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Protein

Tyrosine-protein kinase

Gene

JAK3

Organism
Tetraodon fluviatilis (Green pufferfish) (Chelonodon fluviatilis)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei854ATPUniRule annotation1
Active sitei948Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi827 – 835ATPUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinaseUniRule annotation (EC:2.7.10.2UniRule annotation)
Gene namesi
Name:JAK3Imported
OrganismiTetraodon fluviatilis (Green pufferfish) (Chelonodon fluviatilis)Imported
Taxonomic identifieri47145 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaTetraodontiformesTetradontoideaTetraodontidaeTetraodon

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Structurei

3D structure databases

ProteinModelPortaliQ9PWD0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 363FERMInterPro annotationAdd BLAST334
Domaini382 – 481SH2InterPro annotationAdd BLAST100
Domaini526 – 782Protein kinaseInterPro annotationAdd BLAST257
Domaini821 – 1098Protein kinaseInterPro annotationAdd BLAST278

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.UniRule annotation
Contains 1 SH2 domain.UniRule annotation
Contains 2 protein kinase domains.UniRule annotation

Phylogenomic databases

HOVERGENiHBG006195.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR019748. FERM_central.
IPR000299. FERM_domain.
IPR011009. Kinase-like_dom.
IPR011993. PH_dom-like.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016251. Tyr_kinase_non-rcpt_Jak/Tyk2.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 2 hits.
PF00017. SH2. 1 hit.
[Graphical view]
PIRSFiPIRSF000636. TyrPK_Jak. 1 hit.
PRINTSiPR01823. JANUSKINASE.
PR00109. TYRKINASE.
SMARTiSM00295. B41. 1 hit.
SM00252. SH2. 1 hit.
SM00219. TyrKc. 2 hits.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF55550. SSF55550. 2 hits.
SSF56112. SSF56112. 2 hits.
PROSITEiPS50057. FERM_3. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 2 hits.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9PWD0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLAEEEFAP LVIRDRGGSQ TSSSSAGGSL QVHLYFVPAT KKATTIHMTS
60 70 80 90 100
GQISAENVCI QAGKKSGILP VYIGLFGLAS ADLSFWYPPS HMFNTEENLH
110 120 130 140 150
VCFRVRFFFG NWFDQGPRTA CRYSLTRDRT SPVLDHSGIA YLFAQLRTDF
160 170 180 190 200
TSSEAGLSPP LTTQDECLGL AVLDLWRLAK EQQSSVKDLC KSVSYKSCLP
210 220 230 240 250
KSHRVDIEKR NWVERFRIRN TLKHFLKKFG SCAVDDCNLK LMYLTALAGI
260 270 280 290 300
QPSLGSETFH VDPSSSCLNS RSAVSLVQVT GEIGIQTSEG CEGVVWQTFC
310 320 330 340 350
DFKEITDISI KRICREQVPN DSRMVTITRK DDACLEVAFQ SLKEALSLVS
360 370 380 390 400
LVDGYFRLTT DSTHYFCQDT APPSILEGIK NHCHGPITSE FAVNKLKKWG
410 420 430 440 450
SEDGTFLLRK SPQDYGEFFL TVSAAGTPLG LDYKDCLVIK NKHYSLPGVS
460 470 480 490 500
KSFSSLKELT VYYQQNKLLL ADVPVRLSRC CPPRSQELTN LIIMRNSSFV
510 520 530 540 550
EAQLSPTLEG NKLIHIQFQM IKYEDLQWGE SHGQGSFTRL FKGYKSNLSE
560 570 580 590 600
GGKRVSVFLK ELDVNHRNLW ESFFEAASLM SQFSHKHLIL VYGVTLAVKN
610 620 630 640 650
IMVQEFVEYG ALDLYLKRGR SVSVSWKLDV AKQLASVLTF LEQNNIVHGN
660 670 680 690 700
ICAKNLLLAR EGDPSQSIPP FIKLSDPGIS VLMLGKDVIV DRIPWVAPEV
710 720 730 740 750
LASPENLTLE SDKWSFGATL WELFNNGNNP LLGWDLDMKF YESFQQLPPS
760 770 780 790 800
QWTELADLIN QCMDYQADFR PSCRSIIRQL FSLITSDYVI LFATEPDTQF
810 820 830 840 850
PAWRALTPSQ QEQTVFEERH LRYISLLGKG NFGSVELCCY DPLGDNTGEL
860 870 880 890 900
VAVKKLQPSK KSSMEDFKKE VKTLSVLHCE YIVKYKGVCY SMGRLSMGLV
910 920 930 940 950
TEYLPYGSLI GYLENNRHKV DTRRMLLFAS QICKGMEYLQ SLRFVHRDLA
960 970 980 990 1000
ARNILVASES LVKIADFGLT KIIPCNKEYY RVTQPGESPI FWYAPESINE
1010 1020 1030 1040 1050
SRFSHESDVW SFGVVLYELF SYCDINSNPK RLYMQQIGHN VQTPSISLHL
1060 1070 1080 1090 1100
ANILKSNWRL PAPPDCPAKV YSLMKECWLY DFMERPCFSF LGNQIEVIMQ

DERDSFKG
Length:1,108
Mass (Da):125,409
Last modified:May 1, 2000 - v1
Checksum:i6F1BF2D224BCB1F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF091238 Genomic DNA. Translation: AAD50352.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF091238 Genomic DNA. Translation: AAD50352.1.

3D structure databases

ProteinModelPortaliQ9PWD0.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG006195.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR019748. FERM_central.
IPR000299. FERM_domain.
IPR011009. Kinase-like_dom.
IPR011993. PH_dom-like.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016251. Tyr_kinase_non-rcpt_Jak/Tyk2.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 2 hits.
PF00017. SH2. 1 hit.
[Graphical view]
PIRSFiPIRSF000636. TyrPK_Jak. 1 hit.
PRINTSiPR01823. JANUSKINASE.
PR00109. TYRKINASE.
SMARTiSM00295. B41. 1 hit.
SM00252. SH2. 1 hit.
SM00219. TyrKc. 2 hits.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF55550. SSF55550. 2 hits.
SSF56112. SSF56112. 2 hits.
PROSITEiPS50057. FERM_3. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 2 hits.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ9PWD0_TETFL
AccessioniPrimary (citable) accession number: Q9PWD0
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.