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Protein

Zinc metalloproteinase-disintegrin-like cobrin

Gene
N/A
Organism
Naja kaouthia (Monocled cobra) (Naja siamensis)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Snake venom zinc metalloproteinase that may cleave complement protein C3 into C3c-like (C3o).1 Publication

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi196Calcium 1By similarity1
Metal bindingi280Calcium 1By similarity1
Metal bindingi329Zinc; catalyticBy similarity1
Metal bindingi333Zinc; catalyticBy similarity1
Metal bindingi339Zinc; catalyticBy similarity1
Metal bindingi383Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi386Calcium 1By similarity1
Metal bindingi398Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi401Calcium 2By similarity1
Metal bindingi403Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi405Calcium 2By similarity1
Metal bindingi408Calcium 2By similarity1
Metal bindingi411Calcium 2By similarity1
Metal bindingi462Calcium 3By similarity1
Metal bindingi463Calcium 3; via carbonyl oxygenBy similarity1
Metal bindingi465Calcium 3By similarity1
Metal bindingi477Calcium 3By similarity1
Metal bindingi478Calcium 3; via carbonyl oxygenBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionComplement system impairing toxin, Hydrolase, Metalloprotease, Protease, Toxin
LigandCalcium, Metal-binding, Zinc

Protein family/group databases

MEROPSiM12.159.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc metalloproteinase-disintegrin-like cobrin (EC:3.4.24.-)
Alternative name(s):
Snake venom metalloproteinase
Short name:
SVMP
OrganismiNaja kaouthia (Monocled cobra) (Naja siamensis)
Taxonomic identifieri8649 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaElapidaeElapinaeNaja

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 8Sequence analysis8
PropeptideiPRO_00004180339 – 179Sequence analysisAdd BLAST171
ChainiPRO_0000418034180 – 600Zinc metalloproteinase-disintegrin-like cobrinAdd BLAST421

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi304 ↔ 383By similarity
Disulfide bondi344 ↔ 367By similarity
Disulfide bondi346 ↔ 351By similarity
Disulfide bondi399 ↔ 428By similarity
Disulfide bondi410 ↔ 423By similarity
Disulfide bondi412 ↔ 418By similarity
Disulfide bondi422 ↔ 445By similarity
Glycosylationi424N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi436 ↔ 442By similarity
Disulfide bondi441 ↔ 467By similarity
Disulfide bondi454 ↔ 474By similarity
Disulfide bondi461 ↔ 492By similarity
Disulfide bondi486 ↔ 497By similarity
Disulfide bondi504 ↔ 554By similarity
Disulfide bondi519 ↔ 562By similarity
Disulfide bondi532 ↔ 542By similarity
Disulfide bondi549 ↔ 588By similarity
Disulfide bondi582 ↔ 593By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Expressioni

Tissue specificityi

Expressed by the venom gland.

Interactioni

Subunit structurei

Monomer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9PVK7.
SMRiQ9PVK7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini193 – 388Peptidase M12BPROSITE-ProRule annotationAdd BLAST196
Domaini396 – 482DisintegrinPROSITE-ProRule annotationAdd BLAST87

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi460 – 462D/ECD-tripeptide3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi483 – 600Cys-richAdd BLAST118

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG006978.

Family and domain databases

CDDicd04269. ZnMc_adamalysin_II_like. 1 hit.
Gene3Di3.40.390.10. 1 hit.
4.10.70.10. 1 hit.
InterProiView protein in InterPro
IPR006586. ADAM_Cys-rich.
IPR001762. Disintegrin_dom.
IPR036436. Disintegrin_dom_sf.
IPR024079. MetalloPept_cat_dom_sf.
IPR001590. Peptidase_M12B.
IPR002870. Peptidase_M12B_N.
IPR034027. Reprolysin_adamalysin.
PfamiView protein in Pfam
PF08516. ADAM_CR. 1 hit.
PF00200. Disintegrin. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
PRINTSiPR00289. DISINTEGRIN.
SMARTiView protein in SMART
SM00608. ACR. 1 hit.
SM00050. DISIN. 1 hit.
SUPFAMiSSF57552. SSF57552. 1 hit.
PROSITEiView protein in PROSITE
PS50215. ADAM_MEPRO. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.
PS00142. ZINC_PROTEASE. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9PVK7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIQLSWSSII LESGNVNDYE VVYPQKVPAL LKGGVQNPQP ETKYEDTMQY
60 70 80 90 100
EFQVNGEPVV LHLERNKGLF SEDYTETHYA PDGREITTSP PVQDHCYYHG
110 120 130 140 150
YFQNEADSSA VISACDGLKG HFKLQGEIYF IEPLKISDSE AHAIYKDENV
160 170 180 190 200
EEEDETPKIC GVTDTTWESD EPIKKTSLLT NTPEQDRYLQ AEKYIEFYMV
210 220 230 240 250
VDNIMYRHYK RNQLVIKRKV YEMINTMNMI YRRLNFHIAL IGLEIWSNIN
260 270 280 290 300
EINVQSDVKA TLDLFGEWRE KKLLPRKRND NAQLLTGIDF NGTPVGLAYI
310 320 330 340 350
GSICNPKTSA AVVQDYSKST RMVAITMAHE MGHNLGMNHD KGFCTCGFNK
360 370 380 390 400
CVMSTRRTKP AYQFSSCSVR EHQRYLLRDR PQCILNKPLS TDIVSPPICG
410 420 430 440 450
NYFVEVGEEC DCGSPADCQS ACCNATTCKL QHEAQCDSEE CCEKCKFKGA
460 470 480 490 500
GAECRAAKDD CDLPELCTGQ SAECPTDVFQ RNGLPCQNNG YCYNGKCPIM
510 520 530 540 550
TNQCIALRGP GVKVSRDSCF TLNQRTRGCG LCRMEYGRKI PCAAKDVKCG
560 570 580 590 600
RLFCKKRNSM ICNCSISPRD PSYGMVEPGT KCGDGMVCSN RQCVDVKTAY
Length:600
Mass (Da):67,662
Last modified:May 1, 2000 - v1
Checksum:iC7C0D45EBC694290
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF063190 mRNA. Translation: AAF00693.1.

Similar proteinsi

Entry informationi

Entry nameiVM3_NAJKA
AccessioniPrimary (citable) accession number: Q9PVK7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2012
Last sequence update: May 1, 2000
Last modified: November 22, 2017
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families