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Protein

External core antigen

Gene

C

Organism
Hepatitis B virus (HBV)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May regulate immune response to the intracellular capsid in acting as a T-cell tolerogen, by having an immunoregulatory effect which prevents destruction of infected cells by cytotoxic T-cells.UniRule annotation

GO - Molecular functioni

  1. structural molecule activity Source: InterPro

GO - Biological processi

  1. pathogenesis Source: InterPro
  2. viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Viral immunoevasionUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
External core antigenUniRule annotation
Gene namesi
Name:CUniRule annotationImported
Synonyms:preCImported
OrganismiHepatitis B virus (HBV)Imported
Taxonomic identifieri10407 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesHepadnaviridaeOrthohepadnavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Pan troglodytes (Chimpanzee) [TaxID: 9598]

Subcellular locationi

Secreted UniRule annotation

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi23 ↔ 90Combined sources

Post-translational modificationi

Cleaved by host furin.UniRule annotation
Phosphorylated.UniRule annotation

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3V6ZX-ray3.34E/F20-178[»]
ProteinModelPortaliQ9QMH8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the orthohepadnavirus precore antigen family.UniRule annotation

Keywords - Domaini

RepeatSAAS annotation

Family and domain databases

InterProiIPR013195. Hepatitis_B_virus_capsid_N.
IPR002006. Viral_capsid_core_Hepatitis.
[Graphical view]
PfamiPF08290. Hep_core_N. 1 hit.
PF00906. Hepatitis_core. 1 hit.
[Graphical view]
ProDomiPD000874. Vir_capsid_Znf-put_N_Hepatitis. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47852. SSF47852. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9QMH8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQLFHLCLII SCSCPTVQAS KLCLGWLWGM DIDPYKEFGA TVELLSFLPS
60 70 80 90 100
DFFPSVRDLL DTAAALYRDA LESPEHCSPH HTALRQAILC WGELMTLATW
110 120 130 140 150
VGTNLEDPAS RDLVVSYVNT NMGLKFRQLL WFHISCLTFG RETVLEYLVS
160 170 180 190 200
FGVWIRTPPA YRPPNAPILS TLPETTVVRR RGRSPRRRTP SPRRRRSQSP
210
RRRRSQSRES QC
Length:212
Mass (Da):24,322
Last modified:May 1, 2000 - v1
Checksum:i36D77976FBB61196
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ700497 Genomic DNA. Translation: AGB97618.1.
HQ700501 Genomic DNA. Translation: AGB97645.1.
HQ700503 Genomic DNA. Translation: AGB97659.1.
HQ700524 Genomic DNA. Translation: AGB97795.1.
HQ700525 Genomic DNA. Translation: AGB97802.1.
HQ700541 Genomic DNA. Translation: AGB97895.1.
AB033559 Genomic DNA. Translation: BAA85376.1.
PIRiC94409. NKVLA3.
S33686.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ700497 Genomic DNA. Translation: AGB97618.1.
HQ700501 Genomic DNA. Translation: AGB97645.1.
HQ700503 Genomic DNA. Translation: AGB97659.1.
HQ700524 Genomic DNA. Translation: AGB97795.1.
HQ700525 Genomic DNA. Translation: AGB97802.1.
HQ700541 Genomic DNA. Translation: AGB97895.1.
AB033559 Genomic DNA. Translation: BAA85376.1.
PIRiC94409. NKVLA3.
S33686.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3V6ZX-ray3.34E/F20-178[»]
ProteinModelPortaliQ9QMH8.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR013195. Hepatitis_B_virus_capsid_N.
IPR002006. Viral_capsid_core_Hepatitis.
[Graphical view]
PfamiPF08290. Hep_core_N. 1 hit.
PF00906. Hepatitis_core. 1 hit.
[Graphical view]
ProDomiPD000874. Vir_capsid_Znf-put_N_Hepatitis. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47852. SSF47852. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Typing hepatitis B virus by homology in nucleotide sequence: comparison of surface antigen subtypes."
    Okamoto H., Tsuda F., Sakugawa H., Sastrosoewignjo R.I., Imai M., Miyakawa Y., Mayumi M.
    J. Gen. Virol. 69:2575-2583(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Genotype DImported.
  2. "Complete nucleotide sequence of a hepatitis B virus, subtype adw2, and identification of three types of C open reading frame."
    Preisler-Adams S., Schlayer H.J., Peters T., Korp R., Rasenack J.
    Nucleic Acids Res. 21:2258-2258(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  3. Okamoto H.
    Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Genotype DImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: D_F109C_2004Imported, D_KI387C_2005Imported, D_PNG_P043PF_2004Imported, D_PNG_P054PF_2004Imported, D_Samoa_Fa_1991Imported and D_Tonga_Ng_1992Imported.
  5. "Genomic analysis of hepatitis B virus reveals antigen state and genotype as sources of evolutionary rate variation."
    Harrison A., Lemey P., Hurles M., Moyes C., Horn S., Pryor J., Malani J., Supuri M., Masta A., Teriboriki B., Toatu T., Penny D., Rambaut A., Shapiro B.
    Viruses 3:83-101(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: D_F109C_2004Imported, D_KI387C_2005Imported, D_PNG_P043PF_2004Imported, D_PNG_P054PF_2004Imported, D_Samoa_Fa_1991Imported and D_Tonga_Ng_1992Imported.
  6. "Antigenic switching of hepatitis B virus by alternative dimerization of the capsid protein."
    DiMattia M.A., Watts N.R., Stahl S.J., Grimes J.M., Steven A.C., Stuart D.I., Wingfield P.T.
    Structure 21:133-142(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.34 ANGSTROMS) OF 20-178, ACTIVE SITE.

Entry informationi

Entry nameiQ9QMH8_HBV
AccessioniPrimary (citable) accession number: Q9QMH8
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: February 4, 2015
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.