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Protein

Voltage-dependent N-type calcium channel subunit alpha

Gene

CACHA1B

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Calcium channelUniRule annotation, Ion channel, Voltage-gated channelUniRule annotation

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent N-type calcium channel subunit alphaUniRule annotation
Gene namesi
Name:CACHA1BImported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus

Subcellular locationi

  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei89 – 106HelicalSequence analysisAdd BLAST18
Transmembranei127 – 148HelicalSequence analysisAdd BLAST22
Transmembranei160 – 180HelicalSequence analysisAdd BLAST21
Transmembranei215 – 237HelicalSequence analysisAdd BLAST23
Transmembranei291 – 312HelicalSequence analysisAdd BLAST22
Transmembranei324 – 346HelicalSequence analysisAdd BLAST23
Transmembranei489 – 509HelicalSequence analysisAdd BLAST21
Transmembranei515 – 532HelicalSequence analysisAdd BLAST18
Transmembranei614 – 636HelicalSequence analysisAdd BLAST23
Transmembranei692 – 714HelicalSequence analysisAdd BLAST23
Transmembranei1158 – 1177HelicalSequence analysisAdd BLAST20
Transmembranei1197 – 1218HelicalSequence analysisAdd BLAST22
Transmembranei1230 – 1248HelicalSequence analysisAdd BLAST19
Transmembranei1291 – 1313HelicalSequence analysisAdd BLAST23
Transmembranei1403 – 1428HelicalSequence analysisAdd BLAST26
Transmembranei1484 – 1502HelicalSequence analysisAdd BLAST19
Transmembranei1514 – 1540HelicalSequence analysisAdd BLAST27
Transmembranei1607 – 1625HelicalSequence analysisAdd BLAST19
Transmembranei1695 – 1719HelicalSequence analysisAdd BLAST25

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ9PW46.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000013765.

Structurei

3D structure databases

ProteinModelPortaliQ9PW46.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1857 – 1891Ca_chan_IQInterPro annotationAdd BLAST35

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili723 – 750Sequence analysisAdd BLAST28
Coiled coili1010 – 1033Sequence analysisAdd BLAST24

Sequence similaritiesi

Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG2301. Eukaryota.
ENOG410XNP6. LUCA.
HOGENOMiHOG000231530.
HOVERGENiHBG050763.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR031649. GPHH_dom.
IPR005821. Ion_trans_dom.
IPR014873. VDCC_a1su_IQ.
IPR005447. VDCC_N_a1su.
IPR002077. VDCCAlpha1.
[Graphical view]
PANTHERiPTHR10037:SF161. PTHR10037:SF161. 3 hits.
PfamiPF08763. Ca_chan_IQ. 1 hit.
PF16905. GPHH. 1 hit.
PF00520. Ion_trans. 4 hits.
[Graphical view]
PRINTSiPR00167. CACHANNEL.
PR01631. NVDCCALPHA1.
SMARTiSM01062. Ca_chan_IQ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9PW46-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARFGDDLPT RYGGGGPAGA GRGSSRQGGP QAGQRMYKQS MAQRARTMAL
60 70 80 90 100
YNPIPVKQNC FTVNRSLFIF SEDNVIRKYA KRITEWPPFE YMILATIIAN
110 120 130 140 150
CIVLALEQHL PDGDKTPMSE RLDDTEPYFI GIFCFEAGIK IIALGFVFHK
160 170 180 190 200
GSYLRNGWNV MDFVVVLTGI LATAGTDFDL RTLRAVRVLR PLKLVSGIPS
210 220 230 240 250
LQVVLKSIMK AMVPLLQIGL LLFFAIVMFA IIGLEFYMGK FHKTCFSNKT
260 270 280 290 300
GEEVGDFPCG EEPPARQCES GTTCREYWQG PNYGITNFDN ILFAVLTVFQ
310 320 330 340 350
CITMEGWTDI LYNTNDAAGN TWNWLYFIPL IIIGSFFMLN LVLGVLSGEF
360 370 380 390 400
AKERERVENR RAFLKLRRQQ QIERELNGYL EWIFKAEEVM LAEEDKNAEE
410 420 430 440 450
KSPLDGRAAS EGPIQQGTAP AETSSGSSYN MLKRAAIKKS KNDLIHAEEG
460 470 480 490 500
SPFARASLKS GKNESSSYFR RKEKMFRFFI RRMVKAQSFY WIVLCVVALN
510 520 530 540 550
TLCVAMVHYD QPEKLTTALY FAEFVFLGLF LTEMSLKMYG LGPRNYFHSS
560 570 580 590 600
FNYFDFGVIV GSIFEVIWAA VKPGTSFGIS VLRALRLLRI FKVTKYWNSL
610 620 630 640 650
RNLVVSLLNS MKSIISLLFL LFLFIVVFAL LGMQLFGGQF NFRDETPTTN
660 670 680 690 700
FDTFPAAILT VFQILTGEDW NAVMYHGIES QGGVHSGMFS SIYFIVLTLF
710 720 730 740 750
GNYTLLNVFL AIAVDNLANA QELTKDEEEM EEATNQKLAL QKAKEVAEVS
760 770 780 790 800
PMSAANISIA AKQQNSSKSK SVWEQRTSQI RMHNFRASCE ALYNELDPEE
810 820 830 840 850
RVRYATTLHI RPDMKTHLDR PLVVEPRGEG RNNISKLSPV DVQEVEQTKV
860 870 880 890 900
SSTDGAEAPR KHHRHRDKEK LGEQEKGDVT KDENGESGIN NKEERHRQHR
910 920 930 940 950
SRSKEVEGGS KEGKSDRSRG QEGGKRHHRR GSVEEGVEKE HRRHRTHRHS
960 970 980 990 1000
AERQGKEGNG TINGARSERR TRHRGGSRSG NREGEPGSKG ENGEEPHRRH
1010 1020 1030 1040 1050
RFRSRALSTY DSVEKENREK EGETAEKEHQ NHQPKENQCE IEASGSVSIP
1060 1070 1080 1090 1100
VHTLPSTYLQ KVPEQPEDAD NQKNVTRMIQ PPLDKTTTVN IPVTITAPPG
1110 1120 1130 1140 1150
ETTVIPMNNV EFESKTEEKK DVDDLTKNGP KPILPYSSMF ILSPTNPIRR
1160 1170 1180 1190 1200
LFHYIVNLRY FEMVILIVIA LSSIALAAED PVQAESPRND ALKYLDYIFT
1210 1220 1230 1240 1250
GVFTFEMVIK MIDLGLLLHP GSYFRDLWNI LDFIVVSGAL VAFAFSGTKG
1260 1270 1280 1290 1300
KDINTIKSLR VLRVLRPLKT IKRLPKLKAV FDCVVNSLKN VLNILIVYML
1310 1320 1330 1340 1350
FMFIFAVIAV QLFKGRFFYC TDESKELEKD CRGQYLDYEK NEVEAQPREW
1360 1370 1380 1390 1400
KKYEFHYDNV LWALLTLFTV STGEGWPTVL KHSVDATYEE QGPSPGYRME
1410 1420 1430 1440 1450
MSIFYVVYFV VFPFFFVNIF VALIIITFQE QGDKVMSECS LEKNERACID
1460 1470 1480 1490 1500
FAISAKPLTR YMPQNKQSFQ YKMWKFVVSP PFEYFIMVMI ALNTIVLMMK
1510 1520 1530 1540 1550
FYDAPEAYEE MLKCLNIVFT SMFSMECVLK IIAFGVLNYF RDAWNVFDFV
1560 1570 1580 1590 1600
TVLGSITDIL VTEIADTDNF INLSFLRLFR AARLIKLLRQ GYTIRILLWT
1610 1620 1630 1640 1650
FVQSFKALPY VCLLIAMLFF IYAIIGMQVF GNIALNDETS INRHNNFRTF
1660 1670 1680 1690 1700
LQALMLLFRS ATGEAWHEIM LSCLSNRACD PLSGLTKNEC GSDFAYFYFV
1710 1720 1730 1740 1750
SFIFLCSFLM LNLFVAVIMD NFEYLTRDSS ILGPHHLDEF VRVWAEYDPA
1760 1770 1780 1790 1800
ACCRIHYKDM YNLLRVIAPP LGLGKKCPHR VAYKRLVRMN MPISPEDLTV
1810 1820 1830 1840 1850
HFTSTLMALI RTALEIKLAS GGVKQHQCDA ELRKEISLVW PNLSQKTLDL
1860 1870 1880 1890 1900
LVPPHKPDEM TVGKVYAALM IFDFYKQNKS SREQVHQPPG GLCQPGPVSL
1910 1920 1930 1940 1950
FHPLKATLEQ TQPSAFSSAK AFLRQKSSAS LNNGGTLPAP EGGIKESSSW
1960 1970 1980 1990 2000
GTQRTQDVFY ETRTPAFERG HSEEIPIERV VEMREISPTL ANGEHQPGLE
2010 2020 2030 2040 2050
SQGRAASMPR LAAETQRSKA RSPGSYLAPI PDTSPMKRSI STLTPQRPHP
2060 2070 2080 2090 2100
MHLYEYSLER VPTDQVHHHH HHRCHRRKEK KQKSLDRTTH QLADGEAVAQ
2110 2120 2130 2140 2150
SGESSSKDKK QERGRSQERK QHSSSSSEKQ RFYSCDRYGS RDRSQPKSAD
2160 2170
QSRPTSPNGG PEQGPHRQWF G
Length:2,171
Mass (Da):247,057
Last modified:May 1, 2000 - v1
Checksum:i4023DD3D1AFA7EC3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF173017 mRNA. Translation: AAD51820.1.
UniGeneiGga.4317.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF173017 mRNA. Translation: AAD51820.1.
UniGeneiGga.4317.

3D structure databases

ProteinModelPortaliQ9PW46.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000013765.

Proteomic databases

PaxDbiQ9PW46.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG2301. Eukaryota.
ENOG410XNP6. LUCA.
HOGENOMiHOG000231530.
HOVERGENiHBG050763.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR031649. GPHH_dom.
IPR005821. Ion_trans_dom.
IPR014873. VDCC_a1su_IQ.
IPR005447. VDCC_N_a1su.
IPR002077. VDCCAlpha1.
[Graphical view]
PANTHERiPTHR10037:SF161. PTHR10037:SF161. 3 hits.
PfamiPF08763. Ca_chan_IQ. 1 hit.
PF16905. GPHH. 1 hit.
PF00520. Ion_trans. 4 hits.
[Graphical view]
PRINTSiPR00167. CACHANNEL.
PR01631. NVDCCALPHA1.
SMARTiSM01062. Ca_chan_IQ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ9PW46_CHICK
AccessioniPrimary (citable) accession number: Q9PW46
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: October 5, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.