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Q9PVE8

- C330_FUNHE

UniProt

Q9PVE8 - C330_FUNHE

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Protein

Cytochrome P450 3A30

Gene

cyp3a30

Organism
Fundulus heteroclitus (Killifish) (Mummichog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Putative steroid 6-beta-hydroxylase.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi441 – 4411Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 3A30 (EC:1.14.14.1)
Alternative name(s):
CYPIIIA30
Gene namesi
Name:cyp3a30
OrganismiFundulus heteroclitus (Killifish) (Mummichog)
Taxonomic identifieri8078 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaAtherinomorphaeCyprinodontiformesFundulidaeFundulus

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 496496Cytochrome P450 3A30PRO_0000051809Add
BLAST

Expressioni

Tissue specificityi

Highly expressed in liver and intestine. Moderate expression in gill and spleen. Low expression in kidney, brain and heart.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ9PVE8.
SMRiQ9PVE8. Positions 29-495.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

HOVERGENiHBG108567.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9PVE8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGYFYLTAET WTLLVAFVTL LLVYAYWPYG TFKRLGISGP KPVPFFGTML
60 70 80 90 100
HYRRGFFTFD EECKKKYGKV WGIYDGRQPV LCVTDPEIIK AVLVKECLSF
110 120 130 140 150
FTNRRNFRLN GPLYDAVSIA EDDQWKRIRS VLSPSFTSGR LKEMFEIMKN
160 170 180 190 200
HSANLIRSMK KKADKDEPLD LKEFFGSYSM DVVTSTAFSV DIDSLNNPSD
210 220 230 240 250
PFVTNIKKML KFDFLNPLFL AVAFFPFLGP ILEKFELSFF PKSVTDFFYA
260 270 280 290 300
SLEKIKSNRE ASQQKSRVDF LQLMIDSQKN SGAQQDKSLT DHEILSQSMI
310 320 330 340 350
FIFAGYETSS SSLTFLAYNL ATNPEVMKKL QEEIDATFPN KAPVHYQPLM
360 370 380 390 400
EMEYLDCVIN ESLRLFPIAA RLERVAKAAV EINGVVIPKD MVVMIPTWPL
410 420 430 440 450
HRDPEIWPEP EAFKPERFSK KNKDNIDPYI YMPFGSGPRN CIGMRFALVL
460 470 480 490
IKLAVVEILQ QYSFSVCKET EVPFEMDIQG LLAPKRPIQL KLVPRS
Length:496
Mass (Da):57,045
Last modified:August 22, 2003 - v2
Checksum:iC19FF4CE75AB37D4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF105068 mRNA. Translation: AAF14117.2.
PIRiA58612.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF105068 mRNA. Translation: AAF14117.2 .
PIRi A58612.

3D structure databases

ProteinModelPortali Q9PVE8.
SMRi Q9PVE8. Positions 29-495.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG108567.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Hepatic versus extrahepatic expression of CYP3A30 and CYP3A56 in adult killifish (Fundulus heteroclitus)."
    Hegelund T., Celander M.C.
    Aquat. Toxicol. 64:277-291(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Intestine and Liver.
  2. "Isolation of a cytochrome P450 3A cDNA sequence (CYP3A30) from the marine teleost Fundulus heteroclitus and phylogenetic analyses of CYP3A genes."
    Celander M.C., Stegeman J.J.
    Biochem. Biophys. Res. Commun. 236:306-312(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 312-435.
    Tissue: Liver.

Entry informationi

Entry nameiC330_FUNHE
AccessioniPrimary (citable) accession number: Q9PVE8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: August 22, 2003
Last modified: October 29, 2014
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Due to a recent gene duplication event, CYP3A30 and CYP3A56 are very similar. Because of this it was not possible to distinguish between the two genes when measuring the tissue expression.Curated

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3