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Protein

T-box transcription factor TBX5

Gene

TBX5

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

DNA-binding protein that regulates the transcription of several genes and is involved in heart development and limb pattern formation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi63 – 238T-boxPROSITE-ProRule annotationAdd BLAST176

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-GGA-2032785. YAP1- and WWTR1 (TAZ)-stimulated gene expression.

Names & Taxonomyi

Protein namesi
Recommended name:
T-box transcription factor TBX5
Short name:
T-box protein 5
Gene namesi
Name:TBX5
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 15

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  • actin cytoskeleton Source: AgBase
  • actin filament Source: AgBase
  • cytoplasm Source: AgBase
  • nucleus Source: AgBase
  • stress fiber Source: AgBase

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002624671 – 521T-box transcription factor TBX5Add BLAST521

Proteomic databases

PaxDbiQ9PWE8.

Expressioni

Developmental stagei

Early in the developing heart, uniformly expressed throughout the entire cardiac crescent. Upon formation of the linear heart tube, expressed in a graded fashion, stronger near the posterior end and weaker at the anterior end. As the heart tube loops, asymmetric expression continues; it is expressed in the presumptive left ventricle, but not the right ventricle or outflow tract. This pattern of expression is maintained in more mature hearts (PubMed:10373308). First detected in the presumptive wing and leg mesoderm respectively at around stages 14-15. As limb outgrowth proceeds, expressed throughout the mesoderm and in the wing (PubMed:9550719).2 Publications

Gene expression databases

BgeeiENSGALG00000008253.
ExpressionAtlasiQ9PWE8. baseline.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PDLIM7Q679P34EBI-6663870,EBI-6693710

GO - Molecular functioni

  • chaperone binding Source: AgBase
  • LIM domain binding Source: AgBase
  • scaffold protein binding Source: AgBase
  • transcription factor binding Source: Ensembl

Protein-protein interaction databases

IntActiQ9PWE8. 1 interactor.
STRINGi9031.ENSGALP00000013419.

Structurei

3D structure databases

ProteinModelPortaliQ9PWE8.
SMRiQ9PWE8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG3585. Eukaryota.
ENOG410XSTS. LUCA.
HOGENOMiHOG000286001.
HOVERGENiHBG007310.
InParanoidiQ9PWE8.
KOiK10179.
OrthoDBiEOG091G0I8R.
PhylomeDBiQ9PWE8.
TreeFamiTF106341.

Family and domain databases

CDDicd00182. TBOX. 1 hit.
Gene3Di2.60.40.820. 1 hit.
InterProiView protein in InterPro
IPR008967. p53-like_TF_DNA-bd.
IPR001699. TF_T-box.
IPR018186. TF_T-box_CS.
PANTHERiPTHR11267. PTHR11267. 1 hit.
PfamiView protein in Pfam
PF00907. T-box. 1 hit.
PRINTSiPR00937. TBOX.
SMARTiView protein in SMART
SM00425. TBOX. 1 hit.
SUPFAMiSSF49417. SSF49417. 1 hit.
PROSITEiView protein in PROSITE
PS01283. TBOX_1. 1 hit.
PS01264. TBOX_2. 1 hit.
PS50252. TBOX_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9PWE8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADTEEGFGL PSTPVDSEAK ELQAEAKQDP QLGTTSKAPT SPQAAFTQQG
60 70 80 90 100
MEGIKVFLHE RELWLKFHEV GTEMIITKAG RRMFPSYKVK VTGLNPKTKY
110 120 130 140 150
ILLMDIVPAD DHRYKFADNK WSVTGKAEPA MPGRLYVHPD SPATGAHWMR
160 170 180 190 200
QLVSFQKLKL TNNHLDPFGH IILNSMHKYQ PRLHIVKADE NNGFGSKNTA
210 220 230 240 250
FCTHVFPETA FIAVTSYQNH KITQLKIENN PFAKGFRGSD DMELHRMSRM
260 270 280 290 300
QSKEYPVVPR STVRQKVSSN HSPFSGETRV LSTSSNLGSQ YQCENGVSST
310 320 330 340 350
SQDLLPPTNP YPISQEHSQI YHCTKRKDEE CSTTEHPYKK PYMETSPAEE
360 370 380 390 400
DPFYRSSYPQ QQGLNTSYRT ESAQRQACMY ASSAPPTDPV PSLEDISCNT
410 420 430 440 450
WPSVPSYSSC TVSAMQPMDR LPYQHFSAHF TSGPLMPRLS SVANHTSPQI
460 470 480 490 500
GDTHSMFQHQ TSVSHQPIVR QCGPQTGIQS PPSSLQPAEF LYSHGVPRTL
510 520
SPHQYHSVHG VGMVPEWSEN S
Length:521
Mass (Da):58,402
Last modified:May 1, 2000 - v1
Checksum:i17633D0F1DBCE30B
GO

