Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9PW71 (DUS4_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dual specificity protein phosphatase 4

EC=3.1.3.16
EC=3.1.3.48
Alternative name(s):
Mitogen-activated protein kinase phosphatase 2
Short name=MAP kinase phosphatase 2
Short name=MKP-2
Gene names
Name:DUSP4
Synonyms:MKP2
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length375 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2 By similarity.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

Contains 1 rhodanese domain.

Contains 1 tyrosine-protein phosphatase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 375375Dual specificity protein phosphatase 4
PRO_0000094801

Regions

Domain25 – 143119Rhodanese
Domain178 – 375198Tyrosine-protein phosphatase

Sites

Active site2611Phosphocysteine intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9PW71 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 179290D0C2BEEEF1

FASTA37541,052
        10         20         30         40         50         60 
MVAPEGLREM EGSALRRLVG REEASGGRCL LLDCRPFLAH SAGHIRGALN VRCNTIVRRR 

        70         80         90        100        110        120 
AKGAVSLEQI LPAEGEVRAR LRAGLYTAVV LYDERSPRAE ALRDDSTVAL VLRALRRDMA 

       130        140        150        160        170        180 
RADIRLLAGG YERFASEYPE FCAKTKTLSS ISPPSSAESL DLGFSSCGTP LHDQGGPVEI 

       190        200        210        220        230        240 
LPFLYLGSAY HAARRDMLDA LGITALLNVS SDCPNHFEGH YQYKCIPVED NHKADISSWF 

       250        260        270        280        290        300 
MEAIEYIDSV KECCGRVLVH CQAGISRSAT ICLAYLMMKK RVKLEKAFEF VKQRRSIISP 

       310        320        330        340        350        360 
NFSFMGQLLQ FESQVLATSC AVEAASPSGT LRERGKATST PTSQFVFSFP VSVGVHATPS 

       370 
SLPYLHSPIT TSPSC 

« Hide

References

[1]"Identification and characterization of genes upregulated in cells transformed by v-Jun."
Fu S.-L., Waha A., Vogt P.K.
Oncogene 19:3537-3545(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: White leghorn.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF167296 mRNA. Translation: AAD46656.1.
RefSeqNP_990169.1. NM_204838.1.
UniGeneGga.385.

3D structure databases

ProteinModelPortalQ9PW71.
SMRQ9PW71. Positions 174-316.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000037153.

Proteomic databases

PaxDbQ9PW71.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID395642.
KEGGgga:395642.

Organism-specific databases

CTD1846.

Phylogenomic databases

eggNOGCOG2453.
HOGENOMHOG000294080.
HOVERGENHBG007347.
KOK04459.
PhylomeDBQ9PW71.

Family and domain databases

Gene3D3.40.250.10. 1 hit.
InterProIPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR008343. MKP.
IPR001763. Rhodanese-like_dom.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PANTHERPTHR10159. PTHR10159. 1 hit.
PfamPF00782. DSPc. 1 hit.
PF00581. Rhodanese. 1 hit.
[Graphical view]
PIRSFPIRSF000939. MAPK_Ptase. 1 hit.
PRINTSPR01764. MAPKPHPHTASE.
SMARTSM00195. DSPc. 1 hit.
SM00450. RHOD. 1 hit.
[Graphical view]
SUPFAMSSF52821. SSF52821. 1 hit.
PROSITEPS50206. RHODANESE_3. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20815715.
PROQ9PW71.

Entry information

Entry nameDUS4_CHICK
AccessionPrimary (citable) accession number: Q9PW71
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 1, 2000
Last modified: April 16, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families