Q9Q8N6 (KITH_MYXVL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thymidine kinase
EC=2.7.1.21

Gene names

Name:	TK
Ordered Locus Names:	m061R

Organism

Myxoma virus (strain Lausanne) (MYXV) [Reference proteome]

Taxonomic identifier

31530 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Poxviridae › Chordopoxvirinae › Leporipoxvirus › Myxoma virus

Virus host

Oryctolagus cuniculus (Rabbit) [TaxID: 9986]

Protein attributes

Sequence length	178 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + thymidine = ADP + thymidine 5'-phosphate.
Sequence similarities	Belongs to the thymidine kinase family.

Ontologies

Keywords
Biological process	DNA synthesis
Ligand	ATP-binding Metal-binding Nucleotide-binding Zinc
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA replication Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW thymidine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 178	178	Thymidine kinase		PRO_0000174932
Regions
	Nucleotide binding	13 – 20	8	ATP By similarity
	Region	159 – 163	5	Substrate binding By similarity
Sites
	Active site	85	1	Proton acceptor Potential
	Metal binding	140	1	Zinc By similarity
	Metal binding	143	1	Zinc By similarity
	Metal binding	172	1	Zinc By similarity
	Metal binding	175	1	Zinc By similarity
	Binding site	115	1	Substrate; via amide nitrogen By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9Q8N6 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 7F45A011D5D88ADD	FASTA	178	19,945
	10 20 30 40 50 60 MAMYGGQIHL IIGPMFAGKS TELIRLVKRY QIARYKCLVV KYEKDARYGN GVRTHDNTCI 70 80 90 100 110 120 SAVPTASLDD VESISEHVEV IGIDEGQFFP NIVSFCERMA NAGKVLIVAA LDGTFQRKPF 130 140 150 160 170 TNICELIPLA ENVTKLNAVC MYCYKDASFS KRLGNETEIE IIGGSDKYKS VCRKCYFF

References

[1]	"The complete DNA sequence of myxoma virus." Cameron C., Hota-Mitchell S., Chen L., Barrett J.W., Cao J.-X., Macaulay C., Willer D.O., Evans D.H., McFadden G. Virology 264:298-318(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF170726 Genomic DNA. Translation: AAF14949.1.
RefSeq	NP_051775.1. NC_001132.2.
3D structure databases
ProteinModelPortal	Q9Q8N6.
SMR	Q9Q8N6. Positions 6-177.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	932181.
Phylogenomic databases
ProtClustDB	CLSP2509781.
Family and domain databases
InterPro	IPR001267. Thymidine_kinase. IPR020633. Thymidine_kinase_CS. [Graphical view]
PANTHER	PTHR11441. PTHR11441. 1 hit.
Pfam	PF00265. TK. 1 hit. [Graphical view]
PIRSF	PIRSF035805. TK_cell. 1 hit.
PROSITE	PS00603. TK_CELLULAR_TYPE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KITH_MYXVL

Accession

Primary (citable) accession number: Q9Q8N6

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2002
Last sequence update:	May 1, 2000
Last modified:	April 3, 2013
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program