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Protein

RNA-directed RNA polymerase

Gene
N/A
Organism
Striped jack nervous necrosis virus (SjNNV)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

RNA-dependent RNA polymerase which replicates the viral genome composed of 2 RNA segments, RNA1 AND RNA2.Curated

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation

GO - Molecular functioni

  1. nucleotide binding Source: UniProtKB-KW
  2. RNA binding Source: InterPro
  3. RNA-directed RNA polymerase activity Source: UniProtKB-KW

GO - Biological processi

  1. transcription, DNA-templated Source: InterPro
  2. viral RNA genome replication Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

Keywords - Biological processi

Viral RNA replication

Keywords - Ligandi

Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-directed RNA polymerase (EC:2.7.7.48)
Short name:
RdRp
Alternative name(s):
RNA replicase
Short name:
Protein A
OrganismiStriped jack nervous necrosis virus (SjNNV)
Taxonomic identifieri35297 [NCBI]
Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageNodaviridaeBetanodavirus
Virus hostiDicentrarchus labrax (European seabass) (Morone labrax) [TaxID: 13489]
Epinephelus akaara (Hong Kong grouper) (Serranus akaara) [TaxID: 215347]
Hippoglossus hippoglossus (Atlantic halibut) (Pleuronectes hippoglossus) [TaxID: 8267]
Lates calcarifer (Barramundi) (Holocentrus calcarifer) [TaxID: 8187]
Oplegnathus fasciatus (Barred knifejaw) (Scaradon fasciatus) [TaxID: 163134]
ProteomesiUP000000414 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 983983RNA-directed RNA polymerasePRO_0000222450Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ9QAZ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini579 – 701123RdRp catalyticPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the nodaviridae RNA polymerase family.Curated
Contains 1 RdRp catalytic domain.PROSITE-ProRule annotation

Family and domain databases

InterProiIPR007094. RNA-dir_pol_PSvirus.
IPR001788. Tymovirus_RNA-dep_RNA_pol.
[Graphical view]
PfamiPF00978. RdRP_2. 1 hit.
[Graphical view]
PROSITEiPS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QAZ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRFEFELAR MSGAAFCVVT GYRLLTSKWL ADRVEDYRQR VIADRKQILR
60 70 80 90 100
DAAVIRTSIQ KQMELVRISV RKGHSHQEAA TERNSATDTM IGVVEKCGYE
110 120 130 140 150
PYIISPSPRE KEYHGSRQFY SLADFRQDYR RDEITDRHVI VMTDVDYYVD
160 170 180 190 200
MHELVGLGVP ILLYTFQPST VSGEVKDGYF TITDDHVHYR VAGGKDVRHR
210 220 230 240 250
IWNYNQDTMF VRSKPRGFWA SLKQILRDIT GITALCGYLY LKLGIAPFGD
260 270 280 290 300
QVTLFTVDQF KMGEHRNIVS IVPFATCRSN LLKISEYGAE LDYMRYQQRN
310 320 330 340 350
NNANFNAVTY ISQEGPLISL GLEGNFASVQ LPLQDFENIR TAYELSKNNN
360 370 380 390 400
LSDTVRRSAR SCKEAAIIHK CLQAGCDLAS EVVHKPGELA RHYQALGDTY
410 420 430 440 450
DIDPSEQGKC YAREYAPGPL TQTAVFPSES RSNELATIDG RIAGPQAKAK
460 470 480 490 500
SREHITPKMH KVARDFVRHL VPTAGLGRPY PLTYVEEHQT KPLQRARNDA
510 520 530 540 550
NRYHDEFTMI VKAFQKKEAY NAPNYPRNIS TVPHTQNVKL SSYTYAFKEA
560 570 580 590 600
VLQHVPWYMP THTPAEIAEA VQSLAASSTE LVETDYSKFD GTFLRFMREN
610 620 630 640 650
VEFAIYKRWV HLDHLTELST LLGNELQAPA VTRLGIKYDP DCSRLSGSAL
660 670 680 690 700
TTDGNSIANA FVSYLAGRQA GMDDDEAWTW IGIVYGDDGL RSGNVSDALL
710 720 730 740 750
SKTASSLGFD LKIVNRAPRG SPVTFLSRVY LDPWSSPASV QSPLRTLLKL
760 770 780 790 800
HTTCDTQSDI EDVGWAKTQA YLVTDCLTPF IGHWCRAYQR NCTARVVQYA
810 820 830 840 850
DYNDIPFWVK NEDHVGNSWP QSDSVDWNDV VANELGLTTA ELLKHLAALD
860 870 880 890 900
AYTGPVSGLP RLTTSLDLEP KMPVALDGEV QAGPSQQPQT DKDGTSPTGD
910 920 930 940 950
RSAPRRARTA LQDADGRACR SRRSDRSPGK RDANVRDKRQ RRSTTPPRSR
960 970 980
PSVPGPSSSG RRTDGDRVRG GAARQRQRRR SPV
Length:983
Mass (Da):110,630
Last modified:April 30, 2000 - v1
Checksum:iF76890AA597F8BE1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB025018 Genomic RNA. Translation: BAA84210.1.
AB056571 Genomic RNA. Translation: BAB64329.1.
RefSeqiNP_599247.1. NC_003448.1.

Genome annotation databases

GeneIDi991144.
KEGGivg:991144.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB025018 Genomic RNA. Translation: BAA84210.1.
AB056571 Genomic RNA. Translation: BAB64329.1.
RefSeqiNP_599247.1. NC_003448.1.

3D structure databases

ProteinModelPortaliQ9QAZ8.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi991144.
KEGGivg:991144.

Family and domain databases

InterProiIPR007094. RNA-dir_pol_PSvirus.
IPR001788. Tymovirus_RNA-dep_RNA_pol.
[Graphical view]
PfamiPF00978. RdRP_2. 1 hit.
[Graphical view]
PROSITEiPS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Sequence of the non-structural protein gene encoded by RNA1 of striped jack nervous necrosis virus."
    Nagai T., Nishizawa T.
    J. Gen. Virol. 80:3019-3022(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "Establishment of an infectious RNA transcription system for striped jack nervous necrosis virus, the type species of the betanodaviruses."
    Iwamoto T., Mise K., Mori K., Arimoto M., Nakai T., Okuno T.
    J. Gen. Virol. 82:2653-2662(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiRDRP_SJNNV
AccessioniPrimary (citable) accession number: Q9QAZ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 15, 2002
Last sequence update: April 30, 2000
Last modified: March 31, 2015
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.