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Q9QJ37 (DEN_HHV6Z) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein attributes

Sequence length2077 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Deneddylase that deregulates the host cell cycle S phase to create a favorable environment allowing efficient viral genome replication. Interacts with and deneddylates host cullins including CUL1 and CUL4A, thereby reducing their E3 ubiquitin ligase activity. Inhibition of cullins leads to the stabilization of cullin-RING ligase substrates such as host CDN1A/p21, CDKN1B/p27kip and CDC25A, preventing S phase progression. Additionally, acts as a deubiquitinase and cleaves both 'Lys-48' and 'Lys-63'-linked ubiquitin chains By similarity.

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Subunit structure

Interacts with host CUL1 and CUL4A; these interactions inhibit the E3 ligase activity of cullins By similarity.

Subcellular location

Virion tegument. Host cytoplasm. Host nucleus By similarity.

Sequence similarities

Belongs to the herpesviridae deneddylase family.

Contains 2 LRR (leucine-rich) repeats.

Contains 1 peptidase C76 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 20772077Deneddylase
PRO_0000408401

Regions

Domain3 – 221219Peptidase C76
Repeat1096 – 111924LRR 1
Repeat2045 – 206824LRR 2
Coiled coil1185 – 121430 Potential
Compositional bias280 – 2834Poly-Lys

Sites

Active site231 By similarity
Active site1561 By similarity
Active site1581 By similarity
Site101Important for catalytic activity By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9QJ37 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 49D4C3F872A5BDF8

FASTA2,077240,285
        10         20         30         40         50         60 
MKIITSSTNQ NDSKYGPRAG KQCMSNSFSF LHTVYLNGIN NSLNAGTIDA IMEEGYHLDT 

        70         80         90        100        110        120 
ASTLALMLDN SDSQDYRLLT EIPRRIHSRY GVTQHELSRP FNGTLDTQKI DNEVYFGLID 

       130        140        150        160        170        180 
FILYGKTKNC PAFAVITIGV LSRAIFFLNN TLYLFDSHPT EREATAAIYI CQDIEEAYEL 

       190        200        210        220        230        240 
LTAHGTEGFY YDASFIFFIE TSNLSLSSHD AELLILKTYK DPDIAITLDK FSSTEIHDIK 

       250        260        270        280        290        300 
KTDDIGSQQD LVAAKTTYLE RAPQKRKKNS HSLELELNDK KKKDTASLTY YATEVDLIPS 

       310        320        330        340        350        360 
FYELRSQFQS LFHDLKSFPI MKSQFNWTIY LQDSPMNPNQ PFATPFLWNR VFHLLCQIVD 

       370        380        390        400        410        420 
VFVGVGSTND DSSKQKQQTI FINYLLPFKD FSEVFNEALT ACQENNLDIL LIYNNYLCKT 

       430        440        450        460        470        480 
TTFRTLERIL LSKFLAIADN EHEKHYEWVK SWTTQMLQEM PKKLDDIENY LKAYVSQNPV 

       490        500        510        520        530        540 
KHFHEFVCLN KAEKHNIAVL LNEKRKEIQE DIERDKNIFA QLSNFIDKLG ETPALPIESE 

       550        560        570        580        590        600 
NVHKVHTSDI TEAIVPRFMT ESIELPNIST LNNTQQLSLE KQISEKLTNT IHTLRNKFTK 

       610        620        630        640        650        660 
IVQDNYNNLA AGFMPVTELN CLFAYLVNLY FNIEVLKHSG LNINTELLQE VEKLYDNTQF 

       670        680        690        700        710        720 
LRFGTSHFNI NNLSNFTLSI RKMFVDFYNS QKPSDRASEI LAAIESILAD PSKNKTIVNI 

       730        740        750        760        770        780 
EMIKSQLEEL GKMEISTTEN KQTAEITKQI LGDQELTPIY DFLHHLSAYN LPNTTTVKNL 

       790        800        810        820        830        840 
HLHFILEKRP DIAAILHDKI QSILDICIDD MLNDITVPEQ TFSTVLFLVD LFPNSTEKTA 

       850        860        870        880        890        900 
LFESVLTLRQ LAKKCANLKT LEEFDDLAQF ITTNSEQLQN MMKQHFGKKI PTLMDHIKFL 

       910        920        930        940        950        960 
YSQKIITAEE KNWIQRAKTA VITSPEELTA FLATAPTKHA LQTCKPELDK ALQRHMEEQM 

