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Q9PU45

- RADI_CHICK

UniProt

Q9PU45 - RADI_CHICK

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Protein

Radixin

Gene
RDX
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei278 – 2781Phosphatidylinositol By similarity

GO - Biological processi

  1. actin filament capping Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Actin capping

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Radixin
Gene namesi
Name:RDX
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. cytoskeleton Source: UniProtKB-SubCell
  3. extrinsic component of membrane Source: InterPro
  4. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 583583RadixinPRO_0000219424Add
BLAST

Proteomic databases

PaxDbiQ9PU45.
PRIDEiQ9PU45.

Interactioni

Protein-protein interaction databases

IntActiQ9PU45. 1 interaction.
STRINGi9031.ENSGALP00000021028.

Structurei

3D structure databases

ProteinModelPortaliQ9PU45.
SMRiQ9PU45. Positions 1-444, 494-583.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 295291FERMAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni60 – 634Phosphatidylinositol binding By similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi311 – 522212Glu-richAdd
BLAST
Compositional biasi470 – 4778Poly-Pro

Sequence similaritiesi

Contains 1 FERM domain.

Phylogenomic databases

eggNOGiNOG236035.
HOGENOMiHOG000007113.
HOVERGENiHBG002185.
InParanoidiQ9PU45.
KOiK05762.
PhylomeDBiQ9PU45.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR019750. Band_41_fam.
IPR011174. ERM.
IPR011259. ERM_C_dom.
IPR000798. Ez/rad/moesin_like.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR008954. Moesin_tail.
IPR011993. PH_like_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF00769. ERM. 1 hit.
PF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
[Graphical view]
PIRSFiPIRSF002305. ERM. 1 hit.
PRINTSiPR00935. BAND41.
PR00661. ERMFAMILY.
SMARTiSM00295. B41. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF48678. SSF48678. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS00660. FERM_1. 1 hit.
PS00661. FERM_2. 1 hit.
PS50057. FERM_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9PU45-1 [UniParc]FASTAAdd to Basket

« Hide

MPKPINVRVT TMDAELEFAI QPNTTGKQLF DQVVKTVGLR EVWFFGLQYV    50
DSKGYSTWLK LNKKVTQQDV RKENPLQFKF RAKFFPEDVS EELIQEITQR 100
LFFLQVKEAI LNDEIYCPPE TAVLLASYAV QSKYGDYNKE IHKLGYLAND 150
RLLPQRVLEQ HKLTKEQWEE RIQNWHEEHR GMLREDSMME YLKIAQDLEM 200
YGVNYFEIKN KKGTELWLGV DALGLNIYEH DDKLTPKIGF PWSEIRNISF 250
NDKKFVIKPI DKKAPDFVFY APRLRINKRI LALCMGNHEL YMRRRKPDTI 300
EVQQMKAQAR EEKHQKQLER AQLENEKKKR EIAEKEKERI EREKEELMER 350
LRQIEEQTMK AQKELEEQTR RALELDQERK RAKEEAERLE KERRAAEEAK 400
AALAKQAADQ MKNQEQLAAE LAEFTAKIAL LEEAKKKKEE EASEWQHKAF 450
AAQEDLEKTK EELKSVMSAP PPPPPPPVIP PTENEHDEHD ENNAEASAEL 500
SSDGVMNHRS EEERVTETQK NERVKKQLQA LSSELAQARD ETKKTQNDVL 550
HAENVKAGRG KYKTLRQIRQ GNTKQRIDEF EAM 583
Length:583
Mass (Da):68,555
Last modified:May 1, 2000 - v1
Checksum:iBE25634F4798CBE0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ249838 mRNA. Translation: CAB59977.1.
RefSeqiNP_990082.1. NM_204751.1.
UniGeneiGga.4745.

Genome annotation databases

GeneIDi395511.
KEGGigga:395511.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ249838 mRNA. Translation: CAB59977.1 .
RefSeqi NP_990082.1. NM_204751.1.
UniGenei Gga.4745.

3D structure databases

ProteinModelPortali Q9PU45.
SMRi Q9PU45. Positions 1-444, 494-583.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9PU45. 1 interaction.
STRINGi 9031.ENSGALP00000021028.

Proteomic databases

PaxDbi Q9PU45.
PRIDEi Q9PU45.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 395511.
KEGGi gga:395511.

Organism-specific databases

CTDi 5962.

Phylogenomic databases

eggNOGi NOG236035.
HOGENOMi HOG000007113.
HOVERGENi HBG002185.
InParanoidi Q9PU45.
KOi K05762.
PhylomeDBi Q9PU45.

Miscellaneous databases

NextBioi 20815590.
PROi Q9PU45.

Family and domain databases

Gene3Di 1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
InterProi IPR019749. Band_41_domain.
IPR019750. Band_41_fam.
IPR011174. ERM.
IPR011259. ERM_C_dom.
IPR000798. Ez/rad/moesin_like.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR008954. Moesin_tail.
IPR011993. PH_like_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view ]
Pfami PF00769. ERM. 1 hit.
PF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF002305. ERM. 1 hit.
PRINTSi PR00935. BAND41.
PR00661. ERMFAMILY.
SMARTi SM00295. B41. 1 hit.
[Graphical view ]
SUPFAMi SSF47031. SSF47031. 1 hit.
SSF48678. SSF48678. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEi PS00660. FERM_1. 1 hit.
PS00661. FERM_2. 1 hit.
PS50057. FERM_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and expression profile of chicken radixin."
    Li W., Crouch D.H.
    Biochim. Biophys. Acta 1491:327-332(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiRADI_CHICK
AccessioniPrimary (citable) accession number: Q9PU45
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2003
Last sequence update: May 1, 2000
Last modified: June 11, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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