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Protein

Tyrosine-protein kinase

Gene

JAK1

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei997 – 9971Proton acceptorUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinaseUniRule annotation (EC:2.7.10.2UniRule annotation)
Gene namesi
Name:JAK1Imported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiQ9PWM9.
PRIDEiQ9PWM9.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000017948.

Structurei

3D structure databases

ProteinModelPortaliQ9PWM9.
SMRiQ9PWM9. Positions 865-1150.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 414381FERMInterPro annotationAdd
BLAST
Domaini433 – 52088SH2InterPro annotationAdd
BLAST
Domaini576 – 849274Protein kinaseInterPro annotationAdd
BLAST
Domaini869 – 1147279Protein kinaseInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.UniRule annotationSAAS annotation
Contains 1 SH2 domain.UniRule annotation
Contains 2 protein kinase domains.UniRule annotation

Phylogenomic databases

eggNOGiKOG0197. Eukaryota.
COG0515. LUCA.
HOGENOMiHOG000049158.
HOVERGENiHBG006195.
KOiK11217.
PhylomeDBiQ9PWM9.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR019748. FERM_central.
IPR000299. FERM_domain.
IPR011009. Kinase-like_dom.
IPR011993. PH_dom-like.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016251. Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR020776. Tyr_kinase_non-rcpt_Jak1.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 2 hits.
[Graphical view]
PIRSFiPIRSF000636. TyrPK_Jak. 1 hit.
PRINTSiPR01823. JANUSKINASE.
PR01824. JANUSKINASE1.
PR00109. TYRKINASE.
SMARTiSM00295. B41. 1 hit.
SM00252. SH2. 1 hit.
SM00219. TyrKc. 2 hits.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 2 hits.
PROSITEiPS50057. FERM_3. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 2 hits.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9PWM9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQYLNVKEDC KAMAFCAKMR STKKSEVNLE AQHQGLEVLF YLQDKSPICY
60 70 80 90 100
TSGEFTSEEL CIEAAQKCSI SPLCHNLFAL FDENRRLWYA PNQVFKIDEK
110 120 130 140 150
TSQRLYYRMR YYFTNWHGTS ENEPSVWRHS PKKSKNSYDK KLAPEGTPIL
160 170 180 190 200
DANSLEYIFA QGQYDLVREL APIRDPKNDQ EVHEIENECL GMAVLAISHY
210 220 230 240 250
AIKKNVKLPE LPKDISYKHY IPETLNKTIR QRNFLTRIRI NNVFKHFLKE
260 270 280 290 300
FNNKTICDSS VSPRDLKVKY LSTMETLTKY YGAEIFETSS LLISSESEIN
310 320 330 340 350
RFNCGDGEII PLYEVIVTGN NGIQWRLKPS SVQTEKKKKS DGKIKKDEDR
360 370 380 390 400
YKTRDLWNNF SYFPEITHIV IKESTVSINK QDNKKMELKL SSHDEALSFA
410 420 430 440 450
SLIDGYFRLT ADAHHYLCTD VAPPLIEHNI KNGCHGPICT EYAINRLRQE
460 470 480 490 500
GNEAGMYVLR WSCTNFNLIL MTVTCLEGPE MINNSVQYKN FQIEVKKGGY
510 520 530 540 550
FLHGSNRSFA SLKELMDHLK GQILRTDNIS FTLKRCCQPK PREISNLLVA
560 570 580 590 600
TKKAQECQPA YHLGQLSFHR IRKEEIMQGE HLGRGTRTQI YSGILNYKDD
610 620 630 640 650
ENEGYQNEKE IKVLLKVLDP SHRDISLAFF EAASMMRQVS HKHIVFLHGV
660 670 680 690 700
CVRDLENIMV EEFVEFGPLD LFMHRKSELL TTPWKFNVAK QLASALSYLE
710 720 730 740 750
DKDLVHGNVC TKNILLAREG IDTEYGPFIK LSDPGIPITV LSRQECVERI
760 770 780 790 800
PWIAPECVED SKNLSIAADK WSFGTTLWEI CYNGETPLKD KTLAEKERFY
810 820 830 840 850
EGHFMLITPS CKELADLMKQ CMNYDPHQRP FFRAIMRDIN KLEEQNPDIV
860 870 880 890 900
SEKKPVTEVD PTLFEKRFLK RIRDLGEGHF GKVELCRYDP EGDNTGEQVA
910 920 930 940 950
VKSLKPESGG NHIADLKKEI EILRNLYHEN IVKYKGICTE DGGNGIKLIM
960 970 980 990 1000
EFLPSGSLKE YLPRNKNKIN LKQLLRYAVQ ICKGMDYLGS RQYVHRDLAA
1010 1020 1030 1040 1050
RNVLVESENR VKIGDFGLTK AIETDKEYYT VKDDLDSPVF WYAPECLIQS
1060 1070 1080 1090 1100
KFYIASDVWS FGVTLYELLT YCDSESSPMT EFLKMIGPTQ GQMTVARLVR
1110 1120 1130 1140 1150
VLQEEKRLPR PPNCPEEIDQ LMRKCWIFKH DKRTTFHNLI QGFETIMSKM
Length:1,150
Mass (Da):133,116
Last modified:May 1, 2000 - v1
Checksum:iD3AEDDB0BD423A83
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF096264 mRNA. Translation: AAD22628.1.
RefSeqiNP_990201.1. NM_204870.1.
UniGeneiGga.2435.

Genome annotation databases

GeneIDi395681.
KEGGigga:395681.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF096264 mRNA. Translation: AAD22628.1.
RefSeqiNP_990201.1. NM_204870.1.
UniGeneiGga.2435.

3D structure databases

ProteinModelPortaliQ9PWM9.
SMRiQ9PWM9. Positions 865-1150.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000017948.

Proteomic databases

PaxDbiQ9PWM9.
PRIDEiQ9PWM9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi395681.
KEGGigga:395681.

Organism-specific databases

CTDi3716.

Phylogenomic databases

eggNOGiKOG0197. Eukaryota.
COG0515. LUCA.
HOGENOMiHOG000049158.
HOVERGENiHBG006195.
KOiK11217.
PhylomeDBiQ9PWM9.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR019748. FERM_central.
IPR000299. FERM_domain.
IPR011009. Kinase-like_dom.
IPR011993. PH_dom-like.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016251. Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR020776. Tyr_kinase_non-rcpt_Jak1.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 2 hits.
[Graphical view]
PIRSFiPIRSF000636. TyrPK_Jak. 1 hit.
PRINTSiPR01823. JANUSKINASE.
PR01824. JANUSKINASE1.
PR00109. TYRKINASE.
SMARTiSM00295. B41. 1 hit.
SM00252. SH2. 1 hit.
SM00219. TyrKc. 2 hits.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 2 hits.
PROSITEiPS50057. FERM_3. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 2 hits.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning, expression and evolutionary analysis of the avian tyrosine kinase JAK1."
    Bartunek P., Koritschoner N.P., Brett D., Zenke M.
    Gene 230:129-136(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ9PWM9_CHICK
AccessioniPrimary (citable) accession number: Q9PWM9
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: June 8, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.