       970        980        990       1000       1010       1020 
KQTAENDKKH ILTIRNTLEK RLNDILLILK DGQFSSLETV HLNLLETFLK QLQDNDLIIH 

      1030       1040       1050       1060       1070       1080 
FTHALLPVLK DIETTISKTI SDILEKILIK TPLNPEQMSK EEQKYTPLLS FLSKFKKTTF 

      1090       1100       1110       1120       1130       1140 
CTEDVKTEID QMQKSITFLT KIATSTNKYT RISHSVYGQE LNLYEERITE LKKETNKIKE 

      1150       1160       1170       1180       1190       1200 
QLSKEYAVAE KKILLSSQDA KTNKIYLVLN THTLKEIKNT QFRETAFAKA LTVEVNNKEN 

      1210       1220       1230       1240       1250       1260 
QLQELLNHFN AHLKAKMDQN HITKLSFDTK WTAFVSDSRL YFPDFVDIKL QDFISDPFKV 

      1270       1280       1290       1300       1310       1320 
ISQLMNKAAN EMPYIQAEIT LKWLTQLVHD INKFCLSAIS EFGKEAIPFN YAALRDLEYQ 

      1330       1340       1350       1360       1370       1380 
INTKYVEIEN KVICNETVEN TKNIPKLTKL LKELDPKRVA GGQKQYQTLM NKILTSETSM 

      1390       1400       1410       1420       1430       1440 
QQTYEKEQLK KEYFETVNNV ASFKLAFNFP KQRQNVERLM EKFKSLPKGQ PFEKFPEEND 

      1450       1460       1470       1480       1490       1500 
LFSDSLITEN YINGLRALLN FITAAQNYIQ NTLLKQWAVF QQQNFIPIDY SVANVKPISD 

      1510       1520       1530       1540       1550       1560 
LYARLRIERD RQVFYQVNSV FGTQLIVDET GVPLQFHNIF YNAVVKFFSL NYKQIHVPED 

      1570       1580       1590       1600       1610       1620 
TPRLVSSQYK LLSVCKSFII ILQQFWENII TLDLGPYLRD GTQNFKRELI PIVNLKLFIY 

      1630       1640       1650       1660       1670       1680 
IITQAWTASE DSTVSTAFEL PIKQFTLLIL CSHPEYLYGC LSHPTDLVIN SLAKSIDKDS 

      1690       1700       1710       1720       1730       1740 
LYDTFVVSHN PPEKPMHLMR SICIDTQLWQ SAKLMKDTFQ QTFFTQLCPQ NEKFFIYLTA 

      1750       1760       1770       1780       1790       1800 
FLILPYKFLN YIWIQYKPIT FTQRSYQNLI KDLCSEYVHQ NKITMSSVTP HEPDTIKSGE 

      1810       1820       1830       1840       1850       1860 
KITSKITVHK AQNTPTLTRL QAQEYVFDYI LYSFLTGYEM TFAMYIDTIE KTYLLCMRHL 

      1870       1880       1890       1900       1910       1920 
ENVLHDKDFQ SVLRARTFDI NYILKQSWTK NIVEHSIFSV QLNKIVSYLN HTNRATPNIP 

      1930       1940       1950       1960       1970       1980 
LILFNYDNEV VNVYLPPMST DPKKVAFYIK NPFHFPVQEY EATDLISFHL YPKTTDILNQ 

      1990       2000       2010       2020       2030       2040 
LPPNKTVSTR PYNLSSETLT TKNLSEPKFK QPTVTGLMPK SQSIILSTDT NVLETSPDIK 

      2050       2060       2070 
ANTASAAIKD VTLAREQISE FSESINTTLS KLKSLYL 

« Hide

References

[1]"Human herpesvirus 6B genome sequence: coding content and comparison with human herpesvirus 6A."
Dominguez G., Dambaugh T.R., Stamey F.R., Dewhurst S., Inoue N., Pellett P.E.
J. Virol. 73:8040-8052(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF157706 Genomic DNA. Translation: AAD49645.1.
RefSeqNP_050212.1. NC_000898.1.

3D structure databases

ProteinModelPortalQ9QJ37.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1497033.

Family and domain databases

InterProIPR006928. Pept_C76_UL36-USP.
[Graphical view]
PfamPF04843. Herpes_teg_N. 1 hit.
[Graphical view]
PROSITEPS51521. HTUSP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDEN_HHV6Z
AccessionPrimary (citable) accession number: Q9QJ37
Entry history
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: May 1, 2000
Last modified: May 14, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries