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Protein

Non-structural protein 3

Gene
N/A
Organism
Rotavirus C (isolate Human/United Kingdom/Bristol/1989) (RV-C)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei333 – 3342Cleavage; by autolysisSequence Analysis

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Non-structural protein 3
Short name:
NSP3
Cleaved into the following 2 chains:
OrganismiRotavirus C (isolate Human/United Kingdom/Bristol/1989) (RV-C)
Taxonomic identifieri31567 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000007664 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 402402Non-structural protein 3PRO_0000369885Add
BLAST
Chaini1 – 333333p38By similarityPRO_0000369886Add
BLAST
Chaini334 – 40269p8By similarityPRO_0000369887Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ9PY95.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini334 – 40269DRBMPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the rotavirus C NSP3 family.Curated
Contains 1 DRBM (double-stranded RNA-binding) domain.PROSITE-ProRule annotation

Family and domain databases

Gene3Di3.30.160.20. 1 hit.
InterProiIPR014720. dsRNA-bd_dom.
IPR002873. Rotavirus_NSP3.
[Graphical view]
PfamiPF00035. dsrm. 1 hit.
PF01665. Rota_NSP3. 1 hit.
[Graphical view]
SMARTiSM00358. DSRM. 1 hit.
[Graphical view]
SUPFAMiSSF69903. SSF69903. 1 hit.
PROSITEiPS50137. DS_RBD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9PY95-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATQASVEWI FNVAGSAASS SLDKAIKDAG GSENFSKYVI TKFYDNYKDC
60 70 80 90 100
IDDSGVYNAC IGRAKTIDKA LNDPKVAERN EEWYTNVATI SRLDLELAEL
110 120 130 140 150
KLMLSNLGIK REERVLNSMF SVVREKGRSS NVIMMKQNAV KMIEEGKLKI
160 170 180 190 200
KVERNETYTE SLKNKIEELE CIIDAFEKGK DITIDLDAMN GEVKLDGNSC
210 220 230 240 250
SYNSTAALVS TILGTPIKMY NESGQPLFDV GNYMNPKNII EKMIELEIPI
260 270 280 290 300
FKSDYRNNES PDFDSWNERS NLKIVSVNDC HAICIFKFEN NWWCFDDGRL
310 320 330 340 350
KKHNGAGYPL IVANSKFQID KILISGDIEL NPGPDILVTL NDYITKYQLK
360 370 380 390 400
LECTFDIFLE DDGSITYTCY MKLESAEAIG SGRSKKEAKR IAAYDILDQL

GI
Length:402
Mass (Da):45,328
Last modified:May 1, 2000 - v1
Checksum:iD2E3D7F14B6E2E23
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ132203 Genomic RNA. Translation: CAB52751.1.
RefSeqiYP_392486.1. NC_007543.1.

Genome annotation databases

GeneIDi3773128.
KEGGivg:3773128.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ132203 Genomic RNA. Translation: CAB52751.1.
RefSeqiYP_392486.1. NC_007543.1.

3D structure databases

ProteinModelPortaliQ9PY95.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3773128.
KEGGivg:3773128.

Family and domain databases

Gene3Di3.30.160.20. 1 hit.
InterProiIPR014720. dsRNA-bd_dom.
IPR002873. Rotavirus_NSP3.
[Graphical view]
PfamiPF00035. dsrm. 1 hit.
PF01665. Rota_NSP3. 1 hit.
[Graphical view]
SMARTiSM00358. DSRM. 1 hit.
[Graphical view]
SUPFAMiSSF69903. SSF69903. 1 hit.
PROSITEiPS50137. DS_RBD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular characterization of human group C rotavirus genes 6, 7 and 9."
    James V.L., Lambden P.R., Deng Y., Caul E.O., Clarke I.N.
    J. Gen. Virol. 80:3181-3187(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiNSP3_ROTHC
AccessioniPrimary (citable) accession number: Q9PY95
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: May 1, 2000
Last modified: April 1, 2015
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.