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Protein

Hemagglutinin-neuraminidase

Gene

HN

Organism
Newcastle disease virus (strain Kansas) (NDV)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion (By similarity).By similarity
Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins.By similarity

Catalytic activityi

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hemagglutinin, Hydrolase

Keywords - Biological processi

Host-virus interaction, Viral attachment to host cell, Virus entry into host cell

Enzyme and pathway databases

BRENDAi3.2.1.18. 3631.

Protein family/group databases

CAZyiGH83. Glycoside Hydrolase Family 83.

Names & Taxonomyi

Protein namesi
Recommended name:
Hemagglutinin-neuraminidase (EC:3.2.1.18)
Gene namesi
Name:HN
OrganismiNewcastle disease virus (strain Kansas) (NDV)
Taxonomic identifieri332244 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesMononegaviralesParamyxoviridaeAvulavirus
Virus hostiGallus gallus (Chicken) [TaxID: 9031]

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 22IntravirionSequence analysisAdd BLAST22
Transmembranei23 – 45HelicalSequence analysisAdd BLAST23
Topological domaini46 – 571Virion surfaceSequence analysisAdd BLAST526

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host cell membrane, Host membrane, Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001426141 – 577Hemagglutinin-neuraminidaseAdd BLAST577

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi119N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi144N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi341N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi433N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi481N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi538N-linked (GlcNAc...); by hostSequence analysis1

Keywords - PTMi

Glycoprotein

Structurei

Secondary structure

1577
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni130 – 134Combined sources5
Beta strandi136 – 138Combined sources3
Beta strandi144 – 146Combined sources3
Helixi148 – 150Combined sources3
Beta strandi151 – 153Combined sources3
Beta strandi172 – 180Combined sources9
Beta strandi185 – 195Combined sources11
Beta strandi202 – 213Combined sources12
Beta strandi219 – 229Combined sources11
Beta strandi231 – 233Combined sources3
Beta strandi235 – 243Combined sources9
Beta strandi246 – 253Combined sources8
Helixi258 – 263Combined sources6
Beta strandi264 – 266Combined sources3
Beta strandi269 – 276Combined sources8
Beta strandi281 – 285Combined sources5
Helixi288 – 291Combined sources4
Turni292 – 294Combined sources3
Beta strandi295 – 300Combined sources6
Beta strandi306 – 308Combined sources3
Beta strandi311 – 320Combined sources10
Helixi325 – 330Combined sources6
Helixi348 – 357Combined sources10
Helixi362 – 364Combined sources3
Beta strandi368 – 377Combined sources10
Beta strandi379 – 381Combined sources3
Beta strandi387 – 389Combined sources3
Turni393 – 395Combined sources3
Beta strandi402 – 407Combined sources6
Beta strandi410 – 415Combined sources6
Beta strandi423 – 432Combined sources10
Beta strandi435 – 438Combined sources4
Beta strandi442 – 444Combined sources3
Beta strandi473 – 478Combined sources6
Beta strandi484 – 492Combined sources9
Beta strandi495 – 499Combined sources5
Beta strandi501 – 506Combined sources6
Beta strandi515 – 517Combined sources3
Beta strandi523 – 534Combined sources12
Turni535 – 538Combined sources4
Beta strandi539 – 549Combined sources11
Helixi551 – 553Combined sources3
Beta strandi557 – 567Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1E8TX-ray2.50A/B124-577[»]
1E8UX-ray2.00A/B124-577[»]
1E8VX-ray2.00A/B124-577[»]
ProteinModelPortaliQ9Q2W5.
SMRiQ9Q2W5.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Q2W5.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di2.120.10.10. 1 hit.
InterProiIPR016285. Hemagglutn-neuramid.
IPR000665. Hemagglutn/HN.
IPR011040. Sialidases.
[Graphical view]
PfamiPF00423. HN. 1 hit.
[Graphical view]
PIRSFiPIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
SUPFAMiSSF50939. SSF50939. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Q2W5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRAVSQVAL ENDEREAKNT WRLIFRIAIL LLTVVTLATS VASLVYSMGA
60 70 80 90 100
STPSDLVGIP TRISRAEEKI TSALGSNQDV VDRIYKQVAL ESPLALLNTE
110 120 130 140 150
TTIMNAITSL SYQINGAANN SGWGAPIHDP DFIGGIGKEL IVDNASDVTS
160 170 180 190 200
FYPSAFQEHL NFIPAPTTGS GCTRIPSFDM SATHYCYTHN VILSGCRDHS
210 220 230 240 250
HSHQYLALGV LRTTATGRIF FSTLRSISLD DTQNRKSCSV SATPLGCDML
260 270 280 290 300
CSKVTETEEE DYNSAVPTLM AHGRLGFDGQ YHEKDLDVTT LFEDWVANYP
310 320 330 340 350
GVGGGSFIDG RVWFSVYGGL KPNSPSDTVQ EGKYVIYKRY NDTCPDEQDY
360 370 380 390 400
QIRMAKSSYK PGRFGGKRIQ QAILSIKVST SLGEDPVLTV PPNTVTLMGA
410 420 430 440 450
EGRILTVGTS HFLYQRGSSY FSPALLYPMT VSNKTATLHS PYTFNAFTRP
460 470 480 490 500
GSIPCQASAR CPNSCVTGVY TDPYPLIFYR NHTLRGVFGT MLDSEQARLN
510 520 530 540 550
PASAVFDSTS RSRITRVSSS STKAAYTTST CFKVVKTNKT YCLSIAEISN
560 570
TLFGEFRIVP LLVEILKNDG VREARSG
Length:577
Mass (Da):63,111
Last modified:May 1, 2000 - v1
Checksum:i6A1F03C8DD3F7753
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF212323 Genomic RNA. Translation: AAF19984.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF212323 Genomic RNA. Translation: AAF19984.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1E8TX-ray2.50A/B124-577[»]
1E8UX-ray2.00A/B124-577[»]
1E8VX-ray2.00A/B124-577[»]
ProteinModelPortaliQ9Q2W5.
SMRiQ9Q2W5.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGH83. Glycoside Hydrolase Family 83.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BRENDAi3.2.1.18. 3631.

Miscellaneous databases

EvolutionaryTraceiQ9Q2W5.

Family and domain databases

Gene3Di2.120.10.10. 1 hit.
InterProiIPR016285. Hemagglutn-neuramid.
IPR000665. Hemagglutn/HN.
IPR011040. Sialidases.
[Graphical view]
PfamiPF00423. HN. 1 hit.
[Graphical view]
PIRSFiPIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
SUPFAMiSSF50939. SSF50939. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHN_NDVK
AccessioniPrimary (citable) accession number: Q9Q2W5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.