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Q9QCE9

- NCAP_EBOG4

UniProt

Q9QCE9 - NCAP_EBOG4

Protein

Nucleoprotein

Gene

NP

Organism
Zaire ebolavirus (strain Gabon-94) (ZEBOV) (Zaire Ebola virus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid and serves as template for transcription and replication. During replication, encapsidation by NP is coupled to RNA synthesis and all replicative products are resistant to nucleases By similarity.By similarity

    GO - Molecular functioni

    1. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. viral RNA genome packaging Source: InterPro

    Keywords - Molecular functioni

    Ribonucleoprotein

    Keywords - Ligandi

    RNA-binding, Viral nucleoprotein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nucleoprotein
    Alternative name(s):
    Nucleocapsid protein
    Short name:
    Protein N
    Gene namesi
    Name:NP
    OrganismiZaire ebolavirus (strain Gabon-94) (ZEBOV) (Zaire Ebola virus)
    Taxonomic identifieri128947 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesMononegaviralesFiloviridaeEbolavirus
    Virus hostiEpomops franqueti (Franquet's epauleted fruit bat) [TaxID: 77231]
    Homo sapiens (Human) [TaxID: 9606]
    Myonycteris torquata (Little collared fruit bat) [TaxID: 77243]

    Subcellular locationi

    Virion. Host cytoplasm By similarity

    GO - Cellular componenti

    1. helical viral capsid Source: UniProtKB-KW
    2. host cell cytoplasm Source: UniProtKB-SubCell
    3. ribonucleoprotein complex Source: UniProtKB-KW
    4. viral nucleocapsid Source: UniProtKB-KW

    Keywords - Cellular componenti

    Capsid protein, Helical capsid protein, Host cytoplasm, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 739739NucleoproteinPRO_0000222173Add
    BLAST

    Post-translational modificationi

    Phosphorylated and O-glycosylated by host.By similarity

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Subunit structurei

    Homooligomer. Homomultimerizes to form the nucleocapsid. Binds to viral genomic RNA. Interacts with VP35 and VP30 to form the nucleocapsid. Also interacts with VP24 and VP40 By similarity.By similarity

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili334 – 36330Sequence AnalysisAdd
    BLAST

    Domaini

    This protein can be divided into a hydrophobic N-terminal half, and a hydrophilic and highly acidic C-terminal half.By similarity

    Sequence similaritiesi

    Belongs to the filoviruses nucleoprotein family.Curated

    Keywords - Domaini

    Coiled coil

    Family and domain databases

    InterProiIPR008609. Ebola_NP.
    [Graphical view]
    PfamiPF05505. Ebola_NP. 1 hit.
    [Graphical view]
    PIRSFiPIRSF003900. N_FiloV. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9QCE9-1 [UniParc]FASTAAdd to Basket

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    MDSRPQKVWM TPSLTESDMD YHKILTAGLS VQQGIVRQRV IPVYQVNNLE    50
    EICQLIIQAF EAGVDFQESA DSFLLMLCLH HAYQGDYKLF LESGAVKYLE 100
    GHGFRFEVKK RDGVKRLEEL LPAVSSGKNI KRTLAAMPEE ETTEANAGQF 150
    LSFASLFLPK LVVGEKACLR KVQRQIQVHA EQGLIQYPTA WQSVGHMMVI 200
    FRLMRTNFLI KFLLIHQGMH MVAGHDANDA VISNSVAQAR FSGLLIVKTV 250
    LDHILQKTQR GVRLHPLART AKVKNEVNSL KAALSSLAKH GEYAPFARLL 300
    NLSGVNNLEH GLFPQLSAIA LGVATAHGST LAGVNVGEQY QQLREAATEA 350
    EKQLQQYAES RELDHLGLDD QEKKILMNFH QKKNEISFQQ TNAMVTLKKE 400
    RLAKLTEAIT AASLPKTSGH YDDDDDIPFP GPINDDDNPG HQDDDPTDSQ 450
    DTTIPDVVVD PDDGSYGEYQ SYSENGMNAP DDLVLFDLDE DDEDTKPVPN 500
    RSTKGGQQKN SQKGQHTEGR QTQSRPTQNI PGPHRTIHHA SAPLTDNDRR 550
    NEPSGSTSPR MLTPINEEAD PLDDADDETS SLPPLESDDE EQDRDGTSNR 600
    TPTVAPPAPV YRDHSEKKEL PQDERQDQDH TQEARNQDSD NTQPEHSFEE 650
    MYRHILRSQG PFDAVLYYHM MKDEPVVFST SDGKEYTYPD SLEEEYPPWL 700
    TEKEAMNEEN TFVTLDGQQF YWPVMNHKDK FMAILQHHQ 739
    Length:739
    Mass (Da):83,241
    Last modified:May 1, 2000 - v1
    Checksum:i33A96720FFBC638E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y09358 Genomic RNA. Translation: CAA70541.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y09358 Genomic RNA. Translation: CAA70541.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR008609. Ebola_NP.
    [Graphical view ]
    Pfami PF05505. Ebola_NP. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF003900. N_FiloV. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Recombinant Ebola virus nucleoprotein and glycoprotein (Gabon 94 strain) provide new tools for the detection of human infections."
      Prehaud C.J.C., Hellebrand E., Coudrier D., Volchkov V.E., Volchkova V.A., Feldmann B., Le Guenno B., Bouloy M.
      J. Gen. Virol. 79:2565-2572(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiNCAP_EBOG4
    AccessioniPrimary (citable) accession number: Q9QCE9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3