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Q9QJ37

- DEN_HHV6Z

UniProt

Q9QJ37 - DEN_HHV6Z

Protein

Deneddylase

Gene

U31

Organism
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Deneddylase that deregulates the host cell cycle S phase to create a favorable environment allowing efficient viral genome replication. Interacts with and deneddylates host cullins including CUL1 and CUL4A, thereby reducing their E3 ubiquitin ligase activity. Inhibition of cullins leads to the stabilization of cullin-RING ligase substrates such as host CDN1A/p21, CDKN1B/p27kip and CDC25A, preventing S phase progression. Additionally, acts as a deubiquitinase and cleaves both 'Lys-48' and 'Lys-63'-linked ubiquitin chains By similarity.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei10 – 101Important for catalytic activityPROSITE-ProRule annotation
    Active sitei23 – 231PROSITE-ProRule annotation
    Active sitei156 – 1561PROSITE-ProRule annotation
    Active sitei158 – 1581PROSITE-ProRule annotation

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW

    GO - Biological processi

    1. modulation by virus of host protein ubiquitination Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Host-virus interaction, Modulation of host ubiquitin pathway by viral deubiquitinase, Modulation of host ubiquitin pathway by virus, Ubl conjugation pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Deneddylase (EC:3.4.19.12, EC:3.4.22.-)
    Gene namesi
    Name:U31
    OrganismiHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus)
    Taxonomic identifieri36351 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeRoseolovirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    ProteomesiUP000006930: Genome

    Subcellular locationi

    GO - Cellular componenti

    1. host cell cytoplasm Source: UniProtKB-SubCell
    2. host cell nucleus Source: UniProtKB-SubCell
    3. viral tegument Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host cytoplasm, Host nucleus, Virion, Virion tegument

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 20772077DeneddylasePRO_0000408401Add
    BLAST

    Interactioni

    Subunit structurei

    Interacts with host CUL1 and CUL4A; these interactions inhibit the E3 ligase activity of cullins.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9QJ37.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini3 – 221219Peptidase C76PROSITE-ProRule annotationAdd
    BLAST
    Repeati1096 – 111924LRR 1Add
    BLAST
    Repeati2045 – 206824LRR 2Add
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili1185 – 121430Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi280 – 2834Poly-Lys

    Sequence similaritiesi

    Belongs to the herpesviridae deneddylase family.Curated
    Contains 2 LRR (leucine-rich) repeats.Curated
    Contains 1 peptidase C76 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Leucine-rich repeat, Repeat

