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Q9Q9G3

- HEMA_HUTV

UniProt

Q9Q9G3 - HEMA_HUTV

Protein

Hemagglutinin-esterase

Gene

HE

Organism
Human torovirus (HuTV)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Structural protein that makes short spikes at the surface of the virus. Contains receptor binding and receptor-destroying activities. Mediates de-O-acetylation of N-acetyl-9-O-acetylneuraminic acid, which is probably the receptor determinant recognized by the virus on the surface of erythrocytes and susceptible cells. This receptor-destroying activity is important for virus release as it probably helps preventing self-aggregation and ensures the efficient spread of the progeny virus from cell to cell. May serve as a secondary viral attachment protein for initiating infection, the spike protein being the major one. Seems to be a 'luxury' protein that is not absolutely necessary for virus infection in culture. However, its presence in the virus may alter its pathogenicity. May become a target for both the humoral and the cellular branches of the immune system By similarity.By similarity

    Catalytic activityi

    N-acetyl-O-acetylneuraminate + H2O = N-acetylneuraminate + acetate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei37 – 371NucleophileBy similarity
    Active sitei328 – 3281Charge relay systemBy similarity

    GO - Molecular functioni

    1. sialate O-acetylesterase activity Source: UniProtKB-EC

    GO - Biological processi

    1. fusion of virus membrane with host plasma membrane Source: InterPro

    Keywords - Molecular functioni

    Hemagglutinin, Hydrolase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hemagglutinin-esterase (EC:3.1.1.53)
    Short name:
    HE protein
    Alternative name(s):
    E3 glycoprotein
    Gene namesi
    Name:HE
    OrganismiHuman torovirus (HuTV)
    Taxonomic identifieri67605 [NCBI]
    Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageNidoviralesCoronaviridaeTorovirinaeTorovirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]

    Subcellular locationi

    Virion membrane Curated; Single-pass type I membrane protein Curated. Host cell membrane Curated; Single-pass type I membrane protein Curated
    Note: In infected cells becomes incorporated into the envelope of virions during virus assembly at the endoplasmic reticulum and cis Golgi. However, some may escape incorporation into virions and subsequently migrate to the cell surface By similarity.By similarity

    GO - Cellular componenti

    1. host cell plasma membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. viral envelope Source: UniProtKB-KW
    4. virion membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host cell membrane, Host membrane, Membrane, Viral envelope protein, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1414Sequence AnalysisAdd
    BLAST
    Chaini15 – 416402Hemagglutinin-esterasePRO_0000045400Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi41 ↔ 57By similarity
    Glycosylationi59 – 591N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi76 – 761N-linked (GlcNAc...); by hostSequence Analysis
    Disulfide bondi88 ↔ 136By similarity
    Disulfide bondi108 ↔ 156By similarity
    Disulfide bondi192 ↔ 273By similarity
    Disulfide bondi200 ↔ 246By similarity
    Disulfide bondi206 ↔ 213By similarity
    Glycosylationi257 – 2571N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi278 – 2781N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi294 – 2941N-linked (GlcNAc...); by hostSequence Analysis
    Disulfide bondi304 ↔ 309By similarity
    Glycosylationi322 – 3221N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi343 – 3431N-linked (GlcNAc...); by hostSequence Analysis
    Disulfide bondi346 ↔ 371By similarity

    Post-translational modificationi

    N-glycosylated.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Q9G3.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini15 – 393379Virion surfaceSequence AnalysisAdd
    BLAST
    Topological domaini415 – 4162IntravirionSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei394 – 41421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni4 – 121118Esterase domain first partBy similarityAdd
    BLAST
    Regioni122 – 263142Receptor bindingBy similarityAdd
    BLAST
    Regioni264 – 379116Esterase domain second partBy similarityAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi64 – 674Poly-Ser
    Compositional biasi402 – 4054Poly-Val

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Family and domain databases

    InterProiIPR008980. Capsid_hemagglutn.
    IPR007142. Hemagglutn-estrase_core.
    IPR003860. Hemagglutn-estrase_hemagglutn.
    [Graphical view]
    PfamiPF03996. Hema_esterase. 1 hit.
    PF02710. Hema_HEFG. 1 hit.
    [Graphical view]
    SUPFAMiSSF49818. SSF49818. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9Q9G3-1 [UniParc]FASTAAdd to Basket

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    MLSLILFFPS FAFAVTPVTP YFGPLYITFN CCLFGDSRSD CTKVQSPMSL    50
    DNPQNFCPNF SLKSSSSMFF SIHYNNHSSL VLFDNFNCRI EKVYYNGVNL 100
    SPRNQYSCYD EGVDSYMELK TSFNIKLNQM ATILRCIKLI QLKARSSFTT 150
    LQDVVCRTNK YLPNNPTFAL LSDTVPTWVQ FVLPDLSGKT ICIKYLVPFC 200
    HLNHGCFTAG SSCPPFGVSY VSDSFNYGFN DATPYIGLAE SHDNVCDYLF 250
    VEAGTHNASI VGNFLFYPTK SYCFNTMNFT VPVQAIQSIW SEGNESDDAI 300
    AEACKPPFCI YYSKTTPYTV TNGSNADHRD DEVRMMVRGL LYNSSCISAQ 350
    GSTPLALYST AMLYAPIYGS CPQYVKLFDT SGSESVDVIS SSYFVATWVL 400
    LVVVVILIFV IISFFC 416
    Length:416
    Mass (Da):46,534
    Last modified:May 1, 2000 - v1
    Checksum:i13607F00B989ACD8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF159585 mRNA. Translation: AAF00614.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF159585 mRNA. Translation: AAF00614.1 .

    3D structure databases

    ProteinModelPortali Q9Q9G3.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR008980. Capsid_hemagglutn.
    IPR007142. Hemagglutn-estrase_core.
    IPR003860. Hemagglutn-estrase_hemagglutn.
    [Graphical view ]
    Pfami PF03996. Hema_esterase. 1 hit.
    PF02710. Hema_HEFG. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49818. SSF49818. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The novel hemagglutinin-esterase genes of human torovirus and Breda virus."
      Duckmanton L., Tellier R., Richardson C., Petric M.
      Virus Res. 64:137-149(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiHEMA_HUTV
    AccessioniPrimary (citable) accession number: Q9Q9G3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2006
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3