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Protein

Cerberus

Gene

CER1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cytokine that acts as a regulator of the activity of Nodal/BMP pathways during the establishment of bilateral asymmetry in the head and trunk of the embryo.1 Publication

GO - Molecular functioni

GO - Biological processi

  • anterior/posterior axis specification Source: Ensembl
  • bone mineralization Source: Ensembl
  • cell migration involved in gastrulation Source: Ensembl
  • determination of dorsal identity Source: Ensembl
  • determination of left/right asymmetry in lateral mesoderm Source: BHF-UCL
  • growth plate cartilage chondrocyte proliferation Source: Ensembl
  • heart looping Source: BHF-UCL
  • mesendoderm development Source: BHF-UCL
  • negative regulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry Source: AgBase
  • negative regulation of cell proliferation Source: Ensembl
  • negative regulation of gene expression Source: AgBase
  • negative regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry Source: BHF-UCL
  • nervous system development Source: Ensembl
  • positive regulation of gene expression Source: AgBase
  • regulation of heart looping Source: AgBase
  • sequestering of BMP in extracellular matrix Source: GO_Central
  • signal transduction involved in regulation of gene expression Source: GO_Central
  • ureteric bud development Source: Ensembl

Keywordsi

Molecular functionCytokine

Enzyme and pathway databases

ReactomeiR-GGA-201451 Signaling by BMP

Names & Taxonomyi

Protein namesi
Recommended name:
Cerberus
Gene namesi
Name:CER1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome Z

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000000671320 – 272CerberusAdd BLAST253

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi168 ↔ 215PROSITE-ProRule annotation
Disulfide bondi182 ↔ 229PROSITE-ProRule annotation
Disulfide bondi192 ↔ 245PROSITE-ProRule annotation
Disulfide bondi196 ↔ 247PROSITE-ProRule annotation
Glycosylationi228N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9PWB0

Expressioni

Developmental stagei

At embryonic stage 8 is expressed in the left lateral plate mesoderm, bilaterally in the head and in a small horizontal domain coincident with the second caudal somite. By stage 9, expression in the right side of the head has disappeared and all remaining expression in both the head and trunk is on the left. The most medial domain of expression expands caudally as new somites form.1 Publication

Inductioni

By SHH signaling both in the head and in the trunk. On the left side in the head was also controlled by NODAL.1 Publication

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000008711

Structurei

3D structure databases

SMRiQ9PWB0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini168 – 253CTCKPROSITE-ProRule annotationAdd BLAST86

Sequence similaritiesi

Belongs to the DAN family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IGR5 Eukaryota
ENOG410YX4Y LUCA
GeneTreeiENSGT00530000063926
HOGENOMiHOG000231309
HOVERGENiHBG050902
InParanoidiQ9PWB0
OMAiCFGKCGS
OrthoDBiEOG091G0IOA
PhylomeDBiQ9PWB0
TreeFamiTF106445

Family and domain databases

Gene3Di2.10.90.101 hit
InterProiView protein in InterPro
IPR016860 Cerberus
IPR006207 Cys_knot_C
IPR029034 Cystine-knot_cytokine
IPR004133 DAN
PANTHERiPTHR15273 PTHR15273, 1 hit
PfamiView protein in Pfam
PF03045 DAN, 1 hit
PIRSFiPIRSF027807 Cerberus, 1 hit
SMARTiView protein in SMART
SM00041 CT, 1 hit
PROSITEiView protein in PROSITE
PS01225 CTCK_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9PWB0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLLLLQLLV LSCLGDTEPQ PDSQQRKRRP LQHLFYLDRN LLESQSFHEL
60 70 80 90 100
VGENPVGVKE TQEEPSFFIA FPQTAGESQK QGEKKMSRFI LPNAELYAHQ
110 120 130 140 150
DLRTWAAPKE ISPVENFSPS YYSNKRDVEP PYRKDAKKFW DHFMLRKNSA
160 170 180 190 200
SEEVVLPIKT NEMHQETCRT LPFSQSVAHE SCEKVIVQNN LCFGKCSSFH
210 220 230 240 250
VPGPDDRLYT FCSKCLPTKF SMKHLDLNCT SSVPVVKKVM IVEECNCETQ
260 270
KIEDPLLGSR QSDFLGNLPE HN
Length:272
Mass (Da):31,225
Last modified:May 1, 2000 - v1
Checksum:i36E4C9F719711BCA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF139721 mRNA Translation: AAD51610.1
UniGeneiGga.355

Genome annotation databases

EnsembliENSGALT00000008725; ENSGALP00000008711; ENSGALG00000005434

Similar proteinsi

Entry informationi

Entry nameiCER1_CHICK
AccessioniPrimary (citable) accession number: Q9PWB0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: May 1, 2000
Last modified: November 22, 2017
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome