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Q9PVE8

- C330_FUNHE

UniProt

Q9PVE8 - C330_FUNHE

Protein

Cytochrome P450 3A30

Gene

cyp3a30

Organism
Fundulus heteroclitus (Killifish) (Mummichog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 2 (22 Aug 2003)
      Previous versions | rss
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    Functioni

    Putative steroid 6-beta-hydroxylase.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi441 – 4411Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 3A30 (EC:1.14.14.1)
    Alternative name(s):
    CYPIIIA30
    Gene namesi
    Name:cyp3a30
    OrganismiFundulus heteroclitus (Killifish) (Mummichog)
    Taxonomic identifieri8078 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaAtherinomorphaeCyprinodontiformesFundulidaeFundulus

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 496496Cytochrome P450 3A30PRO_0000051809Add
    BLAST

    Expressioni

    Tissue specificityi

    Highly expressed in liver and intestine. Moderate expression in gill and spleen. Low expression in kidney, brain and heart.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliQ9PVE8.
    SMRiQ9PVE8. Positions 29-495.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    HOVERGENiHBG108567.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR008072. Cyt_P450_E_CYP3A.
    IPR002402. Cyt_P450_E_grp-II.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00464. EP450II.
    PR01689. EP450IICYP3A.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9PVE8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGYFYLTAET WTLLVAFVTL LLVYAYWPYG TFKRLGISGP KPVPFFGTML    50
    HYRRGFFTFD EECKKKYGKV WGIYDGRQPV LCVTDPEIIK AVLVKECLSF 100
    FTNRRNFRLN GPLYDAVSIA EDDQWKRIRS VLSPSFTSGR LKEMFEIMKN 150
    HSANLIRSMK KKADKDEPLD LKEFFGSYSM DVVTSTAFSV DIDSLNNPSD 200
    PFVTNIKKML KFDFLNPLFL AVAFFPFLGP ILEKFELSFF PKSVTDFFYA 250
    SLEKIKSNRE ASQQKSRVDF LQLMIDSQKN SGAQQDKSLT DHEILSQSMI 300
    FIFAGYETSS SSLTFLAYNL ATNPEVMKKL QEEIDATFPN KAPVHYQPLM 350
    EMEYLDCVIN ESLRLFPIAA RLERVAKAAV EINGVVIPKD MVVMIPTWPL 400
    HRDPEIWPEP EAFKPERFSK KNKDNIDPYI YMPFGSGPRN CIGMRFALVL 450
    IKLAVVEILQ QYSFSVCKET EVPFEMDIQG LLAPKRPIQL KLVPRS 496
    Length:496
    Mass (Da):57,045
    Last modified:August 22, 2003 - v2
    Checksum:iC19FF4CE75AB37D4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF105068 mRNA. Translation: AAF14117.2.
    PIRiA58612.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF105068 mRNA. Translation: AAF14117.2 .
    PIRi A58612.

    3D structure databases

    ProteinModelPortali Q9PVE8.
    SMRi Q9PVE8. Positions 29-495.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG108567.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR008072. Cyt_P450_E_CYP3A.
    IPR002402. Cyt_P450_E_grp-II.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00464. EP450II.
    PR01689. EP450IICYP3A.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Hepatic versus extrahepatic expression of CYP3A30 and CYP3A56 in adult killifish (Fundulus heteroclitus)."
      Hegelund T., Celander M.C.
      Aquat. Toxicol. 64:277-291(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Intestine and Liver.
    2. "Isolation of a cytochrome P450 3A cDNA sequence (CYP3A30) from the marine teleost Fundulus heteroclitus and phylogenetic analyses of CYP3A genes."
      Celander M.C., Stegeman J.J.
      Biochem. Biophys. Res. Commun. 236:306-312(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 312-435.
      Tissue: Liver.

    Entry informationi

    Entry nameiC330_FUNHE
    AccessioniPrimary (citable) accession number: Q9PVE8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 27, 2002
    Last sequence update: August 22, 2003
    Last modified: October 1, 2014
    This is version 78 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Caution

    Due to a recent gene duplication event, CYP3A30 and CYP3A56 are very similar. Because of this it was not possible to distinguish between the two genes when measuring the tissue expression.Curated

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3