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Protein

Poly(A) polymerase catalytic subunit

Gene

PAPL

Organism
Myxoma virus (strain Lausanne) (MYXV)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Polymerase that creates the 3'-poly(A) tail of mRNA's.

Catalytic activityi

ATP + RNA(n) = diphosphate + RNA(n+1).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei192 – 1921By similarity
Active sitei194 – 1941By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. polynucleotide adenylyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. mRNA processing Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

mRNA processing, Transcription

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Poly(A) polymerase catalytic subunit (EC:2.7.7.19)
Alternative name(s):
Poly(A) polymerase large subunit
Short name:
PAP-L
Gene namesi
Name:PAPL
Ordered Locus Names:m027L
OrganismiMyxoma virus (strain Lausanne) (MYXV)
Taxonomic identifieri31530 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeLeporipoxvirus
Virus hostiOryctolagus cuniculus (Rabbit) [TaxID: 9986]
ProteomesiUP000000867 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 470470Poly(A) polymerase catalytic subunitPRO_0000308936Add
BLAST

Interactioni

Subunit structurei

Heterodimer of a large (catalytic) subunit and a small (regulatory) subunit.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9Q8R9.
SMRiQ9Q8R9. Positions 7-468.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR024231. Pox_polyA_pol_nucTrfase.
IPR024397. Poxvirus_polyA_pol_cat_C.
IPR024398. Poxvirus_polyA_pol_cat_N.
[Graphical view]
PfamiPF03296. Pox_polyA_pol. 1 hit.
PF12629. Pox_polyA_pol_C. 1 hit.
PF12630. Pox_polyA_pol_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Q8R9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNARIAELLH NYLGRPPSLS EYHMLKLQHR NIQKIIAFNK DIFISLIKKN
60 70 80 90 100
KKKFFSDIDL TSSEIKTSVL SYFSKQRDTY SIGKLYTIIE LQTILVSTYT
110 120 130 140 150
DVLGVLTLKG PDMFPSSTRY DIKSIKQIAT SALHAMNVAV LSDKVMGRHN
160 170 180 190 200
VSPLVSNVNA LMEEYLRRHN KNCICYGSYS LHLLNPEVKY GDIDILQTNS
210 220 230 240 250
RTFLIDLAFL IKFITGSNVI LLKVPYLKNY MVLKDKDDNH IIDSFNIRQE
260 270 280 290 300
TMQVIPKVLI DNIYIVDPAL QLMSMFKMFS QIDRLEDLAR NPEKLTVRLA
310 320 330 340 350
TLMEYVRVKY GVILNGESNH MPMKGVLDKD KRIIVMDTSG YNFSFKKCFV
360 370 380 390 400
YMDESSLSSD ILDLNADDAV DFENVSNSAY LVKGDVLYTY FSNTILLSDP
410 420 430 440 450
DTIHEISNKA MSAHILIYQI LTGNDIRQPL SDLVNSLMYN EKVLIHEVIP
460 470
RDKKTGKHGI IDIEKDIITH
Length:470
Mass (Da):53,836
Last modified:May 1, 2000 - v1
Checksum:i65A8F42653A85D0F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF170726 Genomic DNA. Translation: AAF14915.1.
RefSeqiNP_051741.1. NC_001132.2.

Genome annotation databases

GeneIDi932202.
KEGGivg:932202.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF170726 Genomic DNA. Translation: AAF14915.1.
RefSeqiNP_051741.1. NC_001132.2.

3D structure databases

ProteinModelPortaliQ9Q8R9.
SMRiQ9Q8R9. Positions 7-468.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi932202.
KEGGivg:932202.

Family and domain databases

InterProiIPR024231. Pox_polyA_pol_nucTrfase.
IPR024397. Poxvirus_polyA_pol_cat_C.
IPR024398. Poxvirus_polyA_pol_cat_N.
[Graphical view]
PfamiPF03296. Pox_polyA_pol. 1 hit.
PF12629. Pox_polyA_pol_C. 1 hit.
PF12630. Pox_polyA_pol_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiPAP1_MYXVL
AccessioniPrimary (citable) accession number: Q9Q8R9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: May 1, 2000
Last modified: April 1, 2015
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.