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Protein

Genome polyprotein

Gene
N/A
Organism
West Nile virus (WNV)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + H2O = ADP + phosphate.SAAS annotation
NTP + H2O = NDP + phosphate.SAAS annotation
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).SAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei1556 – 15561Charge relay system; for serine protease NS3 activityUniRule annotation
Active sitei1580 – 15801Charge relay system; for serine protease NS3 activityUniRule annotation
Active sitei1640 – 16401Charge relay system; for serine protease NS3 activityUniRule annotation
Binding sitei2584 – 25841S-adenosyl-L-homocysteineCombined sources
Binding sitei2674 – 26741S-adenosyl-L-homocysteineCombined sources

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

HelicaseSAAS annotation, Hydrolase, Nucleotidyltransferase, Protease, RNA-directed RNA polymeraseSAAS annotation, Serine proteaseSAAS annotation, Transferase

Keywords - Biological processi

Activation of host autophagy by virusSAAS annotation, Fusion of virus membrane with host endosomal membraneSAAS annotation, Fusion of virus membrane with host membrane, Host-virus interaction, Viral attachment to host cellSAAS annotation, Viral penetration into host cytoplasm, Viral RNA replicationSAAS annotation, Virus entry into host cell

Keywords - Ligandi

ATP-binding, Nucleotide-binding, RNA-bindingSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Genome polyproteinSAAS annotation
OrganismiWest Nile virus (WNV)Imported
Taxonomic identifieri11082 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stageFlaviviridaeFlavivirusJapanese encephalitis virus group
Virus hostiAedes [TaxID: 7158]
Amblyomma variegatum (Tropical bont tick) [TaxID: 34610]
Aves [TaxID: 8782]
Culex [TaxID: 53527]
Homo sapiens (Human) [TaxID: 9606]
Hyalomma marginatum [TaxID: 34627]
Mansonia uniformis [TaxID: 308735]
Mimomyia [TaxID: 308737]
Rhipicephalus [TaxID: 34630]

Subcellular locationi

  • Virion membrane SAAS annotation; Multi-pass membrane protein SAAS annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei44 – 6623HelicalSequence analysisAdd
BLAST
Transmembranei107 – 12620HelicalSequence analysisAdd
BLAST
Transmembranei250 – 26920HelicalSequence analysisAdd
BLAST
Transmembranei276 – 29217HelicalSequence analysisAdd
BLAST
Transmembranei743 – 76422HelicalSequence analysisAdd
BLAST
Transmembranei1179 – 119719HelicalSequence analysisAdd
BLAST
Transmembranei1217 – 123822HelicalSequence analysisAdd
BLAST
Transmembranei1245 – 126117HelicalSequence analysisAdd
BLAST
Transmembranei1281 – 130525HelicalSequence analysisAdd
BLAST
Transmembranei1312 – 133019HelicalSequence analysisAdd
BLAST
Transmembranei1342 – 136625HelicalSequence analysisAdd
BLAST
Transmembranei1378 – 139619HelicalSequence analysisAdd
BLAST
Transmembranei1402 – 142019HelicalSequence analysisAdd
BLAST
Transmembranei1472 – 149827HelicalSequence analysisAdd
BLAST
Transmembranei2174 – 219522HelicalSequence analysisAdd
BLAST
Transmembranei2204 – 222219HelicalSequence analysisAdd
BLAST
Transmembranei2228 – 224518HelicalSequence analysisAdd
BLAST
Transmembranei2257 – 227923HelicalSequence analysisAdd
BLAST
Transmembranei2312 – 232918HelicalSequence analysisAdd
BLAST
Transmembranei2350 – 237324HelicalSequence analysisAdd
BLAST
Transmembranei2379 – 239820HelicalSequence analysisAdd
BLAST
Transmembranei2446 – 246520HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Capsid proteinSAAS annotation, Host membraneSAAS annotation, Membrane, Virion

