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Protein
Submitted name:

Insulin-like growth factor 2

Gene

igf2a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • insulin-like growth factor receptor binding Source: ZFIN

GO - Biological processi

  • notochord development Source: ZFIN
  • somitogenesis Source: ZFIN
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Insulin-like growth factor 2Imported
Gene namesi
Name:igf2aImported
Synonyms:Igf2Imported, igf2Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

ZFINiZDB-GENE-991111-3. igf2a.

Subcellular locationi

  • Secreted UniRule annotationSAAS annotation

GO - Cellular componenti

  • extracellular region Source: ZFIN
  • extracellular space Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

SecretedSAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4040Sequence analysisAdd
BLAST
Chaini41 – 197157Sequence analysisPRO_5004331141Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDbiQ9PUD0.

Interactioni

GO - Molecular functioni

  • insulin-like growth factor receptor binding Source: ZFIN

Protein-protein interaction databases

STRINGi7955.ENSDARP00000016954.

Structurei

3D structure databases

ProteinModelPortaliQ9PUD0.
SMRiQ9PUD0. Positions 42-104.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini42 – 9756IlGFInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the insulin family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IJ2T. Eukaryota.
ENOG4111MIV. LUCA.
HOVERGENiHBG006137.
KOiK13769.
PhylomeDBiQ9PUD0.

Family and domain databases

Gene3Di1.10.100.10. 1 hit.
InterProiIPR022334. IGF2.
IPR013576. IGF2_C.
IPR016179. Insulin-like.
IPR022350. Insulin-like_growth_factor.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamiPF08365. IGF2_C. 1 hit.
PF00049. Insulin. 1 hit.
[Graphical view]
PRINTSiPR02002. INSLNLIKEGF.
PR02006. INSLNLIKEGF2.
PR00276. INSULINFAMLY.
ProDomiPD005188. IGF2_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 1 hit.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9PUD0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDYHVFCAS CRKTEETRTT MRSLIVFVLS LSMLISNVTA GETLCGGELV
60 70 80 90 100
DTLQFVCGED GFYISRPNRS NSRRPQRGIV EECCFRSCEL HLLQQYCAKP
110 120 130 140 150
VKSERDVSST SLQVFPVSQA LHKDTINVKY SKYEVWQQKA AQRLRRGVPS
160 170 180 190
ILLARKFRRQ MEKIQDEEQT SFHRPLMTLP NRQPAIVPHV QISTSRK
Length:197
Mass (Da):22,700
Last modified:May 1, 2000 - v1
Checksum:iCAE67764378FA627
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF194333 mRNA. Translation: AAF07193.1.
RefSeqiNP_571508.1. NM_131433.1.
UniGeneiDr.8145.

Genome annotation databases

GeneIDi30710.
KEGGidre:30710.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF194333 mRNA. Translation: AAF07193.1.
RefSeqiNP_571508.1. NM_131433.1.
UniGeneiDr.8145.

3D structure databases

ProteinModelPortaliQ9PUD0.
SMRiQ9PUD0. Positions 42-104.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000016954.

Proteomic databases

PaxDbiQ9PUD0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi30710.
KEGGidre:30710.

Organism-specific databases

CTDi30710.
ZFINiZDB-GENE-991111-3. igf2a.

Phylogenomic databases

eggNOGiENOG410IJ2T. Eukaryota.
ENOG4111MIV. LUCA.
HOVERGENiHBG006137.
KOiK13769.
PhylomeDBiQ9PUD0.

Family and domain databases

Gene3Di1.10.100.10. 1 hit.
InterProiIPR022334. IGF2.
IPR013576. IGF2_C.
IPR016179. Insulin-like.
IPR022350. Insulin-like_growth_factor.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamiPF08365. IGF2_C. 1 hit.
PF00049. Insulin. 1 hit.
[Graphical view]
PRINTSiPR02002. INSLNLIKEGF.
PR02006. INSLNLIKEGF2.
PR00276. INSULINFAMLY.
ProDomiPD005188. IGF2_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 1 hit.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Characterization of zebrafish Igf2 and Peg1/Mest genes."
    Yang S.K., Hahn Y., Chung J.H.
    Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ9PUD0_DANRE
AccessioniPrimary (citable) accession number: Q9PUD0
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: June 8, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.