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Q9PU45 (RADI_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein attributes

Sequence length583 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane By similarity.

Subcellular location

Cell membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Cytoplasmcytoskeleton By similarity.

Sequence similarities

Contains 1 FERM domain.

Ontologies

Keywords
   Cellular componentCell membrane
Cytoplasm
Cytoskeleton
Membrane
   LigandActin-binding
   Molecular functionActin capping
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processactin filament capping

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-KW

cytoskeleton

Inferred from electronic annotation. Source: UniProtKB-SubCell

extrinsic component of membrane

Inferred from electronic annotation. Source: InterPro

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 583583Radixin
PRO_0000219424

Regions

Domain5 – 295291FERM
Region60 – 634Phosphatidylinositol binding By similarity
Compositional bias311 – 522212Glu-rich
Compositional bias470 – 4778Poly-Pro

Sites

Binding site2781Phosphatidylinositol By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9PU45 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: BE25634F4798CBE0

FASTA58368,555
        10         20         30         40         50         60 
MPKPINVRVT TMDAELEFAI QPNTTGKQLF DQVVKTVGLR EVWFFGLQYV DSKGYSTWLK 

        70         80         90        100        110        120 
LNKKVTQQDV RKENPLQFKF RAKFFPEDVS EELIQEITQR LFFLQVKEAI LNDEIYCPPE 

       130        140        150        160        170        180 
TAVLLASYAV QSKYGDYNKE IHKLGYLAND RLLPQRVLEQ HKLTKEQWEE RIQNWHEEHR 

       190        200        210        220        230        240 
GMLREDSMME YLKIAQDLEM YGVNYFEIKN KKGTELWLGV DALGLNIYEH DDKLTPKIGF 

       250        260        270        280        290        300 
PWSEIRNISF NDKKFVIKPI DKKAPDFVFY APRLRINKRI LALCMGNHEL YMRRRKPDTI 

       310        320        330        340        350        360 
EVQQMKAQAR EEKHQKQLER AQLENEKKKR EIAEKEKERI EREKEELMER LRQIEEQTMK 

       370        380        390        400        410        420 
AQKELEEQTR RALELDQERK RAKEEAERLE KERRAAEEAK AALAKQAADQ MKNQEQLAAE 

       430        440        450        460        470        480 
LAEFTAKIAL LEEAKKKKEE EASEWQHKAF AAQEDLEKTK EELKSVMSAP PPPPPPPVIP 

       490        500        510        520        530        540 
PTENEHDEHD ENNAEASAEL SSDGVMNHRS EEERVTETQK NERVKKQLQA LSSELAQARD 

       550        560        570        580 
ETKKTQNDVL HAENVKAGRG KYKTLRQIRQ GNTKQRIDEF EAM 

« Hide

References

[1]"Cloning and expression profile of chicken radixin."
Li W., Crouch D.H.
Biochim. Biophys. Acta 1491:327-332(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ249838 mRNA. Translation: CAB59977.1.
RefSeqNP_990082.1. NM_204751.1.
UniGeneGga.4745.

3D structure databases

ProteinModelPortalQ9PU45.
SMRQ9PU45. Positions 1-444, 494-583.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9PU45. 1 interaction.
STRING9031.ENSGALP00000021028.

Proteomic databases

PaxDbQ9PU45.
PRIDEQ9PU45.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID395511.
KEGGgga:395511.

Organism-specific databases

CTD5962.

Phylogenomic databases

eggNOGNOG236035.
HOGENOMHOG000007113.
HOVERGENHBG002185.
InParanoidQ9PU45.
KOK05762.
PhylomeDBQ9PU45.

Family and domain databases

Gene3D1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
InterProIPR019749. Band_41_domain.
IPR019750. Band_41_fam.
IPR011174. ERM.
IPR011259. ERM_C_dom.
IPR000798. Ez/rad/moesin_like.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR008954. Moesin_tail.
IPR011993. PH_like_dom.
[Graphical view]
PfamPF00769. ERM. 1 hit.
PF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
[Graphical view]
PIRSFPIRSF002305. ERM. 1 hit.
PRINTSPR00935. BAND41.
PR00661. ERMFAMILY.
SMARTSM00295. B41. 1 hit.
[Graphical view]
SUPFAMSSF47031. SSF47031. 1 hit.
SSF48678. SSF48678. 1 hit.
PROSITEPS00660. FERM_1. 1 hit.
PS00661. FERM_2. 1 hit.
PS50057. FERM_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20815590.
PROQ9PU45.

Entry information

Entry nameRADI_CHICK
AccessionPrimary (citable) accession number: Q9PU45
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2003
Last sequence update: May 1, 2000
Last modified: April 16, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families