Reviewed, UniProtKB/Swiss-Prot Q9PYY5 (CATV_GVXN)

Names and origin

Protein names

Recommended name:
    Viral cathepsin
      Short name=V-cath
    EC=3.4.22.50
Alternative name(s):
    Cysteine proteinase
      Short name=CP

Gene names

Name:	VCATH
Synonyms:	58

Organism

Xestia c-nigrum granulosis virus (XnGV) (Xestia c-nigrum granulovirus)

Taxonomic identifier

51677 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Baculoviridae › Betabaculovirus

Virus host

Xestia [TaxID: 320016]

Protein attributes

Sequence length	346 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Cysteine protease that plays an essential role in host liquefaction to facilitate horizontal transmission of the virus. May participate in the degradation of foreign protein expressed by the baculovirus system By similarity.
Catalytic activity	Endopeptidase of broad specificity, hydrolyzing substrates of both cathepsin L and cathepsin B.
Post-translational modification	Synthesized as an inactive proenzyme and activated by proteolytic removal of the inhibitory propeptide By similarity.
Sequence similarities	Belongs to the peptidase C1 family.

Ontologies

Keywords
Domain	Signal
Molecular function	Hydrolase Protease Thiol protease
PTM	Disulfide bond Glycoprotein Zymogen
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: InterPro
Molecular function	cysteine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 28	28	Potential
	Propeptide	29 – 133	105	Activation peptide Potential		PRO_0000322219
	Chain	134 – 346	213	Viral cathepsin		PRO_0000050589
Sites
	Active site	157	1	By similarity
	Active site	289	1	By similarity
	Active site	309	1	By similarity
Amino acid modifications
	Glycosylation	175	1	N-linked (GlcNAc...); by host Potential
	Glycosylation	230	1	N-linked (GlcNAc...); by host Potential
	Disulfide bond	154 ↔ 195		By similarity
	Disulfide bond	188 ↔ 228		By similarity
	Disulfide bond	281 ↔ 330		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9PYY5-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 4B82DB0376C7C951	FASTA	346	38,819
	10 20 30 40 50 60 MLFFNFYKHI MFLPWVFCVA LLTLNVCAVS YIAYDMSNAQ ELFNEFVVKY NKVYKDDQEK 70 80 90 100 110 120 EARFEIFKQN LADINARNAL EDSAMFEINS RADISSNELL QKLTGLKLSL MRGEKKNSFC 130 140 150 160 170 180 TPTVISGDSS GKVPDSFDWR DRNSVTSVKM QKECGSCWAF SAVANIESLY HIKHNVSLDL 190 200 210 220 230 240 SEQQLVDCDK VNNGCNGGLM SWAFEGIIRA GGISYEAPYP YTGVDGVCKN TTRYVQLSGC 250 260 270 280 290 300 YAYDLRSEKK LRQVLHEKGP VSVAIDVVDL TNYKSGVAKH CSVDHGLNHG VLLVGYGQEN 310 320 330 340 DVKYWTLKNS WGSDWGEQGF FRIKRDVNSC GILNQFAASA ILSSSS

References

[1]	"Sequence analysis of the Xestia c-nigrum granulovirus genome." Hayakawa T., Ko R., Okano K., Seong S.I., Goto C., Maeda S. Virology 262:277-297(1999) [PubMed: 10502508] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF162221 Genomic DNA. Translation: AAF05172.1.
RefSeq	NP_059206.1.
3D structure databases
HSSP	HSSP built from PDB template 1JQP based on UniProtKB P80067.
ModBase	Search...
Protein family/group databases
MEROPS	C01.047.
Genome annotation databases
GeneID	1442292.
Family and domain databases
InterPro	IPR000169. Pept_cys_AS. IPR013128. Peptidase_C1A. IPR000668. Peptidase_C1A_C. IPR013201. Prot_inhib_I29. [Graphical view]
PANTHER	PTHR12411. Peptidase_C1A. 1 hit.
Pfam	PF08246. Inhibitor_I29. 1 hit. PF00112. Peptidase_C1. 1 hit. [Graphical view]
PRINTS	PR00705. PAPAIN.
ProDom	PD000158. Peptidase_C1. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00645. Pept_C1. 1 hit. [Graphical view]
PROSITE	PS00640. THIOL_PROTEASE_ASN. 1 hit. PS00139. THIOL_PROTEASE_CYS. 1 hit. PS00639. THIOL_PROTEASE_HIS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CATV_GVXN

Accession

Primary (citable) accession number: Q9PYY5

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
Last sequence update:	May 1, 2000
Last modified:	May 5, 2009
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Virus (Virus annotation project)