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Protein
Submitted name:

V-1 protease

Gene

ORF

Organism
Human immunodeficiency virus 1
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. aspartic-type endopeptidase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Aspartyl proteaseUniRule annotation, Hydrolase, Protease

Names & Taxonomyi

Protein namesi
Submitted name:
V-1 proteaseImported
Gene namesi
Name:ORFImported
OrganismiHuman immunodeficiency virus 1Imported
Taxonomic identifieri11676 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ANKZF1Q9H8Y52EBI-6248094,EBI-724848From a different organism.
ARRB2P321213EBI-6248094,EBI-714559From a different organism.
CCAR2Q8N1635EBI-6248094,EBI-355410From a different organism.
DIAPH1O606102EBI-6248094,EBI-3959709From a different organism.
DOK1Q997042EBI-6248094,EBI-1384360From a different organism.
EIF3AQ141525EBI-6248094,EBI-366617From a different organism.
EIF3CQ996135EBI-6248094,EBI-353741From a different organism.
EIF3DO153715EBI-6248094,EBI-353818From a different organism.
EIF3EP602285EBI-6248094,EBI-347740From a different organism.
EIF3FO003033EBI-6248094,EBI-711990From a different organism.
EIF3HO153723EBI-6248094,EBI-709735From a different organism.
EIF3KQ9UBQ55EBI-6248094,EBI-354344From a different organism.
EIF3LQ9Y2625EBI-6248094,EBI-373519From a different organism.
EIF3MQ7L2H72EBI-6248094,EBI-353901From a different organism.
FNIP1Q8TF403EBI-6248094,EBI-2946919From a different organism.
FOXC1Q129483EBI-6248094,EBI-1175253From a different organism.
IFT122Q9HBG63EBI-6248094,EBI-2805994From a different organism.
LIMD1Q9UGP45EBI-6248094,EBI-2652871From a different organism.
MCM4P339913EBI-6248094,EBI-374938From a different organism.
NFU1Q9UMS03EBI-6248094,EBI-725252From a different organism.
OSBPL3Q9H4L55EBI-6248094,EBI-1051317From a different organism.
OSBPL6Q9BZF33EBI-6248094,EBI-2372709From a different organism.
PARP4Q9UKK33EBI-6248094,EBI-2623021From a different organism.
POLE3Q9NRF95EBI-6248094,EBI-744901From a different organism.
POLE4Q9NR332EBI-6248094,EBI-867034From a different organism.
PUM2Q8TB723EBI-6248094,EBI-311190From a different organism.
SF3A3Q128743EBI-6248094,EBI-1051880From a different organism.
SSSCA1O602324EBI-6248094,EBI-741415From a different organism.
TRPS1Q9UHF73EBI-6248094,EBI-2556151From a different organism.
VBP1P617583EBI-6248094,EBI-357430From a different organism.

Protein-protein interaction databases

IntActiQ9Q2G4. 55 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9Q2G4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains peptidase A2 domain.SAAS annotation

Family and domain databases

Gene3Di2.40.70.10. 1 hit.
InterProiIPR001969. Aspartic_peptidase_AS.
IPR018061. Pept_A2A_retrovirus_sg.
IPR001995. Peptidase_A2_cat.
IPR021109. Peptidase_aspartic_dom.
[Graphical view]
PfamiPF00077. RVP. 1 hit.
[Graphical view]
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiPS50175. ASP_PROT_RETROV. 1 hit.
PS00141. ASP_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q9Q2G4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
PQITLWQRPL VTIKIGGQLK EALLDTGADD TVLEEMNLPG RWKPKMIGGI
60 70 80 90
GGFIKVRQYD QILIEICGHK AIGTVLVGPT PVNIIGRNLL TQIGCTLNF
Length:99
Mass (Da):10,820
Last modified:May 1, 2000 - v1
Checksum:i189F5EE42D82533D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei99 – 991Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ279608 mRNA. Translation: CAB66021.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ279608 mRNA. Translation: CAB66021.1.

3D structure databases

ProteinModelPortaliQ9Q2G4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9Q2G4. 55 interactions.

Chemistry

BindingDBiQ9Q2G4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di2.40.70.10. 1 hit.
InterProiIPR001969. Aspartic_peptidase_AS.
IPR018061. Pept_A2A_retrovirus_sg.
IPR001995. Peptidase_A2_cat.
IPR021109. Peptidase_aspartic_dom.
[Graphical view]
PfamiPF00077. RVP. 1 hit.
[Graphical view]
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiPS50175. ASP_PROT_RETROV. 1 hit.
PS00141. ASP_PROTEASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Servais J.A.
    Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Variant human immunodeficiency virus type 1 proteases and response to combination therapy including a protease inhibitor."
    Servais J., Lambert C., Fontaine E., Plesseria J.M., Robert I., Arendt V., Staub T., Schneider F., Hemmer R., Burtonboy G., Schmit J.C.
    Antimicrob. Agents Chemother. 45:893-900(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "Comparison of DNA sequencing and a line probe assay for detection of human immunodeficiency virus type 1 drug resistance mutations in patients failing highly active antiretroviral therapy."
    Servais J., Lambert C., Fontaine E., Plesseria J.M., Robert I., Arendt V., Staub T., Schneider F., Hemmer R., Burtonboy G., Schmit J.C.
    J. Clin. Microbiol. 39:454-459(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ9Q2G4_9HIV1
AccessioniPrimary (citable) accession number: Q9Q2G4
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: March 4, 2015
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.