Q9PVS4 (HXC4_ORYLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeobox protein Hox-C4

Gene names

Name:	hoxc4
Synonyms:	hoxc4a

Organism

Oryzias latipes (Medaka fish) (Japanese ricefish) [Reference proteome]

Taxonomic identifier

8090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Actinopterygii › Actinopteri › Neopterygii › Teleostei › Elopocephala › Clupeocephala › Euteleostei › Neognathi › Neoteleostei › Eurypterygii › Ctenosquamata › Acanthomorpha › Euacanthomorpha › Holacanthopterygii › Acanthopterygii › Euacanthopterygii › Percomorpha › Smegmamorpha › Atherinomorpha › Beloniformes › Adrianichthyoidei › Adrianichthyidae › Oryziinae › Oryzias

Protein attributes

Sequence length	261 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the Antp homeobox family. Deformed subfamily. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 261	261	Homeobox protein Hox-C4		PRO_0000200168
Regions
	DNA binding	154 – 213	60	Homeobox
	Motif	133 – 138	6	Antp-type hexapeptide

Sequences

	Sequence		Length	Mass (Da)
	Q9PVS4 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 01890A19997E2B94	FASTA	261	29,373
	10 20 30 40 50 60 MIMSSYLMES NYIDPKFPPC EEYSQNNYIP DSPEYYSRAR DTGYQHHHQE LYPPRASYQE 70 80 90 100 110 120 RQYNCASIPE PDTPRGHGIP HSAHLLAGKG QPASCETPQL SMSPATPPAA ASACNQATPE 130 140 150 160 170 180 HPNSTASSKQ PVVYPWMKKI HVSTVNSGYN GTEPKRSRTA YTRQQVLELE KEFHYNRYLT 190 200 210 220 230 240 RRRRIEIAHT LVLSERQIKI WFQNRRMKWK KDHRLPNTKV RSSSSGSNTS SAAGGVAAAS 250 260 ATNSGPDELS GAQHGEDITR L

References

[1]	"Hox genes of the medakafish Oryzias latipes." Kondo S., Naruse K., Shima A. Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB026955 mRNA. Translation: BAA86238.1.
RefSeq	NP_001098348.1. NM_001104878.2.
UniGene	Ola.24.
3D structure databases
ProteinModelPortal	Q9PVS4.
SMR	Q9PVS4. Positions 131-214.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSORLT00000009979; ENSORLP00000009978; ENSORLG00000007955.
GeneID	100125418.
KEGG	ola:100125418.
Organism-specific databases
CTD	30345.
Phylogenomic databases
eggNOG	NOG314883.
GeneTree	ENSGT00700000104090.
HOVERGEN	HBG016849.
InParanoid	Q9PVS4.
KO	K09304.
OMA	ERQYNCA.
OrthoDB	EOG4GTKF7.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR017995. Homeobox_antennapedia. IPR001827. Homeobox_Antennapedia_CS. IPR017970. Homeobox_CS. IPR020479. Homeobox_metazoa. IPR001356. Homeodomain. IPR009057. Homeodomain-like. [Graphical view]
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00025. ANTENNAPEDIA. PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00032. ANTENNAPEDIA. 1 hit. PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HXC4_ORYLA

Accession

Primary (citable) accession number: Q9PVS4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 27, 2002
Last sequence update:	May 1, 2000
Last modified:	May 1, 2013
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program