Sequence cautioni

The sequence AAC41299 differs from that shown. Reason: Frameshift at several positions.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF033671 mRNA. Translation: AAC41299.1. Frameshift.
AF069396 mRNA. Translation: AAC23683.2.
RefSeqiNP_989504.1. NM_204173.1.
XP_015150318.1. XM_015294832.1.
UniGeneiGga.961.

Genome annotation databases

EnsembliENSGALT00000013434; ENSGALP00000013419; ENSGALG00000008253.
GeneIDi373988.
KEGGigga:373988.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF033671 mRNA. Translation: AAC41299.1. Frameshift.
AF069396 mRNA. Translation: AAC23683.2.
RefSeqiNP_989504.1. NM_204173.1.
XP_015150318.1. XM_015294832.1.
UniGeneiGga.961.

3D structure databases

ProteinModelPortaliQ9PWE8.
SMRiQ9PWE8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9PWE8. 1 interactor.
STRINGi9031.ENSGALP00000013419.

Proteomic databases

PaxDbiQ9PWE8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000013434; ENSGALP00000013419; ENSGALG00000008253.
GeneIDi373988.
KEGGigga:373988.

Organism-specific databases

CTDi6910.

Phylogenomic databases

eggNOGiKOG3585. Eukaryota.
ENOG410XSTS. LUCA.
HOGENOMiHOG000286001.
HOVERGENiHBG007310.
InParanoidiQ9PWE8.
KOiK10179.
OrthoDBiEOG091G0I8R.
PhylomeDBiQ9PWE8.
TreeFamiTF106341.

Enzyme and pathway databases

ReactomeiR-GGA-2032785. YAP1- and WWTR1 (TAZ)-stimulated gene expression.

Miscellaneous databases

PROiPR:Q9PWE8.

Gene expression databases

BgeeiENSGALG00000008253.
ExpressionAtlasiQ9PWE8. baseline.

Family and domain databases

CDDicd00182. TBOX. 1 hit.
Gene3Di2.60.40.820. 1 hit.
InterProiView protein in InterPro
IPR008967. p53-like_TF_DNA-bd.
IPR001699. TF_T-box.
IPR018186. TF_T-box_CS.
PANTHERiPTHR11267. PTHR11267. 1 hit.
PfamiView protein in Pfam
PF00907. T-box. 1 hit.
PRINTSiPR00937. TBOX.
SMARTiView protein in SMART
SM00425. TBOX. 1 hit.
SUPFAMiSSF49417. SSF49417. 1 hit.
PROSITEiView protein in PROSITE
PS01283. TBOX_1. 1 hit.
PS01264. TBOX_2. 1 hit.
PS50252. TBOX_3. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTBX5_CHICK
AccessioniPrimary (citable) accession number: Q9PWE8
Secondary accession number(s): O73719
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: May 1, 2000
Last modified: May 10, 2017
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.