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Protein

ETS translocation variant 4

Gene

etv4

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional activator that binds to the (5'-CCGGA[AT]-3') motif. May control the acquisition of specific cell fates at an early stage during development of the somites and nervous system. May mediate the cellular effects of the fibroblast growth factors on embryogenesis.

Miscellaneous

Transcriptional activation activity is enhanced by Raf1, ERK and PKA.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi350 – 430ETSPROSITE-ProRule annotationAdd BLAST81

GO - Molecular functioni

GO - Biological processi

  • embryo development ending in birth or egg hatching Source: UniProtKB
  • limb morphogenesis Source: ZFIN
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • pronephric nephron tubule epithelial cell differentiation Source: ZFIN
  • pronephros development Source: ZFIN
  • regulation of transcription, DNA-templated Source: UniProtKB
  • regulation of transcription by RNA polymerase II Source: GO_Central
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
ETS translocation variant 4
Alternative name(s):
Polyomavirus enhancer activator 3 homolog
Short name:
Protein PEA3
Gene namesi
Name:etv4
Synonyms:pea3
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-990415-71 etv4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002041201 – 494ETS translocation variant 4Add BLAST494

Post-translational modificationi

Phosphorylated.Curated

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9PUQ1

Expressioni

Tissue specificityi

In the embryo, expressed ubiquitously until the late blastula stage, in the marginal zone of gastrula stages, in the presumptive forebrain and hindbrain and in the trunk region of early somite stages. In later stages, also expressed in Rohon-Beard neurons, epiphysis, lateral line placodes, pectoral fin buds, developing lens and heart.4 Publications

Developmental stagei

First detected in the embryo after 4.3 hours.

Inductioni

By the fibroblast growth factors FGF3 and FGF8.2 Publications

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000016969

Structurei

3D structure databases

ProteinModelPortaliQ9PUQ1
SMRiQ9PUQ1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi47 – 78Asp/Glu-rich (acidic)Add BLAST32

Sequence similaritiesi

Belongs to the ETS family.Curated

Phylogenomic databases

eggNOGiKOG3806 Eukaryota
ENOG410Z0ZF LUCA
HOGENOMiHOG000230986
HOVERGENiHBG000231
InParanoidiQ9PUQ1
PhylomeDBiQ9PUQ1

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR000418 Ets_dom
IPR006715 ETS_PEA3_N
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00178 Ets, 1 hit
PF04621 ETS_PEA3_N, 1 hit
PRINTSiPR00454 ETSDOMAIN
SMARTiView protein in SMART
SM00413 ETS, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00345 ETS_DOMAIN_1, 1 hit
PS00346 ETS_DOMAIN_2, 1 hit
PS50061 ETS_DOMAIN_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q9PUQ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDYKMDGYLD QQVPYTLANR SQGNGPLNRL LMATKRKYMD AELPPQESED
60 70 80 90 100
LFQDLSQLQE TWLTEAQVPD SDEQFVPDFH SENSVAFHSP PVKIKKEPQS
110 120 130 140 150
PGSDPSQSCS HKQSFSYPNG EQCLYASAYE QKRAAVAGAG GSKSSCPATP
160 170 180 190 200
MSPMQHYSPK PTVGTRQESG YMNPPSSSQS HACHSHSYPM NPSSRFPSGS
210 220 230 240 250
AEMCPPFASQ GQALQRIDPA HASGGGGGGY HRQHSDPCLP YPPQQTFKQE
260 270 280 290 300
YMDPLYDRAA HINGPQPQRF PPAHMMVKQE PTDYTYEPDV PGCPSMYHHN
310 320 330 340 350
EGYSNPQHNS EGYMFENDSR VVPEKFEGEV KQEGGSVFRE GAPYQRRGSL
360 370 380 390 400
QLWQFLVALL DDPSNAHFIA WTGRGMEFKL IEPEEVARLW GIEKNRPAMN
410 420 430 440 450
YDKLSRSLRY YYEKGIMQKV AGERYVYKFV CEPEALITLA FPDNQRPSLK
460 470 480 490
AEFERYVNEE DTVPLSHLDE GVSYPPEPAA TNMGPQPYSK GYMY
Length:494
Mass (Da):55,621
Last modified:October 10, 2002 - v2
Checksum:i81492553EA25C362
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti148A → G in AAD50434 (PubMed:10534622).Curated1
Sequence conflicti177S → A in AAD50434 (PubMed:10534622).Curated1
Sequence conflicti217 – 218ID → MH in AAD50434 (PubMed:10534622).Curated2
Sequence conflicti224 – 226Missing in AAD50434 (PubMed:10534622).Curated3
Sequence conflicti392 – 393IE → MQ in AAD50434 (PubMed:10534622).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ003200 mRNA Translation: CAA05980.1
AF168008 mRNA Translation: AAD50434.1
UniGeneiDr.75840

Similar proteinsi

Entry informationi

Entry nameiETV4_DANRE
AccessioniPrimary (citable) accession number: Q9PUQ1
Secondary accession number(s): O57586
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: October 10, 2002
Last modified: March 28, 2018
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health