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Q9PY94

- NSP1_ROTHC

UniProt

Q9PY94 - NSP1_ROTHC

Protein

Non-structural protein 1

Gene
N/A
Organism
Rotavirus C (isolate Human/United Kingdom/Bristol/1989) (RV-C)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri40 – 6930Sequence AnalysisAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. suppression by virus of host IRF3 activity Source: UniProtKB-KW
    2. suppression by virus of host IRF7 activity Source: UniProtKB-KW
    3. suppression by virus of host NF-kappaB transcription factor activity Source: UniProtKB-KW

    Keywords - Biological processi

    Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host IRF3 by virus, Inhibition of host IRF7 by virus, Inhibition of host NF-kappa-B by virus, Inhibition of host RLR pathway by virus, Viral immunoevasion

    Keywords - Ligandi

    Metal-binding, RNA-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Non-structural protein 1
    Short name:
    NSP1
    Alternative name(s):
    NCVP2
    Non-structural RNA-binding protein 53
    Short name:
    NS53
    OrganismiRotavirus C (isolate Human/United Kingdom/Bristol/1989) (RV-C)
    Taxonomic identifieri31567 [NCBI]
    Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    ProteomesiUP000007664: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 394394Non-structural protein 1PRO_0000369881Add
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the rotavirus C NSP1 family.Curated

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri40 – 6930Sequence AnalysisAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Family and domain databases

    InterProiIPR002148. Rotavirus_NSP1.
    [Graphical view]
    PfamiPF00981. Rota_NS53. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9PY94-1 [UniParc]FASTAAdd to Basket

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    MANSFREMLY WYRKIIDRKL PCVNVNIWRR EIAYKANGIC LNCLNECKVC    50
    PCDYCGIRHK CENCLNSDCF MNTNNEFNSH RWITFDEEPS QMVLFEYWIM 100
    YKDYFLSKFN YNYKAQLKIL NMNKNRRFHI NESKKKALSV PITSQYLKFK 150
    FNNKIYIMFG TFLTSKIQPW IQLKSLKVGY IQSLNVDRCA KLIATKGMFA 200
    TNSFKSSCIT EINARRPISE CDYLIEACLC NENNEWKFSA VMGRDKIPVT 250
    KSLAMKYFCK NINTELFYYG HSKCHVVSEC PRWNQQLRVL NASTLNIIFR 300
    RQFMNEVVEW FENFTQLTGM HYDFIKTCVY NKVIISHFRK EIEDYINSGK 350
    KISLSSVIPD GHALYTNIDI LRISLMLAID VALNRIESQQ MDVL 394
    Length:394
    Mass (Da):46,642
    Last modified:May 1, 2000 - v1
    Checksum:i4FAB1BB841EDCF29
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ132204 Genomic RNA. Translation: CAB52752.1.
    RefSeqiYP_392487.1. NC_007544.1.

    Genome annotation databases

    GeneIDi3773134.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ132204 Genomic RNA. Translation: CAB52752.1 .
    RefSeqi YP_392487.1. NC_007544.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3773134.

    Family and domain databases

    InterProi IPR002148. Rotavirus_NSP1.
    [Graphical view ]
    Pfami PF00981. Rota_NS53. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular characterization of human group C rotavirus genes 6, 7 and 9."
      James V.L., Lambden P.R., Deng Y., Caul E.O., Clarke I.N.
      J. Gen. Virol. 80:3181-3187(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiNSP1_ROTHC
    AccessioniPrimary (citable) accession number: Q9PY94
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3