    Family and domain databases

    InterProiIPR006928. Pept_C76_UL36-USP.
    [Graphical view]
    PfamiPF04843. Herpes_teg_N. 1 hit.
    [Graphical view]
    PROSITEiPS51521. HTUSP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9QJ37-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKIITSSTNQ NDSKYGPRAG KQCMSNSFSF LHTVYLNGIN NSLNAGTIDA     50
    IMEEGYHLDT ASTLALMLDN SDSQDYRLLT EIPRRIHSRY GVTQHELSRP 100
    FNGTLDTQKI DNEVYFGLID FILYGKTKNC PAFAVITIGV LSRAIFFLNN 150
    TLYLFDSHPT EREATAAIYI CQDIEEAYEL LTAHGTEGFY YDASFIFFIE 200
    TSNLSLSSHD AELLILKTYK DPDIAITLDK FSSTEIHDIK KTDDIGSQQD 250
    LVAAKTTYLE RAPQKRKKNS HSLELELNDK KKKDTASLTY YATEVDLIPS 300
    FYELRSQFQS LFHDLKSFPI MKSQFNWTIY LQDSPMNPNQ PFATPFLWNR 350
    VFHLLCQIVD VFVGVGSTND DSSKQKQQTI FINYLLPFKD FSEVFNEALT 400
    ACQENNLDIL LIYNNYLCKT TTFRTLERIL LSKFLAIADN EHEKHYEWVK 450
    SWTTQMLQEM PKKLDDIENY LKAYVSQNPV KHFHEFVCLN KAEKHNIAVL 500
    LNEKRKEIQE DIERDKNIFA QLSNFIDKLG ETPALPIESE NVHKVHTSDI 550
    TEAIVPRFMT ESIELPNIST LNNTQQLSLE KQISEKLTNT IHTLRNKFTK 600
    IVQDNYNNLA AGFMPVTELN CLFAYLVNLY FNIEVLKHSG LNINTELLQE 650
    VEKLYDNTQF LRFGTSHFNI NNLSNFTLSI RKMFVDFYNS QKPSDRASEI 700
    LAAIESILAD PSKNKTIVNI EMIKSQLEEL GKMEISTTEN KQTAEITKQI 750
    LGDQELTPIY DFLHHLSAYN LPNTTTVKNL HLHFILEKRP DIAAILHDKI 800
    QSILDICIDD MLNDITVPEQ TFSTVLFLVD LFPNSTEKTA LFESVLTLRQ 850
    LAKKCANLKT LEEFDDLAQF ITTNSEQLQN MMKQHFGKKI PTLMDHIKFL 900
    YSQKIITAEE KNWIQRAKTA VITSPEELTA FLATAPTKHA LQTCKPELDK 950
    ALQRHMEEQM KQTAENDKKH ILTIRNTLEK RLNDILLILK DGQFSSLETV 1000
    HLNLLETFLK QLQDNDLIIH FTHALLPVLK DIETTISKTI SDILEKILIK 1050
    TPLNPEQMSK EEQKYTPLLS FLSKFKKTTF CTEDVKTEID QMQKSITFLT 1100
    KIATSTNKYT RISHSVYGQE LNLYEERITE LKKETNKIKE QLSKEYAVAE 1150
    KKILLSSQDA KTNKIYLVLN THTLKEIKNT QFRETAFAKA LTVEVNNKEN 1200
    QLQELLNHFN AHLKAKMDQN HITKLSFDTK WTAFVSDSRL YFPDFVDIKL 1250
    QDFISDPFKV ISQLMNKAAN EMPYIQAEIT LKWLTQLVHD INKFCLSAIS 1300
    EFGKEAIPFN YAALRDLEYQ INTKYVEIEN KVICNETVEN TKNIPKLTKL 1350
    LKELDPKRVA GGQKQYQTLM NKILTSETSM QQTYEKEQLK KEYFETVNNV 1400
    ASFKLAFNFP KQRQNVERLM EKFKSLPKGQ PFEKFPEEND LFSDSLITEN 1450
    YINGLRALLN FITAAQNYIQ NTLLKQWAVF QQQNFIPIDY SVANVKPISD 1500
    LYARLRIERD RQVFYQVNSV FGTQLIVDET GVPLQFHNIF YNAVVKFFSL 1550
    NYKQIHVPED TPRLVSSQYK LLSVCKSFII ILQQFWENII TLDLGPYLRD 1600
    GTQNFKRELI PIVNLKLFIY IITQAWTASE DSTVSTAFEL PIKQFTLLIL 1650
    CSHPEYLYGC LSHPTDLVIN SLAKSIDKDS LYDTFVVSHN PPEKPMHLMR 1700
    SICIDTQLWQ SAKLMKDTFQ QTFFTQLCPQ NEKFFIYLTA FLILPYKFLN 1750
    YIWIQYKPIT FTQRSYQNLI KDLCSEYVHQ NKITMSSVTP HEPDTIKSGE 1800
    KITSKITVHK AQNTPTLTRL QAQEYVFDYI LYSFLTGYEM TFAMYIDTIE 1850
    KTYLLCMRHL ENVLHDKDFQ SVLRARTFDI NYILKQSWTK NIVEHSIFSV 1900
    QLNKIVSYLN HTNRATPNIP LILFNYDNEV VNVYLPPMST DPKKVAFYIK 1950
    NPFHFPVQEY EATDLISFHL YPKTTDILNQ LPPNKTVSTR PYNLSSETLT 2000
    TKNLSEPKFK QPTVTGLMPK SQSIILSTDT NVLETSPDIK ANTASAAIKD 2050
    VTLAREQISE FSESINTTLS KLKSLYL 2077
    Length:2,077
    Mass (Da):240,285
    Last modified:May 1, 2000 - v1
    Checksum:i49D4C3F872A5BDF8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF157706 Genomic DNA. Translation: AAD49645.1.
    RefSeqiNP_050212.1. NC_000898.1.

    Genome annotation databases

    GeneIDi1497033.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF157706 Genomic DNA. Translation: AAD49645.1 .
    RefSeqi NP_050212.1. NC_000898.1.

    3D structure databases

    ProteinModelPortali Q9QJ37.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 1497033.

    Family and domain databases

    InterProi IPR006928. Pept_C76_UL36-USP.
    [Graphical view ]
    Pfami PF04843. Herpes_teg_N. 1 hit.
    [Graphical view ]
    PROSITEi PS51521. HTUSP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human herpesvirus 6B genome sequence: coding content and comparison with human herpesvirus 6A."
      Dominguez G., Dambaugh T.R., Stamey F.R., Dewhurst S., Inoue N., Pellett P.E.
      J. Virol. 73:8040-8052(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiDEN_HHV6Z
    AccessioniPrimary (citable) accession number: Q9QJ37
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 3, 2011
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3