins. Entering capsid are transported along microtubules to the nucleus. Phosphorylation of the capsid is thought to induce exposure of nuclear localization signal in the C-terminal portion of the capsid protein that allows binding to the nuclear pore complex via the importin (karyopherin-) alpha and beta. Capsids are imported in intact form through the nuclear pore into the nuclear basket, where it probably binds NUP153. Only capsids that contain the mature viral genome can release the viral DNA and capsid protein into the nucleoplasm. Immature capsids get stucked in the basket. Capsids encapsulate the pre-genomic RNA and the P protein. Pre-genomic RNA is reverse transcribed into DNA while the capsid is still in the cytoplasm. The capsid can then either be directed to the nucleus, providing more genome for transcription, or bud through the endoplasmic reticulum to provide new virions.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotation, RNA-bindingUniRule annotation
Biological processCytoplasmic inwards viral transport, Host-virus interaction, Microtubular inwards viral transportUniRule annotation, Viral immunoevasionUniRule annotation, Viral penetration into host nucleusUniRule annotation, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Capsid proteinUniRule annotation
Alternative name(s):
Core antigenUniRule annotation
Core proteinUniRule annotation
HBcAgUniRule annotation
p21.5UniRule annotation
Gene namesi
Name:CUniRule annotationImported
Synonyms:preCImported
OrganismiHepatitis B virus (HBV)Imported
Taxonomic identifieri10407 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesHepadnaviridaeOrthohepadnavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Pan troglodytes (Chimpanzee) [TaxID: 9598]
Proteomesi
  • UP000131616 Componenti: Genome
  • UP000174133 Componenti: Genome
  • UP000111582 Componenti: Genome
  • UP000160519 Componenti: Genome
  • UP000119845 Componenti: Genome
  • UP000137845 Componenti: Genome
  • UP000116163 Componenti: Genome
  • UP000115088 Componenti: Genome
  • UP000137274 Componenti: Genome
  • UP000167433 Componenti: Genome
  • UP000154625 Componenti: Genome
  • UP000100292 Componenti: Genome

Subcellular locationi

  • Secreted UniRule annotation
  • Virion UniRule annotation
  • Host cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Capsid protein, Host cytoplasmUniRule annotation, T=4 icosahedral capsid proteinUniRule annotation, Virion

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi23 ↔ 90Combined sources
Modified residuei184Phosphoserine; by hostUniRule annotation1
Modified residuei191Phosphoserine; by hostUniRule annotation1
Modified residuei199Phosphoserine; by hostUniRule annotation1

Post-translational modificationi

Cleaved by host furin.UniRule annotation
Phosphorylated by host SRPK1, SRPK2, and maybe protein kinase C or GAPDH. Phosphorylation is critical for pregenomic RNA packaging. Protein kinase C phosphorylation is stimulated by HBx protein and may play a role in transport of the viral genome to the nucleus at the late step during viral replication cycle.UniRule annotation

Keywords - PTMi

PhosphoproteinUniRule annotation

Interactioni

Subunit structurei

Homodimerizes, then multimerizes. Interacts with cytosol exposed regions of viral L glycoprotein present in the reticulum-to-Golgi compartment. Interacts with human FLNB. Phosphorylated form interacts with host importin alpha; this interaction depends on the exposure of the NLS, which itself depends upon genome maturation and/or phosphorylation of the capsid protein. Interacts with host NUP153.UniRule annotation

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3V6ZX-ray3.34E/F20-178[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 27Hep_core_NInterPro annotationAdd BLAST27

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni206 – 212RNA bindingUniRule annotation7

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi187 – 204Bipartite nuclear localization signalUniRule annotationAdd BLAST18

Sequence similaritiesi

Belongs to the orthohepadnavirus core antigen family.UniRule annotation
Belongs to the orthohepadnavirus precore antigen family.UniRule annotation

Keywords - Domaini

RepeatUniRule annotationSAAS annotation

Family and domain databases

Gene3Di1.10.4090.10. 1 hit.
HAMAPiMF_04076. HBV_HBEAG. 1 hit.
InterProiView protein in InterPro
IPR013195. Hepatitis_B_virus_capsid_N.
IPR002006. Hepatitis_core.
IPR036459. Viral_capsid_core_dom_sf_HBV.
PfamiView protein in Pfam
PF08290. Hep_core_N. 1 hit.
PF00906. Hepatitis_core. 3 hits.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD000874. Vir_capsid_Znf-put_N_Hepatitis. 1 hit.
SUPFAMiSSF47852. SSF47852. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9QMH8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLFHLCLII SCSCPTVQAS KLCLGWLWGM DIDPYKEFGA TVELLSFLPS
60 70 80 90 100
DFFPSVRDLL DTAAALYRDA LESPEHCSPH HTALRQAILC WGELMTLATW
110 120 130 140 150
VGTNLEDPAS RDLVVSYVNT NMGLKFRQLL WFHISCLTFG RETVLEYLVS
160 170 180 190 200
FGVWIRTPPA YRPPNAPILS TLPETTVVRR RGRSPRRRTP SPRRRRSQSP
210
RRRRSQSRES QC
Length:212
Mass (Da):24,322
Last modified:May 1, 2000 - v1
Checksum:i36D77976FBB61196
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ700497 Genomic DNA. Translation: AGB97618.1.
HQ700501 Genomic DNA. Translation: AGB97645.1.
HQ700503 Genomic DNA. Translation: AGB97659.1.
HQ700524 Genomic DNA. Translation: AGB97795.1.
HQ700525 Genomic DNA. Translation: AGB97802.1.
HQ700541 Genomic DNA. Translation: AGB97895.1.
KM606744 Genomic DNA. Translation: AIW67997.1.
KM524345 Genomic DNA. Translation: AJA30208.1.
HQ700581 Genomic DNA. Translation: AJF41506.1.
HQ700583 Genomic DNA. Translation: AJF41520.1.
HQ700584 Genomic DNA. Translation: AJF41527.1.
AB033559 Genomic DNA. Translation: BAA85376.1.
PIRiC94409. NKVLA3.
S33686.

Similar proteinsi

Entry informationi

Entry nameiQ9QMH8_HBV
AccessioniPrimary (citable) accession number: Q9QMH8
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: January 31, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteomeImported