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Q9PW71

- DUS4_CHICK

UniProt

Q9PW71 - DUS4_CHICK

Protein

Dual specificity protein phosphatase 4

Gene

DUSP4

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    • Comment

    Functioni

    Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2.By similarity

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei261 – 2611Phosphocysteine intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. MAP kinase tyrosine/serine/threonine phosphatase activity Source: InterPro
    2. protein tyrosine phosphatase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Enzyme and pathway databases

    ReactomeiREACT_25273. Activated TAK1 mediates Jun kinases (JNK) phosphorylation and activation.
    REACT_25370. Activated TAK1 mediates p38 MAP kinase phosphorylation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dual specificity protein phosphatase 4 (EC:3.1.3.16, EC:3.1.3.48)
    Alternative name(s):
    Mitogen-activated protein kinase phosphatase 2
    Short name:
    MAP kinase phosphatase 2
    Short name:
    MKP-2
    Gene namesi
    Name:DUSP4
    Synonyms:MKP2
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 375375Dual specificity protein phosphatase 4PRO_0000094801Add
    BLAST

    Proteomic databases

    PaxDbiQ9PW71.

    Interactioni

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000037153.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9PW71.
    SMRiQ9PW71. Positions 174-316.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini25 – 143119RhodanesePROSITE-ProRule annotationAdd
    BLAST
    Domaini178 – 375198Tyrosine-protein phosphataseAdd
    BLAST

    Sequence similaritiesi

    Contains 1 rhodanese domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG2453.
    HOGENOMiHOG000294080.
    HOVERGENiHBG007347.
    KOiK04459.
    PhylomeDBiQ9PW71.

    Family and domain databases

    Gene3Di3.40.250.10. 1 hit.
    3.90.190.10. 1 hit.
    InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR008343. MKP.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR001763. Rhodanese-like_dom.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view]
    PANTHERiPTHR10159. PTHR10159. 1 hit.
    PfamiPF00782. DSPc. 1 hit.
    PF00581. Rhodanese. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000939. MAPK_Ptase. 1 hit.
    PRINTSiPR01764. MAPKPHPHTASE.
    SMARTiSM00195. DSPc. 1 hit.
    SM00450. RHOD. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    SSF52821. SSF52821. 1 hit.
    PROSITEiPS50206. RHODANESE_3. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9PW71-1 [UniParc]FASTAAdd to Basket

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    MVAPEGLREM EGSALRRLVG REEASGGRCL LLDCRPFLAH SAGHIRGALN    50
    VRCNTIVRRR AKGAVSLEQI LPAEGEVRAR LRAGLYTAVV LYDERSPRAE 100
    ALRDDSTVAL VLRALRRDMA RADIRLLAGG YERFASEYPE FCAKTKTLSS 150
    ISPPSSAESL DLGFSSCGTP LHDQGGPVEI LPFLYLGSAY HAARRDMLDA 200
    LGITALLNVS SDCPNHFEGH YQYKCIPVED NHKADISSWF MEAIEYIDSV 250
    KECCGRVLVH CQAGISRSAT ICLAYLMMKK RVKLEKAFEF VKQRRSIISP 300
    NFSFMGQLLQ FESQVLATSC AVEAASPSGT LRERGKATST PTSQFVFSFP 350
    VSVGVHATPS SLPYLHSPIT TSPSC 375
    Length:375
    Mass (Da):41,052
    Last modified:May 1, 2000 - v1
    Checksum:i179290D0C2BEEEF1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF167296 mRNA. Translation: AAD46656.1.
    RefSeqiNP_990169.1. NM_204838.1.
    UniGeneiGga.385.

    Genome annotation databases

    GeneIDi395642.
    KEGGigga:395642.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF167296 mRNA. Translation: AAD46656.1 .
    RefSeqi NP_990169.1. NM_204838.1.
    UniGenei Gga.385.

    3D structure databases

    ProteinModelPortali Q9PW71.
    SMRi Q9PW71. Positions 174-316.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000037153.

    Proteomic databases

    PaxDbi Q9PW71.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 395642.
    KEGGi gga:395642.

    Organism-specific databases

    CTDi 1846.

    Phylogenomic databases

    eggNOGi COG2453.
    HOGENOMi HOG000294080.
    HOVERGENi HBG007347.
    KOi K04459.
    PhylomeDBi Q9PW71.

    Enzyme and pathway databases

    Reactomei REACT_25273. Activated TAK1 mediates Jun kinases (JNK) phosphorylation and activation.
    REACT_25370. Activated TAK1 mediates p38 MAP kinase phosphorylation.

    Miscellaneous databases

    NextBioi 20815715.
    PROi Q9PW71.

    Family and domain databases

    Gene3Di 3.40.250.10. 1 hit.
    3.90.190.10. 1 hit.
    InterProi IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR008343. MKP.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR001763. Rhodanese-like_dom.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view ]
    PANTHERi PTHR10159. PTHR10159. 1 hit.
    Pfami PF00782. DSPc. 1 hit.
    PF00581. Rhodanese. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000939. MAPK_Ptase. 1 hit.
    PRINTSi PR01764. MAPKPHPHTASE.
    SMARTi SM00195. DSPc. 1 hit.
    SM00450. RHOD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    SSF52821. SSF52821. 1 hit.
    PROSITEi PS50206. RHODANESE_3. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of genes upregulated in cells transformed by v-Jun."
      Fu S.-L., Waha A., Vogt P.K.
      Oncogene 19:3537-3545(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: White leghorn.

    Entry informationi

    Entry nameiDUS4_CHICK
    AccessioniPrimary (citable) accession number: Q9PW71
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2001
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3