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Protein

Dual specificity protein phosphatase 4

Gene

DUSP4

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2.By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei261Phosphocysteine intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Enzyme and pathway databases

ReactomeiR-GGA-437980. Activated TAK1 mediates p38 MAP kinase phosphorylation.
R-GGA-437986. Activated TAK1 mediates Jun kinases (JNK) phosphorylation and activation.

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity protein phosphatase 4 (EC:3.1.3.16By similarity, EC:3.1.3.48By similarity)
Alternative name(s):
Mitogen-activated protein kinase phosphatase 2
Short name:
MAP kinase phosphatase 2
Short name:
MKP-2
Gene namesi
Name:DUSP4
Synonyms:MKP2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

  • Nucleus By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000948011 – 375Dual specificity protein phosphatase 4Add BLAST375

Proteomic databases

PaxDbiQ9PW71.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000018606.

Structurei

3D structure databases

ProteinModelPortaliQ9PW71.
SMRiQ9PW71.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 143RhodanesePROSITE-ProRule annotationAdd BLAST119
Domaini178 – 375Tyrosine-protein phosphataseAdd BLAST198

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1716. Eukaryota.
COG2453. LUCA.
HOGENOMiHOG000294080.
HOVERGENiHBG007347.
InParanoidiQ9PW71.
KOiK04459.
PhylomeDBiQ9PW71.

Family and domain databases

CDDicd00127. DSPc. 1 hit.
Gene3Di3.40.250.10. 1 hit.
3.90.190.10. 1 hit.
InterProiView protein in InterPro
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR024950. DUSP.
IPR008343. MKP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR001763. Rhodanese-like_dom.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
IPR020422. TYR_PHOSPHATASE_DUAL_dom.
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiView protein in Pfam
PF00782. DSPc. 1 hit.
PF00581. Rhodanese. 1 hit.
PIRSFiPIRSF000939. MAPK_Ptase. 1 hit.
PRINTSiPR01764. MAPKPHPHTASE.
SMARTiView protein in SMART
SM00195. DSPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
SM00450. RHOD. 1 hit.
SUPFAMiSSF52799. SSF52799. 1 hit.
SSF52821. SSF52821. 1 hit.
PROSITEiView protein in PROSITE
PS50206. RHODANESE_3. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9PW71-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVAPEGLREM EGSALRRLVG REEASGGRCL LLDCRPFLAH SAGHIRGALN
60 70 80 90 100
VRCNTIVRRR AKGAVSLEQI LPAEGEVRAR LRAGLYTAVV LYDERSPRAE
110 120 130 140 150
ALRDDSTVAL VLRALRRDMA RADIRLLAGG YERFASEYPE FCAKTKTLSS
160 170 180 190 200
ISPPSSAESL DLGFSSCGTP LHDQGGPVEI LPFLYLGSAY HAARRDMLDA
210 220 230 240 250
LGITALLNVS SDCPNHFEGH YQYKCIPVED NHKADISSWF MEAIEYIDSV
260 270 280 290 300
KECCGRVLVH CQAGISRSAT ICLAYLMMKK RVKLEKAFEF VKQRRSIISP
310 320 330 340 350
NFSFMGQLLQ FESQVLATSC AVEAASPSGT LRERGKATST PTSQFVFSFP
360 370
VSVGVHATPS SLPYLHSPIT TSPSC
Length:375
Mass (Da):41,052
Last modified:May 1, 2000 - v1
Checksum:i179290D0C2BEEEF1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF167296 mRNA. Translation: AAD46656.1.
RefSeqiNP_990169.1. NM_204838.1.
UniGeneiGga.385.

Genome annotation databases

GeneIDi395642.
KEGGigga:395642.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiDUS4_CHICK
AccessioniPrimary (citable) accession number: Q9PW71
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 1, 2000
Last modified: March 15, 2017
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families