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Q9PY82

- MUNS_REOVJ

UniProt

Q9PY82 - MUNS_REOVJ

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Protein
Protein mu-NS
Gene
M3
Organism
Reovirus type 2 (strain D5/Jones) (T2J) (Mammalian orthoreovirus 2)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Non-structural protein with ssRNA-binding activity. Is probably involved in the formation of viral inclusions, where the assembly of cores and the replication of viral RNA are thought to occur. Together with mu-2, recruits the other core proteins to these inclusions By similarity.

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein mu-NS
Short name:
MuNS
Gene namesi
Name:M3
OrganismiReovirus type 2 (strain D5/Jones) (T2J) (Mammalian orthoreovirus 2)
Taxonomic identifieri10885 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSpinareovirinaeOrthoreovirus
Virus hostiMammalia [TaxID: 40674]
ProteomesiUP000006370: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 721721Protein mu-NS
PRO_0000345002Add
BLAST

Post-translational modificationi

The N-terminus is blocked By similarity.

Interactioni

Subunit structurei

Interacts with mu-2, sigma-NS, inner capsid proteins lambda-1 and sigma-2, and outer capsid protein lambda-2; in viral inclusions By similarity.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 1313Interaction with sigma-NS By similarity
Add
BLAST
Regioni14 – 4027Interaction with mu-2 By similarity
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili523 – 55634 Reviewed prediction
Add
BLAST
Coiled coili632 – 68655 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative initiation. Align

Isoform mu-NS (identifier: Q9PY82-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MASFKGFSAN TVPVSKTRKD TSSLTATPGL RAPSMSSPVD MAQSREFLTK    50
AIEHGSMSIP YQHVNVPKVD RKVVSLVVRP FSAGAFSISG VISPAHAYLL 100
ECLPQLEQAM AFVASPEAFQ ASDVAKRFTI KPGMSLQDAI TAFINFVSAM 150
LKMTVTRQNF DVIIAEIERL ASSGVVNRTE EAKVADEELM LFGLDHRAPQ 200
QIDVSEPVGI SRAVEIQTTN NVHLAPGLGN IDPEIYNEGR FMFMQHKPLA 250
ADQSYFTTET ADYFKIYPTY DEHDGRMVDQ KQSGLILCTK DEVLAEQTIF 300
KLDVPDDKTV HLLDRDDDHV VARFTRVFIE DVAPSHHAAQ RSNQRSLLDD 350
LYANTQVVSV TPSALRWVIK HGVSDGIVNR KNVKICVGFD PLYTLATSNG 400
LSLCSILMDE KLSVLNSACK MTLRSLLKTH RDLDLHRAFQ RVISQSYASL 450
MCYYHPSRKL AYGELLFMSS QSDTVDGIKL QLDASRQCHE CPLLQQKIVE 500
LEKHLIVQKS ASSDPTPVAL QPLLSQLREL SSEVTRLQMD LSRTQAINTR 550
LEADVKSAQS CSLDMYLKHH TCINSHVKED ELMDAVRIAP DVRQELMLKR 600
KATRQEWWER IARETSTTFQ SKIDELTLMN GKQAHEISEL RDSVTNYEKQ 650
VAELVSTITQ NQTTYQQELQ ALVAKNIELD ALNQRQAKSV RITSSLLSAT 700
PIDAVDGASD LIDFSVPADE L 721
Length:721
Mass (Da):80,505
Last modified:May 1, 2000 - v1
Checksum:i0C08763E6E278153
GO
Isoform mu-NSC (identifier: Q9PY82-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-40: Missing.

Note: It is unsure whether Met-41 is the initiator.

Show »
Length:681
Mass (Da):76,394
Checksum:i9BC36D73C106E79B
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4040Missing in isoform mu-NSC.
VSP_034869Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF174383 mRNA. Translation: AAF13170.1.

Keywords - Coding sequence diversityi

Alternative initiation

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF174383 mRNA. Translation: AAF13170.1 .

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. "Mammalian reovirus M3 gene sequences and conservation of coiled-coil motifs near the carboxyl terminus of the microNS protein."
    McCutcheon A.M., Broering T.J., Nibert M.L.
    Virology 264:16-24(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA], ALTERNATIVE INITIATION.

Entry informationi

Entry nameiMUNS_REOVJ
AccessioniPrimary (citable) accession number: Q9PY82
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: May 1, 2000
Last modified: April 3, 2013
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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