Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Complement component C8 beta chain

Gene

c8b

Organism
Paralichthys olivaceus (Bastard halibut) (Hippoglossus olivaceus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Complement alternate pathway, Complement pathway, Cytolysis, Immunity, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Complement component C8 beta chain
Alternative name(s):
Complement component 8 subunit beta
Gene namesi
Name:c8b
OrganismiParalichthys olivaceus (Bastard halibut) (Hippoglossus olivaceus)
Taxonomic identifieri8255 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataCarangariaPleuronectiformesPleuronectoideiParalichthyidaeParalichthys

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane attack complex, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
PropeptideiPRO_000002359931 – 46By similarityAdd BLAST16
ChainiPRO_000002360047 – 588Complement component C8 beta chainAdd BLAST542

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi59 ↔ 94By similarity
Glycosylationi64C-linked (Man)By similarity1
Glycosylationi67C-linked (Man)By similarity1
Disulfide bondi70 ↔ 73By similarity
Disulfide bondi104 ↔ 112By similarity
Disulfide bondi118 ↔ 129By similarity
Disulfide bondi123 ↔ 142By similarity
Disulfide bondi136 ↔ 151By similarity
Disulfide bondi374 ↔ 399By similarity
Glycosylationi548C-linked (Man)By similarity1
Glycosylationi551C-linked (Man)By similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Heterotrimer of 3 chains: alpha, beta and gamma. The alpha and gamma chains are disulfide bonded. Component of the membrane attack complex (MAC). MAC assembly is initiated by proteolytic cleavage of C5 into C5a and C5b. C5b sequentially binds C6, C7, C8 and multiple copies of the pore-forming subunit C9 (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9PVW7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini58 – 113TSP type-1 1PROSITE-ProRule annotationAdd BLAST56
Domaini115 – 152LDL-receptor class APROSITE-ProRule annotationAdd BLAST38
Domaini154 – 500MACPFPROSITE-ProRule annotationAdd BLAST347
Domaini501 – 531EGF-likeAdd BLAST31
Domaini542 – 588TSP type-1 2PROSITE-ProRule annotationAdd BLAST47

Sequence similaritiesi

Belongs to the complement C6/C7/C8/C9 family.Curated
Contains 1 EGF-like domain.Curated
Contains 1 LDL-receptor class A domain.PROSITE-ProRule annotation
Contains 1 MACPF domain.PROSITE-ProRule annotation
Contains 2 TSP type-1 domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

HOVERGENiHBG106489.

Family and domain databases

InterProiIPR013032. EGF-like_CS.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
IPR001862. MAC_perforin.
IPR020864. MACPF.
IPR020863. MACPF_CS.
IPR000884. TSP1_rpt.
[Graphical view]
PfamiPF00057. Ldl_recept_a. 1 hit.
PF01823. MACPF. 1 hit.
[Graphical view]
PRINTSiPR00764. COMPLEMENTC9.
SMARTiSM00192. LDLa. 1 hit.
SM00457. MACPF. 1 hit.
SM00209. TSP1. 2 hits.
[Graphical view]
SUPFAMiSSF57424. SSF57424. 1 hit.
SSF82895. SSF82895. 2 hits.
PROSITEiPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS01209. LDLRA_1. 1 hit.
PS50068. LDLRA_2. 1 hit.
PS00279. MACPF_1. 1 hit.
PS51412. MACPF_2. 1 hit.
PS50092. TSP1. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9PVW7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFRVAIPRSA LNLHSCLLHV TLSLVLISKA AITTAGNEDS DVREARSVSD
60 70 80 90 100
QQVVHPVDCV ISDWSAWSRC DTCQKKRYRY AKLDQPSQFG GEPCHFHDME
110 120 130 140 150
DEACDVPDRY TCDSIPLCEG FLCTQTGRCI HRTLQCNGED DCGDMSDEVG
160 170 180 190 200
CKKVPKPCRQ EAEEYWGIEN LAKGINILNS NLEGLVLDNR YYAGSCLPQY
210 220 230 240 250
IQDVRFRKPH NLQQYTLETK GSYDFNVQSF ESYSDYMDYS MRERMTQTIV
260 270 280 290 300
SIGFAIPGIA EFGFNYNNAK VTRSIQKIRR ASSKINSFVS AKAELELAQY
310 320 330 340 350
MLRSDDLMLH PEFLQRLRSL PQAYVYGEYR QIYRDYGTHY ITEAALGGEY
360 370 380 390 400
EHTIILDKEK LAKTDYSLED YKSCTQAGLK IGANIYGVYV SAGIEGGSCN
410 420 430 440 450
GLLNEMGEDT AIGSSVEDFV AVVRGGSSES ITGLVSKKLP TPQLMRLWGE
460 470 480 490 500
GVRFNPDFIR KTTRPLYELV TSKDFSHDAT LKRNLKRALS EYLAESSSCR
510 520 530 540 550
CAPCHNNGVA VLRGTRCDCV CPTGYTGRGC EITQRKKQIA TDGSWSCWGA
560 570 580
WSSCSGRKMS RSRQCNNPVP SDGGLACRGL QQESTDCF
Length:588
Mass (Da):65,872
Last modified:May 1, 2000 - v1
Checksum:i0C525BB95E7AC2AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020962 mRNA. Translation: BAA86877.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020962 mRNA. Translation: BAA86877.1.

3D structure databases

ProteinModelPortaliQ9PVW7.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG106489.

Family and domain databases

InterProiIPR013032. EGF-like_CS.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
IPR001862. MAC_perforin.
IPR020864. MACPF.
IPR020863. MACPF_CS.
IPR000884. TSP1_rpt.
[Graphical view]
PfamiPF00057. Ldl_recept_a. 1 hit.
PF01823. MACPF. 1 hit.
[Graphical view]
PRINTSiPR00764. COMPLEMENTC9.
SMARTiSM00192. LDLa. 1 hit.
SM00457. MACPF. 1 hit.
SM00209. TSP1. 2 hits.
[Graphical view]
SUPFAMiSSF57424. SSF57424. 1 hit.
SSF82895. SSF82895. 2 hits.
PROSITEiPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS01209. LDLRA_1. 1 hit.
PS50068. LDLRA_2. 1 hit.
PS00279. MACPF_1. 1 hit.
PS51412. MACPF_2. 1 hit.
PS50092. TSP1. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCO8B_PAROL
AccessioniPrimary (citable) accession number: Q9PVW7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.