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Q9QAZ8

- RDRP_SJNNV

UniProt

Q9QAZ8 - RDRP_SJNNV

Protein

RNA-directed RNA polymerase

Gene
N/A
Organism
Striped jack nervous necrosis virus (SjNNV)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    RNA-dependent RNA polymerase which replicates the viral genome composed of 2 RNA segments, RNA1 AND RNA2.Curated

    Catalytic activityi

    Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation

    GO - Molecular functioni

    1. nucleotide binding Source: UniProtKB-KW
    2. RNA binding Source: InterPro
    3. RNA-directed RNA polymerase activity Source: UniProtKB-KW

    GO - Biological processi

    1. transcription, DNA-templated Source: InterPro
    2. viral RNA genome replication Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

    Keywords - Biological processi

    Viral RNA replication

    Keywords - Ligandi

    Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RNA-directed RNA polymerase (EC:2.7.7.48)
    Short name:
    RdRp
    Alternative name(s):
    RNA replicase
    Short name:
    Protein A
    OrganismiStriped jack nervous necrosis virus (SjNNV)
    Taxonomic identifieri35297 [NCBI]
    Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageNodaviridaeBetanodavirus
    Virus hostiDicentrarchus labrax (European seabass) (Morone labrax) [TaxID: 13489]
    Epinephelus akaara (Hong Kong grouper) (Serranus akaara) [TaxID: 215347]
    Hippoglossus hippoglossus (Atlantic halibut) (Pleuronectes hippoglossus) [TaxID: 8267]
    Lates calcarifer (Barramundi) (Holocentrus calcarifer) [TaxID: 8187]
    Oplegnathus fasciatus (Barred knifejaw) (Scaradon fasciatus) [TaxID: 163134]
    ProteomesiUP000000414: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 983983RNA-directed RNA polymerasePRO_0000222450Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ9QAZ8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini579 – 701123RdRp catalyticPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the nodaviridae RNA polymerase family.Curated
    Contains 1 RdRp catalytic domain.PROSITE-ProRule annotation

    Family and domain databases

    InterProiIPR007094. RNA-dir_pol_PSvirus.
    IPR001788. Tymovirus_RNA-dep_RNA_pol.
    [Graphical view]
    PfamiPF00978. RdRP_2. 1 hit.
    [Graphical view]
    PROSITEiPS50507. RDRP_SSRNA_POS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9QAZ8-1 [UniParc]FASTAAdd to Basket

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    MRRFEFELAR MSGAAFCVVT GYRLLTSKWL ADRVEDYRQR VIADRKQILR    50
    DAAVIRTSIQ KQMELVRISV RKGHSHQEAA TERNSATDTM IGVVEKCGYE 100
    PYIISPSPRE KEYHGSRQFY SLADFRQDYR RDEITDRHVI VMTDVDYYVD 150
    MHELVGLGVP ILLYTFQPST VSGEVKDGYF TITDDHVHYR VAGGKDVRHR 200
    IWNYNQDTMF VRSKPRGFWA SLKQILRDIT GITALCGYLY LKLGIAPFGD 250
    QVTLFTVDQF KMGEHRNIVS IVPFATCRSN LLKISEYGAE LDYMRYQQRN 300
    NNANFNAVTY ISQEGPLISL GLEGNFASVQ LPLQDFENIR TAYELSKNNN 350
    LSDTVRRSAR SCKEAAIIHK CLQAGCDLAS EVVHKPGELA RHYQALGDTY 400
    DIDPSEQGKC YAREYAPGPL TQTAVFPSES RSNELATIDG RIAGPQAKAK 450
    SREHITPKMH KVARDFVRHL VPTAGLGRPY PLTYVEEHQT KPLQRARNDA 500
    NRYHDEFTMI VKAFQKKEAY NAPNYPRNIS TVPHTQNVKL SSYTYAFKEA 550
    VLQHVPWYMP THTPAEIAEA VQSLAASSTE LVETDYSKFD GTFLRFMREN 600
    VEFAIYKRWV HLDHLTELST LLGNELQAPA VTRLGIKYDP DCSRLSGSAL 650
    TTDGNSIANA FVSYLAGRQA GMDDDEAWTW IGIVYGDDGL RSGNVSDALL 700
    SKTASSLGFD LKIVNRAPRG SPVTFLSRVY LDPWSSPASV QSPLRTLLKL 750
    HTTCDTQSDI EDVGWAKTQA YLVTDCLTPF IGHWCRAYQR NCTARVVQYA 800
    DYNDIPFWVK NEDHVGNSWP QSDSVDWNDV VANELGLTTA ELLKHLAALD 850
    AYTGPVSGLP RLTTSLDLEP KMPVALDGEV QAGPSQQPQT DKDGTSPTGD 900
    RSAPRRARTA LQDADGRACR SRRSDRSPGK RDANVRDKRQ RRSTTPPRSR 950
    PSVPGPSSSG RRTDGDRVRG GAARQRQRRR SPV 983
    Length:983
    Mass (Da):110,630
    Last modified:May 1, 2000 - v1
    Checksum:iF76890AA597F8BE1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB025018 Genomic RNA. Translation: BAA84210.1.
    AB056571 Genomic RNA. Translation: BAB64329.1.
    RefSeqiNP_599247.1. NC_003448.1.

    Genome annotation databases

    GeneIDi991144.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB025018 Genomic RNA. Translation: BAA84210.1 .
    AB056571 Genomic RNA. Translation: BAB64329.1 .
    RefSeqi NP_599247.1. NC_003448.1.

    3D structure databases

    ProteinModelPortali Q9QAZ8.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 991144.

    Family and domain databases

    InterProi IPR007094. RNA-dir_pol_PSvirus.
    IPR001788. Tymovirus_RNA-dep_RNA_pol.
    [Graphical view ]
    Pfami PF00978. RdRP_2. 1 hit.
    [Graphical view ]
    PROSITEi PS50507. RDRP_SSRNA_POS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence of the non-structural protein gene encoded by RNA1 of striped jack nervous necrosis virus."
      Nagai T., Nishizawa T.
      J. Gen. Virol. 80:3019-3022(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    2. "Establishment of an infectious RNA transcription system for striped jack nervous necrosis virus, the type species of the betanodaviruses."
      Iwamoto T., Mise K., Mori K., Arimoto M., Nakai T., Okuno T.
      J. Gen. Virol. 82:2653-2662(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiRDRP_SJNNV
    AccessioniPrimary (citable) accession number: Q9QAZ8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 16, 2002
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3