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Q9PU45

- RADI_CHICK

UniProt

Q9PU45 - RADI_CHICK

Protein

Radixin

Gene

RDX

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei278 – 2781PhosphatidylinositolBy similarity

    GO - Biological processi

    1. actin filament capping Source: UniProtKB-KW

    Keywords - Molecular functioni

    Actin capping

    Keywords - Ligandi

    Actin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Radixin
    Gene namesi
    Name:RDX
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    Cell membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity. Cytoplasmcytoskeleton By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-KW
    2. cytoskeleton Source: UniProtKB-SubCell
    3. extrinsic component of membrane Source: InterPro
    4. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Cytoskeleton, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 583583RadixinPRO_0000219424Add
    BLAST

    Proteomic databases

    PaxDbiQ9PU45.
    PRIDEiQ9PU45.

    Interactioni

    Protein-protein interaction databases

    IntActiQ9PU45. 1 interaction.
    STRINGi9031.ENSGALP00000021028.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9PU45.
    SMRiQ9PU45. Positions 1-444, 494-583.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini5 – 295291FERMPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni60 – 634Phosphatidylinositol bindingBy similarity

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi311 – 522212Glu-richAdd
    BLAST
    Compositional biasi470 – 4778Poly-Pro

    Sequence similaritiesi

    Contains 1 FERM domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG236035.
    HOGENOMiHOG000007113.
    HOVERGENiHBG002185.
    InParanoidiQ9PU45.
    KOiK05762.
    PhylomeDBiQ9PU45.

    Family and domain databases

    Gene3Di1.20.80.10. 1 hit.
    2.30.29.30. 1 hit.
    InterProiIPR019749. Band_41_domain.
    IPR019750. Band_41_fam.
    IPR011174. ERM.
    IPR011259. ERM_C_dom.
    IPR000798. Ez/rad/moesin_like.
    IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
    IPR019748. FERM_central.
    IPR019747. FERM_CS.
    IPR000299. FERM_domain.
    IPR018979. FERM_N.
    IPR018980. FERM_PH-like_C.
    IPR008954. Moesin_tail.
    IPR011993. PH_like_dom.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view]
    PfamiPF00769. ERM. 1 hit.
    PF09380. FERM_C. 1 hit.
    PF00373. FERM_M. 1 hit.
    PF09379. FERM_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002305. ERM. 1 hit.
    PRINTSiPR00935. BAND41.
    PR00661. ERMFAMILY.
    SMARTiSM00295. B41. 1 hit.
    [Graphical view]
    SUPFAMiSSF47031. SSF47031. 1 hit.
    SSF48678. SSF48678. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEiPS00660. FERM_1. 1 hit.
    PS00661. FERM_2. 1 hit.
    PS50057. FERM_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9PU45-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPKPINVRVT TMDAELEFAI QPNTTGKQLF DQVVKTVGLR EVWFFGLQYV    50
    DSKGYSTWLK LNKKVTQQDV RKENPLQFKF RAKFFPEDVS EELIQEITQR 100
    LFFLQVKEAI LNDEIYCPPE TAVLLASYAV QSKYGDYNKE IHKLGYLAND 150
    RLLPQRVLEQ HKLTKEQWEE RIQNWHEEHR GMLREDSMME YLKIAQDLEM 200
    YGVNYFEIKN KKGTELWLGV DALGLNIYEH DDKLTPKIGF PWSEIRNISF 250
    NDKKFVIKPI DKKAPDFVFY APRLRINKRI LALCMGNHEL YMRRRKPDTI 300
    EVQQMKAQAR EEKHQKQLER AQLENEKKKR EIAEKEKERI EREKEELMER 350
    LRQIEEQTMK AQKELEEQTR RALELDQERK RAKEEAERLE KERRAAEEAK 400
    AALAKQAADQ MKNQEQLAAE LAEFTAKIAL LEEAKKKKEE EASEWQHKAF 450
    AAQEDLEKTK EELKSVMSAP PPPPPPPVIP PTENEHDEHD ENNAEASAEL 500
    SSDGVMNHRS EEERVTETQK NERVKKQLQA LSSELAQARD ETKKTQNDVL 550
    HAENVKAGRG KYKTLRQIRQ GNTKQRIDEF EAM 583
    Length:583
    Mass (Da):68,555
    Last modified:May 1, 2000 - v1
    Checksum:iBE25634F4798CBE0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ249838 mRNA. Translation: CAB59977.1.
    RefSeqiNP_990082.1. NM_204751.1.
    UniGeneiGga.4745.

    Genome annotation databases

    GeneIDi395511.
    KEGGigga:395511.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ249838 mRNA. Translation: CAB59977.1 .
    RefSeqi NP_990082.1. NM_204751.1.
    UniGenei Gga.4745.

    3D structure databases

    ProteinModelPortali Q9PU45.
    SMRi Q9PU45. Positions 1-444, 494-583.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9PU45. 1 interaction.
    STRINGi 9031.ENSGALP00000021028.

    Proteomic databases

    PaxDbi Q9PU45.
    PRIDEi Q9PU45.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 395511.
    KEGGi gga:395511.

    Organism-specific databases

    CTDi 5962.

    Phylogenomic databases

    eggNOGi NOG236035.
    HOGENOMi HOG000007113.
    HOVERGENi HBG002185.
    InParanoidi Q9PU45.
    KOi K05762.
    PhylomeDBi Q9PU45.

    Miscellaneous databases

    NextBioi 20815590.
    PROi Q9PU45.

    Family and domain databases

    Gene3Di 1.20.80.10. 1 hit.
    2.30.29.30. 1 hit.
    InterProi IPR019749. Band_41_domain.
    IPR019750. Band_41_fam.
    IPR011174. ERM.
    IPR011259. ERM_C_dom.
    IPR000798. Ez/rad/moesin_like.
    IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
    IPR019748. FERM_central.
    IPR019747. FERM_CS.
    IPR000299. FERM_domain.
    IPR018979. FERM_N.
    IPR018980. FERM_PH-like_C.
    IPR008954. Moesin_tail.
    IPR011993. PH_like_dom.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view ]
    Pfami PF00769. ERM. 1 hit.
    PF09380. FERM_C. 1 hit.
    PF00373. FERM_M. 1 hit.
    PF09379. FERM_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002305. ERM. 1 hit.
    PRINTSi PR00935. BAND41.
    PR00661. ERMFAMILY.
    SMARTi SM00295. B41. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47031. SSF47031. 1 hit.
    SSF48678. SSF48678. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEi PS00660. FERM_1. 1 hit.
    PS00661. FERM_2. 1 hit.
    PS50057. FERM_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression profile of chicken radixin."
      Li W., Crouch D.H.
      Biochim. Biophys. Acta 1491:327-332(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiRADI_CHICK
    AccessioniPrimary (citable) accession number: Q9PU45
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2003
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3