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi293 ↔ 320Combined sources
Disulfide bondi350 ↔ 411Combined sources
Disulfide bondi364 ↔ 395Combined sources
Disulfide bondi382 ↔ 406Combined sources
Disulfide bondi480 ↔ 578Combined sources
Disulfide bondi595 ↔ 626Combined sources
Disulfide bondi795 ↔ 806Combined sources
Disulfide bondi846 ↔ 934Combined sources
Glycosylationi921 – 9211N-linked (GlcNAc...)Combined sourcesCAR_5006994889
Glycosylationi966 – 9661N-linked (GlcNAc...)Combined sourcesCAR_5006994888
Disulfide bondi970 ↔ 1014Combined sources
Glycosylationi998 – 9981N-linked (GlcNAc...)Combined sourcesCAR_5006994887
Disulfide bondi1071 ↔ 1120Combined sources
Disulfide bondi1082 ↔ 1103Combined sources
Disulfide bondi1104 ↔ 1107Combined sources

Keywords - PTMi

Disulfide bondSAAS annotation

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2OY0X-ray2.80A/B2534-2795[»]
3I50X-ray3.00E291-692[»]
3IYWelectron microscopy13.70A/B/C291-690[»]
3J0Belectron microscopy10.30A/B/C291-690[»]
3LKZX-ray2.00A/B2529-2828[»]
4O6CX-ray2.75A/B/C/D/E/F791-1143[»]
4O6DX-ray2.59A/B791-1143[»]
4OIEX-ray1.85A963-1143[»]
4OIIX-ray3.00A/B963-1143[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1375 – 1506132FLAVIVIRUS_NS2BInterPro annotationAdd
BLAST
Domaini1506 – 1683178Peptidase S7InterPro annotationAdd
BLAST
Domaini1686 – 1842157Helicase ATP-bindingInterPro annotationAdd
BLAST
Domaini1853 – 2018166Helicase C-terminalInterPro annotationAdd
BLAST
Domaini2529 – 2794266MRNA cap 0-1 NS5-type MTInterPro annotationAdd
BLAST
Domaini3058 – 3210153RdRp catalyticInterPro annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2614 – 26152S-adenosyl-L-homocysteine bindingCombined sources
Regioni2638 – 26392S-adenosyl-L-homocysteine bindingCombined sources
Regioni2659 – 26602S-adenosyl-L-homocysteine bindingCombined sources

Sequence similaritiesi

Contains RdRp catalytic domain.SAAS annotation
Contains helicase ATP-binding domain.SAAS annotation
Contains helicase C-terminal domain.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Family and domain databases

Gene3Di2.60.40.350. 1 hit.
2.60.98.10. 2 hits.
3.30.387.10. 1 hit.
3.40.50.150. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR011492. DEAD_Flavivir.
IPR000069. Env_glycoprot_M_flavivir.
IPR013755. Flav_gly_cen_dom_subdom1.
IPR001122. Flavi_capsidC.
IPR026470. Flavi_E_Stem/Anchor_dom.
IPR001157. Flavi_NS1.
IPR000752. Flavi_NS2A.
IPR000487. Flavi_NS2B.
IPR000404. Flavi_NS4A.
IPR001528. Flavi_NS4B.
IPR002535. Flavi_propep.
IPR000336. Flavivir/Alphavir_Ig-like.
IPR001850. Flavivirus_NS3_S7.
IPR027287. Flavovir_Ig-like.
IPR014412. Gen_Poly_FLV.
IPR011998. Glycoprot_cen/dimer.
IPR013754. GlyE_dim.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR014756. Ig_E-set.
IPR026490. mRNA_cap_0/1_MeTrfase.
IPR027417. P-loop_NTPase.
IPR009003. Peptidase_S1_PA.
IPR000208. RNA-dir_pol_flavivirus.
IPR007094. RNA-dir_pol_PSvirus.
IPR002877. rRNA_MeTrfase_FtsJ_dom.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF01003. Flavi_capsid. 1 hit.
PF07652. Flavi_DEAD. 1 hit.
PF02832. Flavi_glycop_C. 1 hit.
PF00869. Flavi_glycoprot. 1 hit.
PF01004. Flavi_M. 1 hit.
PF00948. Flavi_NS1. 1 hit.
PF01005. Flavi_NS2A. 1 hit.
PF01002. Flavi_NS2B. 1 hit.
PF01350. Flavi_NS4A. 1 hit.
PF01349. Flavi_NS4B. 1 hit.
PF00972. Flavi_NS5. 1 hit.
PF01570. Flavi_propep. 1 hit.
PF01728. FtsJ. 1 hit.
PF00949. Peptidase_S7. 1 hit.
[Graphical view]
PIRSFiPIRSF003817. Gen_Poly_FLV. 1 hit.
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF52540. SSF52540. 2 hits.
SSF53335. SSF53335. 1 hit.
SSF56983. SSF56983. 1 hit.
SSF81296. SSF81296. 1 hit.
TIGRFAMsiTIGR04240. flavi_E_stem. 1 hit.
PROSITEiPS51527. FLAVIVIRUS_NS2B. 1 hit.
PS51528. FLAVIVIRUS_NS3PRO. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS50507. RDRP_SSRNA_POS. 1 hit.
PS51591. RNA_CAP01_NS5_MT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Q6P4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKKPGGPGK SRAVNMLKRG MPRVLSLIGL KRAMLSLIDG KGPIRFVLAL
60 70 80 90 100
LAFFRFTAIA PTRAVLDRWR GVNKQTAMKH LLSFKKELGT LTSAINRRSS
110 120 130 140 150
KQKKRGGKTG IAVMIGLIAS VGAVTLSNFQ GKVMMTVNAT DVTDVITIPT
160 170 180 190 200
AAGKNLCIVR AMDVGYMCDD TITYECPVLS AGNDPEDIDC WCTKSAVYVR
210 220 230 240 250
YGRCTKTRHS RRSRRSLTVQ THGESTLANK KGAWMDSTKA TRYLVKTESW
260 270 280 290 300
ILRNPGYALV AAVIGWMLGS NTMQRVVFVV LLLLVAPAYS FNCLGMSNRD
310 320 330 340 350
FLEGVSGATW VDLVLEGDSC VTIMSKDKPT IDVKMMNMEA ANLAEVRSYC
360 370 380 390 400
YLATVSDLST KAACPTMGEA HNDKRADPAF VCRQGVVDRG WGNGCGLFGK
410 420 430 440 450
GSIDTCAKFA CSTKAIGRTI LKENIKYEVA IFVHGPTTVE SHGNYSTQVG
460 470 480 490 500
ATQAGRFSIT PAAPSYTLKL GEYGEVTVDC EPRSGIDTNA YYVMTVGTKT
510 520 530 540 550
FLVHREWFMD LNLPWSSAGS TVWRNRETLM EFEEPHATKQ SVIALGSQEG
560 570 580 590 600
ALHQALAGAI PVEFSSNTVK LTSGHLKCRV KMEKLQLKGT TYGVCSKAFK
610 620 630 640 650
FLGTPADTGH GTVVLELQYT GTDGPCKVPI SSVASLNDLT PVGRLVTVNP
660 670 680 690 700
FVSVATANAK VLIELEPPFG DSYIVVGRGE QQINHHWHKS GSSIGKAFTT
710 720 730 740 750
TLKGAQRLAA LGDTAWDFGS VGGVFTSVGK AVHQVFGGAF RSLFGGMSWI
760 770 780 790 800
TQGLLGALLL WMGINARDRS IALTFLAVGG VLLFLSVNVH ADTGCAIDIS
810 820 830 840 850
RQELRCGSGV FIHNDVEAWM DRYKYYPETP QGLAKIIQKA HKEGVCGLRS
860 870 880 890 900
VSRLEHQMWE AVKDELNTLL KENGVDLSVV VEKQEGMYKS APKRLTATTE
910 920 930 940 950
KLEIGWKAWG KSILFAPELA NNTFVVDGPE TKECPTQNRA WNSLEVEDFG
960 970 980 990 1000
FGLTSTRMFL KVRESNTTEC DSKIIGTAVK NNLAIHSDLS YWIESRLNDT
1010 1020 1030 1040 1050
WKLERAVLGE VKSCTWPETH TLWGDGILES DLIIPVTLAG PRSNHNRRPG
1060 1070 1080 1090 1100
YKTQNQGPWD EGRVEIDFDY CPGTTVTLSE SCGHRGPATR TTTESGKLIT
1110 1120 1130 1140 1150
DWCCRSCTLP PLRYQTDSGC WYGMEIRPQR HDEKTLVQSQ VNAYNADMID
1160 1170 1180 1190 1200
PFQLGLLVVF LATQEVLRKR WTAKISMPAI LIALLVLVFG GITYTDVLRY
1210 1220 1230 1240 1250
VILVGAAFAE SNSGGDVVHL ALMATFKIQP VFMVASFLKA RWTNQENILL
1260 1270 1280 1290 1300
MLAAVFFQMA YHDARQILLW EIPDVLNSLA VAWMILRAIT FTTTSNVVVP
1310 1320 1330 1340 1350
LLALLTPGLR CLNLDVYRIL LLMVGIGSLI REKRSAAAKK KGASLLCLAL
1360 1370 1380 1390 1400
ASTGLFNPMI LAAGLIACDP NRKRGWPATE VMTAVGLMFA IVGGLAELDI
1410 1420 1430 1440 1450
DSMAIPMTIA GLMFAAFVIS GKSTDMWIER TADISWESDA EITGSSERVD
1460 1470 1480 1490 1500
VRLDDDGNFQ LMNDPGAPWK IWMLRMVCLA ISAYTPWAIL PSVVGFWITL
1510 1520 1530 1540 1550
QYTKRGGVLW DTPSPKEYKK GDTTTGVYRI MTRGLLGSYQ AGAGVMVEGV
1560 1570 1580 1590 1600
FHTLWHTTKG AALMSGEGRL DPYWGSVKED RLCYGGPWKL QHKWNGQDEV
1610 1620 1630 1640 1650
QMIVVEPGKN VKNVQTKPGV FKTPEGEIGA VTLDFPTGTS GSPIVDKNGD
1660 1670 1680 1690 1700
VIGLYGNGVI MPNGSYISAI VQGERMDEPI PAGFEPEMLR KKQITVLDLH
1710 1720 1730 1740 1750
PGAGKTRRIL PQIIKEAINR RLRTAVLAPT RVVAAEMAEA LRGLPIRYQT
1760 1770 1780 1790 1800
SAVPREHNGN EIVDVMCHAT LTHRLMSPHR VPNYNLFVMD EAHFTDPASI
1810 1820 1830 1840 1850
AARGYISTKV ELGEAAAIFM TATPPGTSDP FPESNSPISD LQTEIPDRAW
1860 1870 1880 1890 1900
NSGYEWITEY TGKTVWFVPS VKMGNEIALC LQRAGKKVVQ LNRKSYETEY
1910 1920 1930 1940 1950
PKCKNDDWDF VITTDISEMG ANFKASRVID SRKSVKPTII TEGEGRVILG
1960 1970 1980 1990 2000
EPSAVTAASA AQRRGRIGRN PSQVGDEYCY GGHTNEDDSN FAHWTEARIM
2010 2020 2030 2040 2050
LDNINMPNGL IAQFYQPERE KVYTMDGEYR LRGEERKNFL ELLRTADLPV
2060 2070 2080 2090 2100
WLAYKVAAAG VSYHDRRWCF DGPRTNTILE DNNEVEVITK LGERKILRPR
2110 2120 2130 2140 2150
WIDARVYSDH QALKAFKDFA SGKRSQIGLI EVLGKMPEHF MGKTWEALDT
2160 2170 2180 2190 2200
MYVVATAEKG GRAHRMALEE LPDALQTIAL IALLSVMTMG VFFLLMQRKG
2210 2220 2230 2240 2250
IGKIGLGGAV LGVATFFCWM AEVPGTKIAG MLLLSLLLMI VLIPEPEKQR
2260 2270 2280 2290 2300
SQTDNQLAVF LICVMTLVSA VAANEMGWLD KTKSDISSLF GQRIEVKENF
2310 2320 2330 2340 2350
SMGEFLLDLR PATAWSLYAV TTAVLTPLLK HLITSDYINT SLTSINVQAS
2360 2370 2380 2390 2400
ALFTLARGFP FVDVGVSALL LAAGCWGQVT LTVTVTAATL LFCHYAYMVP
2410 2420 2430 2440 2450
GWQAEAMRSA QRRTAAGIMK NAVVDGIVAT DVPELERTTP IMQKKVGQIM
2460 2470 2480 2490 2500
LILVSLAAVV VNPSVKTVRE AGILITAAAV TLWENGASSV WNATTAIGLC
2510 2520 2530 2540 2550
HIMRGGWLSC LSITWTLIKN MEKPGLKRGG AKGRTLGEVW KERLNQMTKE
2560 2570 2580 2590 2600
EFTRYRKEAI IEVDRSAAKH ARKEGNVTGG HPVSRGTAKL RWLVERRFLE
2610 2620 2630 2640 2650
PVGKVIDLGC GRGGWCYYMA TQKRVQEVRG YTKGGPGHEE PQLVQSYGWN
2660 2670 2680 2690 2700
IVTMKSGVDV FYRPSECCDT LLCDIGESSS SAEVEEHRTI RVLEMVEDWL
2710 2720 2730 2740 2750
HRGPREFCVK VLCPYMPKVI EKMELLQRRY GGGLVRNPLS RNSTHEMYWV
2760 2770 2780 2790 2800
SRASGNVVHS VNMTSQVLLG RMEKRTWKGP QYEEDVNLGS GTRAVGKPLL
2810 2820 2830 2840 2850
NSDTSKIKNR IERLRREYSS TWHHDENHPY RTWNYHGSYD VKPTGSASSL
2860 2870 2880 2890 2900
VNGVVRLLSK PWDTITNVTT MAMTDTTPFG QQRVFKEKVD TKAPEPPEGV
2910 2920 2930 2940 2950
KYVLNETTNW LWAFLAREKR PRMCSREEFI RKVNSNAALG AMFEEQNQWR
2960 2970 2980 2990 3000
SAREAVEDPK FWEMVDEERE AHLRGECHTC IYNMMGKREK KPGEFGKAKG
3010 3020 3030 3040 3050
SRAIWFMWLG ARFLEFEALG FLNEDHWLGR KNSGGGVEGL GLQKLGYILR
3060 3070 3080 3090 3100
EVGTRPGGKI YADDTAGWDT RITRADLENE AKVLELLDGE HRRLARAIIE
3110 3120 3130 3140 3150
LTYRHKVVKV MRPAADGRTV MDVISREDQR GSGQVVTYAL NTFTNLAVQL
3160 3170 3180 3190 3200
VRMMEGEGVI GPDDVEKLTK GKGPKVRTWL FENGEERLSR MAVSGDDCVV
3210 3220 3230 3240 3250
KPLDDRFATS LHFLNAMSKV RKDIQEWKPS TGWYDWQQVP FCSNHFTELI
3260 3270 3280 3290 3300
MKDGRTLVVP CRGQDELVGR ARISPGAGWN VRDTACLAKS YAQMWLLLYF
3310 3320 3330 3340 3350
HRRDLRLMAN AICSAVPVNW VPTGRTTWSI HAGGEWMTTE DMLEVWNRVW
3360 3370 3380 3390 3400
IEENEWMEDK TPVEKWSDVP YSGKREDIWC GSLIGTRARA TWAENIQVAI
3410 3420 3430
NQVRAIIGDE KYVDYMSSLK RYEDTTLVED TVL
Length:3,433
Mass (Da):381,176
Last modified:March 1, 2001 - v2
Checksum:iA742A68D0E55947E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF196835 Genomic RNA. Translation: AAF20092.2.
AF404755 Genomic RNA. Translation: AAM81751.1.
HM488125 Genomic RNA. Translation: ADL27936.1.
HM488126 Genomic RNA. Translation: ADL27937.1.
HM488127 Genomic RNA. Translation: ADL27938.1.
HM488128 Genomic RNA. Translation: ADL27939.1.
KC407666 Genomic RNA. Translation: AGI15883.1.
KM083619 Genomic RNA. Translation: AIO10814.1.
AB185914 Genomic RNA. Translation: BAD34488.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF196835 Genomic RNA. Translation: AAF20092.2.
AF404755 Genomic RNA. Translation: AAM81751.1.
HM488125 Genomic RNA. Translation: ADL27936.1.
HM488126 Genomic RNA. Translation: ADL27937.1.
HM488127 Genomic RNA. Translation: ADL27938.1.
HM488128 Genomic RNA. Translation: ADL27939.1.
KC407666 Genomic RNA. Translation: AGI15883.1.
KM083619 Genomic RNA. Translation: AIO10814.1.
AB185914 Genomic RNA. Translation: BAD34488.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2OY0X-ray2.80A/B2534-2795[»]
3I50X-ray3.00E291-692[»]
3IYWelectron microscopy13.70A/B/C291-690[»]
3J0Belectron microscopy10.30A/B/C291-690[»]
3LKZX-ray2.00A/B2529-2828[»]
4O6CX-ray2.75A/B/C/D/E/F791-1143[»]
4O6DX-ray2.59A/B791-1143[»]
4OIEX-ray1.85A963-1143[»]
4OIIX-ray3.00A/B963-1143[»]
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di2.60.40.350. 1 hit.
2.60.98.10. 2 hits.
3.30.387.10. 1 hit.
3.40.50.150. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR011492. DEAD_Flavivir.
IPR000069. Env_glycoprot_M_flavivir.
IPR013755. Flav_gly_cen_dom_subdom1.
IPR001122. Flavi_capsidC.
IPR026470. Flavi_E_Stem/Anchor_dom.
IPR001157. Flavi_NS1.
IPR000752. Flavi_NS2A.
IPR000487. Flavi_NS2B.
IPR000404. Flavi_NS4A.
IPR001528. Flavi_NS4B.
IPR002535. Flavi_propep.
IPR000336. Flavivir/Alphavir_Ig-like.
IPR001850. Flavivirus_NS3_S7.
IPR027287. Flavovir_Ig-like.
IPR014412. Gen_Poly_FLV.
IPR011998. Glycoprot_cen/dimer.
IPR013754. GlyE_dim.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR014756. Ig_E-set.
IPR026490. mRNA_cap_0/1_MeTrfase.
IPR027417. P-loop_NTPase.
IPR009003. Peptidase_S1_PA.
IPR000208. RNA-dir_pol_flavivirus.
IPR007094. RNA-dir_pol_PSvirus.
IPR002877. rRNA_MeTrfase_FtsJ_dom.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF01003. Flavi_capsid. 1 hit.
PF07652. Flavi_DEAD. 1 hit.
PF02832. Flavi_glycop_C. 1 hit.
PF00869. Flavi_glycoprot. 1 hit.
PF01004. Flavi_M. 1 hit.
PF00948. Flavi_NS1. 1 hit.
PF01005. Flavi_NS2A. 1 hit.
PF01002. Flavi_NS2B. 1 hit.
PF01350. Flavi_NS4A. 1 hit.
PF01349. Flavi_NS4B. 1 hit.
PF00972. Flavi_NS5. 1 hit.
PF01570. Flavi_propep. 1 hit.
PF01728. FtsJ. 1 hit.
PF00949. Peptidase_S7. 1 hit.
[Graphical view]
PIRSFiPIRSF003817. Gen_Poly_FLV. 1 hit.
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF52540. SSF52540. 2 hits.
SSF53335. SSF53335. 1 hit.
SSF56983. SSF56983. 1 hit.
SSF81296. SSF81296. 1 hit.
TIGRFAMsiTIGR04240. flavi_E_stem. 1 hit.
PROSITEiPS51527. FLAVIVIRUS_NS2B. 1 hit.
PS51528. FLAVIVIRUS_NS3PRO. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS50507. RDRP_SSRNA_POS. 1 hit.
PS51591. RNA_CAP01_NS5_MT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NY99-flamingo382-99Imported.
  2. He C., Chen S.
    Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NY99-flamingo382-99Imported.
  3. "Complete genome sequences and phylogenetic analysis of West Nile virus strains isolated from the United States, Europe, and the Middle East."
    Lanciotti R.S., Ebel G.D., Deubel V., Kerst A.J., Murri S., Meyer R., Bowen M., McKinney N., Morrill W.E., Crabtree M.B., Kramer L.D., Roehrig J.T.
    Virology 298:96-105(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: WN NY 2000-grouse3282Imported.
  4. "Viral envelope protein glycosylation is a molecular determinant of the neuroinvasiveness of the New York strain of West Nile virus."
    Shirato K., Miyoshi H., Goto A., Ako Y., Ueki T., Kariwa H., Takashima I.
    J. Gen. Virol. 85:3637-3645(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NY99-6922Imported.
  5. "Structure and function of flavivirus NS5 methyltransferase."
    Zhou Y., Ray D., Zhao Y., Dong H., Ren S., Li Z., Guo Y., Bernard K.A., Shi P.Y., Li H.
