Q9PU45 (RADI_CHICK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Radixin

Gene names

Name:

RDX

Organism

Gallus gallus (Chicken) [Reference proteome]

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Sauropsida › Sauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	583 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane By similarity.
Subcellular location	Cell membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Cytoplasm › cytoskeleton By similarity.
Sequence similarities	Contains 1 FERM domain.

Ontologies

Keywords
Cellular component	Cell membrane Cytoplasm Cytoskeleton Membrane
Ligand	Actin-binding
Molecular function	Actin capping
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	actin filament capping Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell extrinsic to membrane Inferred from electronic annotation. Source: InterPro plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 583	583	Radixin		PRO_0000219424
Regions
	Domain	5 – 295	291	FERM
	Region	60 – 63	4	Phosphatidylinositol binding By similarity
	Compositional bias	311 – 522	212	Glu-rich
	Compositional bias	470 – 477	8	Poly-Pro
Sites
	Binding site	278	1	Phosphatidylinositol By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9PU45 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: BE25634F4798CBE0	FASTA	583	68,555
	10 20 30 40 50 60 MPKPINVRVT TMDAELEFAI QPNTTGKQLF DQVVKTVGLR EVWFFGLQYV DSKGYSTWLK 70 80 90 100 110 120 LNKKVTQQDV RKENPLQFKF RAKFFPEDVS EELIQEITQR LFFLQVKEAI LNDEIYCPPE 130 140 150 160 170 180 TAVLLASYAV QSKYGDYNKE IHKLGYLAND RLLPQRVLEQ HKLTKEQWEE RIQNWHEEHR 190 200 210 220 230 240 GMLREDSMME YLKIAQDLEM YGVNYFEIKN KKGTELWLGV DALGLNIYEH DDKLTPKIGF 250 260 270 280 290 300 PWSEIRNISF NDKKFVIKPI DKKAPDFVFY APRLRINKRI LALCMGNHEL YMRRRKPDTI 310 320 330 340 350 360 EVQQMKAQAR EEKHQKQLER AQLENEKKKR EIAEKEKERI EREKEELMER LRQIEEQTMK 370 380 390 400 410 420 AQKELEEQTR RALELDQERK RAKEEAERLE KERRAAEEAK AALAKQAADQ MKNQEQLAAE 430 440 450 460 470 480 LAEFTAKIAL LEEAKKKKEE EASEWQHKAF AAQEDLEKTK EELKSVMSAP PPPPPPPVIP 490 500 510 520 530 540 PTENEHDEHD ENNAEASAEL SSDGVMNHRS EEERVTETQK NERVKKQLQA LSSELAQARD 550 560 570 580 ETKKTQNDVL HAENVKAGRG KYKTLRQIRQ GNTKQRIDEF EAM

References

[1]	"Cloning and expression profile of chicken radixin." Li W., Crouch D.H. Biochim. Biophys. Acta 1491:327-332(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ249838 mRNA. Translation: CAB59977.1.
IPI	IPI00579612.
RefSeq	NP_990082.1. NM_204751.1.
UniGene	Gga.4745.
3D structure databases
ProteinModelPortal	Q9PU45.
SMR	Q9PU45. Positions 1-444, 494-583.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9PU45. 1 interaction.
STRING	9031.ENSGALP00000021028.
Proteomic databases
PaxDb	Q9PU45.
PRIDE	Q9PU45.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	395511.
KEGG	gga:395511.
Organism-specific databases
CTD	5962.
Phylogenomic databases
eggNOG	NOG236035.
HOGENOM	HOG000007113.
HOVERGEN	HBG002185.
InParanoid	Q9PU45.
KO	K05762.
Family and domain databases
Gene3D	1.20.80.10. 1 hit. 2.30.29.30. 1 hit.
InterPro	IPR019749. Band_41_domain. IPR019750. Band_41_fam. IPR011174. ERM. IPR011259. ERM_C_dom. IPR000798. Ez/rad/moesin_like. IPR014352. FERM/acyl-CoA-bd_prot_3-hlx. IPR019748. FERM_central. IPR019747. FERM_CS. IPR000299. FERM_domain. IPR018979. FERM_N. IPR018980. FERM_PH-like_C. IPR008954. Moesin. IPR011993. PH_like_dom. [Graphical view]
Pfam	PF00769. ERM. 1 hit. PF09380. FERM_C. 1 hit. PF00373. FERM_M. 1 hit. PF09379. FERM_N. 1 hit. [Graphical view]
PIRSF	PIRSF002305. ERM. 1 hit.
PRINTS	PR00935. BAND41. PR00661. ERMFAMILY.
SMART	SM00295. B41. 1 hit. [Graphical view]
SUPFAM	SSF47031. FERM_3-hlx. 1 hit. SSF48678. Moesin. 1 hit.
PROSITE	PS00660. FERM_1. 1 hit. PS00661. FERM_2. 1 hit. PS50057. FERM_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20815590.

Entry information

Entry name

RADI_CHICK

Accession

Primary (citable) accession number: Q9PU45

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2003
Last sequence update:	May 1, 2000
Last modified:	May 1, 2013
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program