Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Frizzled-10

Gene

FZD10

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activation by Wnt7A induces expression of beta-catenin target genes.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, G-protein coupled receptor, Receptor, Transducer
Biological processWnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Frizzled-10
Short name:
Fz-10
Short name:
cFz-10
Gene namesi
Name:FZD10
Synonyms:FZ10
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 229ExtracellularSequence analysisAdd BLAST205
Transmembranei230 – 250Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini251 – 265CytoplasmicSequence analysisAdd BLAST15
Transmembranei266 – 286Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini287 – 314ExtracellularSequence analysisAdd BLAST28
Transmembranei315 – 335Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini336 – 355CytoplasmicSequence analysisAdd BLAST20
Transmembranei356 – 376Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini377 – 397ExtracellularSequence analysisAdd BLAST21
Transmembranei398 – 418Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini419 – 447CytoplasmicSequence analysisAdd BLAST29
Transmembranei448 – 468Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini469 – 506ExtracellularSequence analysisAdd BLAST38
Transmembranei507 – 527Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini528 – 585CytoplasmicSequence analysisAdd BLAST58

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000001300725 – 585Frizzled-10Add BLAST561

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi38 ↔ 99PROSITE-ProRule annotation
Disulfide bondi46 ↔ 92PROSITE-ProRule annotation
Glycosylationi52N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi83 ↔ 121PROSITE-ProRule annotation
Disulfide bondi110 ↔ 151PROSITE-ProRule annotation
Disulfide bondi114 ↔ 138PROSITE-ProRule annotation
Glycosylationi157N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi489N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi499N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9PWH2.

Expressioni

Tissue specificityi

Expressed in the dorsal ectoderm overlying the developing spinal cord.

Developmental stagei

Expressed in the region posterior to the Hensen node at stage 6. Detected in the dorsal domain of the neural tube and the CNS of the developing embryo. In the developing limb, expression starts at stage 18 in the posterior-dorsal region of the distal mesenchyme, and gradually expands to the anterior-distal region. Also found in the feather bud and branchial arch.

Inductioni

By Sonic hedgehog (Shh) in limb bud.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9PWH2. 2 interactors.
STRINGi9031.ENSGALP00000004170.

Structurei

3D structure databases

ProteinModelPortaliQ9PWH2.
SMRiQ9PWH2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 154FZPROSITE-ProRule annotationAdd BLAST122

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi530 – 535Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family membersBy similarity6
Motifi583 – 585PDZ-binding3

Domaini

Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.By similarity
The FZ domain is involved in binding with Wnt ligands.By similarity

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3577. Eukaryota.
ENOG410XRC8. LUCA.
HOGENOMiHOG000233236.
HOVERGENiHBG006977.
InParanoidiQ9PWH2.
KOiK02842.
PhylomeDBiQ9PWH2.

Family and domain databases

Gene3Di1.10.2000.10. 1 hit.
InterProiView protein in InterPro
IPR015526. Frizzled/SFRP.
IPR000539. Frizzled/Smoothened_TM.
IPR020067. Frizzled_dom.
IPR036790. Frizzled_dom_sf.
IPR026549. FZD10.
IPR017981. GPCR_2-like.
PANTHERiPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF86. PTHR11309:SF86. 1 hit.
PfamiView protein in Pfam
PF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
PRINTSiPR00489. FRIZZLED.
SMARTiView protein in SMART
SM00063. FRI. 1 hit.
SM01330. Frizzled. 1 hit.
SUPFAMiSSF63501. SSF63501. 1 hit.
PROSITEiView protein in PROSITE
PS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9PWH2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPAAGNLVR AVLALCWLAE HCAGISSIDI ERPGDGRCQP IEIPMCKDIG
60 70 80 90 100
YNMTRMPNLM GHENQREAAI QLHEFAPLVE YGCHGHLKFF LCSLYAPMCT
110 120 130 140 150
EQVSTPIPAC RVMCEQARLK CSPIMEQFNF KWPDSLDCSK LPNKNDPNYL
160 170 180 190 200
CMEAPNNGSD EPPRGSSMLP PMFRPQRPST GHDLQQHKDS LSRTSCENPG
210 220 230 240 250
KFHHVEKSAS CAPLCTPGVD VYWSKDDKQF AVIWIAIWSI LCFFSSAFTV
260 270 280 290 300
LTFLIDPQRF KYPERPIIFL SMCYCVYSVG YIIRLFSGAE SIACDRDSGQ
310 320 330 340 350
LYVIQEGLES TGCTIVFLVL YYFGMASSLW WVILTLTWFL AAGKKWGHEA
360 370 380 390 400
IEANSSYFHL AAWAIPAVKT IMILVMRRVA GDELTGLCYV GSMDVNALTG
410 420 430 440 450
FVLIPLACYL IIGTSFILSG FVALFHIRRV MKTGGENTDK LEKLMVRIGV
460 470 480 490 500
FSVLYTVPAT CVIACYFYER LNMDYWKIVA SQQKCKMNNQ TKNLDCMMNN
510 520 530 540 550
SIPAVEIFMV KIFMLLVVGI TSGMWIWTSK TLQSWQNVCS RRLKKRSRRK
560 570 580
PASVITSSGI YKKPQHPQKT HLAKYESTLQ PPTCV
Length:585
Mass (Da):65,945
Last modified:May 1, 2000 - v1
Checksum:i3E2A7E747CF9EE4B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023806 mRNA. Translation: BAA83742.1.
AF224320 mRNA. Translation: AAF61100.1.
RefSeqiNP_989429.1. NM_204098.2.
UniGeneiGga.109.

Genome annotation databases

GeneIDi373885.
KEGGigga:373885.

Similar proteinsi

Entry informationi

Entry nameiFZD10_CHICK
AccessioniPrimary (citable) accession number: Q9PWH2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: May 1, 2000
Last modified: October 25, 2017
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families