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Protein

Voltage-dependent N-type calcium channel subunit alpha

Gene

CACHA1B

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Calcium channelUniRule annotation, Ion channel, Voltage-gated channelUniRule annotationSAAS annotation

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent N-type calcium channel subunit alphaUniRule annotation
Gene namesi
Name:CACHA1BImported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus

Subcellular locationi

  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei89 – 10618HelicalSequence analysisAdd
BLAST
Transmembranei127 – 14822HelicalSequence analysisAdd
BLAST
Transmembranei160 – 18021HelicalSequence analysisAdd
BLAST
Transmembranei215 – 23723HelicalSequence analysisAdd
BLAST
Transmembranei291 – 31222HelicalSequence analysisAdd
BLAST
Transmembranei324 – 34623HelicalSequence analysisAdd
BLAST
Transmembranei475 – 49521HelicalSequence analysisAdd
BLAST
Transmembranei501 – 51818HelicalSequence analysisAdd
BLAST
Transmembranei600 – 62223HelicalSequence analysisAdd
BLAST
Transmembranei678 – 70023HelicalSequence analysisAdd
BLAST
Transmembranei1144 – 116320HelicalSequence analysisAdd
BLAST
Transmembranei1183 – 120422HelicalSequence analysisAdd
BLAST
Transmembranei1216 – 123419HelicalSequence analysisAdd
BLAST
Transmembranei1277 – 129923HelicalSequence analysisAdd
BLAST
Transmembranei1389 – 141426HelicalSequence analysisAdd
BLAST
Transmembranei1470 – 148819HelicalSequence analysisAdd
BLAST
Transmembranei1500 – 152627HelicalSequence analysisAdd
BLAST
Transmembranei1593 – 161119HelicalSequence analysisAdd
BLAST
Transmembranei1681 – 170525HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ9PW45.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000013765.

Structurei

3D structure databases

ProteinModelPortaliQ9PW45.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1843 – 187735Ca_chan_IQInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili709 – 73628Sequence analysisAdd
BLAST
Coiled coili996 – 101924Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG2301. Eukaryota.
ENOG410XNP6. LUCA.
HOGENOMiHOG000231530.
HOVERGENiHBG050763.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR031649. GPHH_dom.
IPR005821. Ion_trans_dom.
IPR014873. VDCC_a1su_IQ.
IPR005447. VDCC_N_a1su.
IPR002077. VDCCAlpha1.
[Graphical view]
PANTHERiPTHR10037:SF161. PTHR10037:SF161. 3 hits.
PfamiPF08763. Ca_chan_IQ. 1 hit.
PF16905. GPHH. 1 hit.
PF00520. Ion_trans. 4 hits.
[Graphical view]
PRINTSiPR00167. CACHANNEL.
PR01631. NVDCCALPHA1.
SMARTiSM01062. Ca_chan_IQ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9PW45-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARFGDDLPT RYGGGGPAGA GRGSSRQGGP QAGQRMYKQS MAQRARTMAL
60 70 80 90 100
YNPIPVKQNC FTVNRSLFIF SEDNVIRKYA KRITEWPPFE YMILATIIAN
110 120 130 140 150
CIVLALEQHL PDGDKTPMSE RLDDTEPYFI GIFCFEAGIK IIALGFVFHK
160 170 180 190 200
GSYLRNGWNV MDFVVVLTGI LATAGTDFDL RTLRAVRVLR PLKLVSGIPS
210 220 230 240 250
LQVVLKSIMK AMVPLLQIGL LLFFAIVMFA IIGLEFYMGK FHKTCFSNKT
260 270 280 290 300
GEEVGDFPCG EEPPARQCES GTTCREYWQG PNYGITNFDN ILFAVLTVFQ
310 320 330 340 350
CITMEGWTDI LYNTNDAAGN TWNWLYFIPL IIIGSFFMLN LVLGVLSGEF
360 370 380 390 400
AKERERVENR RAFLKLRRQQ QIERELNGYL EWIFKAEEVM LAEEDKNAEE
410 420 430 440 450
KSPLDMLKRA AIKKSKNDLI HAEEGEDHFT DICSVGSPFA RASLKSGKNE
460 470 480 490 500
SSSYFRRKEK MFRFFIRRMV KAQSFYWIVL CVVALNTLCV AMVHYDQPEK
510 520 530 540 550
LTTALYFAEF VFLGLFLTEM SLKMYGLGPR NYFHSSFNYF DFGVIVGSIF
560 570 580 590 600
EVIWAAVKPG TSFGISVLRA LRLLRIFKVT KYWNSLRNLV VSLLNSMKSI
610 620 630 640 650
ISLLFLLFLF IVVFALLGMQ LFGGQFNFRD ETPTTNFDTF PAAILTVFQI
660 670 680 690 700
LTGEDWNAVM YHGIESQGGV HSGMFSSIYF IVLTLFGNYT LLNVFLAIAV
710 720 730 740 750
DNLANAQELT KDEEEMEEAT NQKLALQKAK EVAEVSPMSA ANISIAAKQQ
760 770 780 790 800
NSSKSKSVWE QRTSQIRMHN FRASCEALYN ELDPEERVRY ATTLHIRPDM
810 820 830 840 850
KTHLDRPLVV EPRGEGRNNI SKLSPVDVQE VEQTKVSSTD GAEAPRKHHR
860 870 880 890 900
HRDKEKLGEQ EKGDVTKDEN GESGINNKEE RHRQHRSRSK EVEGGSKEGK
910 920 930 940 950
SDRSRGQEGG KRHHRRGSVE EGVEKEHRRH RTHRHSAERQ GKEGNGTING
960 970 980 990 1000
ARSERRTRHR GGSRSGNREG EPGSKGENGE EPHRRHRFRS RALSTYDSVE
1010 1020 1030 1040 1050
KENREKEGET AEKEHQNHQP KENQCEIEAS GSVSIPVHTL PSTYLQKVPE
1060 1070 1080 1090 1100
QPEDADNQKN VTRMIQPPLD KTTTVNIPVT ITAPPGETTV IPMNNVEFES
1110 1120 1130 1140 1150
KTEEKKDVDD LTKNGPKPIL PYSSMFILSP TNPIRRLFHY IVNLRYFEMV
1160 1170 1180 1190 1200
ILIVIALSSI ALAAEDPVQA ESPRNDALKY LDYIFTGVFT FEMVIKMIDL
1210 1220 1230 1240 1250
GLLLHPGSYF RDLWNILDFI VVSGALVAFA FSGTKGKDIN TIKSLRVLRV
1260 1270 1280 1290 1300
LRPLKTIKRL PKLKAVFDCV VNSLKNVLNI LIVYMLFMFI FAVIAVQLFK
1310 1320 1330 1340 1350
GRFFYCTDES KELEKDCRGQ YLDYEKNEVE AQPREWKKYE FHYDNVLWAL
1360 1370 1380 1390 1400
LTLFTVSTGE GWPTVLKHSV DATYEEQGPS PGYRMEMSIF YVVYFVVFPF
1410 1420 1430 1440 1450
FFVNIFVALI IITFQEQGDK VMSECSLEKN ERACIDFAIS AKPLTRYMPQ
1460 1470 1480 1490 1500
NKQSFQYKMW KFVVSPPFEY FIMVMIALNT IVLMMKFYDA PEAYEEMLKC
1510 1520 1530 1540 1550
LNIVFTSMFS MECVLKIIAF GVLNYFRDAW NVFDFVTVLG SITDILVTEI
1560 1570 1580 1590 1600
ADTDNFINLS FLRLFRAARL IKLLRQGYTI RILLWTFVQS FKALPYVCLL
1610 1620 1630 1640 1650
IAMLFFIYAI IGMQVFGNIA LNDETSINRH NNFRTFLQAL MLLFRSATGE
1660 1670 1680 1690 1700
AWHEIMLSCL SNRACDPLSG LTKNECGSDF AYFYFVSFIF LCSFLMLNLF
1710 1720 1730 1740 1750
VAVIMDNFEY LTRDSSILGP HHLDEFVRVW AEYDPAACCR IHYKDMYNLL
1760 1770 1780 1790 1800
RVIAPPLGLG KKCPHRVAYK RLVRMNMPIS PEDLTVHFTS TLMALIRTAL
1810 1820 1830 1840 1850
EIKLASGGVK QHQCDAELRK EISLVWPNLS QKTLDLLVPP HKPDEMTVGK
1860 1870 1880 1890 1900
VYAALMIFDF YKQNKSSREQ VHQPPGGLCQ PGPVSLFHPL KATLEQTQPS
1910 1920 1930 1940 1950
AFSSAKAFLR QKSSASLNNG GTLPAPEGGI KESSSWGTQR TQDVFYETRT
1960 1970 1980 1990 2000
PAFERGHSEE IPIERVVEMR EISPTLANGE HQPGLESQGR AASMPRLAAE
2010 2020 2030 2040 2050
TQRSKARSPG SYLAPIPDTS PMKRSISTLT PQRPHPMHLY EYSLERVPTD
2060 2070 2080 2090 2100
QVHHHHHHRC HRRKEKKQKS LDRTTHQLAD GEAVAQSGES SSKDKKQERG
2110 2120 2130 2140 2150
RSQERKQHSS SSSEKQRFYS CDRYGSRDRS QPKSADQSRP TSPNGGPEQG
2160 2170 2180 2190 2200
PHRQGSGSVN GSPLLSTSGA STPCRGRRQL PQTPLTPRPS ITYKTANSSP
2210 2220 2230 2240 2250
VHFSTSPGGL PPFSPGRLSR GLSEHNALLR GDQQPPPAAV ARIGSDPYLG
2260 2270 2280 2290 2300
HRDAADSPIG AAPEDTLTFE EAVATNSGRS SRTSYVSSLT SQSHQARRVP
2310 2320 2330
NGYHYTLGLN TGPGTGTRGR SYYHEADEDD WC
Length:2,332
Mass (Da):264,178
Last modified:May 1, 2000 - v1
Checksum:iECB13B79544F0594
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF173018 mRNA. Translation: AAD51821.1.
UniGeneiGga.4317.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF173018 mRNA. Translation: AAD51821.1.
UniGeneiGga.4317.

3D structure databases

ProteinModelPortaliQ9PW45.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000013765.

Proteomic databases

PaxDbiQ9PW45.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG2301. Eukaryota.
ENOG410XNP6. LUCA.
HOGENOMiHOG000231530.
HOVERGENiHBG050763.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR031649. GPHH_dom.
IPR005821. Ion_trans_dom.
IPR014873. VDCC_a1su_IQ.
IPR005447. VDCC_N_a1su.
IPR002077. VDCCAlpha1.
[Graphical view]
PANTHERiPTHR10037:SF161. PTHR10037:SF161. 3 hits.
PfamiPF08763. Ca_chan_IQ. 1 hit.
PF16905. GPHH. 1 hit.
PF00520. Ion_trans. 4 hits.
[Graphical view]
PRINTSiPR00167. CACHANNEL.
PR01631. NVDCCALPHA1.
SMARTiSM01062. Ca_chan_IQ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ9PW45_CHICK
AccessioniPrimary (citable) accession number: Q9PW45
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.