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Protein
Submitted name:

Fli-1 protein

Gene

fli1a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • angiogenesis Source: ZFIN
  • blood vessel morphogenesis Source: ZFIN
  • cell differentiation Source: GO_Central
  • positive regulation of sequence-specific DNA binding transcription factor activity Source: ZFIN
  • regulation of transcription from RNA polymerase II promoter Source: GO_Central

Keywordsi

Molecular functionDNA-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Fli-1 proteinImported
Submitted name:
Fli-1 proto-oncogene, ETS transcription factor aImported
Submitted name:
Friend leukemia integration 1Imported
Submitted name:
Friend leukemia integration 1aImported
Gene namesi
Name:fli1aImported
Synonyms:fli-1Imported, fli1Imported
ORF Names:CH211-241L24.8-001Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 18

Organism-specific databases

ZFINiZDB-GENE-980526-426. fli1a.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

Expressioni

Gene expression databases

BgeeiENSDARG00000054632.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000071331.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini111 – 197PNTInterPro annotationAdd BLAST87
Domaini280 – 360ETSInterPro annotationAdd BLAST81

Sequence similaritiesi

Belongs to the ETS family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3806. Eukaryota.
ENOG410Z0ZF. LUCA.
GeneTreeiENSGT00760000118907.
HOGENOMiHOG000290658.
HOVERGENiHBG001553.
KOiK09436.
OMAiNPDYGQP.
OrthoDBiEOG091G0EWP.
TreeFamiTF350537.

Family and domain databases

CDDicd08541. SAM_PNT-FLI-1. 1 hit.
Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR000418. Ets_dom.
IPR035575. Fli-1.
IPR003118. Pointed_dom.
IPR013761. SAM/pointed.
IPR035573. SAM_PNT-FLI-1.
IPR036388. WH-like_DNA-bd_sf.
IPR036390. WH_DNA-bd_sf.
PANTHERiPTHR11849:SF161. PTHR11849:SF161. 1 hit.
PfamiView protein in Pfam
PF00178. Ets. 1 hit.
PF02198. SAM_PNT. 1 hit.
PRINTSiPR00454. ETSDOMAIN.
SMARTiView protein in SMART
SM00413. ETS. 1 hit.
SM00251. SAM_PNT. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF47769. SSF47769. 1 hit.
PROSITEiView protein in PROSITE
PS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
PS51433. PNT. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9PU61-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGTIKEALS VVSEDQSLFE PPYAAAAPLP KTDMTASGTQ DYGQTHKINP
60 70 80 90 100
IPPQQEWINQ PVRVNVKREY DHINGSRESP VDCSVGKCNK MVGGTEASQM
110 120 130 140 150
NYTGYMDEKC APPPNMTTNE RRVIVPADPS LWSPDHVRQW LDWAIKEYGL
160 170 180 190 200
QEIDTAMFHS TDGKELCKMS KDDFLRLTSV YNTEVLLSHL NYLRESSSSI
210 220 230 240 250
SYNTPSHADQ SPRLAAKDDA SYDAVRRTGW SNNMHSGKGS PTVVSQSVSK
260 270 280 290 300
NPDQPRPQPD PYQILGPTSS RLANPGSGQI QLWQFLLELL SDSANAGCIT
310 320 330 340 350
WEGTNGEFKM TDPDEVARRW GERKSKPNMN YDKLSRALRY YYDKNIMTKV
360 370 380 390 400
HGKRYAYKFD FHGIAQALQP HPTESTMYKY PSELPYVPSY HAHQQKVNFV
410 420 430 440 450
SPHPPSMPVT SSNFFGPTTP YWSSPPGGIY PNPSVPRHAN SHVPSHLGSY

Y
Length:451
Mass (Da):50,656
Last modified:May 1, 2000 - v1
Checksum:iF437D55D08E3549A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR786562 Genomic DNA. No translation available.
BC066571 mRNA. Translation: AAH66571.1.
AJ249590 mRNA. Translation: CAB56832.1.
BX927076 Genomic DNA. Translation: CAK04698.1.
RefSeqiNP_571423.1. NM_131348.2.
UniGeneiDr.78408.

Genome annotation databases

EnsembliENSDART00000076861; ENSDARP00000071331; ENSDARG00000054632.
GeneIDi30619.
KEGGidre:30619.

Similar proteinsi

Entry informationi

Entry nameiQ9PU61_DANRE
AccessioniPrimary (citable) accession number: Q9PU61
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: October 25, 2017
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported