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Q9Q9G3

- HEMA_HUTV

UniProt

Q9Q9G3 - HEMA_HUTV

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Protein

Hemagglutinin-esterase

Gene
HE
Organism
Human torovirus (HuTV)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Structural protein that makes short spikes at the surface of the virus. Contains receptor binding and receptor-destroying activities. Mediates de-O-acetylation of N-acetyl-9-O-acetylneuraminic acid, which is probably the receptor determinant recognized by the virus on the surface of erythrocytes and susceptible cells. This receptor-destroying activity is important for virus release as it probably helps preventing self-aggregation and ensures the efficient spread of the progeny virus from cell to cell. May serve as a secondary viral attachment protein for initiating infection, the spike protein being the major one. Seems to be a 'luxury' protein that is not absolutely necessary for virus infection in culture. However, its presence in the virus may alter its pathogenicity. May become a target for both the humoral and the cellular branches of the immune system By similarity.

Catalytic activityi

N-acetyl-O-acetylneuraminate + H2O = N-acetylneuraminate + acetate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei37 – 371Nucleophile By similarity
Active sitei223 – 2231Charge relay system By similarity
Active sitei328 – 3281Charge relay system By similarity

GO - Molecular functioni

  1. sialate O-acetylesterase activity Source: UniProtKB-EC

GO - Biological processi

  1. fusion of virus membrane with host plasma membrane Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hemagglutinin, Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Hemagglutinin-esterase (EC:3.1.1.53)
Short name:
HE protein
Alternative name(s):
E3 glycoprotein
Gene namesi
Name:HE
OrganismiHuman torovirus (HuTV)
Taxonomic identifieri67605 [NCBI]
Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageNidoviralesCoronaviridaeTorovirinaeTorovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

Virion membrane; Single-pass type I membrane protein Reviewed prediction. Host cell membrane; Single-pass type I membrane protein Reviewed prediction
Note: In infected cells becomes incorporated into the envelope of virions during virus assembly at the endoplasmic reticulum and cis Golgi. However, some may escape incorporation into virions and subsequently migrate to the cell surface By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini15 – 393379Virion surface Reviewed predictionAdd
BLAST
Transmembranei394 – 41421Helical; Reviewed predictionAdd
BLAST
Topological domaini415 – 4162Intravirion Reviewed prediction

GO - Cellular componenti

  1. host cell plasma membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. viral envelope Source: UniProtKB-KW
  4. virion membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host cell membrane, Host membrane, Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1414 Reviewed predictionAdd
BLAST
Chaini15 – 416402Hemagglutinin-esterasePRO_0000045400Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi41 ↔ 57 By similarity
Glycosylationi59 – 591N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi76 – 761N-linked (GlcNAc...); by host Reviewed prediction
Disulfide bondi108 ↔ 156 By similarity
Disulfide bondi192 ↔ 273 By similarity
Disulfide bondi200 ↔ 246 By similarity
Glycosylationi257 – 2571N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi278 – 2781N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi294 – 2941N-linked (GlcNAc...); by host Reviewed prediction
Disulfide bondi304 ↔ 309 By similarity
Glycosylationi322 – 3221N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi343 – 3431N-linked (GlcNAc...); by host Reviewed prediction
Disulfide bondi346 ↔ 371 By similarity

Post-translational modificationi

N-glycosylated By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ9Q9G3.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni4 – 121118Esterase domain first part By similarityAdd
BLAST
Regioni122 – 263142Receptor binding By similarityAdd
BLAST
Regioni264 – 379116Esterase domain second part By similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi64 – 674Poly-Ser
Compositional biasi402 – 4054Poly-Val

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR008980. Capsid_hemagglutn.
IPR007142. Hemagglutn-estrase_core.
IPR003860. Hemagglutn-estrase_hemagglutn.
[Graphical view]
PfamiPF03996. Hema_esterase. 1 hit.
PF02710. Hema_HEFG. 1 hit.
[Graphical view]
SUPFAMiSSF49818. SSF49818. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Q9G3-1 [UniParc]FASTAAdd to Basket

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MLSLILFFPS FAFAVTPVTP YFGPLYITFN CCLFGDSRSD CTKVQSPMSL    50
DNPQNFCPNF SLKSSSSMFF SIHYNNHSSL VLFDNFNCRI EKVYYNGVNL 100
SPRNQYSCYD EGVDSYMELK TSFNIKLNQM ATILRCIKLI QLKARSSFTT 150
LQDVVCRTNK YLPNNPTFAL LSDTVPTWVQ FVLPDLSGKT ICIKYLVPFC 200
HLNHGCFTAG SSCPPFGVSY VSDSFNYGFN DATPYIGLAE SHDNVCDYLF 250
VEAGTHNASI VGNFLFYPTK SYCFNTMNFT VPVQAIQSIW SEGNESDDAI 300
AEACKPPFCI YYSKTTPYTV TNGSNADHRD DEVRMMVRGL LYNSSCISAQ 350
GSTPLALYST AMLYAPIYGS CPQYVKLFDT SGSESVDVIS SSYFVATWVL 400
LVVVVILIFV IISFFC 416
Length:416
Mass (Da):46,534
Last modified:May 1, 2000 - v1
Checksum:i13607F00B989ACD8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF159585 mRNA. Translation: AAF00614.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF159585 mRNA. Translation: AAF00614.1 .

3D structure databases

ProteinModelPortali Q9Q9G3.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR008980. Capsid_hemagglutn.
IPR007142. Hemagglutn-estrase_core.
IPR003860. Hemagglutn-estrase_hemagglutn.
[Graphical view ]
Pfami PF03996. Hema_esterase. 1 hit.
PF02710. Hema_HEFG. 1 hit.
[Graphical view ]
SUPFAMi SSF49818. SSF49818. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The novel hemagglutinin-esterase genes of human torovirus and Breda virus."
    Duckmanton L., Tellier R., Richardson C., Petric M.
    Virus Res. 64:137-149(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiHEMA_HUTV
AccessioniPrimary (citable) accession number: Q9Q9G3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: May 1, 2000
Last modified: April 16, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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