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Q9QJ37

- DEN_HHV6Z

UniProt

Q9QJ37 - DEN_HHV6Z

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Protein
Deneddylase
Gene
U31
Organism
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Deneddylase that deregulates the host cell cycle S phase to create a favorable environment allowing efficient viral genome replication. Interacts with and deneddylates host cullins including CUL1 and CUL4A, thereby reducing their E3 ubiquitin ligase activity. Inhibition of cullins leads to the stabilization of cullin-RING ligase substrates such as host CDN1A/p21, CDKN1B/p27kip and CDC25A, preventing S phase progression. Additionally, acts as a deubiquitinase and cleaves both 'Lys-48' and 'Lys-63'-linked ubiquitin chains By similarity.

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei10 – 101Important for catalytic activity By similarity
Active sitei23 – 231 By similarity
Active sitei156 – 1561 By similarity
Active sitei158 – 1581 By similarity

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW

GO - Biological processi

  1. modulation by virus of host protein ubiquitination Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Host-virus interaction, Modulation of host ubiquitin pathway by viral deubiquitinase, Modulation of host ubiquitin pathway by virus, Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Deneddylase (EC:3.4.19.12, EC:3.4.22.-)
Gene namesi
Name:U31
OrganismiHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus)
Taxonomic identifieri36351 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeRoseolovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000006930: Genome

Subcellular locationi

GO - Cellular componenti

  1. host cell cytoplasm Source: UniProtKB-SubCell
  2. host cell nucleus Source: UniProtKB-SubCell
  3. viral tegument Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host cytoplasm, Host nucleus, Virion, Virion tegument

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 20772077Deneddylase
PRO_0000408401Add
BLAST

Interactioni

Subunit structurei

Interacts with host CUL1 and CUL4A; these interactions inhibit the E3 ligase activity of cullins By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ9QJ37.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 221219Peptidase C76
Add
BLAST
Repeati1096 – 111924LRR 1
Add
BLAST
Repeati2045 – 206824LRR 2
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1185 – 121430 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi280 – 2834Poly-Lys

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Leucine-rich repeat, Repeat

Family and domain databases

InterProiIPR006928. Pept_C76_UL36-USP.
[Graphical view]
PfamiPF04843. Herpes_teg_N. 1 hit.
[Graphical view]
PROSITEiPS51521. HTUSP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QJ37-1 [UniParc]FASTAAdd to Basket

