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Protein

Voltage-dependent N-type calcium channel subunit alpha

Gene

CACHA1B

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Calcium channelUniRule annotation, Ion channel, Voltage-gated channelUniRule annotation

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent N-type calcium channel subunit alphaUniRule annotation
Gene namesi
Name:CACHA1BImported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus

Subcellular locationi

  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei89 – 106HelicalSequence analysisAdd BLAST18
Transmembranei127 – 148HelicalSequence analysisAdd BLAST22
Transmembranei160 – 180HelicalSequence analysisAdd BLAST21
Transmembranei215 – 237HelicalSequence analysisAdd BLAST23
Transmembranei291 – 312HelicalSequence analysisAdd BLAST22
Transmembranei324 – 346HelicalSequence analysisAdd BLAST23
Transmembranei500 – 520HelicalSequence analysisAdd BLAST21
Transmembranei526 – 543HelicalSequence analysisAdd BLAST18
Transmembranei625 – 647HelicalSequence analysisAdd BLAST23
Transmembranei703 – 725HelicalSequence analysisAdd BLAST23
Transmembranei1169 – 1188HelicalSequence analysisAdd BLAST20
Transmembranei1208 – 1229HelicalSequence analysisAdd BLAST22
Transmembranei1241 – 1259HelicalSequence analysisAdd BLAST19
Transmembranei1302 – 1324HelicalSequence analysisAdd BLAST23
Transmembranei1414 – 1439HelicalSequence analysisAdd BLAST26
Transmembranei1495 – 1513HelicalSequence analysisAdd BLAST19
Transmembranei1525 – 1551HelicalSequence analysisAdd BLAST27
Transmembranei1618 – 1636HelicalSequence analysisAdd BLAST19
Transmembranei1706 – 1730HelicalSequence analysisAdd BLAST25

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ9PUM6.

PTM databases

iPTMnetiQ9PUM6.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000013765.

Structurei

3D structure databases

ProteinModelPortaliQ9PUM6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1868 – 1902Ca_chan_IQInterPro annotationAdd BLAST35

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili734 – 761Sequence analysisAdd BLAST28
Coiled coili1021 – 1044Sequence analysisAdd BLAST24

Sequence similaritiesi

Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG2301. Eukaryota.
ENOG410XNP6. LUCA.
HOGENOMiHOG000231530.
HOVERGENiHBG050763.
KOiK04849.
PhylomeDBiQ9PUM6.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR031649. GPHH_dom.
IPR005821. Ion_trans_dom.
IPR014873. VDCC_a1su_IQ.
IPR005447. VDCC_N_a1su.
IPR002077. VDCCAlpha1.
[Graphical view]
PANTHERiPTHR10037:SF161. PTHR10037:SF161. 3 hits.
PfamiPF08763. Ca_chan_IQ. 1 hit.
PF16905. GPHH. 1 hit.
PF00520. Ion_trans. 4 hits.
[Graphical view]
PRINTSiPR00167. CACHANNEL.
PR01631. NVDCCALPHA1.
SMARTiSM01062. Ca_chan_IQ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9PUM6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARFGDDLPT RYGGGGPAGA GRGSSRQGGP QAGQRMYKQS MAQRARTMAL
60 70 80 90 100
YNPIPVKQNC FTVNRSLFIF SEDNVIRKYA KRITEWPPFE YMILATIIAN
110 120 130 140 150
CIVLALEQHL PDGDKTPMSE RLDDTEPYFI GIFCFEAGIK IIALGFVFHK
160 170 180 190 200
GSYLRNGWNV MDFVVVLTGI LATAGTDFDL RTLRAVRVLR PLKLVSGIPS
210 220 230 240 250
LQVVLKSIMK AMVPLLQIGL LLFFAIVMFA IIGLEFYMGK FHKTCFSNKT
260 270 280 290 300
GEEVGDFPCG EEPPARQCES GTTCREYWQG PNYGITNFDN ILFAVLTVFQ
310 320 330 340 350
CITMEGWTDI LYNTNDAAGN TWNWLYFIPL IIIGSFFMLN LVLGVLSGEF
360 370 380 390 400
AKERERVENR RAFLKLRRQQ QIERELNGYL EWIFKAEEVM LAEEDKNAEE
410 420 430 440 450
KSPLDGRAAS EGPIQQGTAP AETSSGSSYN MLKRAAIKKS KNDLIHAEEG
460 470 480 490 500
EDHFTDICSV GSPFARASLK SGKNESSSYF RRKEKMFRFF IRRMVKAQSF
510 520 530 540 550
YWIVLCVVAL NTLCVAMVHY DQPEKLTTAL YFAEFVFLGL FLTEMSLKMY
560 570 580 590 600
GLGPRNYFHS SFNYFDFGVI VGSIFEVIWA AVKPGTSFGI SVLRALRLLR
610 620 630 640 650
IFKVTKYWNS LRNLVVSLLN SMKSIISLLF LLFLFIVVFA LLGMQLFGGQ
660 670 680 690 700
FNFRDETPTT NFDTFPAAIL TVFQILTGED WNAVMYHGIE SQGGVHSGMF
710 720 730 740 750
SSIYFIVLTL FGNYTLLNVF LAIAVDNLAN AQELTKDEEE MEEATNQKLA
760 770 780 790 800
LQKAKEVAEV SPMSAANISI AAKQQNSSKS KSVWEQRTSQ IRMHNFRASC
810 820 830 840 850
EALYNELDPE ERVRYATTLH IRPDMKTHLD RPLVVEPRGE GRNNISKLSP
860 870 880 890 900
VDVQEVEQTK VSSTDGAEAP RKHHRHRDKE KLGEQEKGDV TKDENGESGI
910 920 930 940 950
NNKEERHRQH RSRSKEVEGG SKEGKSDRSR GQEGGKRHHR RGSVEEGVEK
960 970 980 990 1000
EHRRHRTHRH SAERQGKEGN GTINGARSER RTRHRGGSRS GNREGEPGSK
1010 1020 1030 1040 1050
GENGEEPHRR HRFRSRALST YDSVEKENRE KEGETAEKEH QNHQPKENQC
1060 1070 1080 1090 1100
EIEASGSVSI PVHTLPSTYL QKVPEQPEDA DNQKNVTRMI QPPLDKTTTV
1110 1120 1130 1140 1150
NIPVTITAPP GETTVIPMNN VEFESKTEEK KDVDDLTKNG PKPILPYSSM
1160 1170 1180 1190 1200
FILSPTNPIR RLFHYIVNLR YFEMVILIVI ALSSIALAAE DPVQAESPRN
1210 1220 1230 1240 1250
DALKYLDYIF TGVFTFEMVI KMIDLGLLLH PGSYFRDLWN ILDFIVVSGA
1260 1270 1280 1290 1300
LVAFAFSGTK GKDINTIKSL RVLRVLRPLK TIKRLPKLKA VFDCVVNSLK
1310 1320 1330 1340 1350
NVLNILIVYM LFMFIFAVIA VQLFKGRFFY CTDESKELEK DCRGQYLDYE
1360 1370 1380 1390 1400
KNEVEAQPRE WKKYEFHYDN VLWALLTLFT VSTGEGWPTV LKHSVDATYE
1410 1420 1430 1440 1450
EQGPSPGYRM EMSIFYVVYF VVFPFFFVNI FVALIIITFQ EQGDKVMSEC
1460 1470 1480 1490 1500
SLEKNERACI DFAISAKPLT RYMPQNKQSF QYKMWKFVVS PPFEYFIMVM
1510 1520 1530 1540 1550
IALNTIVLMM KFYDAPEAYE EMLKCLNIVF TSMFSMECVL KIIAFGVLNY
1560 1570 1580 1590 1600
FRDAWNVFDF VTVLGSITDI LVTEIADTDN FINLSFLRLF RAARLIKLLR
1610 1620 1630 1640 1650
QGYTIRILLW TFVQSFKALP YVCLLIAMLF FIYAIIGMQV FGNIALNDET
1660 1670 1680 1690 1700
SINRHNNFRT FLQALMLLFR SATGEAWHEI MLSCLSNRAC DPLSGLTKNE
1710 1720 1730 1740 1750
CGSDFAYFYF VSFIFLCSFL MLNLFVAVIM DNFEYLTRDS SILGPHHLDE
1760 1770 1780 1790 1800
FVRVWAEYDP AACCRIHYKD MYNLLRVIAP PLGLGKKCPH RVAYKRLVRM
1810 1820 1830 1840 1850
NMPISPEDLT VHFTSTLMAL IRTALEIKLA SGGVKQHQCD AELRKEISLV
1860 1870 1880 1890 1900
WPNLSQKTLD LLVPPHKPDE MTVGKVYAAL MIFDFYKQNK SSREQVHQPP
1910 1920 1930 1940 1950
GGLCQPGPVS LFHPLKATLE QTQPSAFSSA KAFLRQKSSA SLNNGGTLPA
1960 1970 1980 1990 2000
PEGGIKESSS WGTQRTQDVF YETRTPAFER GHSEEIPIER VVEMREISPT
2010 2020 2030 2040 2050
LANGEHQPGL ESQGRAASMP RLAAETQRSK ARSPGSYLAP IPDTSPMKRS
2060 2070 2080 2090 2100
ISTLTPQRPH PMHLYEYSLE RVPTDQVHHH HHHRCHRRKE KKQKSLDRTT
2110 2120 2130 2140 2150
HQLADGEAVA QSGESSSKDK KQERGRSQER KQHSSSSSEK QRFYSCDRYG
2160 2170 2180 2190 2200
SRDRSQPKSA DQSRPTSPNG GPEQGPHRQG SGSVNGSPLL STSGASTPCR
2210 2220 2230 2240 2250
GRRQLPQTPL TPRPSITYKT ANSSPVHFST SPGGLPPFSP GRLSRGLSEH
2260 2270 2280 2290 2300
NALLRGDQQP PPAAVARIGS DPYLGHRDAA DSPIGAAPED TLTFEEAVAT
2310 2320 2330 2340 2350
NSGRSSRTSY VSSLTSQSHQ ARRVPNGYHY TLGLNTGPGT GTRGRSYYHE

ADEDDWC
Length:2,357
Mass (Da):266,584
Last modified:May 1, 2000 - v1
Checksum:i7CC7F5424E4F82A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF173012 mRNA. Translation: AAD51815.1.
RefSeqiNP_989624.1. NM_204293.1.
UniGeneiGga.4317.

Genome annotation databases

GeneIDi374169.
KEGGigga:374169.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF173012 mRNA. Translation: AAD51815.1.
RefSeqiNP_989624.1. NM_204293.1.
UniGeneiGga.4317.

3D structure databases

ProteinModelPortaliQ9PUM6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000013765.

PTM databases

iPTMnetiQ9PUM6.

Proteomic databases

PaxDbiQ9PUM6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi374169.
KEGGigga:374169.

Organism-specific databases

CTDi774.

Phylogenomic databases

eggNOGiKOG2301. Eukaryota.
ENOG410XNP6. LUCA.
HOGENOMiHOG000231530.
HOVERGENiHBG050763.
KOiK04849.
PhylomeDBiQ9PUM6.

Miscellaneous databases

PROiQ9PUM6.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR031649. GPHH_dom.
IPR005821. Ion_trans_dom.
IPR014873. VDCC_a1su_IQ.
IPR005447. VDCC_N_a1su.
IPR002077. VDCCAlpha1.
[Graphical view]
PANTHERiPTHR10037:SF161. PTHR10037:SF161. 3 hits.
PfamiPF08763. Ca_chan_IQ. 1 hit.
PF16905. GPHH. 1 hit.
PF00520. Ion_trans. 4 hits.
[Graphical view]
PRINTSiPR00167. CACHANNEL.
PR01631. NVDCCALPHA1.
SMARTiSM01062. Ca_chan_IQ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ9PUM6_CHICK
AccessioniPrimary (citable) accession number: Q9PUM6
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: October 5, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.