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Protein

Non-structural protein 1

Gene
N/A
Organism
Rotavirus C (isolate Human/United Kingdom/Bristol/1989) (RV-C)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri40 – 6930Sequence AnalysisAdd
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. RNA binding Source: UniProtKB-KW

GO - Biological processi

  1. suppression by virus of host IRF3 activity Source: UniProtKB-KW
  2. suppression by virus of host IRF7 activity Source: UniProtKB-KW
  3. suppression by virus of host NF-kappaB transcription factor activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host IRF3 by virus, Inhibition of host IRF7 by virus, Inhibition of host NF-kappa-B by virus, Inhibition of host RLR pathway by virus, Viral immunoevasion

Keywords - Ligandi

Metal-binding, RNA-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Non-structural protein 1
Short name:
NSP1
Alternative name(s):
NCVP2
Non-structural RNA-binding protein 53
Short name:
NS53
OrganismiRotavirus C (isolate Human/United Kingdom/Bristol/1989) (RV-C)
Taxonomic identifieri31567 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000007664: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 394394Non-structural protein 1PRO_0000369881Add
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the rotavirus C NSP1 family.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri40 – 6930Sequence AnalysisAdd
BLAST

Keywords - Domaini

Zinc-finger

Family and domain databases

InterProiIPR002148. Rotavirus_NSP1.
[Graphical view]
PfamiPF00981. Rota_NS53. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9PY94-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANSFREMLY WYRKIIDRKL PCVNVNIWRR EIAYKANGIC LNCLNECKVC
60 70 80 90 100
PCDYCGIRHK CENCLNSDCF MNTNNEFNSH RWITFDEEPS QMVLFEYWIM
110 120 130 140 150
YKDYFLSKFN YNYKAQLKIL NMNKNRRFHI NESKKKALSV PITSQYLKFK
160 170 180 190 200
FNNKIYIMFG TFLTSKIQPW IQLKSLKVGY IQSLNVDRCA KLIATKGMFA
210 220 230 240 250
TNSFKSSCIT EINARRPISE CDYLIEACLC NENNEWKFSA VMGRDKIPVT
260 270 280 290 300
KSLAMKYFCK NINTELFYYG HSKCHVVSEC PRWNQQLRVL NASTLNIIFR
310 320 330 340 350
RQFMNEVVEW FENFTQLTGM HYDFIKTCVY NKVIISHFRK EIEDYINSGK
360 370 380 390
KISLSSVIPD GHALYTNIDI LRISLMLAID VALNRIESQQ MDVL
Length:394
Mass (Da):46,642
Last modified:May 1, 2000 - v1
Checksum:i4FAB1BB841EDCF29
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ132204 Genomic RNA. Translation: CAB52752.1.
RefSeqiYP_392487.1. NC_007544.1.

Genome annotation databases

GeneIDi3773134.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ132204 Genomic RNA. Translation: CAB52752.1.
RefSeqiYP_392487.1. NC_007544.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3773134.

Family and domain databases

InterProiIPR002148. Rotavirus_NSP1.
[Graphical view]
PfamiPF00981. Rota_NS53. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular characterization of human group C rotavirus genes 6, 7 and 9."
    James V.L., Lambden P.R., Deng Y., Caul E.O., Clarke I.N.
    J. Gen. Virol. 80:3181-3187(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiNSP1_ROTHC
AccessioniPrimary (citable) accession number: Q9PY94
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: May 1, 2000
Last modified: January 7, 2015
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.