Q9Q944 (PAP1_RFVKA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Poly(A) polymerase catalytic subunit
EC=2.7.7.19

Alternative name(s):
Poly(A) polymerase large subunit
Short name=PAP-L

Gene names

Name:	PAPL
Ordered Locus Names:	s027L

Organism

Rabbit fibroma virus (strain Kasza) (RFV) (Shope fibroma virus (strain Kasza)) [Reference proteome]

Taxonomic identifier

10272 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Poxviridae › Chordopoxvirinae › Leporipoxvirus › Rabbit fibroma virus

Virus host

Oryctolagus cuniculus (Rabbit) [TaxID: 9986]

Protein attributes

Sequence length	470 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Polymerase that creates the 3'-poly(A) tail of mRNA's.
Catalytic activity	ATP + RNA(n) = diphosphate + RNA(n+1).
Subunit structure	Heterodimer of a large (catalytic) subunit and a small (regulatory) subunit By similarity.
Sequence similarities	Belongs to the poxviridae poly(A) polymerase catalytic subunit family.

Ontologies

Keywords
Biological process	Transcription mRNA processing
Ligand	ATP-binding Nucleotide-binding
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	mRNA processing Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW polynucleotide adenylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 470	470	Poly(A) polymerase catalytic subunit		PRO_0000308939
Sites
	Active site	192	1	By similarity
	Active site	194	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9Q944 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 52E6BC4F2F215A9E	FASTA	470	53,841
	10 20 30 40 50 60 MNARIADLLY NYLGRPPSLS EYHMLKLQHR NIQKIIAFNK DIFISLIKKN KKKFFSDIDL 70 80 90 100 110 120 TSSEIKTSVL SYFSKQRDTY SIGKLYTIIE LQTILVSTYT DVLGVLTLKG PDMFPSSTRY 130 140 150 160 170 180 DIKSIKQIAT SALHAMNVAV ISDKVMGRHN VSPLVSNVNA LMEEYLRRHN KNCICYGSYS 190 200 210 220 230 240 LYLLNPEVKY GDIDILQTNS RTFLIDLAFL IKFITGSNVV LLKVPYLKNY MVLKDKDDNH 250 260 270 280 290 300 IIDSFNIRQE TMQVIPKVLI DNIYIVDPAL QLMSMFKMFS QIDRLEDLAR NPEKLTVRLA 310 320 330 340 350 360 TLMEYVRVKY GIILNGESNH MPMKGVLDKD KRIIDVDTSG YNFSFKKCYV YLDESSLSSD 370 380 390 400 410 420 ILDLNADDAV DFENVSNSAY LINGDVLYTY FSNTILLSDP DTIHEISNKA MSAHILIYQI 430 440 450 460 470 LTGNDIRQPL SDLVNSLMYN EKVLIHEVIP RDKKTGKHGI VDIEKDIITH

References

[1]	"The complete genome sequence of shope (Rabbit) fibroma virus." Willer D.O., McFadden G., Evans D.H. Virology 264:319-343(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF170722 Genomic DNA. Translation: AAF17910.1.
RefSeq	NP_051916.1. NC_001266.1.
3D structure databases
ProteinModelPortal	Q9Q944.
SMR	Q9Q944. Positions 8-468.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1486871.
Phylogenomic databases
ProtClustDB	PHA2996.
Family and domain databases
InterPro	IPR024231. Pox_polyA_pol_nucTrfase. IPR004976. Poxvirus_polyA_pol_cat. IPR024397. Poxvirus_polyA_pol_cat_C. IPR024398. Poxvirus_polyA_pol_cat_N. [Graphical view]
Pfam	PF03296. Pox_polyA_pol. 1 hit. PF12629. Pox_polyA_pol_C. 1 hit. PF12630. Pox_polyA_pol_N. 1 hit. [Graphical view]
PIRSF	PIRSF015693. VAC-48L_nuct. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PAP1_RFVKA

Accession

Primary (citable) accession number: Q9Q944

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	May 1, 2000
Last modified:	April 3, 2013
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program