Q9PY82 (MUNS_REOVJ) Reviewed, UniProtKB/Swiss-Prot
Last modified April 3, 2013. Version 33. History...
Names and origin
|Protein names||Recommended name:|
|Organism||Reovirus type 2 (strain D5/Jones) (T2J) (Mammalian orthoreovirus 2) [Complete proteome]|
|Taxonomic identifier||10885 [NCBI]|
|Taxonomic lineage||Viruses › dsRNA viruses › Reoviridae › Spinareovirinae › Orthoreovirus ›|
|Virus host||Mammalia [TaxID: 40674]|
|Sequence length||721 AA.|
|Protein existence||Evidence at transcript level|
General annotation (Comments)
Non-structural protein with ssRNA-binding activity. Is probably involved in the formation of viral inclusions, where the assembly of cores and the replication of viral RNA are thought to occur. Together with mu-2, recruits the other core proteins to these inclusions By similarity.
Interacts with mu-2, sigma-NS, inner capsid proteins lambda-1 and sigma-2, and outer capsid protein lambda-2; in viral inclusions By similarity.
The N-terminus is blocked By similarity.
Belongs to the orthoreovirus mu-NS protein family.
|This entry describes 2 isoforms produced by alternative initiation. [Align] [Select]|
|Isoform mu-NS (identifier: Q9PY82-1) |
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
|Isoform mu-NSC (identifier: Q9PY82-2) |
The sequence of this isoform differs from the canonical sequence as follows:
|Note: It is unsure whether Met-41 is the initiator.|
Sequence annotation (Features)
|Feature key||Position(s)||Length||Description||Graphical view||Feature identifier|
|Chain||1 – 721||721||Protein mu-NS||PRO_0000345002|
|Region||1 – 13||13||Interaction with sigma-NS By similarity|
|Region||14 – 40||27||Interaction with mu-2 By similarity|
|Coiled coil||523 – 556||34||Potential|
|Coiled coil||632 – 686||55||Potential|
|Alternative sequence||1 – 40||40||Missing in isoform mu-NSC.||VSP_034869|
|||"Mammalian reovirus M3 gene sequences and conservation of coiled-coil motifs near the carboxyl terminus of the microNS protein."|
McCutcheon A.M., Broering T.J., Nibert M.L.
Virology 264:16-24(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA], ALTERNATIVE INITIATION.
|Accession||Primary (citable) accession number: Q9PY82|
|Entry status||Reviewed (UniProtKB/Swiss-Prot)|
|Annotation program||Viral Protein Annotation Program|
Index of protein domains and families