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Q9Q2W5

- HN_NDVK

UniProt

Q9Q2W5 - HN_NDVK

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Protein

Hemagglutinin-neuraminidase

Gene
HN
Organism
Newcastle disease virus (strain Kansas) (NDV)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion By similarity.
Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins By similarity.

Catalytic activityi

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

GO - Molecular functioni

  1. exo-alpha-(2->3)-sialidase activity Source: UniProtKB-EC
  2. exo-alpha-(2->6)-sialidase activity Source: UniProtKB-EC
  3. exo-alpha-(2->8)-sialidase activity Source: UniProtKB-EC

GO - Biological processi

  1. viral entry into host cell Source: UniProtKB-KW
  2. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hemagglutinin, Hydrolase

Keywords - Biological processi

Host-virus interaction, Viral attachment to host cell, Virus entry into host cell

Protein family/group databases

CAZyiGH83. Glycoside Hydrolase Family 83.

Names & Taxonomyi

Protein namesi
Recommended name:
Hemagglutinin-neuraminidase (EC:3.2.1.18)
Gene namesi
Name:HN
OrganismiNewcastle disease virus (strain Kansas) (NDV)
Taxonomic identifieri332244 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesMononegaviralesParamyxoviridaeParamyxovirinaeAvulavirus
Virus hostiGallus gallus (Chicken) [TaxID: 9031]

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2222Intravirion Reviewed predictionAdd
BLAST
Transmembranei23 – 4523Helical; Reviewed predictionAdd
BLAST
Topological domaini46 – 571526Virion surface Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. host cell plasma membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. viral envelope Source: UniProtKB-KW
  4. virion membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host cell membrane, Host membrane, Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 577577Hemagglutinin-neuraminidasePRO_0000142614Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi119 – 1191N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi144 – 1441N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi341 – 3411N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi433 – 4331N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi481 – 4811N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi538 – 5381N-linked (GlcNAc...); by host Reviewed prediction

Keywords - PTMi

Glycoprotein

Structurei

Secondary structure

1
577
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni130 – 1345
Beta strandi136 – 1383
Beta strandi144 – 1463
Helixi148 – 1503
Beta strandi151 – 1533
Beta strandi172 – 1809
Beta strandi185 – 19511
Beta strandi202 – 21312
Beta strandi219 – 22911
Beta strandi231 – 2333
Beta strandi235 – 2439
Beta strandi246 – 2538
Helixi258 – 2636
Beta strandi264 – 2663
Beta strandi269 – 2768
Beta strandi281 – 2855
Helixi288 – 2914
Turni292 – 2943
Beta strandi295 – 3006
Beta strandi306 – 3083
Beta strandi311 – 32010
Helixi325 – 3306
Helixi348 – 35710
Helixi362 – 3643
Beta strandi368 – 37710
Beta strandi379 – 3813
Beta strandi387 – 3893
Turni393 – 3953
Beta strandi402 – 4076
Beta strandi410 – 4156
Beta strandi423 – 43210
Beta strandi435 – 4384
Beta strandi442 – 4443
Beta strandi473 – 4786
Beta strandi484 – 4929
Beta strandi495 – 4995
Beta strandi501 – 5066
Beta strandi515 – 5173
Beta strandi523 – 53412
Turni535 – 5384
Beta strandi539 – 54911
Helixi551 – 5533
Beta strandi557 – 56711

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1E8TX-ray2.50A/B124-577[»]
1E8UX-ray2.00A/B124-577[»]
1E8VX-ray2.00A/B124-577[»]
ProteinModelPortaliQ9Q2W5.
SMRiQ9Q2W5. Positions 124-572.

Miscellaneous databases

EvolutionaryTraceiQ9Q2W5.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di2.120.10.10. 1 hit.
InterProiIPR000665. Hemagglutn-neuramid.
IPR016285. Hemagglutn-neuramid_paramyxo.
IPR011040. Sialidases.
[Graphical view]
PfamiPF00423. HN. 1 hit.
[Graphical view]
PIRSFiPIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
SUPFAMiSSF50939. SSF50939. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Q2W5-1 [UniParc]FASTAAdd to Basket

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MDRAVSQVAL ENDEREAKNT WRLIFRIAIL LLTVVTLATS VASLVYSMGA    50
STPSDLVGIP TRISRAEEKI TSALGSNQDV VDRIYKQVAL ESPLALLNTE 100
TTIMNAITSL SYQINGAANN SGWGAPIHDP DFIGGIGKEL IVDNASDVTS 150
FYPSAFQEHL NFIPAPTTGS GCTRIPSFDM SATHYCYTHN VILSGCRDHS 200
HSHQYLALGV LRTTATGRIF FSTLRSISLD DTQNRKSCSV SATPLGCDML 250
CSKVTETEEE DYNSAVPTLM AHGRLGFDGQ YHEKDLDVTT LFEDWVANYP 300
GVGGGSFIDG RVWFSVYGGL KPNSPSDTVQ EGKYVIYKRY NDTCPDEQDY 350
QIRMAKSSYK PGRFGGKRIQ QAILSIKVST SLGEDPVLTV PPNTVTLMGA 400
EGRILTVGTS HFLYQRGSSY FSPALLYPMT VSNKTATLHS PYTFNAFTRP 450
GSIPCQASAR CPNSCVTGVY TDPYPLIFYR NHTLRGVFGT MLDSEQARLN 500
PASAVFDSTS RSRITRVSSS STKAAYTTST CFKVVKTNKT YCLSIAEISN 550
TLFGEFRIVP LLVEILKNDG VREARSG 577
Length:577
Mass (Da):63,111
Last modified:May 1, 2000 - v1
Checksum:i6A1F03C8DD3F7753
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF212323 Genomic RNA. Translation: AAF19984.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF212323 Genomic RNA. Translation: AAF19984.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1E8T X-ray 2.50 A/B 124-577 [» ]
1E8U X-ray 2.00 A/B 124-577 [» ]
1E8V X-ray 2.00 A/B 124-577 [» ]
ProteinModelPortali Q9Q2W5.
SMRi Q9Q2W5. Positions 124-572.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH83. Glycoside Hydrolase Family 83.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei Q9Q2W5.

Family and domain databases

Gene3Di 2.120.10.10. 1 hit.
InterProi IPR000665. Hemagglutn-neuramid.
IPR016285. Hemagglutn-neuramid_paramyxo.
IPR011040. Sialidases.
[Graphical view ]
Pfami PF00423. HN. 1 hit.
[Graphical view ]
PIRSFi PIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
SUPFAMi SSF50939. SSF50939. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Crystallization of Newcastle disease virus hemagglutinin-neuraminidase glycoprotein."
    Takimoto T., Taylor G.L., Crennell S.J., Scroggs R.A., Portner A.
    Virology 270:208-214(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "Crystal structure of the multifunctional paramyxovirus hemagglutinin-neuraminidase."
    Crennell S., Takimoto T., Portner A., Taylor G.
    Nat. Struct. Biol. 7:1068-1074(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 124-577.

Entry informationi

Entry nameiHN_NDVK
AccessioniPrimary (citable) accession number: Q9Q2W5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: May 1, 2000
Last modified: April 16, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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