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Q9PVY6

- PSA7A_XENLA

UniProt

Q9PVY6 - PSA7A_XENLA

Protein

Proteasome subunit alpha type-7-A

Gene

psma7-a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

    Catalytic activityi

    Cleavage of peptide bonds with very broad specificity.PROSITE-ProRule annotation

    GO - Molecular functioni

    1. threonine-type endopeptidase activity Source: UniProtKB-KW

    GO - Biological processi

    1. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Threonine protease

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Proteasome subunit alpha type-7-A (EC:3.4.25.1)
    Alternative name(s):
    Proteasome subunit alpha 4-A
    Gene namesi
    Name:psma7-a
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-974602. psma7.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell
    3. proteasome core complex Source: UniProtKB
    4. proteasome core complex, alpha-subunit complex Source: InterPro

    Keywords - Cellular componenti

    Cytoplasm, Nucleus, Proteasome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 248248Proteasome subunit alpha type-7-APRO_0000124147Add
    BLAST

    Post-translational modificationi

    Phosphorylated in G2 phase.

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ9PVY6.

    Interactioni

    Subunit structurei

    The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel By similarity.By similarity

    Protein-protein interaction databases

    BioGridi98959. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9PVY6.
    SMRiQ9PVY6. Positions 2-232.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase T1A family.PROSITE-ProRule annotation

    Phylogenomic databases

    HOVERGENiHBG003005.
    KOiK02731.

    Family and domain databases

    Gene3Di3.60.20.10. 1 hit.
    InterProiIPR029055. Ntn_hydrolases_N.
    IPR000426. Proteasome_asu_N.
    IPR023332. Proteasome_suA-type.
    IPR001353. Proteasome_sua/b.
    [Graphical view]
    PfamiPF00227. Proteasome. 1 hit.
    PF10584. Proteasome_A_N. 1 hit.
    [Graphical view]
    SMARTiSM00948. Proteasome_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF56235. SSF56235. 1 hit.
    PROSITEiPS00388. PROTEASOME_ALPHA_1. 1 hit.
    PS51475. PROTEASOME_ALPHA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9PVY6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSYDRAITVF SPDGHLFQVE YAQEAVKKGS TAVGVRGKEI VVLGVEKKSV    50
    AKLQDERTVR KICALDENVF MAFAGLTADA RIVINRARVE CQSHRLTVED 100
    PVTVEYITRY IASLKQRYTQ SNGRRPFGIS ALIVGFDFDG TPRLYQTDPS 150
    GTYHAWKANA IGRGAKSVRE FLEKHYTDEA IETDDLTIKL VIKALLEVVQ 200
    SGGKNIELAV MRRDQPLKIL NPEEIERYVA EIEKEKEENE KKKQKKTT 248
    Length:248
    Mass (Da):28,036
    Last modified:May 1, 2000 - v1
    Checksum:iB62213FED11C3A60
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB004782 mRNA. Translation: BAA86962.1.
    BC084072 mRNA. Translation: AAH84072.1.
    RefSeqiNP_001081054.1. NM_001087585.1.
    UniGeneiXl.921.

    Genome annotation databases

    GeneIDi394357.
    KEGGixla:394357.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB004782 mRNA. Translation: BAA86962.1 .
    BC084072 mRNA. Translation: AAH84072.1 .
    RefSeqi NP_001081054.1. NM_001087585.1.
    UniGenei Xl.921.

    3D structure databases

    ProteinModelPortali Q9PVY6.
    SMRi Q9PVY6. Positions 2-232.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 98959. 1 interaction.

    Proteomic databases

    PRIDEi Q9PVY6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 394357.
    KEGGi xla:394357.

    Organism-specific databases

    CTDi 394357.
    Xenbasei XB-GENE-974602. psma7.

    Phylogenomic databases

    HOVERGENi HBG003005.
    KOi K02731.

    Family and domain databases

    Gene3Di 3.60.20.10. 1 hit.
    InterProi IPR029055. Ntn_hydrolases_N.
    IPR000426. Proteasome_asu_N.
    IPR023332. Proteasome_suA-type.
    IPR001353. Proteasome_sua/b.
    [Graphical view ]
    Pfami PF00227. Proteasome. 1 hit.
    PF10584. Proteasome_A_N. 1 hit.
    [Graphical view ]
    SMARTi SM00948. Proteasome_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56235. SSF56235. 1 hit.
    PROSITEi PS00388. PROTEASOME_ALPHA_1. 1 hit.
    PS51475. PROTEASOME_ALPHA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of the Xenopus 20S proteasome alpha 4 subunit which is modified in the meiotic cell cycle."
      Tokumoto M., Horiguchi R., Nagahama Y., Tokumoto T.
      Gene 239:301-308(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Ovary.
    2. NIH - Xenopus Gene Collection (XGC) project
      Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo.

    Entry informationi

    Entry nameiPSA7A_XENLA
    AccessioniPrimary (citable) accession number: Q9PVY6
    Secondary accession number(s): Q5XHI5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 8, 2000
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3