    J. Virol. 81:3891-3903(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.80 ANGSTROMS) OF 2534-2795 IN COMPLEX WITH S-ADENOSYL-L-HOMOCYSTEINE.
  6. Cited for: X-RAY CRYSTALLOGRAPHY (3.00 ANGSTROMS) OF 291-692, DISULFIDE BONDS.
  7. "Structural and functional analyses of a conserved hydrophobic pocket of flavivirus methyltransferase."
    Dong H., Liu L., Zou G., Zhao Y., Li Z., Lim S.P., Shi P.Y., Li H.
    J. Biol. Chem. 285:32586-32595(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 2529-2828.
  8. "Neutralization of West Nile virus by cross-linking of its surface proteins with Fab fragments of the human monoclonal antibody CR4354."
    Kaufmann B., Vogt M.R., Goudsmit J., Holdaway H.A., Aksyuk A.A., Chipman P.R., Kuhn R.J., Diamond M.S., Rossmann M.G.
    Proc. Natl. Acad. Sci. U.S.A. 107:18950-18955(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY ELECTRON MICROSCOPY (13.70 ANGSTROMS) OF 291-690, DISULFIDE BONDS.
  9. "Molecular evolution of West Nile virus in a northern temperate region: Connecticut, USA 1999-2008."
    Armstrong P.M., Vossbrinck C.R., Andreadis T.G., Anderson J.F., Pesko K.N., Newman R.M., Lennon N.J., Birren B.W., Ebel G.D., Henn M.R.
    Virology 417:203-210(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: WNV-1/US/BID-V4186/1999Imported, WNV-1/US/BID-V4187/1999Imported, WNV-1/US/BID-V4188/1999Imported and WNV-1/US/BID-V4189/1999Imported.
  10. Gao Y.W., Fan S.T., Sun H.T., Wang Z., Gao X.L., Li Y.G., Wang T.C., Zhang K., Xu W.W., Yu Z.J., Xia X.Z.
    Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NY-99Imported.
  11. Cited for: STRUCTURE BY ELECTRON MICROSCOPY (10.30 ANGSTROMS) OF 291-690.
  12. "Complete Genome Sequence of West Nile Virus Strains Used for the Formulation of CBER/FDA RNA Reference Reagents and Lot Release Panels for Nucleic Acid Testing."
    Grinev A., Anez G., Rios M.
    Genome Announc. 2:e00811-e00814(2014)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NY99P2Imported.
  13. "Structural basis of Flavivirus NS1 assembly and antibody recognition."
    Edeling M.A., Diamond M.S., Fremont D.H.
    Proc. Natl. Acad. Sci. U.S.A. 111:4285-4290(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 963-1143, DISULFIDE BONDS.
  14. "Flavivirus NS1 structures reveal surfaces for associations with membranes and the immune system."
    Akey D.L., Brown W.C., Dutta S., Konwerski J., Jose J., Jurkiw T.J., DelProposto J., Ogata C.M., Skiniotis G., Kuhn R.J., Smith J.L.
    Science 343:881-885(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.59 ANGSTROMS) OF 791-1143, GLYCOSYLATION AT ASN-921; ASN-966 AND ASN-998, DISULFIDE BONDS.

Entry informationi

Entry nameiQ9Q6P4_WNV
AccessioniPrimary (citable) accession number: Q9Q6P4
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: March 1, 2001
Last modified: May 11, 2016
This is version 143 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.