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Protein

Cytochrome P450 3A30

Gene

cyp3a30

Organism
Fundulus heteroclitus (Killifish) (Mummichog)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Putative steroid 6-beta-hydroxylase.

Caution

Due to a recent gene duplication event, CYP3A30 and CYP3A56 are very similar. Because of this it was not possible to distinguish between the two genes when measuring the tissue expression.Curated

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi441Iron (heme axial ligand)By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 3A30 (EC:1.14.14.1)
Alternative name(s):
CYPIIIA30
Gene namesi
Name:cyp3a30
OrganismiFundulus heteroclitus (Killifish) (Mummichog)
Taxonomic identifieri8078 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaAtherinomorphaeCyprinodontiformesFundulidaeFundulus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000518091 – 496Cytochrome P450 3A30Add BLAST496

Proteomic databases

PRIDEiQ9PVE8

Expressioni

Tissue specificityi

Highly expressed in liver and intestine. Moderate expression in gill and spleen. Low expression in kidney, brain and heart.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ9PVE8
SMRiQ9PVE8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

HOVERGENiHBG108567

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR008072 Cyt_P450_E_CYP3A
IPR002402 Cyt_P450_E_grp-II
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00464 EP450II
PR01689 EP450IICYP3A
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequencei

Sequence statusi: Complete.

Q9PVE8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGYFYLTAET WTLLVAFVTL LLVYAYWPYG TFKRLGISGP KPVPFFGTML
60 70 80 90 100
HYRRGFFTFD EECKKKYGKV WGIYDGRQPV LCVTDPEIIK AVLVKECLSF
110 120 130 140 150
FTNRRNFRLN GPLYDAVSIA EDDQWKRIRS VLSPSFTSGR LKEMFEIMKN
160 170 180 190 200
HSANLIRSMK KKADKDEPLD LKEFFGSYSM DVVTSTAFSV DIDSLNNPSD
210 220 230 240 250
PFVTNIKKML KFDFLNPLFL AVAFFPFLGP ILEKFELSFF PKSVTDFFYA
260 270 280 290 300
SLEKIKSNRE ASQQKSRVDF LQLMIDSQKN SGAQQDKSLT DHEILSQSMI
310 320 330 340 350
FIFAGYETSS SSLTFLAYNL ATNPEVMKKL QEEIDATFPN KAPVHYQPLM
360 370 380 390 400
EMEYLDCVIN ESLRLFPIAA RLERVAKAAV EINGVVIPKD MVVMIPTWPL
410 420 430 440 450
HRDPEIWPEP EAFKPERFSK KNKDNIDPYI YMPFGSGPRN CIGMRFALVL
460 470 480 490
IKLAVVEILQ QYSFSVCKET EVPFEMDIQG LLAPKRPIQL KLVPRS
Length:496
Mass (Da):57,045
Last modified:August 22, 2003 - v2
Checksum:iC19FF4CE75AB37D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF105068 mRNA Translation: AAF14117.2
PIRiA58612
UniGeneiFhe.1269

Similar proteinsi

Entry informationi

Entry nameiC330_FUNHE
AccessioniPrimary (citable) accession number: Q9PVE8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: August 22, 2003
Last modified: May 23, 2018
This is version 91 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

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