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Protein

V-set and immunoglobulin domain-containing protein 1

Gene

VSIG1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
V-set and immunoglobulin domain-containing protein 1
Alternative name(s):
ChT1 thymocyte antigen
Gene namesi
Name:VSIG1
Synonyms:ChT1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 233ExtracellularSequence analysisAdd BLAST212
Transmembranei234 – 254HelicalSequence analysisAdd BLAST21
Topological domaini255 – 335CytoplasmicSequence analysisAdd BLAST81

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_500014719422 – 335V-set and immunoglobulin domain-containing protein 1Add BLAST314

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi43 ↔ 115PROSITE-ProRule annotation
Disulfide bondi160 ↔ 210PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9PWR4.

Expressioni

Tissue specificityi

Expressed in thymocytes.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000013480.

Structurei

3D structure databases

ProteinModelPortaliQ9PWR4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 136Ig-like V-typeAdd BLAST115
Domaini139 – 226Ig-like C2-typeAdd BLAST88

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi258 – 264Poly-Lys7

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IINS. Eukaryota.
ENOG4111JZM. LUCA.
HOGENOMiHOG000154830.
HOVERGENiHBG106684.
InParanoidiQ9PWR4.
PhylomeDBiQ9PWR4.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
IPR029861. VSIG1.
[Graphical view]
PANTHERiPTHR12231:SF115. PTHR12231:SF115. 1 hit.
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
SM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9PWR4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFPTMLKIFP ILATLAGHVH GVVVTVPEKT VNVKTGGNAT LLCTYTSSQP
60 70 80 90 100
LGNFFIQWSF YSAKESQLHT IYYYSEGQSY SYGEFKDRIT AATSPGNASI
110 120 130 140 150
TISNMQPSDT GSYTCEVFSP QDDAGQSQKS VIVNVLVKPS KPFCKIEGTP
160 170 180 190 200
EKGHLIYLLC KCDQGLPHPT YRWYKVDENT LTPVTEYFNP DTGILYIGNL
210 220 230 240 250
TTFETGHYRC IASNIMGNST CELDLTSMHS DGNIVAGALI GAILAAVIIC
260 270 280 290 300
AIVWVLTKKA KKKKSSSNEM QVMAQKQSNA EYAQVPNEEN TPATAVLPSN
310 320 330
ATNEQPSADE AAAPETPEND EKHEVQKEET AGSSF
Length:335
Mass (Da):36,509
Last modified:May 1, 2000 - v1
Checksum:iAA6159598079B438
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti20H → R in AAD17523 (PubMed:9862345).Curated1
Sequence conflicti167P → S in AAD17523 (PubMed:9862345).Curated1
Sequence conflicti246A → D in CAA74390 (Ref. 1) Curated1
Sequence conflicti293 – 294AT → QP in AAD17523 (PubMed:9862345).Curated2
Sequence conflicti314P → S in AAD17523 (PubMed:9862345).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14063 mRNA. Translation: CAA74390.1.
Y14064 mRNA. Translation: CAA74391.1.
AF061023 Genomic DNA. Translation: AAD17523.1.
RefSeqiNP_001001745.1. NM_001001745.1.
UniGeneiGga.424.

Genome annotation databases

GeneIDi414795.
KEGGigga:414795.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14063 mRNA. Translation: CAA74390.1.
Y14064 mRNA. Translation: CAA74391.1.
AF061023 Genomic DNA. Translation: AAD17523.1.
RefSeqiNP_001001745.1. NM_001001745.1.
UniGeneiGga.424.

3D structure databases

ProteinModelPortaliQ9PWR4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000013480.

Proteomic databases

PaxDbiQ9PWR4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi414795.
KEGGigga:414795.

Organism-specific databases

CTDi340547.

Phylogenomic databases

eggNOGiENOG410IINS. Eukaryota.
ENOG4111JZM. LUCA.
HOGENOMiHOG000154830.
HOVERGENiHBG106684.
InParanoidiQ9PWR4.
PhylomeDBiQ9PWR4.

Miscellaneous databases

PROiQ9PWR4.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
IPR029861. VSIG1.
[Graphical view]
PANTHERiPTHR12231:SF115. PTHR12231:SF115. 1 hit.
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
SM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVSIG1_CHICK
AccessioniPrimary (citable) accession number: Q9PWR4
Secondary accession number(s): Q9YGH1, Q9YGV5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 1, 2000
Last modified: June 8, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.