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Q9Q2W5

- HN_NDVK

UniProt

Q9Q2W5 - HN_NDVK

Protein

Hemagglutinin-neuraminidase

Gene

HN

Organism
Newcastle disease virus (strain Kansas) (NDV)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion By similarity.By similarity
    Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins.By similarity

    Catalytic activityi

    Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

    GO - Molecular functioni

    1. exo-alpha-(2->3)-sialidase activity Source: UniProtKB-EC
    2. exo-alpha-(2->6)-sialidase activity Source: UniProtKB-EC
    3. exo-alpha-(2->8)-sialidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. viral entry into host cell Source: UniProtKB-KW
    2. virion attachment to host cell Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hemagglutinin, Hydrolase

    Keywords - Biological processi

    Host-virus interaction, Viral attachment to host cell, Virus entry into host cell

    Protein family/group databases

    CAZyiGH83. Glycoside Hydrolase Family 83.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hemagglutinin-neuraminidase (EC:3.2.1.18)
    Gene namesi
    Name:HN
    OrganismiNewcastle disease virus (strain Kansas) (NDV)
    Taxonomic identifieri332244 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesMononegaviralesParamyxoviridaeParamyxovirinaeAvulavirus
    Virus hostiGallus gallus (Chicken) [TaxID: 9031]

    Subcellular locationi

    GO - Cellular componenti

    1. host cell plasma membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. viral envelope Source: UniProtKB-KW
    4. virion membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host cell membrane, Host membrane, Membrane, Viral envelope protein, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 577577Hemagglutinin-neuraminidasePRO_0000142614Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi119 – 1191N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi144 – 1441N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi341 – 3411N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi433 – 4331N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi481 – 4811N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi538 – 5381N-linked (GlcNAc...); by hostSequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    Secondary structure

    1
    577
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni130 – 1345
    Beta strandi136 – 1383
    Beta strandi144 – 1463
    Helixi148 – 1503
    Beta strandi151 – 1533
    Beta strandi172 – 1809
    Beta strandi185 – 19511
    Beta strandi202 – 21312
    Beta strandi219 – 22911
    Beta strandi231 – 2333
    Beta strandi235 – 2439
    Beta strandi246 – 2538
    Helixi258 – 2636
    Beta strandi264 – 2663
    Beta strandi269 – 2768
    Beta strandi281 – 2855
    Helixi288 – 2914
    Turni292 – 2943
    Beta strandi295 – 3006
    Beta strandi306 – 3083
    Beta strandi311 – 32010
    Helixi325 – 3306
    Helixi348 – 35710
    Helixi362 – 3643
    Beta strandi368 – 37710
    Beta strandi379 – 3813
    Beta strandi387 – 3893
    Turni393 – 3953
    Beta strandi402 – 4076
    Beta strandi410 – 4156
    Beta strandi423 – 43210
    Beta strandi435 – 4384
    Beta strandi442 – 4443
    Beta strandi473 – 4786
    Beta strandi484 – 4929
    Beta strandi495 – 4995
    Beta strandi501 – 5066
    Beta strandi515 – 5173
    Beta strandi523 – 53412
    Turni535 – 5384
    Beta strandi539 – 54911
    Helixi551 – 5533
    Beta strandi557 – 56711

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1E8TX-ray2.50A/B124-577[»]
    1E8UX-ray2.00A/B124-577[»]
    1E8VX-ray2.00A/B124-577[»]
    ProteinModelPortaliQ9Q2W5.
    SMRiQ9Q2W5. Positions 124-572.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9Q2W5.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2222IntravirionSequence AnalysisAdd
    BLAST
    Topological domaini46 – 571526Virion surfaceSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei23 – 4523HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di2.120.10.10. 1 hit.
    InterProiIPR000665. Hemagglutn-neuramid.
    IPR016285. Hemagglutn-neuramid_paramyxo.
    IPR011040. Sialidases.
    [Graphical view]
    PfamiPF00423. HN. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
    SUPFAMiSSF50939. SSF50939. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9Q2W5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDRAVSQVAL ENDEREAKNT WRLIFRIAIL LLTVVTLATS VASLVYSMGA    50
    STPSDLVGIP TRISRAEEKI TSALGSNQDV VDRIYKQVAL ESPLALLNTE 100
    TTIMNAITSL SYQINGAANN SGWGAPIHDP DFIGGIGKEL IVDNASDVTS 150
    FYPSAFQEHL NFIPAPTTGS GCTRIPSFDM SATHYCYTHN VILSGCRDHS 200
    HSHQYLALGV LRTTATGRIF FSTLRSISLD DTQNRKSCSV SATPLGCDML 250
    CSKVTETEEE DYNSAVPTLM AHGRLGFDGQ YHEKDLDVTT LFEDWVANYP 300
    GVGGGSFIDG RVWFSVYGGL KPNSPSDTVQ EGKYVIYKRY NDTCPDEQDY 350
    QIRMAKSSYK PGRFGGKRIQ QAILSIKVST SLGEDPVLTV PPNTVTLMGA 400
    EGRILTVGTS HFLYQRGSSY FSPALLYPMT VSNKTATLHS PYTFNAFTRP 450
    GSIPCQASAR CPNSCVTGVY TDPYPLIFYR NHTLRGVFGT MLDSEQARLN 500
    PASAVFDSTS RSRITRVSSS STKAAYTTST CFKVVKTNKT YCLSIAEISN 550
    TLFGEFRIVP LLVEILKNDG VREARSG 577
    Length:577
    Mass (Da):63,111
    Last modified:May 1, 2000 - v1
    Checksum:i6A1F03C8DD3F7753
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF212323 Genomic RNA. Translation: AAF19984.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF212323 Genomic RNA. Translation: AAF19984.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1E8T X-ray 2.50 A/B 124-577 [» ]
    1E8U X-ray 2.00 A/B 124-577 [» ]
    1E8V X-ray 2.00 A/B 124-577 [» ]
    ProteinModelPortali Q9Q2W5.
    SMRi Q9Q2W5. Positions 124-572.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GH83. Glycoside Hydrolase Family 83.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei Q9Q2W5.

    Family and domain databases

    Gene3Di 2.120.10.10. 1 hit.
    InterProi IPR000665. Hemagglutn-neuramid.
    IPR016285. Hemagglutn-neuramid_paramyxo.
    IPR011040. Sialidases.
    [Graphical view ]
    Pfami PF00423. HN. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
    SUPFAMi SSF50939. SSF50939. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Crystallization of Newcastle disease virus hemagglutinin-neuraminidase glycoprotein."
      Takimoto T., Taylor G.L., Crennell S.J., Scroggs R.A., Portner A.
      Virology 270:208-214(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    2. "Crystal structure of the multifunctional paramyxovirus hemagglutinin-neuraminidase."
      Crennell S., Takimoto T., Portner A., Taylor G.
      Nat. Struct. Biol. 7:1068-1074(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 124-577.

    Entry informationi

    Entry nameiHN_NDVK
    AccessioniPrimary (citable) accession number: Q9Q2W5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2005
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3