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MKIITSSTNQ NDSKYGPRAG KQCMSNSFSF LHTVYLNGIN NSLNAGTIDA     50
IMEEGYHLDT ASTLALMLDN SDSQDYRLLT EIPRRIHSRY GVTQHELSRP 100
FNGTLDTQKI DNEVYFGLID FILYGKTKNC PAFAVITIGV LSRAIFFLNN 150
TLYLFDSHPT EREATAAIYI CQDIEEAYEL LTAHGTEGFY YDASFIFFIE 200
TSNLSLSSHD AELLILKTYK DPDIAITLDK FSSTEIHDIK KTDDIGSQQD 250
LVAAKTTYLE RAPQKRKKNS HSLELELNDK KKKDTASLTY YATEVDLIPS 300
FYELRSQFQS LFHDLKSFPI MKSQFNWTIY LQDSPMNPNQ PFATPFLWNR 350
VFHLLCQIVD VFVGVGSTND DSSKQKQQTI FINYLLPFKD FSEVFNEALT 400
ACQENNLDIL LIYNNYLCKT TTFRTLERIL LSKFLAIADN EHEKHYEWVK 450
SWTTQMLQEM PKKLDDIENY LKAYVSQNPV KHFHEFVCLN KAEKHNIAVL 500
LNEKRKEIQE DIERDKNIFA QLSNFIDKLG ETPALPIESE NVHKVHTSDI 550
TEAIVPRFMT ESIELPNIST LNNTQQLSLE KQISEKLTNT IHTLRNKFTK 600
IVQDNYNNLA AGFMPVTELN CLFAYLVNLY FNIEVLKHSG LNINTELLQE 650
VEKLYDNTQF LRFGTSHFNI NNLSNFTLSI RKMFVDFYNS QKPSDRASEI 700
LAAIESILAD PSKNKTIVNI EMIKSQLEEL GKMEISTTEN KQTAEITKQI 750
LGDQELTPIY DFLHHLSAYN LPNTTTVKNL HLHFILEKRP DIAAILHDKI 800
QSILDICIDD MLNDITVPEQ TFSTVLFLVD LFPNSTEKTA LFESVLTLRQ 850
LAKKCANLKT LEEFDDLAQF ITTNSEQLQN MMKQHFGKKI PTLMDHIKFL 900
YSQKIITAEE KNWIQRAKTA VITSPEELTA FLATAPTKHA LQTCKPELDK 950
ALQRHMEEQM KQTAENDKKH ILTIRNTLEK RLNDILLILK DGQFSSLETV 1000
HLNLLETFLK QLQDNDLIIH FTHALLPVLK DIETTISKTI SDILEKILIK 1050
TPLNPEQMSK EEQKYTPLLS FLSKFKKTTF CTEDVKTEID QMQKSITFLT 1100
KIATSTNKYT RISHSVYGQE LNLYEERITE LKKETNKIKE QLSKEYAVAE 1150
KKILLSSQDA KTNKIYLVLN THTLKEIKNT QFRETAFAKA LTVEVNNKEN 1200
QLQELLNHFN AHLKAKMDQN HITKLSFDTK WTAFVSDSRL YFPDFVDIKL 1250
QDFISDPFKV ISQLMNKAAN EMPYIQAEIT LKWLTQLVHD INKFCLSAIS 1300
EFGKEAIPFN YAALRDLEYQ INTKYVEIEN KVICNETVEN TKNIPKLTKL 1350
LKELDPKRVA GGQKQYQTLM NKILTSETSM QQTYEKEQLK KEYFETVNNV 1400
ASFKLAFNFP KQRQNVERLM EKFKSLPKGQ PFEKFPEEND LFSDSLITEN 1450
YINGLRALLN FITAAQNYIQ NTLLKQWAVF QQQNFIPIDY SVANVKPISD 1500
LYARLRIERD RQVFYQVNSV FGTQLIVDET GVPLQFHNIF YNAVVKFFSL 1550
NYKQIHVPED TPRLVSSQYK LLSVCKSFII ILQQFWENII TLDLGPYLRD 1600
GTQNFKRELI PIVNLKLFIY IITQAWTASE DSTVSTAFEL PIKQFTLLIL 1650
CSHPEYLYGC LSHPTDLVIN SLAKSIDKDS LYDTFVVSHN PPEKPMHLMR 1700
SICIDTQLWQ SAKLMKDTFQ QTFFTQLCPQ NEKFFIYLTA FLILPYKFLN 1750
YIWIQYKPIT FTQRSYQNLI KDLCSEYVHQ NKITMSSVTP HEPDTIKSGE 1800
KITSKITVHK AQNTPTLTRL QAQEYVFDYI LYSFLTGYEM TFAMYIDTIE 1850
KTYLLCMRHL ENVLHDKDFQ SVLRARTFDI NYILKQSWTK NIVEHSIFSV 1900
QLNKIVSYLN HTNRATPNIP LILFNYDNEV VNVYLPPMST DPKKVAFYIK 1950
NPFHFPVQEY EATDLISFHL YPKTTDILNQ LPPNKTVSTR PYNLSSETLT 2000
TKNLSEPKFK QPTVTGLMPK SQSIILSTDT NVLETSPDIK ANTASAAIKD 2050
VTLAREQISE FSESINTTLS KLKSLYL 2077
Length:2,077
Mass (Da):240,285
Last modified:May 1, 2000 - v1
Checksum:i49D4C3F872A5BDF8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF157706 Genomic DNA. Translation: AAD49645.1.
RefSeqiNP_050212.1. NC_000898.1.

Genome annotation databases

GeneIDi1497033.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF157706 Genomic DNA. Translation: AAD49645.1 .
RefSeqi NP_050212.1. NC_000898.1.

3D structure databases

ProteinModelPortali Q9QJ37.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 1497033.

Family and domain databases

InterProi IPR006928. Pept_C76_UL36-USP.
[Graphical view ]
Pfami PF04843. Herpes_teg_N. 1 hit.
[Graphical view ]
PROSITEi PS51521. HTUSP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Human herpesvirus 6B genome sequence: coding content and comparison with human herpesvirus 6A."
    Dominguez G., Dambaugh T.R., Stamey F.R., Dewhurst S., Inoue N., Pellett P.E.
    J. Virol. 73:8040-8052(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiDEN_HHV6Z
AccessioniPrimary (citable) accession number: Q9QJ37
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: May 1, 2000
Last modified: May 14, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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