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Protein

Sphingosine 1-phosphate receptor 3

Gene

s1pr3

Organism
Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Sphingosine 1-phosphate receptor 3
Short name:
S1P receptor 3
Short name:
S1P3
Alternative name(s):
Sphingosine 1-phosphate receptor Edg-3
Short name:
S1P receptor Edg-3
Gene namesi
Name:s1pr3
Synonyms:edg3
OrganismiTakifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Taxonomic identifieri31033 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaTetraodontiformesTetradontoideaTetraodontidaeTakifugu
Proteomesi
  • UP000005226 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 34ExtracellularBy similarityAdd BLAST34
Transmembranei35 – 55Helical; Name=1By similarityAdd BLAST21
Topological domaini56 – 64CytoplasmicBy similarity9
Transmembranei65 – 85Helical; Name=2By similarityAdd BLAST21
Topological domaini86 – 105ExtracellularBy similarityAdd BLAST20
Transmembranei106 – 126Helical; Name=3By similarityAdd BLAST21
Topological domaini127 – 144CytoplasmicBy similarityAdd BLAST18
Transmembranei145 – 165Helical; Name=4By similarityAdd BLAST21
Topological domaini166 – 186ExtracellularBy similarityAdd BLAST21
Transmembranei187 – 207Helical; Name=5By similarityAdd BLAST21
Topological domaini208 – 235CytoplasmicBy similarityAdd BLAST28
Transmembranei236 – 256Helical; Name=6By similarityAdd BLAST21
Topological domaini257 – 271ExtracellularBy similarityAdd BLAST15
Transmembranei272 – 292Helical; Name=7By similarityAdd BLAST21
Topological domaini293 – 384CytoplasmicBy similarityAdd BLAST92

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000694231 – 384Sphingosine 1-phosphate receptor 3Add BLAST384

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi12N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ9PUQ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiQ9PUQ8.

Family and domain databases

InterProiIPR004062. EDG3_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004061. S1P_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01524. EDG3RECEPTOR.
PR00237. GPCRRHODOPSN.
PR01523. S1PRECEPTOR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9PUQ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMINPLIYLH YNYTGKLDHR PTVGTSPGTR DPKTIAFLVV CSFIILENLT
60 70 80 90 100
VLLAIWKNHR FHNRMYFFIG NLALCDLLAS VAYLVNLLLS GEKTLQLSPV
110 120 130 140 150
LWFVREGSMF VTLGASIFSL LAIAIERHLT MIKMRPYDAS KNYRVFLLIG
160 170 180 190 200
TCWLVAVLLG ALPILGWNCL GNLPDCSTIL PLYTKKYVAF CIIVFIVLLL
210 220 230 240 250
AMSVLYARIY ILVKSSSQKV SKHRNSEHAM SLLRTVIIVV GVFIACWMPI
260 270 280 290 300
FVLLLLDVAC ERPCPILYKA DWFIAVAVLN SAMNPIIYTL ASREMRRAFL
310 320 330 340 350
GLVCGVCYRG NGSGNDSGNK QFQEPSRSRS KSWSSQTHPN QSQQSSRPAE
360 370 380
LDREQETGHG EISVVAGGAA QASQREGEGG NGGR
Length:384
Mass (Da):42,712
Last modified:May 1, 2000 - v1
Checksum:i92B0DDF6BBD0E3BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF164114 Genomic DNA. Translation: AAF07896.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF164114 Genomic DNA. Translation: AAF07896.1.

3D structure databases

ProteinModelPortaliQ9PUQ8.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

InParanoidiQ9PUQ8.

Family and domain databases

InterProiIPR004062. EDG3_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004061. S1P_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01524. EDG3RECEPTOR.
PR00237. GPCRRHODOPSN.
PR01523. S1PRECEPTOR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS1PR3_TAKRU
AccessioniPrimary (citable) accession number: Q9PUQ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: May 1, 2000
Last modified: May 11, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.