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Protein

Genome polyprotein

Gene
N/A
Organism
Foot-and-mouth disease virus - type C
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

NTP + H2O = NDP + phosphate.SAAS annotation
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).SAAS annotation
Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.SAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi2095MagnesiumCombined sources1
Metal bindingi2097MagnesiumCombined sources1
Metal bindingi2196MagnesiumCombined sources1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHelicaseSAAS annotation, Hydrolase, Ion channel, Nucleotidyltransferase, Protease, RNA-bindingSAAS annotation, RNA-directed RNA polymeraseSAAS annotation, Thiol proteaseSAAS annotation, Transferase, Viral ion channelSAAS annotation
Biological processHost-virus interaction, Ion transport, Transport, Viral attachment to host cellSAAS annotation, Viral RNA replicationSAAS annotation, Virus entry into host cell
LigandATP-binding, MagnesiumCombined sources, Metal-bindingCombined sources, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Genome polyproteinSAAS annotation
OrganismiFoot-and-mouth disease virus - type CImported
Taxonomic identifieri12116 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stagePicornaviralesPicornaviridaeAphthovirus
Proteomesi
  • UP000180769 Componenti: Genome

Subcellular locationi

  • Host cytoplasmic vesicle membrane SAAS annotation; Peripheral membrane protein SAAS annotation; Cytoplasmic side SAAS annotation
  • Virion SAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

Capsid proteinSAAS annotation, Host cytoplasmSAAS annotation, Host cytoplasmic vesicleSAAS annotation, Host membraneSAAS annotation, Membrane, Virion

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3KLVX-ray2.60A1858-2327[»]
3KMQX-ray2.11A1858-2327[»]
3KMSX-ray2.20A1858-2327[»]
3KNAX-ray2.80A1858-2327[»]
3KOAX-ray2.40A1858-2327[»]
ProteinModelPortaliQ9QCE3
SMRiQ9QCE3
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9QCE3

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1184 – 1348SF3 helicaseInterPro annotationAdd BLAST165
Domaini2091 – 2209RdRp catalyticInterPro annotationAdd BLAST119

