Reviewed, UniProtKB/Swiss-Prot Q9PWD3 (HXA5_MORSA)

Names and origin

Protein names

Recommended name:
    Homeobox protein Hox-A5

Gene names

Name:

hoxa5

Organism

Morone saxatilis (Striped bass)

Taxonomic identifier

34816 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Euteleostei › Neoteleostei › Acanthomorpha › Acanthopterygii › Percomorpha › Perciformes › Percoidei › Moronidae › Morone

Protein attributes

Sequence length	281 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the Antp homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Gene Ontology (GO)
Biological process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 281	281	Homeobox protein Hox-A5		PRO_0000200064
Regions
	DNA binding	205 – 264	60	Homeobox
	Motif	187 – 192	6	Antp-type hexapeptide
	Compositional bias	232 – 235	4	Poly-Arg
	Compositional bias	275 – 278	4	Poly-Gly

Sequences

	Sequence		Length	Mass (Da)
	Q9PWD3-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 5726D13D47C8AE35	FASTA	281	31,124
	10 20 30 40 50 60 MSSYFVNSFC GRYPNGADFQ LHNYGDHSTA NDQYRDSTAM HSSRYGYGYN GMDLTVGRAG 70 80 90 100 110 120 TGHFVGNERT QGYSPSHSAA TTPSVEPVRY TQSANSTGTS SLSPPPDPLP CSSVASSSPV 130 140 150 160 170 180 TETQSQHRAV KNSITTPCST PCSSSNGGTL LLNRDCVSKA SPLEEEKPAG SAPTTPQNVS 190 200 210 220 230 240 DSTQPQIYPW MRKLHINHDL AGPEGKRART AYTRYQTLEL EKEFHFNRYL TRRRRIEIAH 250 260 270 280 ALCLSERQIK IWFQNRRMKW KKDNKLKSMN MAAAGGGGYR P

References

[1]	"Genomic organization of the Hoxa4-Hoxa10 region from Morone saxatilis: implications for Hox gene evolution among vertebrates." Snell E.A., Scemama J.L., Stellwag E.J. J. Exp. Zool. 285:41-49(1999) [PubMed: 10327649] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF089743 Genomic DNA. Translation: AAD46398.1.
3D structure databases
SMR	Q9PWD3. Positions 206-267.
ModBase	Search...
Phylogenomic databases
HOVERGEN	Q9PWD3.
Family and domain databases
InterPro	IPR001356. Homeobox. IPR017995. Homeobox_antennapedia. IPR001827. Homeobox_Antennapedia_CS. IPR017970. Homeobox_CS. IPR020479. Homeobox_region. IPR009057. Homeodomain-like. IPR012287. Homeodomain-rel. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00025. ANTENNAPEDIA. PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
PROSITE	PS00032. ANTENNAPEDIA. 1 hit. PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HXA5_MORSA

Accession

Primary (citable) accession number: Q9PWD3

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2001
Last sequence update:	May 1, 2000
Last modified:	November 24, 2009
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)