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Q9Q944

- PAP1_RFVKA

UniProt

Q9Q944 - PAP1_RFVKA

Protein

Poly(A) polymerase catalytic subunit

Gene

PAPL

Organism
Rabbit fibroma virus (strain Kasza) (RFV) (Shope fibroma virus (strain Kasza))
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Polymerase that creates the 3'-poly(A) tail of mRNA's.

    Catalytic activityi

    ATP + RNA(n) = diphosphate + RNA(n+1).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei192 – 1921By similarity
    Active sitei194 – 1941By similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. polynucleotide adenylyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. mRNA processing Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    mRNA processing, Transcription

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Poly(A) polymerase catalytic subunit (EC:2.7.7.19)
    Alternative name(s):
    Poly(A) polymerase large subunit
    Short name:
    PAP-L
    Gene namesi
    Name:PAPL
    Ordered Locus Names:s027L
    OrganismiRabbit fibroma virus (strain Kasza) (RFV) (Shope fibroma virus (strain Kasza))
    Taxonomic identifieri10272 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeLeporipoxvirus
    Virus hostiOryctolagus cuniculus (Rabbit) [TaxID: 9986]
    ProteomesiUP000000868: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 470470Poly(A) polymerase catalytic subunitPRO_0000308939Add
    BLAST

    Interactioni

    Subunit structurei

    Heterodimer of a large (catalytic) subunit and a small (regulatory) subunit.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Q944.
    SMRiQ9Q944. Positions 8-468.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    InterProiIPR024231. Pox_polyA_pol_nucTrfase.
    IPR004976. Poxvirus_polyA_pol_cat.
    IPR024397. Poxvirus_polyA_pol_cat_C.
    IPR024398. Poxvirus_polyA_pol_cat_N.
    [Graphical view]
    PfamiPF03296. Pox_polyA_pol. 1 hit.
    PF12629. Pox_polyA_pol_C. 1 hit.
    PF12630. Pox_polyA_pol_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015693. VAC-48L_nuct. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9Q944-1 [UniParc]FASTAAdd to Basket

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    MNARIADLLY NYLGRPPSLS EYHMLKLQHR NIQKIIAFNK DIFISLIKKN    50
    KKKFFSDIDL TSSEIKTSVL SYFSKQRDTY SIGKLYTIIE LQTILVSTYT 100
    DVLGVLTLKG PDMFPSSTRY DIKSIKQIAT SALHAMNVAV ISDKVMGRHN 150
    VSPLVSNVNA LMEEYLRRHN KNCICYGSYS LYLLNPEVKY GDIDILQTNS 200
    RTFLIDLAFL IKFITGSNVV LLKVPYLKNY MVLKDKDDNH IIDSFNIRQE 250
    TMQVIPKVLI DNIYIVDPAL QLMSMFKMFS QIDRLEDLAR NPEKLTVRLA 300
    TLMEYVRVKY GIILNGESNH MPMKGVLDKD KRIIDVDTSG YNFSFKKCYV 350
    YLDESSLSSD ILDLNADDAV DFENVSNSAY LINGDVLYTY FSNTILLSDP 400
    DTIHEISNKA MSAHILIYQI LTGNDIRQPL SDLVNSLMYN EKVLIHEVIP 450
    RDKKTGKHGI VDIEKDIITH 470
    Length:470
    Mass (Da):53,841
    Last modified:May 1, 2000 - v1
    Checksum:i52E6BC4F2F215A9E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF170722 Genomic DNA. Translation: AAF17910.1.
    RefSeqiNP_051916.1. NC_001266.1.

    Genome annotation databases

    GeneIDi1486871.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF170722 Genomic DNA. Translation: AAF17910.1 .
    RefSeqi NP_051916.1. NC_001266.1.

    3D structure databases

    ProteinModelPortali Q9Q944.
    SMRi Q9Q944. Positions 8-468.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 1486871.

    Family and domain databases

    InterProi IPR024231. Pox_polyA_pol_nucTrfase.
    IPR004976. Poxvirus_polyA_pol_cat.
    IPR024397. Poxvirus_polyA_pol_cat_C.
    IPR024398. Poxvirus_polyA_pol_cat_N.
    [Graphical view ]
    Pfami PF03296. Pox_polyA_pol. 1 hit.
    PF12629. Pox_polyA_pol_C. 1 hit.
    PF12630. Pox_polyA_pol_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015693. VAC-48L_nuct. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of shope (Rabbit) fibroma virus."
      Willer D.O., McFadden G., Evans D.H.
      Virology 264:319-343(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiPAP1_RFVKA
    AccessioniPrimary (citable) accession number: Q9Q944
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 23, 2007
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3