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Protein

ETS translocation variant 4

Gene

etv4

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional activator that binds to the (5'-CCGGA[AT]-3') motif. May control the acquisition of specific cell fates at an early stage during development of the somites and nervous system. May mediate the cellular effects of the fibroblast growth factors on embryogenesis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi350 – 43081ETSPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • embryo development Source: UniProtKB
  • limb morphogenesis Source: ZFIN
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • pronephros development Source: ZFIN
  • regulation of transcription, DNA-templated Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ETS translocation variant 4
Alternative name(s):
Polyomavirus enhancer activator 3 homolog
Short name:
Protein PEA3
Gene namesi
Name:etv4
Synonyms:pea3
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-990415-71. etv4.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 494494ETS translocation variant 4PRO_0000204120Add
BLAST

Post-translational modificationi

Phosphorylated.Curated

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9PUQ1.

Expressioni

Tissue specificityi

In the embryo, expressed ubiquitously until the late blastula stage, in the marginal zone of gastrula stages, in the presumptive forebrain and hindbrain and in the trunk region of early somite stages. In later stages, also expressed in Rohon-Beard neurons, epiphysis, lateral line placodes, pectoral fin buds, developing lens and heart.4 Publications

Developmental stagei

First detected in the embryo after 4.3 hours.

Inductioni

By the fibroblast growth factors FGF3 and FGF8.2 Publications

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000016969.

Structurei

3D structure databases

ProteinModelPortaliQ9PUQ1.
SMRiQ9PUQ1. Positions 348-437.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi47 – 7832Asp/Glu-rich (acidic)Add
BLAST

Sequence similaritiesi

Belongs to the ETS family.Curated
Contains 1 ETS DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3806. Eukaryota.
ENOG410Z0ZF. LUCA.
HOGENOMiHOG000230986.
HOVERGENiHBG000231.
InParanoidiQ9PUQ1.
PhylomeDBiQ9PUQ1.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR000418. Ets_dom.
IPR006715. ETS_PEA3_N.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00178. Ets. 1 hit.
PF04621. ETS_PEA3_N. 1 hit.
[Graphical view]
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9PUQ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDYKMDGYLD QQVPYTLANR SQGNGPLNRL LMATKRKYMD AELPPQESED
60 70 80 90 100
LFQDLSQLQE TWLTEAQVPD SDEQFVPDFH SENSVAFHSP PVKIKKEPQS
110 120 130 140 150
PGSDPSQSCS HKQSFSYPNG EQCLYASAYE QKRAAVAGAG GSKSSCPATP
160 170 180 190 200
MSPMQHYSPK PTVGTRQESG YMNPPSSSQS HACHSHSYPM NPSSRFPSGS
210 220 230 240 250
AEMCPPFASQ GQALQRIDPA HASGGGGGGY HRQHSDPCLP YPPQQTFKQE
260 270 280 290 300
YMDPLYDRAA HINGPQPQRF PPAHMMVKQE PTDYTYEPDV PGCPSMYHHN
310 320 330 340 350
EGYSNPQHNS EGYMFENDSR VVPEKFEGEV KQEGGSVFRE GAPYQRRGSL
360 370 380 390 400
QLWQFLVALL DDPSNAHFIA WTGRGMEFKL IEPEEVARLW GIEKNRPAMN
410 420 430 440 450
YDKLSRSLRY YYEKGIMQKV AGERYVYKFV CEPEALITLA FPDNQRPSLK
460 470 480 490
AEFERYVNEE DTVPLSHLDE GVSYPPEPAA TNMGPQPYSK GYMY
Length:494
Mass (Da):55,621
Last modified:October 10, 2002 - v2
Checksum:i81492553EA25C362
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti148 – 1481A → G in AAD50434 (PubMed:10534622).Curated
Sequence conflicti177 – 1771S → A in AAD50434 (PubMed:10534622).Curated
Sequence conflicti217 – 2182ID → MH in AAD50434 (PubMed:10534622).Curated
Sequence conflicti224 – 2263Missing in AAD50434 (PubMed:10534622).Curated
Sequence conflicti392 – 3932IE → MQ in AAD50434 (PubMed:10534622).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ003200 mRNA. Translation: CAA05980.1.
AF168008 mRNA. Translation: AAD50434.1.
UniGeneiDr.75840.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ003200 mRNA. Translation: CAA05980.1.
AF168008 mRNA. Translation: AAD50434.1.
UniGeneiDr.75840.

3D structure databases

ProteinModelPortaliQ9PUQ1.
SMRiQ9PUQ1. Positions 348-437.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000016969.

Proteomic databases

PaxDbiQ9PUQ1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ZFINiZDB-GENE-990415-71. etv4.

Phylogenomic databases

eggNOGiKOG3806. Eukaryota.
ENOG410Z0ZF. LUCA.
HOGENOMiHOG000230986.
HOVERGENiHBG000231.
InParanoidiQ9PUQ1.
PhylomeDBiQ9PUQ1.

Miscellaneous databases

PROiQ9PUQ1.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR000418. Ets_dom.
IPR006715. ETS_PEA3_N.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00178. Ets. 1 hit.
PF04621. ETS_PEA3_N. 1 hit.
[Graphical view]
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular characterization of the zebrafish PEA3 ETS-domain transcription factor."
    Brown L.A., Amores A., Schilling T.F., Jowett T., Baert J.-L., de Launoit Y., Sharrocks A.D.
    Oncogene 17:93-104(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DNA-BINDING, REGULATION OF ACTIVITY.
    Tissue: Embryo.
  2. "Expression of the Ets transcription factors erm and pea3 in early zebrafish development."
    Muenchberg S.R., Ober E.A., Steinbeisser H.
    Mech. Dev. 88:233-236(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Embryo.
  3. "Zebrafish pea3 and erm are general targets of FGF8 signaling."
    Roehl H., Nuesslein-Volhard C.
    Curr. Biol. 11:503-507(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, INDUCTION BY FGF8.
  4. "Tight transcriptional control of the ETS domain factors Erm and Pea3 by Fgf signaling during early zebrafish development."
    Raible F., Brand M.
    Mech. Dev. 107:105-117(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, INDUCTION BY FGF3 AND FGF8.

Entry informationi

Entry nameiETV4_DANRE
AccessioniPrimary (citable) accession number: Q9PUQ1
Secondary accession number(s): O57586
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: October 10, 2002
Last modified: June 8, 2016
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Transcriptional activation activity is enhanced by Raf1, ERK and PKA.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.