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Q9Q8N6 (KITH_MYXVL) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thymidine kinase

EC=2.7.1.21
Gene names
Name:TK
Ordered Locus Names:m061R
OrganismMyxoma virus (strain Lausanne) (MYXV) [Reference proteome]
Taxonomic identifier31530 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeLeporipoxvirus
Virus hostOryctolagus cuniculus (Rabbit) [TaxID: 9986]

Protein attributes

Sequence length178 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + thymidine = ADP + thymidine 5'-phosphate.

Sequence similarities

Belongs to the thymidine kinase family.

Ontologies

Keywords
   Biological processDNA synthesis
   LigandATP-binding
Metal-binding
Nucleotide-binding
Zinc
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processDNA replication

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

thymidine kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 178178Thymidine kinase
PRO_0000174932

Regions

Nucleotide binding13 – 208ATP By similarity
Region159 – 1635Substrate binding By similarity

Sites

Active site851Proton acceptor Potential
Metal binding1401Zinc By similarity
Metal binding1431Zinc By similarity
Metal binding1721Zinc By similarity
Metal binding1751Zinc By similarity
Binding site1151Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9Q8N6 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 7F45A011D5D88ADD

FASTA17819,945
        10         20         30         40         50         60 
MAMYGGQIHL IIGPMFAGKS TELIRLVKRY QIARYKCLVV KYEKDARYGN GVRTHDNTCI 

        70         80         90        100        110        120 
SAVPTASLDD VESISEHVEV IGIDEGQFFP NIVSFCERMA NAGKVLIVAA LDGTFQRKPF 

       130        140        150        160        170 
TNICELIPLA ENVTKLNAVC MYCYKDASFS KRLGNETEIE IIGGSDKYKS VCRKCYFF 

« Hide

References

[1]"The complete DNA sequence of myxoma virus."
Cameron C., Hota-Mitchell S., Chen L., Barrett J.W., Cao J.-X., Macaulay C., Willer D.O., Evans D.H., McFadden G.
Virology 264:298-318(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF170726 Genomic DNA. Translation: AAF14949.1.
RefSeqNP_051775.1. NC_001132.2.

3D structure databases

ProteinModelPortalQ9Q8N6.
SMRQ9Q8N6. Positions 6-177.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID932181.

Family and domain databases

InterProIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PANTHERPTHR11441. PTHR11441. 1 hit.
PfamPF00265. TK. 1 hit.
[Graphical view]
PIRSFPIRSF035805. TK_cell. 1 hit.
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKITH_MYXVL
AccessionPrimary (citable) accession number: Q9Q8N6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: May 1, 2000
Last modified: May 14, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families