Sequence similaritiesi

Belongs to the picornaviruses polyprotein family.SAAS annotation

Family and domain databases

CDDicd00205 rhv_like, 3 hits
Gene3Di2.60.120.20, 3 hits
4.10.90.10, 1 hit
InterProiView protein in InterPro
IPR015031 Capsid_VP4_Picornavir
IPR037080 Capsid_VP4_sf_Picornavirus
IPR004080 FMDV_VP1_coat
IPR004004 Helic/Pol/Pept_Calicivir-typ
IPR000605 Helicase_SF3_ssDNA/RNA_vir
IPR014759 Helicase_SF3_ssRNA_vir
IPR027417 P-loop_NTPase
IPR008739 Peptidase_C28
IPR000199 Peptidase_C3A/C3B_picornavir
IPR009003 Peptidase_S1_PA
IPR001676 Picornavirus_capsid
IPR033703 Rhv-like
IPR001205 RNA-dir_pol_C
IPR007094 RNA-dir_pol_PSvirus
IPR029053 Viral_coat
PfamiView protein in Pfam
PF05408 Peptidase_C28, 1 hit
PF00548 Peptidase_C3, 1 hit
PF00680 RdRP_1, 1 hit
PF00073 Rhv, 3 hits
PF00910 RNA_helicase, 1 hit
PF08935 VP4_2, 1 hit
PRINTSiPR00918 CALICVIRUSNS
PR01542 FMDVP1COAT
SUPFAMiSSF50494 SSF50494, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50507 RDRP_SSRNA_POS, 1 hit
PS51218 SF3_HELICASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QCE3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTTDCFIAV VNAIKEVIAL FLPRTAGKME FTLHDGEKKV FYSRPNNHDN
60 70 80 90 100
CWLNTILQLF RYVDEPFFDW VYNSPENLTL EAIKQLEELT GLDLREGGPP
110 120 130 140 150
ALVIWNIKHL LHTGIGTASR PSEVCMVDGT DMCLADFHAG IFMKGREHAV
160 170 180 190 200
FACVTSNGWY AIDDEDFYPW TPDPSDVLVF VPYDQEPLNE GWKASVQRKL
210 220 230 240 250
KGAGQSSPAT GSQNQSGNTG SIINNYYMQQ YQNSMDTQLG DNAISGGSNE
260 270 280 290 300
GSTDTTSTHT TNTQNNDWFS KLASSAFSGL FGALLADKKT EETTLLEDRI
310 320 330 340 350
LTTRNGHTTS TTQSSVGVTF GYATAEDSTS GPNTSGLETR VHQAERFFKM
360 370 380 390 400
ALFDWVPSQN FGHMHKVVLP HEPKGVYGGL VKSYAYMRNG WDVEVTAVGN
410 420 430 440 450
QFNGGCLLVA LVPEMGDISD REKYQLTLYP HQFINPRTNM TAHITVPYVG
460 470 480 490 500
VNRYDQYKQH RPWTLVVMVV APLTTNTVGA QQIKVYANIA PTNVHVAGEL
510 520 530 540 550
PSKEGIFPVA VSAGYGHLVT TDPKTADPAY GKVYNPPRTA LPGRFTNYLD
560 570 580 590 600
VAEACPTFLM FENVPYVSTR TDGQRLLAKF DVSLAAKHMS NTYLAGLAQY
610 620 630 640 650
YTQYTGTINL HFMFTGPTDA KARYMVAYVP PGMDAPDNPE EAAHCIHAEW
660 670 680 690 700
DTGLNSKFTF SIPYISAADY AYTASHEAET TCVQGWVCVY QITHGKADAD
710 720 730 740 750
ALVVSASAGK DFELRLPVDA RQQTTTTGES ADPVTTTVEN YGGETQVQRR
760 770 780 790 800
HHTDVAFVLD RFVKVTVSDN QHTLDVMQAH KDNIVGALLR AATYYFSDLE
810 820 830 840 850
IAVAHTGKLT WVPNGAPVSA LNNTTNPTAY HKGPVTRLAL PYTAPHRVLA
860 870 880 890 900
TAYTGTTTYT ASARGDLAHL KTTHARHLPT SFNFGAVKAE TITELLVRMK
910 920 930 940 950
RAELYCPRPI LPIQPTDDRH KQPLVAPAKQ LLNFDLLKLA GDVESNPGPF
960 970 980 990 1000
FFSDVRSNFS KLVETINQMQ EDMSTRHGPD FNRLVSAFEE LASGVKAIRT
1010 1020 1030 1040 1050
GLDEAKPWYK LIKLLSRLSC MAAVAARSKD PVLVAIMLAD TGLEILDSTF
1060 1070 1080 1090 1100
VVKKISDSLS SLFHVPAPAF SFGAPILLAG LVKVASSFFR STPEDLERAE
1110 1120 1130 1140 1150
KQLKARDIND IFAILKNGEW LVKLILAIRD WIKAWIASEE KYVTMTDLVP
1160 1170 1180 1190 1200
GILEKQRDLN DPSKYKDAKE WLDNTRQVCL KSGNVHIANL CKVVAPAPSK
1210 1220 1230 1240 1250
SRPEPVVVCL RGKSGQGKSF LANVLAQAIS THLTGRTDSV WYCPPDPDHF
1260 1270 1280 1290 1300
DGYNQQTVVV MDDLGQNPDG KDFKYFAQMV STTGFIPPMA SLEDKGKPFN
1310 1320 1330 1340 1350
SKVIIATTNL YSGFTPKTMV CPDALNRRFH FDIDVSAKDG YKTNNKLDII
1360 1370 1380 1390 1400
KALEDTHTNP VAMFQYDCAL LNGMAVEMKR LQQDMFKPQP PLQNVYQLVQ
1410 1420 1430 1440 1450
EVIERVELHE KVSSHPIFKQ ISIPSQKSVL YFLIEKGQHE AAIEFFEGMV
1460 1470 1480 1490 1500
HDSIKEELRP LIQQTSFVKR AFKRLKENFE IVALCLTLLA NIVIMIRETH
1510 1520 1530 1540 1550
KRQKMVDDAV NEYIEKANIT TDDQTLDEAE KNPLETSGAS TVGFRERTLP
1560 1570 1580 1590 1600
GQKARDDVNS EPAQPTEEQP QAEGPYAGPL ERQRPLKVRA KLPRQEGPYA
1610 1620 1630 1640 1650
GPMERQKPLK VKARAPVVKE GPYEGPVKKP VALKVKAKNL IVTESGAPPT
1660 1670 1680 1690 1700
DLQKMVMGNT KPVELILDGK TVAICCATGV FGTAYLVPRH LFAEKYDKIM
1710 1720 1730 1740 1750
LDGRALTDSD YRVFEFEIKV KGQDMLSDAA LMVLHRGNRV RDITKHFRDV
1760 1770 1780 1790 1800
ARMKKGTPVV GVINNADVGR LIFSGEALTY KDIVVCMDGD TMPGLFAYKA
1810 1820 1830 1840 1850
ATKAGYCGGA VLAKDGADTF IVGTHSAGGN GVGYCSCVSR SMLLKMKAHI
1860 1870 1880 1890 1900
DPEPHHEGLI VDTRDVEERV HVMRKTKLAP TVAHGVFNPE FGPAALSNKD
1910 1920 1930 1940 1950
PRLNEGVVLD EVIFSKHKGD TKMSAEDKAL FRRCAADYAS RLHSVLGTAN
1960 1970 1980 1990 2000
APLSIYEAIK GVDGLDAMEP DTAPGLPWAL QGKRRGALID FENGTVGPEV
2010 2020 2030 2040 2050
EAALKLMEKR EYKFACQTFL KDEIRPMEKV RAGKTRIVDV LPVEHILYTR
2060 2070 2080 2090 2100
MMIGRFCAQM HSNNGPQIGS AVGCNPDVDW QRFGTHFAQY RNVWDVDYSA
2110 2120 2130 2140 2150
FDANHCSDAM NIMFEEVFRT EFGFHPNAEW ILKTLVNTEH AYENKRITVE
2160 2170 2180 2190 2200
GGMPSGCSAT SIINTILNNI YVLYALRRHY EGVELDTYTM ISYGDDIVVA
2210 2220 2230 2240 2250
SDYDLDFEAL KPHFKSLGQT ITPADKSDKG FVLGHSITDV TFLKRHFHMD
2260 2270 2280 2290 2300
YGTGFYKPVM ASKTLEAILS FARRGTIQEK LISVAGLAVH SGPDEYRRLF
2310 2320
EPFQGLFEIP SYRSLYLRWV NAVCGDA
Length:2,327
Mass (Da):258,168
Last modified:May 1, 2000 - v1
Checksum:i21648E945A5229D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ133359 Genomic RNA Translation: CAB60266.1

Similar proteinsi

Entry informationi

Entry nameiQ9QCE3_9PICO
AccessioniPrimary (citable) accession number: Q9QCE3
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteomeImported

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