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Protein

Tyrosine-protein kinase

Gene

JAK3

Organism
Tetraodon fluviatilis (Green pufferfish) (Chelonodon fluviatilis)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei854ATPUniRule annotation1
Active sitei948Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi827 – 835ATPUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinaseUniRule annotation (EC:2.7.10.2UniRule annotation)
Gene namesi
Name:JAK3Imported
OrganismiTetraodon fluviatilis (Green pufferfish) (Chelonodon fluviatilis)Imported
Taxonomic identifieri47145 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaTetraodontiformesTetradontoideaTetraodontidaeTetraodon

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Structurei

3D structure databases

ProteinModelPortaliQ9PWD0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 363FERMInterPro annotationAdd BLAST334
Domaini382 – 481SH2InterPro annotationAdd BLAST100
Domaini526 – 782Protein kinaseInterPro annotationAdd BLAST257
Domaini821 – 1098Protein kinaseInterPro annotationAdd BLAST278

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.UniRule annotation

Keywords - Domaini

SH2 domainPROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG006195

Family and domain databases

Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR019749 Band_41_domain
IPR035963 FERM_2
IPR000299 FERM_domain
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR016251 Tyr_kinase_non-rcpt_Jak/Tyk2
PfamiView protein in Pfam
PF07714 Pkinase_Tyr, 2 hits
PF00017 SH2, 1 hit
PIRSFiPIRSF000636 TyrPK_Jak, 1 hit
PRINTSiPR01823 JANUSKINASE
PR00109 TYRKINASE
SMARTiView protein in SMART
SM00295 B41, 1 hit
SM00252 SH2, 1 hit
SM00219 TyrKc, 2 hits
SUPFAMiSSF47031 SSF47031, 1 hit
SSF55550 SSF55550, 2 hits
SSF56112 SSF56112, 2 hits
PROSITEiView protein in PROSITE
PS50057 FERM_3, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 2 hits
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS50001 SH2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9PWD0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLAEEEFAP LVIRDRGGSQ TSSSSAGGSL QVHLYFVPAT KKATTIHMTS
60 70 80 90 100
GQISAENVCI QAGKKSGILP VYIGLFGLAS ADLSFWYPPS HMFNTEENLH
110 120 130 140 150
VCFRVRFFFG NWFDQGPRTA CRYSLTRDRT SPVLDHSGIA YLFAQLRTDF
160 170 180 190 200
TSSEAGLSPP LTTQDECLGL AVLDLWRLAK EQQSSVKDLC KSVSYKSCLP
210 220 230 240 250
KSHRVDIEKR NWVERFRIRN TLKHFLKKFG SCAVDDCNLK LMYLTALAGI
260 270 280 290 300
QPSLGSETFH VDPSSSCLNS RSAVSLVQVT GEIGIQTSEG CEGVVWQTFC
310 320 330 340 350
DFKEITDISI KRICREQVPN DSRMVTITRK DDACLEVAFQ SLKEALSLVS
360 370 380 390 400
LVDGYFRLTT DSTHYFCQDT APPSILEGIK NHCHGPITSE FAVNKLKKWG
410 420 430 440 450
SEDGTFLLRK SPQDYGEFFL TVSAAGTPLG LDYKDCLVIK NKHYSLPGVS
460 470 480 490 500
KSFSSLKELT VYYQQNKLLL ADVPVRLSRC CPPRSQELTN LIIMRNSSFV
510 520 530 540 550
EAQLSPTLEG NKLIHIQFQM IKYEDLQWGE SHGQGSFTRL FKGYKSNLSE
560 570 580 590 600
GGKRVSVFLK ELDVNHRNLW ESFFEAASLM SQFSHKHLIL VYGVTLAVKN
610 620 630 640 650
IMVQEFVEYG ALDLYLKRGR SVSVSWKLDV AKQLASVLTF LEQNNIVHGN
660 670 680 690 700
ICAKNLLLAR EGDPSQSIPP FIKLSDPGIS VLMLGKDVIV DRIPWVAPEV
710 720 730 740 750
LASPENLTLE SDKWSFGATL WELFNNGNNP LLGWDLDMKF YESFQQLPPS
760 770 780 790 800
QWTELADLIN QCMDYQADFR PSCRSIIRQL FSLITSDYVI LFATEPDTQF
810 820 830 840 850
PAWRALTPSQ QEQTVFEERH LRYISLLGKG NFGSVELCCY DPLGDNTGEL
860 870 880 890 900
VAVKKLQPSK KSSMEDFKKE VKTLSVLHCE YIVKYKGVCY SMGRLSMGLV
910 920 930 940 950
TEYLPYGSLI GYLENNRHKV DTRRMLLFAS QICKGMEYLQ SLRFVHRDLA
960 970 980 990 1000
ARNILVASES LVKIADFGLT KIIPCNKEYY RVTQPGESPI FWYAPESINE
1010 1020 1030 1040 1050
SRFSHESDVW SFGVVLYELF SYCDINSNPK RLYMQQIGHN VQTPSISLHL
1060 1070 1080 1090 1100
ANILKSNWRL PAPPDCPAKV YSLMKECWLY DFMERPCFSF LGNQIEVIMQ

DERDSFKG
Length:1,108
Mass (Da):125,409
Last modified:May 1, 2000 - v1
Checksum:i6F1BF2D224BCB1F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF091238 Genomic DNA Translation: AAD50352.1

Similar proteinsi

Entry informationi

Entry nameiQ9PWD0_TETFL
AccessioniPrimary (citable) accession number: Q9PWD0
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: March 28, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health