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Q9PW71

- DUS4_CHICK

UniProt

Q9PW71 - DUS4_CHICK

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Protein

Dual specificity protein phosphatase 4

Gene

DUSP4

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2.By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei261 – 2611Phosphocysteine intermediatePROSITE-ProRule annotation

GO - Molecular functioni

  1. MAP kinase tyrosine/serine/threonine phosphatase activity Source: InterPro
  2. protein tyrosine phosphatase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Enzyme and pathway databases

ReactomeiREACT_25273. Activated TAK1 mediates Jun kinases (JNK) phosphorylation and activation.
REACT_25370. Activated TAK1 mediates p38 MAP kinase phosphorylation.

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity protein phosphatase 4 (EC:3.1.3.16, EC:3.1.3.48)
Alternative name(s):
Mitogen-activated protein kinase phosphatase 2
Short name:
MAP kinase phosphatase 2
Short name:
MKP-2
Gene namesi
Name:DUSP4
Synonyms:MKP2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 375375Dual specificity protein phosphatase 4PRO_0000094801Add
BLAST

Proteomic databases

PaxDbiQ9PW71.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000037153.

Structurei

3D structure databases

ProteinModelPortaliQ9PW71.
SMRiQ9PW71. Positions 174-316.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 143119RhodanesePROSITE-ProRule annotationAdd
BLAST
Domaini178 – 375198Tyrosine-protein phosphataseAdd
BLAST

Sequence similaritiesi

Contains 1 rhodanese domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG2453.
HOGENOMiHOG000294080.
HOVERGENiHBG007347.
InParanoidiQ9PW71.
KOiK04459.
PhylomeDBiQ9PW71.

Family and domain databases

Gene3Di3.40.250.10. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR008343. MKP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR001763. Rhodanese-like_dom.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
PF00581. Rhodanese. 1 hit.
[Graphical view]
PIRSFiPIRSF000939. MAPK_Ptase. 1 hit.
PRINTSiPR01764. MAPKPHPHTASE.
SMARTiSM00195. DSPc. 1 hit.
SM00450. RHOD. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
SSF52821. SSF52821. 1 hit.
PROSITEiPS50206. RHODANESE_3. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9PW71-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVAPEGLREM EGSALRRLVG REEASGGRCL LLDCRPFLAH SAGHIRGALN
60 70 80 90 100
VRCNTIVRRR AKGAVSLEQI LPAEGEVRAR LRAGLYTAVV LYDERSPRAE
110 120 130 140 150
ALRDDSTVAL VLRALRRDMA RADIRLLAGG YERFASEYPE FCAKTKTLSS
160 170 180 190 200
ISPPSSAESL DLGFSSCGTP LHDQGGPVEI LPFLYLGSAY HAARRDMLDA
210 220 230 240 250
LGITALLNVS SDCPNHFEGH YQYKCIPVED NHKADISSWF MEAIEYIDSV
260 270 280 290 300
KECCGRVLVH CQAGISRSAT ICLAYLMMKK RVKLEKAFEF VKQRRSIISP
310 320 330 340 350
NFSFMGQLLQ FESQVLATSC AVEAASPSGT LRERGKATST PTSQFVFSFP
360 370
VSVGVHATPS SLPYLHSPIT TSPSC
Length:375
Mass (Da):41,052
Last modified:May 1, 2000 - v1
Checksum:i179290D0C2BEEEF1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF167296 mRNA. Translation: AAD46656.1.
RefSeqiNP_990169.1. NM_204838.1.
UniGeneiGga.385.

Genome annotation databases

GeneIDi395642.
KEGGigga:395642.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF167296 mRNA. Translation: AAD46656.1 .
RefSeqi NP_990169.1. NM_204838.1.
UniGenei Gga.385.

3D structure databases

ProteinModelPortali Q9PW71.
SMRi Q9PW71. Positions 174-316.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000037153.

Proteomic databases

PaxDbi Q9PW71.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 395642.
KEGGi gga:395642.

Organism-specific databases

CTDi 1846.

Phylogenomic databases

eggNOGi COG2453.
HOGENOMi HOG000294080.
HOVERGENi HBG007347.
InParanoidi Q9PW71.
KOi K04459.
PhylomeDBi Q9PW71.

Enzyme and pathway databases

Reactomei REACT_25273. Activated TAK1 mediates Jun kinases (JNK) phosphorylation and activation.
REACT_25370. Activated TAK1 mediates p38 MAP kinase phosphorylation.

Miscellaneous databases

NextBioi 20815715.
PROi Q9PW71.

Family and domain databases

Gene3Di 3.40.250.10. 1 hit.
3.90.190.10. 1 hit.
InterProi IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR008343. MKP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR001763. Rhodanese-like_dom.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view ]
PANTHERi PTHR10159. PTHR10159. 1 hit.
Pfami PF00782. DSPc. 1 hit.
PF00581. Rhodanese. 1 hit.
[Graphical view ]
PIRSFi PIRSF000939. MAPK_Ptase. 1 hit.
PRINTSi PR01764. MAPKPHPHTASE.
SMARTi SM00195. DSPc. 1 hit.
SM00450. RHOD. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 1 hit.
SSF52821. SSF52821. 1 hit.
PROSITEi PS50206. RHODANESE_3. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification and characterization of genes upregulated in cells transformed by v-Jun."
    Fu S.-L., Waha A., Vogt P.K.
    Oncogene 19:3537-3545(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: White leghorn.

Entry informationi

Entry nameiDUS4_CHICK
AccessioniPrimary (citable) accession number: Q9PW71
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3