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Q9Q2G4

- Q9Q2G4_9HIV1

UniProt

Q9Q2G4 - Q9Q2G4_9HIV1

Protein
Submitted name:

V-1 protease

Gene

ORF

Organism
Human immunodeficiency virus 1
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Molecular functioni

    1. aspartic-type endopeptidase activity Source: UniProtKB-KW
    2. protein binding Source: IntAct

    Keywords - Molecular functioni

    Aspartyl proteaseUniRule annotation, Hydrolase, Protease

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    V-1 proteaseImported
    Gene namesi
    Name:ORFImported
    OrganismiHuman immunodeficiency virus 1Imported
    Taxonomic identifieri11676 [NCBI]
    Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
    Virus hostiHomo sapiens (Human) [TaxID: 9606]

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ANKZF1Q9H8Y52EBI-6248094,EBI-724848From a different organism.
    ARRB2P321213EBI-6248094,EBI-714559From a different organism.
    CCAR2Q8N1635EBI-6248094,EBI-355410From a different organism.
    DIAPH1O606102EBI-6248094,EBI-3959709From a different organism.
    DOK1Q997042EBI-6248094,EBI-1384360From a different organism.
    EIF3AQ141525EBI-6248094,EBI-366617From a different organism.
    EIF3CQ996135EBI-6248094,EBI-353741From a different organism.
    EIF3DO153715EBI-6248094,EBI-353818From a different organism.
    EIF3EP602285EBI-6248094,EBI-347740From a different organism.
    EIF3FO003033EBI-6248094,EBI-711990From a different organism.
    EIF3HO153723EBI-6248094,EBI-709735From a different organism.
    EIF3KQ9UBQ55EBI-6248094,EBI-354344From a different organism.
    EIF3LQ9Y2625EBI-6248094,EBI-373519From a different organism.
    EIF3MQ7L2H72EBI-6248094,EBI-353901From a different organism.
    FNIP1Q8TF403EBI-6248094,EBI-2946919From a different organism.
    FOXC1Q129483EBI-6248094,EBI-1175253From a different organism.
    IFT122Q9HBG63EBI-6248094,EBI-2805994From a different organism.
    LIMD1Q9UGP45EBI-6248094,EBI-2652871From a different organism.
    MCM4P339913EBI-6248094,EBI-374938From a different organism.
    NFU1Q9UMS03EBI-6248094,EBI-725252From a different organism.
    OSBPL3Q9H4L55EBI-6248094,EBI-1051317From a different organism.
    OSBPL6Q9BZF33EBI-6248094,EBI-2372709From a different organism.
    PARP4Q9UKK33EBI-6248094,EBI-2623021From a different organism.
    POLE3Q9NRF95EBI-6248094,EBI-744901From a different organism.
    POLE4Q9NR332EBI-6248094,EBI-867034From a different organism.
    PUM2Q8TB723EBI-6248094,EBI-311190From a different organism.
    SF3A3Q128743EBI-6248094,EBI-1051880From a different organism.
    SSSCA1O602324EBI-6248094,EBI-741415From a different organism.
    TRPS1Q9UHF73EBI-6248094,EBI-2556151From a different organism.
    VBP1P617583EBI-6248094,EBI-357430From a different organism.

    Protein-protein interaction databases

    IntActiQ9Q2G4. 55 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Q2G4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains peptidase A2 domain.SAAS annotation

    Family and domain databases

    Gene3Di2.40.70.10. 1 hit.
    InterProiIPR001969. Aspartic_peptidase_AS.
    IPR018061. Pept_A2A_retrovirus_sg.
    IPR001995. Peptidase_A2_cat.
    IPR021109. Peptidase_aspartic_dom.
    [Graphical view]
    PfamiPF00077. RVP. 1 hit.
    [Graphical view]
    SUPFAMiSSF50630. SSF50630. 1 hit.
    PROSITEiPS50175. ASP_PROT_RETROV. 1 hit.
    PS00141. ASP_PROTEASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q9Q2G4-1 [UniParc]FASTAAdd to Basket

    « Hide

    PQITLWQRPL VTIKIGGQLK EALLDTGADD TVLEEMNLPG RWKPKMIGGI   50
    GGFIKVRQYD QILIEICGHK AIGTVLVGPT PVNIIGRNLL TQIGCTLNF 99
    Length:99
    Mass (Da):10,820
    Last modified:May 1, 2000 - v1
    Checksum:i189F5EE42D82533D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported
    Non-terminal residuei99 – 991Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ279608 mRNA. Translation: CAB66021.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ279608 mRNA. Translation: CAB66021.1 .

    3D structure databases

    ProteinModelPortali Q9Q2G4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9Q2G4. 55 interactions.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 2.40.70.10. 1 hit.
    InterProi IPR001969. Aspartic_peptidase_AS.
    IPR018061. Pept_A2A_retrovirus_sg.
    IPR001995. Peptidase_A2_cat.
    IPR021109. Peptidase_aspartic_dom.
    [Graphical view ]
    Pfami PF00077. RVP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50630. SSF50630. 1 hit.
    PROSITEi PS50175. ASP_PROT_RETROV. 1 hit.
    PS00141. ASP_PROTEASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Servais J.A.
      Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "Variant human immunodeficiency virus type 1 proteases and response to combination therapy including a protease inhibitor."
      Servais J., Lambert C., Fontaine E., Plesseria J.M., Robert I., Arendt V., Staub T., Schneider F., Hemmer R., Burtonboy G., Schmit J.C.
      Antimicrob. Agents Chemother. 45:893-900(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    3. "Comparison of DNA sequencing and a line probe assay for detection of human immunodeficiency virus type 1 drug resistance mutations in patients failing highly active antiretroviral therapy."
      Servais J., Lambert C., Fontaine E., Plesseria J.M., Robert I., Arendt V., Staub T., Schneider F., Hemmer R., Burtonboy G., Schmit J.C.
      J. Clin. Microbiol. 39:454-459(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ9Q2G4_9HIV1
    AccessioniPrimary (citable) accession number: Q9Q2G4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 1, 2000
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)