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Protein
Submitted name:

N-type calcium channel alpha-1B cdB4 variant

Gene

CACHA1B

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Calcium channelUniRule annotation, Ion channel, Voltage-gated channelUniRule annotationSAAS annotation

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Submitted name:
N-type calcium channel alpha-1B cdB4 variantImported
Gene namesi
Name:CACHA1BImported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus

Subcellular locationi

  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei89 – 10618HelicalSequence analysisAdd
BLAST
Transmembranei127 – 14822HelicalSequence analysisAdd
BLAST
Transmembranei160 – 18021HelicalSequence analysisAdd
BLAST
Transmembranei215 – 23723HelicalSequence analysisAdd
BLAST
Transmembranei291 – 31222HelicalSequence analysisAdd
BLAST
Transmembranei324 – 34623HelicalSequence analysisAdd
BLAST
Transmembranei464 – 48421HelicalSequence analysisAdd
BLAST
Transmembranei490 – 50718HelicalSequence analysisAdd
BLAST
Transmembranei589 – 61123HelicalSequence analysisAdd
BLAST
Transmembranei667 – 68923HelicalSequence analysisAdd
BLAST
Transmembranei1133 – 115220HelicalSequence analysisAdd
BLAST
Transmembranei1172 – 119322HelicalSequence analysisAdd
BLAST
Transmembranei1205 – 122319HelicalSequence analysisAdd
BLAST
Transmembranei1266 – 128823HelicalSequence analysisAdd
BLAST
Transmembranei1378 – 140326HelicalSequence analysisAdd
BLAST
Transmembranei1459 – 147719HelicalSequence analysisAdd
BLAST
Transmembranei1489 – 151527HelicalSequence analysisAdd
BLAST
Transmembranei1582 – 160019HelicalSequence analysisAdd
BLAST
Transmembranei1670 – 169425HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ9PUM3.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000013765.

Structurei

3D structure databases

ProteinModelPortaliQ9PUM3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1832 – 186635Ca_chan_IQInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili698 – 72528Sequence analysisAdd
BLAST
Coiled coili985 – 100824Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG2301. Eukaryota.
ENOG410XNP6. LUCA.
HOGENOMiHOG000231530.
HOVERGENiHBG050763.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR031649. GPHH_dom.
IPR005821. Ion_trans_dom.
IPR014873. VDCC_a1su_IQ.
IPR005447. VDCC_N_a1su.
IPR002077. VDCCAlpha1.
[Graphical view]
PANTHERiPTHR10037:SF161. PTHR10037:SF161. 3 hits.
PfamiPF08763. Ca_chan_IQ. 1 hit.
PF16905. GPHH. 1 hit.
PF00520. Ion_trans. 4 hits.
[Graphical view]
PRINTSiPR00167. CACHANNEL.
PR01631. NVDCCALPHA1.
SMARTiSM01062. Ca_chan_IQ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9PUM3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARFGDDLPT RYGGGGPAGA GRGSSRQGGP QAGQRMYKQS MAQRARTMAL
60 70 80 90 100
YNPIPVKQNC FTVNRSLFIF SEDNVIRKYA KRITEWPPFE YMILATIIAN
110 120 130 140 150
CIVLALEQHL PDGDKTPMSE RLDDTEPYFI GIFCFEAGIK IIALGFVFHK
160 170 180 190 200
GSYLRNGWNV MDFVVVLTGI LATAGTDFDL RTLRAVRVLR PLKLVSGIPS
210 220 230 240 250
LQVVLKSIMK AMVPLLQIGL LLFFAIVMFA IIGLEFYMGK FHKTCFSNKT
260 270 280 290 300
GEEVGDFPCG EEPPARQCES GTTCREYWQG PNYGITNFDN ILFAVLTVFQ
310 320 330 340 350
CITMEGWTDI LYNTNDAAGN TWNWLYFIPL IIIGSFFMLN LVLGVLSGEF
360 370 380 390 400
AKERERVENR RAFLKLRRQQ QIERELNGYL EWIFKAEEVM LAEEDKNAEE
410 420 430 440 450
KSPLDMLKRA AIKKSKNDLI HAEEGSPFAR ASLKSGKNES SSYFRRKEKM
460 470 480 490 500
FRFFIRRMVK AQSFYWIVLC VVALNTLCVA MVHYDQPEKL TTALYFAEFV
510 520 530 540 550
FLGLFLTEMS LKMYGLGPRN YFHSSFNYFD FGVIVGSIFE VIWAAVKPGT
560 570 580 590 600
SFGISVLRAL RLLRIFKVTK YWNSLRNLVV SLLNSMKSII SLLFLLFLFI
610 620 630 640 650
VVFALLGMQL FGGQFNFRDE TPTTNFDTFP AAILTVFQIL TGEDWNAVMY
660 670 680 690 700
HGIESQGGVH SGMFSSIYFI VLTLFGNYTL LNVFLAIAVD NLANAQELTK
710 720 730 740 750
DEEEMEEATN QKLALQKAKE VAEVSPMSAA NISIAAKQQN SSKSKSVWEQ
760 770 780 790 800
RTSQIRMHNF RASCEALYNE LDPEERVRYA TTLHIRPDMK THLDRPLVVE
810 820 830 840 850
PRGEGRNNIS KLSPVDVQEV EQTKVSSTDG AEAPRKHHRH RDKEKLGEQE
860 870 880 890 900
KGDVTKDENG ESGINNKEER HRQHRSRSKE VEGGSKEGKS DRSRGQEGGK
910 920 930 940 950
RHHRRGSVEE GVEKEHRRHR THRHSAERQG KEGNGTINGA RSERRTRHRG
960 970 980 990 1000
GSRSGNREGE PGSKGENGEE PHRRHRFRSR ALSTYDSVEK ENREKEGETA
1010 1020 1030 1040 1050
EKEHQNHQPK ENQCEIEASG SVSIPVHTLP STYLQKVPEQ PEDADNQKNV
1060 1070 1080 1090 1100
TRMIQPPLDK TTTVNIPVTI TAPPGETTVI PMNNVEFESK TEEKKDVDDL
1110 1120 1130 1140 1150
TKNGPKPILP YSSMFILSPT NPIRRLFHYI VNLRYFEMVI LIVIALSSIA
1160 1170 1180 1190 1200
LAAEDPVQAE SPRNDALKYL DYIFTGVFTF EMVIKMIDLG LLLHPGSYFR
1210 1220 1230 1240 1250
DLWNILDFIV VSGALVAFAF SGTKGKDINT IKSLRVLRVL RPLKTIKRLP
1260 1270 1280 1290 1300
KLKAVFDCVV NSLKNVLNIL IVYMLFMFIF AVIAVQLFKG RFFYCTDESK
1310 1320 1330 1340 1350
ELEKDCRGQY LDYEKNEVEA QPREWKKYEF HYDNVLWALL TLFTVSTGEG
1360 1370 1380 1390 1400
WPTVLKHSVD ATYEEQGPSP GYRMEMSIFY VVYFVVFPFF FVNIFVALII
1410 1420 1430 1440 1450
ITFQEQGDKV MSECSLEKNE RACIDFAISA KPLTRYMPQN KQSFQYKMWK
1460 1470 1480 1490 1500
FVVSPPFEYF IMVMIALNTI VLMMKFYDAP EAYEEMLKCL NIVFTSMFSM
1510 1520 1530 1540 1550
ECVLKIIAFG VLNYFRDAWN VFDFVTVLGS ITDILVTEIA DTDNFINLSF
1560 1570 1580 1590 1600
LRLFRAARLI KLLRQGYTIR ILLWTFVQSF KALPYVCLLI AMLFFIYAII
1610 1620 1630 1640 1650
GMQVFGNIAL NDETSINRHN NFRTFLQALM LLFRSATGEA WHEIMLSCLS
1660 1670 1680 1690 1700
NRACDPLSGL TKNECGSDFA YFYFVSFIFL CSFLMLNLFV AVIMDNFEYL
1710 1720 1730 1740 1750
TRDSSILGPH HLDEFVRVWA EYDPAACCRI HYKDMYNLLR VIAPPLGLGK
1760 1770 1780 1790 1800
KCPHRVAYKR LVRMNMPISP EDLTVHFTST LMALIRTALE IKLASGGVKQ
1810 1820 1830 1840 1850
HQCDAELRKE ISLVWPNLSQ KTLDLLVPPH KPDEMTVGKV YAALMIFDFY
1860 1870 1880 1890 1900
KQNKSSREQV HQPPGGLCQP GPVSLFHPLK ATLEQTQPSA FSSAKAFLRQ
1910 1920 1930 1940 1950
KSSASLNNGG TLPAPEGGIK ESSSWGTQRT QDVFYETRTP AFERGHSEEI
1960 1970 1980 1990 2000
PIERVVEMRE ISPTLANGEH QPGLESQGRA ASMPRLAAET QRSKARSPGS
2010 2020 2030 2040 2050
YLAPIPDTSP MKRSISTLTP QRPHPMHLYE YSLERVPTDQ VHHHHHHRCH
2060 2070 2080 2090 2100
RRKEKKQKSL DRTTHQLADG EAVAQSGESS SKDKKQERGR SQERKQHSSS
2110 2120 2130 2140
SSEKQRFYSC DRYGSRDRSQ PKSADQSRPT SPNGGPEQGP HRQWFG
Length:2,146
Mass (Da):244,651
Last modified:May 1, 2000 - v1
Checksum:i281BBECAC494AE49
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF173015 mRNA. Translation: AAD51818.1.
UniGeneiGga.4317.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF173015 mRNA. Translation: AAD51818.1.
UniGeneiGga.4317.

3D structure databases

ProteinModelPortaliQ9PUM3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000013765.

Proteomic databases

PaxDbiQ9PUM3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG2301. Eukaryota.
ENOG410XNP6. LUCA.
HOGENOMiHOG000231530.
HOVERGENiHBG050763.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR031649. GPHH_dom.
IPR005821. Ion_trans_dom.
IPR014873. VDCC_a1su_IQ.
IPR005447. VDCC_N_a1su.
IPR002077. VDCCAlpha1.
[Graphical view]
PANTHERiPTHR10037:SF161. PTHR10037:SF161. 3 hits.
PfamiPF08763. Ca_chan_IQ. 1 hit.
PF16905. GPHH. 1 hit.
PF00520. Ion_trans. 4 hits.
[Graphical view]
PRINTSiPR00167. CACHANNEL.
PR01631. NVDCCALPHA1.
SMARTiSM01062. Ca_chan_IQ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and functional expression of novel N-type Ca(2+) channel variants."
    Lu Q., Dunlap K.
    J. Biol. Chem. 274:34566-34575(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Dorsal root ganglion neuronsImported.

Entry informationi

Entry nameiQ9PUM3_CHICK
AccessioniPrimary (citable) accession number: Q9PUM3
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: March 16, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.