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Q9PVY6 (PSA7A_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Proteasome subunit alpha type-7-A

EC=3.4.25.1
Alternative name(s):
Proteasome subunit alpha 4-A
Gene names
Name:psma7-a
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length248 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

Catalytic activity

Cleavage of peptide bonds with very broad specificity.

Subunit structure

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Post-translational modification

Phosphorylated in G2 phase.

Sequence similarities

Belongs to the peptidase T1A family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 248248Proteasome subunit alpha type-7-A
PRO_0000124147

Sequences

Sequence LengthMass (Da)Tools
Q9PVY6 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: B62213FED11C3A60

FASTA24828,036
        10         20         30         40         50         60 
MSYDRAITVF SPDGHLFQVE YAQEAVKKGS TAVGVRGKEI VVLGVEKKSV AKLQDERTVR 

        70         80         90        100        110        120 
KICALDENVF MAFAGLTADA RIVINRARVE CQSHRLTVED PVTVEYITRY IASLKQRYTQ 

       130        140        150        160        170        180 
SNGRRPFGIS ALIVGFDFDG TPRLYQTDPS GTYHAWKANA IGRGAKSVRE FLEKHYTDEA 

       190        200        210        220        230        240 
IETDDLTIKL VIKALLEVVQ SGGKNIELAV MRRDQPLKIL NPEEIERYVA EIEKEKEENE 


KKKQKKTT 

« Hide

References

« Hide 'large scale' references
[1]"Identification of the Xenopus 20S proteasome alpha 4 subunit which is modified in the meiotic cell cycle."
Tokumoto M., Horiguchi R., Nagahama Y., Tokumoto T.
Gene 239:301-308(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Ovary.
[2]NIH - Xenopus Gene Collection (XGC) project
Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB004782 mRNA. Translation: BAA86962.1.
BC084072 mRNA. Translation: AAH84072.1.
RefSeqNP_001081054.1. NM_001087585.1.
UniGeneXl.921.

3D structure databases

ProteinModelPortalQ9PVY6.
SMRQ9PVY6. Positions 2-232.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid98959. 1 interaction.

Proteomic databases

PRIDEQ9PVY6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID394357.
KEGGxla:394357.

Organism-specific databases

CTD394357.
XenbaseXB-GENE-974602. psma7.

Phylogenomic databases

HOVERGENHBG003005.
KOK02731.

Family and domain databases

Gene3D3.60.20.10. 1 hit.
InterProIPR029055. Ntn_hydrolases_N.
IPR000426. Proteasome_asu_N.
IPR023332. Proteasome_suA-type.
IPR001353. Proteasome_sua/b.
[Graphical view]
PfamPF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
[Graphical view]
SMARTSM00948. Proteasome_A_N. 1 hit.
[Graphical view]
SUPFAMSSF56235. SSF56235. 1 hit.
PROSITEPS00388. PROTEASOME_ALPHA_1. 1 hit.
PS51475. PROTEASOME_ALPHA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePSA7A_XENLA
AccessionPrimary (citable) accession number: Q9PVY6
Secondary accession number(s): Q5XHI5
Entry history
Integrated into UniProtKB/Swiss-Prot: December 8, 2000
Last sequence update: May 1, 2000
Last modified: June 11, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries