Reviewed, UniProtKB/Swiss-Prot Q9QB93 (NTP1_YMTV)

Names and origin

Protein names

Recommended name:
    Nucleoside triphosphatase I
    EC=3.6.1.15
Alternative name(s):
    Nucleoside triphosphate phosphohydrolase I
      Short name=NPH I

Gene names

Name:	NPH1
Ordered Locus Names:	88L
ORF Names:	B5L

Organism

Yaba monkey tumor virus (YMTV)

Taxonomic identifier

38804 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Poxviridae › Chordopoxvirinae › Yatapoxvirus

Virus host

Erythrocebus patas (Red guenon) (Cercopithecus patas) [TaxID: 9538]
Macaca (macaques) [TaxID: 9539]
Papio hamadryas (Hamadryas baboon) [TaxID: 9557]
Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	631 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Serves two roles in transcription; it acts in concert with viral termination factor/capping enzyme to catalyze release of UUUUUNU-containing nascent RNA from the elongation complex, and it acts by itself as a polymerase elongation factor to facilitate readthrough of intrinsic pause sites By similarity.
Catalytic activity	NTP + H2O = NDP + phosphate.
Subunit structure	Monomer.
Sequence similarities	Belongs to the helicase family. NPH I subfamily. Contains 1 helicase ATP-binding domain. Contains 1 helicase C-terminal domain.

Ontologies

Keywords
Biological process	Transcription
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
Gene Ontology (GO)
Biological process	transcription Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW DNA binding Inferred from electronic annotation. Source: InterPro helicase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 631	631	Nucleoside triphosphatase I		PRO_0000099098
Regions
	Domain	42 – 204	163	Helicase ATP-binding
	Domain	367 – 536	170	Helicase C-terminal
	Nucleotide binding	55 – 62	8	ATP By similarity
	Motif	141 – 144	4	DEXH box

Sequences

	Sequence		Length	Mass (Da)
	Q9QB93-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 06561CA08C729EFF	FASTA	631	72,579
	10 20 30 40 50 60 MSRQHAAYID YALNRMKKMP IEMLGSDTIT LKPYQHFVAK VFLGLDTMHS ILLFHDTGVG 70 80 90 100 110 120 KTITTVFILK HLKDIYTNWT ILLLVKKALV EDPWMNTILK YSPEIIKNCI FINYDDKNFH 130 140 150 160 170 180 NKFFTNIKTI SSRSRVCVVL DECHNFISKS LIKEDGKQRP TKSVYNYLSK NISLNNNKMI 190 200 210 220 230 240 CLSATPIVNN VREFTMIVNL LRPKIIQFQS LFENKNLVNE KELIDKLGGI CSYIVNDEFS 250 260 270 280 290 300 IFDDVEGSQS FAKKTVYMHY VNMTKQQEII YQKAKIAEIK SGIASFRIYR RMAATFSFDS 310 320 330 340 350 360 FPDKKKKTID EITLELGALY KDFVNYVNKK SFSNNAIKLF KSGKGLTGDS NPLDISLLSE 370 380 390 400 410 420 LRQKSCKFTE VCLKILASPG KCLVFEPFIN QSGIEVLLVY FSVFCITSVE FSSRTKDTRI 430 440 450 460 470 480 KNVFEFNKES NTNGEQIKVC VFSISGGEGI SFFSINDIFI LDMTWNEASL KQIVGRAIRL 490 500 510 520 530 540 NSHANTPPNR RYVNVYFIIA RLSSGEPTVD EDLINIIKTK SKEFFQLFKV FKESSIEWIY 550 560 570 580 590 600 KNKKDFYPIN DESGWRALTS RVVDVNVKSK RTVQLAQGQN IWFSNSSRMV TIHKGFKTSD 610 620 630 GKIFDVDGNF IQNMPINPII KIHNDKLVYI I

References

[1]

"Complete genomic sequence and comparative analysis of the tumorigenic poxvirus Yaba monkey tumor virus." Brunetti C.R., Amano H., Ueda Y., Qin J., Miyamura T., Suzuki T., Li X., Barrett J.W., McFadden G. J. Virol. 77:13335-13347(2003) [PubMed: 14645589] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY386371 Genomic DNA. Translation: AAR07444.1.
RefSeq	NP_938343.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2943701.
Enzyme and pathway databases
BRENDA	3.6.1.15. 294360.
Family and domain databases
InterPro	IPR014001. DEAD-like_N. IPR001650. DNA/RNA_helicase_C. IPR014021. Helicase_SF1/SF2_ATP-bd. IPR013676. NPHI_C. IPR000330. SNF2_N. [Graphical view]
Pfam	PF00271. Helicase_C. 1 hit. PF08469. NPHI_C. 1 hit. PF00176. SNF2_N. 1 hit. [Graphical view]
SMART	SM00487. DEXDc. 1 hit. [Graphical view]
PROSITE	PS51192. HELICASE_ATP_BIND_1. 1 hit. PS51194. HELICASE_CTER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NTP1_YMTV

Accession

Primary (citable) accession number: Q9QB93

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	May 1, 2000
Last modified:	June 16, 2009
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Virus (Virus annotation project)