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Protein

Homeobox protein Hox-A4a

Gene

hoxa4a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi147 – 206HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-A4a
Alternative name(s):
Homeobox protein Zf-26
Hoxx4
Gene namesi
Name:hoxa4a
Synonyms:hoxx4, zf26
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 19

Organism-specific databases

ZFINiZDB-GENE-000823-4. hoxa4a.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002000531 – 245Homeobox protein Hox-A4aAdd BLAST245

Proteomic databases

PaxDbiQ9PWL5.

Expressioni

Developmental stagei

First expressed at the 1-somite stage. At the 10-somite stage, weakly expressed in the paraxial mesoderm with an anterior expression limit at somite 1. At the 20-somite stage, expressed within the developing CNS with an anterior expression limit adjacent to the rhombomere 7/8 boundary.2 Publications

Gene expression databases

BgeeiENSDARG00000036231.
ExpressionAtlasiQ9PWL5. differential.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000074915.

Structurei

3D structure databases

ProteinModelPortaliQ9PWL5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi126 – 131Antp-type hexapeptide6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi231 – 234Poly-Gln4

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489. Eukaryota.
ENOG410ZTBY. LUCA.
GeneTreeiENSGT00760000118940.
HOGENOMiHOG000231179.
HOVERGENiHBG016849.
InParanoidiQ9PWL5.
PhylomeDBiQ9PWL5.
TreeFamiTF352857.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9PWL5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIMSSYLINS NYIEPSFPPC EEYHQNGYMP VSSDYYERPK DPGFPHHEEA
60 70 80 90 100
SYPRSNYQEQ SYDYGNVSTN DLNDFSDRHH AQPQSVSQNH GPRLTTESCV
110 120 130 140 150
GSDGNKDCSL VSDALPGSQK SKEPVVYPWM KKVHVNTVTA SYSGGVPKRS
160 170 180 190 200
RTAYTRQQAL ELEKEFHFNR YLTRRRRVEI AHTMCLSERQ VKIWFQNRRM
210 220 230 240
KWKKDHKLPN TKIRSSSSAP SNHHVKTDAT QQQQTLLPTP CSSNL
Length:245
Mass (Da):28,288
Last modified:July 11, 2006 - v2
Checksum:i1AF7F6F0C13B4F10
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti214 – 232RSSSS…DATQQ → APRALHPPTITWKRTPLS in AAD15939 (PubMed:9831563).CuratedAdd BLAST19
Sequence conflicti226K → E in CAA74285 (PubMed:9425135).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071246 Genomic DNA. Translation: AAD15939.1.
CR382300 Genomic DNA. Translation: CAK10850.1.
BC122457 mRNA. Translation: AAI22458.1.
DQ060533 mRNA. Translation: AAY67911.1.
M76382 Genomic DNA. Translation: AAA50034.1.
Y13947 mRNA. Translation: CAA74285.1.
PIRiS34415.
RefSeqiNP_571610.1. NM_131535.1.
UniGeneiDr.159437.

Genome annotation databases

EnsembliENSDART00000169074; ENSDARP00000134767; ENSDARG00000103862.
GeneIDi58050.
KEGGidre:58050.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071246 Genomic DNA. Translation: AAD15939.1.
CR382300 Genomic DNA. Translation: CAK10850.1.
BC122457 mRNA. Translation: AAI22458.1.
DQ060533 mRNA. Translation: AAY67911.1.
M76382 Genomic DNA. Translation: AAA50034.1.
Y13947 mRNA. Translation: CAA74285.1.
PIRiS34415.
RefSeqiNP_571610.1. NM_131535.1.
UniGeneiDr.159437.

3D structure databases

ProteinModelPortaliQ9PWL5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000074915.

Proteomic databases

PaxDbiQ9PWL5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000169074; ENSDARP00000134767; ENSDARG00000103862.
GeneIDi58050.
KEGGidre:58050.

Organism-specific databases

CTDi58050.
ZFINiZDB-GENE-000823-4. hoxa4a.

Phylogenomic databases

eggNOGiKOG0489. Eukaryota.
ENOG410ZTBY. LUCA.
GeneTreeiENSGT00760000118940.
HOGENOMiHOG000231179.
HOVERGENiHBG016849.
InParanoidiQ9PWL5.
PhylomeDBiQ9PWL5.
TreeFamiTF352857.

Miscellaneous databases

PROiQ9PWL5.

Gene expression databases

BgeeiENSDARG00000036231.
ExpressionAtlasiQ9PWL5. differential.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHXA4A_DANRE
AccessioniPrimary (citable) accession number: Q9PWL5
Secondary accession number(s): O42371
, Q05784, Q0P3T8, Q1L970, Q4PRB0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: July 11, 2006
Last modified: November 30, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.