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Protein
Submitted name:

Pepsinogen C

Gene

cPgC

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei91PROSITE-ProRule annotation1
Active sitei276PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAspartyl proteasePROSITE-ProRule annotation, Hydrolase, Protease

Protein family/group databases

MEROPSiA01.003.

Names & Taxonomyi

Protein namesi
Submitted name:
Pepsinogen CImported
Gene namesi
Name:cPgCImported
Synonyms:PGCImported
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 26

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_500934871917 – 389Sequence analysisAdd BLAST373

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSGALG00000003435.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000005433.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini73 – 386Peptidase A1InterPro annotationAdd BLAST314

Sequence similaritiesi

Belongs to the peptidase A1 family.PROSITE-ProRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG1339. Eukaryota.
ENOG410XNV7. LUCA.
GeneTreeiENSGT00760000118929.
HOGENOMiHOG000197681.
HOVERGENiHBG000482.
KOiK01377.
OMAiGIESTYL.
OrthoDBiEOG091G0JP7.
TreeFamiTF314990.

Family and domain databases

Gene3Di2.40.70.10. 2 hits.
InterProiView protein in InterPro
IPR001461. Aspartic_peptidase_A1.
IPR001969. Aspartic_peptidase_AS.
IPR012848. Aspartic_peptidase_N.
IPR033121. PEPTIDASE_A1.
IPR021109. Peptidase_aspartic_dom.
PANTHERiPTHR13683. PTHR13683. 1 hit.
PfamiView protein in Pfam
PF07966. A1_Propeptide. 1 hit.
PF00026. Asp. 1 hit.
PRINTSiPR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiView protein in PROSITE
PS00141. ASP_PROTEASE. 2 hits.
PS51767. PEPTIDASE_A1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9PWK1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRLILTVLC LHLCEGILRV PLKKGKSIRE AMKESGVLHD YLANHRHYDP
60 70 80 90 100
AYKFFSNFAT AYEPLANNMD MSYYGEISIG TPPQNFLVLF DTGSSNLWVP
110 120 130 140 150
STLCQSQACA NHNEFDPNES STFSTQDEFF SLQYGSGSLT GIFGFDTVTI
160 170 180 190 200
QGISITNQEF GLSETEPGTS FLYSPFDGIL GLAFPSISAG GATTVMQKML
210 220 230 240 250
QENLLDFPVF SFYLSGQEGS QGGELVFGGV DPNLYTGQIT WTPVTQTTYW
260 270 280 290 300
QIGIEDFAVG GQSSGWCSQG CQGIVDTGTS LLTVPNQVFT ELMQYIGAQA
310 320 330 340 350
DDSGQYVASC SNIEYMPTIT FVISGTSFPL PPSAYMLQSN SDYCTVGIES
360 370 380
TYLPSQTGQP LWILGDVFLR VYYSIYDMGN NQVGFATAV
Length:389
Mass (Da):42,526
Last modified:May 1, 2000 - v1
Checksum:iBF95671C3A76ED78
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC164569 Genomic DNA. No translation available.
AB025282 mRNA. Translation: BAA76893.1.
PIRiJE0371.
RefSeqiNP_990208.1. NM_204877.2.
UniGeneiGga.401.

Genome annotation databases

EnsembliENSGALT00000005443; ENSGALP00000005433; ENSGALG00000003435.
GeneIDi395690.
KEGGigga:395690.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC164569 Genomic DNA. No translation available.
AB025282 mRNA. Translation: BAA76893.1.
PIRiJE0371.
RefSeqiNP_990208.1. NM_204877.2.
UniGeneiGga.401.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000005433.

Protein family/group databases

MEROPSiA01.003.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000005443; ENSGALP00000005433; ENSGALG00000003435.
GeneIDi395690.
KEGGigga:395690.

Organism-specific databases

CTDi5225.

Phylogenomic databases

eggNOGiKOG1339. Eukaryota.
ENOG410XNV7. LUCA.
GeneTreeiENSGT00760000118929.
HOGENOMiHOG000197681.
HOVERGENiHBG000482.
KOiK01377.
OMAiGIESTYL.
OrthoDBiEOG091G0JP7.
TreeFamiTF314990.

Gene expression databases

BgeeiENSGALG00000003435.

Family and domain databases

Gene3Di2.40.70.10. 2 hits.
InterProiView protein in InterPro
IPR001461. Aspartic_peptidase_A1.
IPR001969. Aspartic_peptidase_AS.
IPR012848. Aspartic_peptidase_N.
IPR033121. PEPTIDASE_A1.
IPR021109. Peptidase_aspartic_dom.
PANTHERiPTHR13683. PTHR13683. 1 hit.
PfamiView protein in Pfam
PF07966. A1_Propeptide. 1 hit.
PF00026. Asp. 1 hit.
PRINTSiPR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiView protein in PROSITE
PS00141. ASP_PROTEASE. 2 hits.
PS51767. PEPTIDASE_A1. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ9PWK1_CHICK
AccessioniPrimary (citable) accession number: Q9PWK1
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: February 15, 2017
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.